Edarbyclor® Tablets for High Blood Pressure

Edarbyclor® is a combination prescription tablet for adults with high blood pressure. It pairs an angiotensin II receptor blocker with a thiazide-like diuretic to help lower blood pressure when one medicine is not enough. This page explains how it works, who it suits, dosing basics, and how to order from Canada with US delivery.

CanadianInsulin is a prescription referral service. We verify your prescription with your clinic, and licensed Canadian pharmacies dispense your order.

What Edarbyclor® Is and How It Works

Edarbyclor® combines azilsartan medoxomil and chlorthalidone in a once-daily tablet. Azilsartan blocks angiotensin II type 1 receptors, relaxing blood vessels and reducing aldosterone effects. Chlorthalidone increases sodium and water excretion by the kidneys, which lowers plasma volume and helps reduce blood pressure.

The two components work through complementary pathways. Together, they provide a stronger blood pressure reduction than either component alone. Ordering online from Canada with US shipping helps many patients access Canadian pricing through a simple referral process.

Who Edarbyclor® Is For

Edarbyclor is indicated for adults with hypertension when monotherapy does not adequately control blood pressure. It can be used as initial therapy in patients who are likely to need multiple agents, or as a next step when current treatment is not sufficient. For condition-related browsing, see the High Blood Pressure category.

Do not use during pregnancy. Medicines that act on the renin–angiotensin system can cause injury and even death to the developing fetus. Avoid in patients with anuria, a history of hypersensitivity to chlorthalidone or sulfonamide-derived diuretics, or known hypersensitivity to any component.

Use caution in patients with severe renal impairment, bilateral renal artery stenosis, volume depletion, or severe hepatic impairment. Chlorthalidone may increase uric acid and precipitate gout, alter electrolytes, and affect glucose tolerance. Review risks in people with gout, diabetes, or electrolyte imbalances.

Dosage and Usage

Follow your prescriber’s directions. Typical label-based approaches include:

• Starting dose: 40 mg azilsartan medoxomil with 12.5 mg chlorthalidone once daily.
• Titration: Increase after assessing response, often at intervals of about 2 to 4 weeks.
• Typical titration steps: 40/25 mg, 80/12.5 mg, and up to 80/25 mg once daily as needed and tolerated.
• Maximum recommended dose: 80 mg azilsartan medoxomil with 25 mg chlorthalidone once daily.

Edarbyclor may be taken with or without food. If switching from individual components, your prescriber may select the nearest equivalent combination strength. When uncertain, defer to the official label and your clinician’s guidance.

Strengths and Forms

Film‑coated tablets in the following commonly available strengths:

• 40 mg azilsartan medoxomil / 12.5 mg chlorthalidone
• 40 mg azilsartan medoxomil / 25 mg chlorthalidone
• 80 mg azilsartan medoxomil / 12.5 mg chlorthalidone
• 80 mg azilsartan medoxomil / 25 mg chlorthalidone

Availability may vary by pharmacy and region. Tablet color and imprint differ by strength.

Missed Dose and Timing

Take the missed dose the same day you remember. If it is close to the next dose, skip the missed dose and resume your regular schedule. Do not double up to make up a missed dose. Aim for consistent daily timing to support steady blood pressure control.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep in the original container with the label intact. Protect from excess moisture and heat. When traveling, carry your medicine in your hand luggage, keep the labeled container with you, and pack a small buffer supply if your prescriber permits. Use original packaging for security screening and easy identification.

Benefits

• Two proven mechanisms in a single once-daily tablet.
• Helps lower blood pressure when one agent is insufficient.
• Simplifies therapy compared to taking two separate medicines.
• Flexible strengths allow step-up titration to a target regimen.
• Lowering blood pressure reduces the risk of cardiovascular problems over time.

Side Effects and Safety

• Dizziness or lightheadedness, especially when starting or increasing the dose
• Headache or fatigue
• Nausea or stomach discomfort
• Electrolyte changes, including low potassium or low sodium
• Increased uric acid, which may trigger gout in susceptible patients
• Increased urination
• Muscle cramps or weakness

Serious or rare risks include symptomatic hypotension, kidney function changes, severe electrolyte disturbances, acute gout, photosensitivity reactions, and hypersensitivity including angioedema (rare with ARBs). Discontinue if pregnancy is detected and contact the prescriber. Monitor kidney function and electrolytes as directed, particularly in patients with chronic kidney disease or those taking interacting medicines.

Drug Interactions and Cautions

• Do not combine with aliskiren in people with diabetes; avoid in renal impairment unless advised.
• ACE inhibitors or other ARBs: increased risk of kidney issues and hyperkalemia when overlapped.
• NSAIDs: may blunt antihypertensive effect and increase kidney risk, especially in older adults or dehydrated patients.
• Lithium: risk of elevated lithium levels and toxicity; avoid or monitor closely.
• Potassium supplements, potassium‑sparing diuretics, or salt substitutes: risk of high potassium with ARB component.
• Other diuretics or laxatives: additive fluid and electrolyte losses.
• Alcohol: may enhance hypotension and dizziness.
• Bile acid sequestrants: can affect absorption of certain thiazide-type diuretics; separate dosing if used.

People with diabetes should know that thiazide-type diuretics may affect glucose control. Kidney or liver impairment requires careful monitoring. For a broader view of cardiovascular therapy classes, see Hypertension Cardiovascular.

What to Expect Over Time

Blood pressure lowering usually begins within the first one to two weeks, with full effect often seen after several weeks of consistent dosing. Your clinician may adjust the strength to reach goals. Many patients remain on a stable once-daily dose long term, along with lifestyle measures such as reduced sodium intake, regular activity, and weight management as directed by their care team.

Compare With Alternatives

Other options for hypertension include ACE inhibitors, ARBs used alone, thiazide or thiazide-like diuretics, or other combination tablets. Educational overviews on related therapies include How Altace Supports and Ramipril Uses. Beta blockers are sometimes chosen when specific indications exist; see Bystolic Helps Control for patient-focused details.

Loop diuretics are used when fluid overload is present or in certain comorbid conditions. An example is Lasix®, a furosemide formulation. Your prescriber selects a class based on your medical history, kidney function, and treatment goals.

Pricing and Access

Edarbyclor is available with Canadian pricing and US delivery from Canada. To check today’s Edarbyclor price and compare strengths, view the product page and follow the checkout steps. If you prefer savings on a longer supply, request an extended fill if your prescription allows. Our checkout is encrypted to help protect personal and payment information.

To explore similar therapy options and compare categories, visit Heart Health Medications.

Availability and Substitutions

Availability can vary by strength. If a particular tablet is temporarily unavailable, a prescriber may recommend a different strength, a different combination, or individual components. Pharmacists dispense from licensed Canadian pharmacies once the prescription is verified with your clinic. Specific restock timing is not guaranteed.

Patient Suitability and Cost Saving Tips

• Good candidates: adults with hypertension who need two agents in a single tablet.
• Not suitable: pregnant patients, people with anuria, or those with known hypersensitivity.
• Use caution: chronic kidney disease, liver impairment, gout, diabetes, or electrolyte disturbances.
• Savings ideas: ask about a 90‑day fill, align refills to reduce shipping fees, and use the lowest effective strength that meets goals.
• Practical steps: set reminders for daily dosing, schedule periodic blood pressure checks, and complete requested lab monitoring.

Questions to Ask Your Clinician

• Is Edarbyclor appropriate for my blood pressure goals and medical history?
• Which starting strength best matches my current therapy?
• When should labs be checked for kidney function and electrolytes?
• What side effects should I watch for in the first few weeks?
• How should I adjust if I miss a dose?
• Could any of my current medicines interact with this therapy?
• Would a longer supply help reduce my overall medication costs?

Authoritative Sources

• DailyMed: Edarbyclor Prescribing Information
• Manufacturer Prescribing Information (US)
• Health Canada Drug Product Database

Ready to start? Order Edarbyclor for US delivery from Canada. This information is educational and does not replace advice from your healthcare professional.