Komboglyze® Tablets for Type 2 Diabetes

Komboglyze is a prescription combination tablet that contains saxagliptin and metformin. It is used with diet and exercise to improve blood sugar control in adults with type 2 diabetes. This page explains how it works, who it suits, and key facts for safe use.

What Komboglyze Is and How It Works

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Komboglyze® combines two agents that target high blood sugar in different ways. Saxagliptin is a DPP‑4 inhibitor that helps your body increase insulin release after meals and decrease glucagon. Metformin is a biguanide that reduces liver glucose output and improves insulin sensitivity. This dual approach may lower fasting and post‑meal glucose.

You can access the same Canadian formulations with Type 2 Diabetes resources and US shipping from Canada. If you pay without insurance, this page outlines practical steps for affordability. For a primer on common drug classes, see our overview of Common Medications.

Who It’s For

This medicine is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It may be considered when metformin alone is insufficient, or to replace separate tablets of saxagliptin and metformin.

It is not for type 1 diabetes or for treating diabetic ketoacidosis. Use may not be appropriate in people with significant kidney disease, severe liver impairment, or a history of lactic acidosis. Safety and efficacy in pediatric patients are not established.

Dosage and Usage

Follow your prescriber’s directions and the official label. These tablets are typically taken twice daily with meals to reduce stomach upset. Swallow tablets whole with water.

Your starting dose and any adjustments depend on your prior therapy and kidney function. If you are switching from separate components, a clinician may select comparable total daily doses. Kidney function should be assessed before starting and monitored periodically. If you develop dehydration, severe infection, or conditions affecting kidney function, your prescriber may reassess ongoing use.

Avoid excessive alcohol intake while using this treatment. Alcohol increases the risk of lactic acidosis with metformin. If you require iodinated contrast imaging, metformin‑containing therapy may need temporary interruption per label guidance.

Strengths and Forms

This treatment is supplied as immediate‑release tablets in fixed combinations of saxagliptin 2.5 mg or 5 mg with metformin 500 mg, 850 mg, or 1000 mg. Availability may vary by pharmacy and region.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is almost time for the next dose. If it is close to the next dose, skip the missed tablet and resume your regular schedule. Do not take two doses at once.

Try to take doses with meals at consistent times each day. Consistency can help minimize stomach effects and support steady glucose control.

Storage and Travel Basics

Store tablets at room temperature in the original container, protected from moisture. Keep the bottle tightly closed and out of reach of children and pets. Do not use tablets past the labeled expiration date.

When traveling, carry medicine in your hand luggage with a copy of your prescription. Keep the label visible for security screening. Pack a small buffer supply in case of delays, and maintain your dosing schedule as closely as possible across time zones. If a clinician provides a travel letter, keep it with your medications.

Pen Handling and Sharps Disposal

No pens or injections are involved. These are oral tablets, so sharps containers are not required.

Benefits

This combination targets complementary pathways in glucose regulation. Using one co‑formulated tablet instead of two separate agents can simplify routines. Taking doses with meals may help tolerability.

When used as directed, the therapy may help lower fasting glucose and post‑meal spikes. Over time, improving day‑to‑day control can support A1C reduction as part of a broader diabetes plan.

Side Effects and Safety

• Digestive effects: diarrhea, nausea, stomach upset
• Headache or dizziness
• Upper respiratory tract symptoms
• Fatigue
• Decreased vitamin B12 levels with long‑term metformin use

Serious but less common risks include lactic acidosis with metformin, pancreatitis, severe allergic reactions, and heart failure risk signals reported with DPP‑4 inhibitors like saxagliptin. Hypoglycemia can occur when combined with insulin or a sulfonylurea. Seek urgent care for symptoms such as rapid breathing, persistent nausea or vomiting, severe abdominal pain, unusual sleepiness, swelling of legs, or new shortness of breath.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you use. Strong CYP3A4/5 inhibitors may increase saxagliptin exposure. Drugs that compete for renal tubular secretion may affect metformin levels. Alcohol increases the risk of lactic acidosis. Temporarily stopping metformin is often recommended around iodinated contrast procedures.

Inform your clinician if you have kidney or liver disease, heart failure, dehydration, heavy alcohol use, or a history of pancreatitis. Do not start new medications or supplements without checking for interactions.

What to Expect Over Time

Digestive upset is most common when starting or after a dose change and may improve as your body adjusts. Consistent dosing with meals, healthy nutrition, and regular activity can support effectiveness. Your prescriber may order periodic labs, including kidney function and A1C, to monitor response and safety.

Plan refills ahead of time so you do not miss doses. If you prefer mail order, Komboglyze ships to US through our cross‑border service. Set reminders for dosing and refills to support steady daily use.

Compare With Alternatives

Other prescription combinations may suit different needs. Extended‑release sitagliptin plus metformin offers once‑daily dosing; see Janumet XR for an alternative DPP‑4 option. For a DPP‑4–free approach that increases urinary glucose excretion, consider canagliflozin with metformin in Invokamet. Discuss the class, formulation, and dosing schedule that best fit your plan.

Pricing and Access

Canadian pricing can help lower your out‑of‑pocket costs. You can review the Komboglyze price on this page and compare options. We support encrypted checkout and prescription verification when required.

We offer Combination Tablets for adults managing type 2 diabetes. US patients can order with confidence and receive medications that Ships from Canada to US. If you are looking for deals, check our Current Promotions for any seasonal offers.

Availability and Substitutions

If a strength is unavailable, a prescriber may recommend a therapeutically appropriate alternative in the same or a different class. You can Non-Insulin options while you order Komboglyze. Stock can vary by pharmacy and region; we do not provide restock dates.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need dual‑agent control using a DPP‑4 inhibitor and metformin. It may not be suitable for those with advanced kidney disease, unstable heart failure, or a history of lactic acidosis or pancreatitis. Your clinician will assess benefits and risks for your situation.

To reduce costs, consider multi‑month fills if your prescriber agrees, and set refill reminders to avoid last‑minute orders. You can also look for a Komboglyze coupon on our site and compare strengths your prescriber deems interchangeable. Savings may be meaningful for those paying without insurance.

Questions to Ask Your Clinician

• Starting dose choice: how is my initial dose determined?
• Kidney monitoring: how often should labs be checked?
• Side effects plan: what should I do if stomach upset persists?
• Interaction risk: are any of my medicines a concern?
• Procedure planning: should I stop before contrast imaging?
• Long‑term goals: what A1C target is right for me?

Authoritative Sources

For full prescribing details, see the manufacturer’s combination label for saxagliptin with metformin on AstraZeneca’s site (Kombiglyze XR). AstraZeneca Prescribing Information provides mechanism, dosing, and safety information consistent with this class.

The FDA maintains official drug labeling; you can review DPP‑4 inhibitor and metformin combination references there. See the FDA DailyMed Database for current labels.

Health Canada lists authorized products and monographs. Consult the Health Canada Drug Product Database for Canadian market information.

Next Steps

Ready to buy Komboglyze? Place your order with prompt, express, cold-chain shipping and temperature-controlled handling when required.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.