Synthroid® Tablets for Hypothyroidism

Synthroid® is a brand of levothyroxine, a thyroid hormone replacement used to treat hypothyroidism. It helps restore normal hormone levels so your body can regulate energy, metabolism, and growth. This page explains key facts, safe use, and how to access US delivery from Canada, including typical options if you pay without insurance.

What Synthroid Is and How It Works

This medicine contains levothyroxine sodium, a synthetic form of thyroxine (T4). It replaces or supplements the hormone your thyroid would normally produce. After absorption, it is converted in the body to triiodothyronine (T3), the active hormone that influences metabolism in most tissues.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

The treatment is dosed to normalize your thyroid-stimulating hormone (TSH) and free T4 levels over time. It is not indicated for weight loss and may cause serious effects if used with appetite suppressants. Follow your prescriber’s plan and the approved labeling.

Who It’s For

This therapy is used for primary, secondary, or tertiary hypothyroidism of any cause, including autoimmune thyroiditis and post-surgical or post-radioiodine states. It is also used for pituitary TSH suppression in certain goiter or thyroid cancer contexts, as directed by a specialist.

People with uncorrected adrenal insufficiency, acute myocardial infarction, or untreated thyrotoxicosis should not use levothyroxine. Use caution in patients with cardiovascular disease, arrhythmias, or osteoporosis risk. In pregnancy, replacement therapy is usually continued; dosing needs may change under clinician supervision.

For additional condition context and education, see our category resource on Hypothyroidism.

Dosage and Usage

Take levothyroxine once daily on an empty stomach with a full glass of water. The usual advice is to take it 30 to 60 minutes before breakfast, or consistently at bedtime at least 3 hours after the evening meal. Consistency of timing and relation to food helps maintain even absorption.

Swallow tablets whole. Do not split, crush, or chew unless your prescriber instructs otherwise. Certain medications and supplements can bind thyroid hormone in the gut. Separate dosing from calcium, iron, antacids, bile acid sequestrants, sucralfate, and some fiber products by several hours.

Your dose is individualized. Clinicians may start low and adjust based on labs and symptoms. If the label or your doctor provides different timing or spacing instructions, follow those instructions. For broader endocrine topics affecting dosing and labs, explore our category for Endocrine Thyroid.

Strengths and Forms

Tablets are available in multiple color-coded strengths to support precise titration. Availability can vary by pharmacy and stock status. Commonly published strengths include 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg, and 300 mcg.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is close to the next scheduled dose, skip the missed tablet and resume your regular schedule. Do not double up. If missed doses occur often, talk with your prescriber about ways to improve consistency.

Storage and Travel Basics

Store tablets in the original container with the lid tightly closed, protected from light and moisture, and out of reach of children and pets. Keep it in a dry location away from humidity, such as steam from showers. Do not store in a car or near heat sources.

When you travel, carry your medicine in your hand luggage along with a copy of your prescription. Keep it in its labeled container to avoid mix-ups at security checkpoints. If crossing borders, bring your prescription details and a medication list. Maintain a consistent daily schedule across time zones when possible. Use a pill organizer only if it stays dry and protected from light.

Benefits

Thyroid hormone replacement can restore normal metabolic function and help relieve symptoms of hypothyroidism. A once-daily schedule supports routine adherence. Multiple strengths allow fine-tuning to match your clinical targets, and color-coding helps distinguish doses.

Consistent, monitored therapy may help stabilize energy, cognition, and cardiovascular function. Regular follow-up and lab monitoring guide safe, individualized dosing.

Side Effects and Safety

• Headache, nervousness, or irritability
• Palpitations or faster heartbeat
• Tremor or anxiety
• Diarrhea or increased appetite
• Heat intolerance or sweating
• Sleep difficulty

Serious effects can occur with overtreatment or rapid dose changes, including chest pain, shortness of breath, arrhythmias, or signs of bone loss over time. Allergic reactions to inactive ingredients are rare but possible. If you use insulin or sulfonylureas for diabetes, thyroid hormone changes may alter glycemic control; your clinician might adjust your diabetes plan. For background on endocrine overlap, see our article Thyroid Disease and Diabetes.

Drug Interactions and Cautions

Absorption can be reduced by calcium carbonate, ferrous sulfate, aluminum- or magnesium-containing antacids, sucralfate, cholestyramine, colestipol, sevelamer, orlistat, and some fiber or soy products. Separate these items from your dose as advised on the label or by your prescriber. Proton pump inhibitors and H2 blockers may also affect absorption in some patients.

Metabolism or effect can be influenced by enzyme inducers, amiodarone, estrogen therapy, and changes in binding proteins. Warfarin sensitivity can increase as thyroid status normalizes; clinicians monitor INR closely. Digoxin effects may shift with thyroid status. If you manage diabetes, monitor glucose more closely when your thyroid dose changes. For a broader overview of hormone networks, review our article Endocrine System.

What to Expect Over Time

Clinicians often assess TSH and free T4 after dose changes to guide further adjustments. Many symptoms relate to either under- or over-replacement, so report changes promptly. Because levothyroxine has a long half-life, steady-state and symptom changes can take time.

Consistency is the foundation. Take tablets at the same time daily under the same conditions, and avoid interacting foods or supplements near your dose. Refill early so you do not run out, and keep follow-up appointments for lab checks.

Compare With Alternatives

Other levothyroxine brands and dosage forms exist, such as Levoxyl and Tirosint. Some patients remain on a single product long term to avoid variability. Veterinary formulations serve animal patients; for canine therapy information, see Thyro-Tabs and browse our category for Pet Medications when your veterinarian prescribes them.

Costs vary by product and pharmacy. If you compare options, consider co-pays, dispensing fees, and monitoring needs along with the synthroid price without insurance. Talk with your prescriber before switching products, since excipients and bioavailability can differ.

Pricing and Access

Canadian pricing may offer value for patients paying cash. Review current Synthroid price details on the product page and consider whether a 90-day fill fits your plan. We provide clear product information so you can compare options across strengths.

Many shoppers look at synthroid cost alongside consultation and lab follow-up needs. Transparent checkout and order tracking help you manage expenses and timing. Ships from Canada to US is available with standard prescription verification. For occasional offers, visit our Promotions page. We use encrypted checkout to protect your information.

Availability and Substitutions

Availability can vary by strength and package size. If a specific tablet strength is unavailable, your prescriber may recommend a temporary alternative strength or a different approved brand at an equivalent dose. Any substitution should be guided by your clinician to maintain stable thyroid levels.

If you pay cash, consider total out-of-pocket cost across a longer fill period, such as a multi-month supply, to reduce trips and potential fees. You may also review our educational article Diabetes and Thyroid for context on endocrine care across therapies. US shipping from Canada supports access when local stock is limited.

Patient Suitability and Cost-Saving Tips

Good candidates include adults and children with hypothyroidism who can follow consistent daily dosing and lab monitoring. People with significant cardiac disease or adrenal insufficiency require careful supervision. Do not use this treatment for weight loss.

For costs, multi-month fills can reduce per-fill fees, and aligning refills with lab schedules can simplify care. Set reminders so you do not miss a dose. If you are seeking deals widely advertised as cheap synthroid, compare total therapy value rather than unit price alone, including lab checks and follow-up visits.

Keep one manufacturer when possible to support consistent absorption. If your clinician changes strength, ask whether pill color will differ so you can check the bottle on pickup. Pharmacist counseling can help with timing around supplements and common diet interactions.

Questions to Ask Your Clinician

• Target labs: What TSH and free T4 range should we aim for?
• Dosing details: Morning or bedtime, and how to separate from supplements?
• Interactions: Which vitamins, antacids, or bile binders should I separate?
• Monitoring: How often should labs be checked after a change?
• Consistency: Should I avoid switching between products or manufacturers?
• Special cases: What if I become pregnant or my weight changes?
• Plan: What signs of over- or under-treatment should I report?

Authoritative Sources

For full prescribing information and patient counseling, see the manufacturer’s site from AbbVie; their professional resources summarize indications, dosing, and safety in detail. Visit the manufacturer website for official guidance and resources.

DailyMed provides the FDA-approved label, including contraindications, interactions, and excipient details for tablets by strength. Review the FDA label on DailyMed for comprehensive information.

Health Canada’s Drug Product Database lists Canadian product details and regulatory status for levothyroxine. Search Health Canada’s Drug Product Database for levothyroxine.

Ready to proceed? Check pricing, upload your prescription, and complete checkout with prompt, express, cold-chain shipping and temperature-controlled handling when required.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.