Janumet XR® Tablets for Type 2 Diabetes

Janumet XR® is a prescription tablet that combines sitagliptin and extended-release metformin. It helps lower blood sugar in adults with type 2 diabetes. This page explains how it works, who it suits, and how to use it. You can buy at Canadian pricing with US delivery from Canada. It also outlines ways to reduce your out-of-pocket cost without insurance.

CanadianInsulin is a prescription referral service. We verify your prescription with your clinic, and licensed Canadian pharmacies dispense your order.

What Janumet XR® Is and How It Works

Janumet XR® contains two medicines. Sitagliptin is a DPP-4 inhibitor. It helps your body increase incretin hormones, which boost insulin release and lower glucagon after meals. Metformin extended-release is a biguanide. It reduces liver glucose production and improves insulin sensitivity. Together, they help improve fasting and post-meal blood sugar.

This combination is taken once daily with a meal. The XR design releases metformin slowly. That may improve stomach tolerability for some people compared with immediate-release forms. You get US delivery from Canada through our service after we confirm your prescription.

Who Janumet XR® Is For

Janumet XR is for adults with type 2 diabetes when diet and exercise alone do not control blood sugar. It may be used alone or with other diabetes medicines, such as insulin or sulfonylureas, when advised by your clinician.

It is not for type 1 diabetes or for diabetic ketoacidosis. People with severe kidney problems should not take metformin-containing products. Do not use if you have acute or chronic metabolic acidosis, including diabetic ketoacidosis. Tell your clinician if you have a history of pancreatitis, liver disease, heart failure, or alcohol misuse.

Dosage and Usage

Use exactly as prescribed. Swallow tablets whole with an evening meal, unless your clinician directs otherwise. Do not crush, split, or chew XR tablets.

When metformin is new to you, clinicians often start low and increase slowly to reduce stomach side effects. Step-ups typically occur in 500 mg metformin XR increments at weekly intervals as tolerated. The maximum recommended daily dose is sitagliptin 100 mg and metformin XR 2000 mg. If you already take sitagliptin and metformin separately, your clinician may switch you to a matching total daily dose using Janumet XR.

If you also use insulin or a sulfonylurea, your clinician may monitor you more closely. The combination can raise the chance of low blood sugar.

When rules vary by patient factors, defer to the official label and your prescriber’s instructions.

Strengths and Forms

Janumet XR is an oral extended-release tablet. Commonly available strengths combine sitagliptin with metformin XR in these pairs:

• 50 mg sitagliptin / 500 mg metformin XR
• 50 mg sitagliptin / 1000 mg metformin XR
• 100 mg sitagliptin / 1000 mg metformin XR

Availability can vary by market and pharmacy inventory.

Missed Dose and Timing

If you miss a dose, take it when you remember that same day with food. If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time. Keep doses as consistent as possible day to day.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and away from moisture and heat. Carry your medicine in your hand luggage during travel. Keep in original labeled packaging for screening. Do not store in a car glovebox or other hot places.

Benefits

This combination targets blood sugar through two mechanisms. It helps lower fasting and post-meal values. The XR format supports once-daily dosing. Many patients find this convenient. The extended-release metformin may reduce stomach upset versus immediate-release for some people.

Lowering your A1C as directed can reduce the risk of diabetes complications. Your clinician may pair the medicine with diet and activity for best results.

Side Effects and Safety

• Common: diarrhea, nausea, stomach discomfort, gas
• Headache or mild upper respiratory symptoms
• Metallic taste or decreased appetite

Serious but less common effects include lactic acidosis with metformin, which is rare but serious. Symptoms may include unusual muscle pain, trouble breathing, extreme tiredness, or slow heartbeat. Sitagliptin has been associated with pancreatitis in rare cases. Seek urgent care for severe abdominal pain that may radiate to the back. Severe allergic reactions can occur. Stop the medicine and get help if you develop rash, swelling, or difficulty breathing. Hypoglycemia can occur, especially when used with insulin or a sulfonylurea.

Drug Interactions and Cautions

Tell your clinician and pharmacist about all medicines and supplements you take.

• Iodinated contrast agents may require metformin to be held around imaging procedures.
• Alcohol increases the risk of lactic acidosis; limit intake.
• Carbonic anhydrase inhibitors such as topiramate may raise acidosis risk.
• Cationic drugs eliminated by renal tubular secretion, like cimetidine, may interact with metformin.
• Some medicines, such as dolutegravir or ranolazine, may raise metformin levels.

Kidney function should be reviewed before starting and periodically. Do not use if eGFR is severely reduced. Use caution with liver disease or conditions causing hypoxia.

What to Expect Over Time

Blood sugar may improve within the first weeks. A1C changes are usually assessed after several months. Stomach side effects, if they occur, often lessen as your body adjusts or after the dose is titrated. Keep consistent meals and activity. Track fasting and post-meal readings as directed. Share results with your clinician for ongoing adjustments.

Compare With Alternatives

Several prescription combinations also pair metformin with another agent. If you need a DPP-4 alternative to sitagliptin, your clinician may consider saxagliptin with metformin, available as Komboglyze® 2 5 Mg. Another option from a different class combines an SGLT2 inhibitor with metformin, such as Xigduo® 60 Tablets. Your prescriber will weigh kidney function, cardiovascular history, tolerance, and treatment goals when choosing among them.

Pricing and Access

You can access Canadian pricing with US delivery. Many patients see meaningful cash-pay savings compared with typical US retail. Review current price options and choose a tablet strength that matches your prescription.

Start your request to compare total cost and shipping fees before you proceed. If you follow manufacturer-labeled strengths and multi-month fills, you may lower per-tablet cost. See our Promotions page for current offers.

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Availability and Substitutions

Stock can vary by strength. If a selected strength is unavailable, your prescriber may suggest an equivalent total daily dose or a comparable alternative. We do not promise restock dates. Your order will ship only with a valid prescription that matches the item and strength.

Patient Suitability and Cost Saving Tips

Janumet XR may suit adults who prefer once-daily dosing and need dual therapy. It may not suit people with significant kidney disease or those with recurrent pancreatitis. Share your full medical history, including alcohol use and heart or liver conditions.

• Ask your clinician about a 90-day supply to reduce per-unit cost.
• Use refill reminders so you do not miss doses.
• Take with food to improve stomach comfort.
• Confirm your lab schedule for kidney function and B12 when advised.
• Review other medicines to reduce interaction risk and prevent duplicate therapy.

Questions to Ask Your Clinician

• Is my current A1C a good fit for starting this combination?
• What starting dose and titration plan do you recommend for me?
• How should I monitor glucose at home with this medication?
• Do I need to adjust insulin or a sulfonylurea to avoid lows?
• Are there concerns with my kidney function or planned contrast imaging?
• What signs of pancreatitis or lactic acidosis should I watch for?
• Would an alternative combination be better for my health history?

Authoritative Sources

• Merck Product Information
• FDA DailyMed Label
• Health Canada Drug Product Database

Explore More

Learn about combination therapy choices and background on incretin-based treatments in our resources. See dosing details in Janumet® Dosage. For class comparisons, review Januvia® Vs Janumet. Browse options for managing blood sugar under Type 2 Diabetes and Glycemic Control.

Ready to proceed? Start your request for US delivery from Canada. This page is informational and does not replace the advice of your healthcare professional.