Invokamet® Tablets for Type 2 Diabetes

Invokamet® is a prescription tablet for adults with type 2 diabetes. It combines canagliflozin and metformin to help lower blood sugar alongside diet and exercise. Ships from Canada to US and suitable for those paying without insurance.

What Invokamet Is and How It Works

This medicine combines two agents that target different pathways. Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, which helps the kidneys remove excess glucose through urine. Metformin is a biguanide that reduces liver glucose production and improves insulin sensitivity. Together, the treatment can support A1C reduction when used with a nutrition and activity plan.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

Invokamet® is not for people with type 1 diabetes or diabetic ketoacidosis. It should be used as part of a broader care plan for Type 2 Diabetes that includes regular monitoring and follow-up. You can review background science on metformin’s actions here: Metformin Mechanism.

Who It’s For

This medicine is indicated to improve glycemic control in adults with type 2 diabetes, when diet and exercise alone are not enough. It may be used in patients starting combination therapy or those already taking components separately.

People with severe kidney disease, metabolic acidosis, or a history of serious lactic acidosis should avoid this therapy. If you need extended-release therapy, your prescriber may consider Invokamet XR for once-daily dosing.

Dosage and Usage

Dosing is individualized based on current regimen, clinical response, and tolerance. For immediate-release tablets, dosing is typically twice daily with meals to help reduce stomach upset. Swallow tablets whole with water. Do not crush or chew.

Your prescriber adjusts the components to match your needs. Follow the exact directions on your prescription label. If you move from the individual drugs to the combination, the total daily amounts are usually matched to your prior therapy.

Defer to the official prescribing information for full dosing details, including renal function considerations and maximum daily doses. Your care team may reassess dosing after lab monitoring or changes in other medications.

Strengths and Forms

Tablets are supplied in strengths that pair canagliflozin with metformin. Common immediate-release presentations include:

• 50 mg/500 mg
• 50 mg/1000 mg
• 150 mg/500 mg
• 150 mg/1000 mg

Extended-release metformin is available in a related once-daily option, referenced as Invokamet XR. Availability may vary by pharmacy and region.

For those comparing options, you can browse other combination medicines within our Combination Tablets category. You can also explore broader Diabetes Medications to understand class differences with your clinician.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is almost time for your next dose. If it is close to the next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once.

Try to take doses with meals at consistent times. Setting reminders can help support steady adherence.

Storage and Travel Basics

Store tablets at room temperature in the original container and keep the bottle tightly closed. Protect from excessive heat and moisture. Keep out of reach of children and pets.

When you travel, carry your medicine in your hand luggage. Bring a copy of your prescription and any necessary documentation. Use a pill organizer if helpful, but retain original labels for security checks.

Benefits

This combination targets both renal glucose reabsorption and hepatic glucose output. The dual approach may improve fasting and post-meal glucose values when used with lifestyle measures. Twice-daily dosing with meals can fit common routines for many adults.

Using a single co-formulated tablet may reduce pill burden compared to taking two separate medicines. This can simplify daily schedules and may aid adherence.

Side Effects and Safety

• Gastrointestinal upset, such as diarrhea or nausea
• Genital yeast infections and urinary tract infections
• Increased urination and possible thirst
• Dizziness or lightheadedness from volume depletion
• Headache or mild fatigue

Serious but uncommon risks include lactic acidosis (a medical emergency), ketoacidosis, severe urinary or genital infections including rare perineal infections, acute kidney injury, and rare bone fractures. Lower limb amputation risk has been observed with the SGLT2 component in some settings; review your vascular history. Hypoglycemia can occur when used with insulin or sulfonylureas.

Seek urgent medical attention for severe abdominal pain, rapid breathing, confusion, or persistent vomiting. Discuss personal risk factors such as renal function, dehydration, surgical procedures, and alcohol intake with your clinician.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you use. Diuretics, ACE inhibitors, and ARBs may increase the risk of dehydration or changes in kidney function. Strong enzyme inducers like rifampin, carbamazepine, and phenytoin may reduce SGLT2 exposure. Carbonic anhydrase inhibitors and excessive alcohol can raise lactic acidosis risk.

Iodinated contrast procedures may require temporary interruption of metformin-containing therapy in some patients; follow your care team’s guidance. Digoxin levels may increase with canagliflozin. Cimetidine and other agents can affect metformin clearance.

What to Expect Over Time

With regular use and adherence to diet and activity plans, many patients see improved glucose readings during daily monitoring. A1C is typically reassessed at routine intervals. Your prescriber may adjust your regimen based on labs, tolerability, and goals.

Staying hydrated, taking doses with meals, and reporting new symptoms early can help support safe, steady use. Keep a log of blood glucose, notable side effects, and any changes in other medicines.

Compare With Alternatives

Other approved combinations pair different classes with metformin. An SGLT2 plus metformin option is Synjardy, while a DPP-4 plus metformin option is Janumet XR. Discuss how class differences fit your goals, kidney function, and preference for immediate-release or extended-release metformin.

For deeper background on metformin formulations, see this overview: Metformin vs ER.

Pricing and Access

We display Invokamet price clearly on the product page. You can also look for an Invokamet coupon when available. If you are comparison-shopping, remember that US delivery from Canada helps many patients access Canadian pricing.

Ordering through CanadianInsulin includes encrypted checkout and support from licensed pharmacies. If you are searching for seasonal offers, visit our Promotions page for current platform-wide notices.

Availability and Substitutions

Stock can vary by strength and form. If a selected tablet is unavailable, your prescriber may recommend a comparable alternative or adjust the component doses separately. We list Invokamet price Canada to support transparent decisions.

Your care team decides whether to continue, substitute, or separate components based on your response and lab results.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults who need combination therapy and can take tablets with meals. It may not be appropriate for people with advanced kidney disease, a history of lactic acidosis, or frequent genital infections. Review your surgical plans and hydration status before starting.

To manage expenses, consider multi-month fills if appropriate. Set refill reminders to avoid gaps. You can Order Invokamet online through CanadianInsulin after your prescription is verified. If you change insurance or prescribers, keep an updated medication list to streamline renewals.

Questions to Ask Your Clinician

• Is this combination appropriate for my kidney function?
• How should I monitor glucose and labs while on this therapy?
• What signs of lactic acidosis or ketoacidosis should I watch for?
• Could dehydration or diuretics increase my risks?
• Should I pause this medicine for surgery or contrast scans?
• Would an extended-release option fit my routine better?

Authoritative Sources

Review official details before starting therapy. See the manufacturer’s information, the FDA label, or Health Canada’s monograph for comprehensive safety data and administration instructions.

• FDA Prescribing Information for canagliflozin and metformin
• Health Canada Drug Product Database entry
• Metformin Mechanism reference article

Ready to proceed? Buy Invokamet with prompt, express, temperature-controlled handling when required.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.