Komboglyze® Tablets for Type 2 Diabetes

Komboglyze® is a prescription tablet that combines saxagliptin and metformin. It helps control blood sugar in adults with type 2 diabetes. This page explains how the medicine works, who it suits, and how to use it. We also outline access, safety, and options for US delivery from Canada. If you pay cash, we note the Komboglyze price without insurance so you can compare options.

What Komboglyze Is and How It Works

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The treatment contains two agents that act in complementary ways. Saxagliptin is a DPP-4 inhibitor. It helps your body increase insulin release after meals and lowers glucagon levels. This can reduce post-meal glucose. Metformin is a biguanide. It decreases glucose production in the liver and improves how your body uses insulin. Together, the class combination can improve overall glycemic control when diet and exercise alone are not enough.

It does not treat type 1 diabetes or diabetic ketoacidosis. It is intended for adults diagnosed with type 2 diabetes when both components are appropriate. Your clinician will confirm suitability based on your medical history and current medicines.

Learn more about the condition itself in our category guide Type 2 Diabetes.

Who It’s For

This medicine is used as an adjunct to diet and exercise to improve blood glucose in adults with type 2 diabetes. It may be used when patients are inadequately controlled on metformin alone, on a DPP-4 inhibitor alone, or already taking both components separately.

Do not use if you have severe kidney impairment, acute or chronic metabolic acidosis, or known hypersensitivity to either component. Use caution if you have a history of pancreatitis or heart failure. Your clinician may avoid the therapy if your kidney function is significantly reduced, or if you are at high risk for lactic acidosis. It is not for type 1 diabetes.

To understand how each class contributes, see our explainer on DPP-4 inhibitors: DPP 4 Inhibitors, and our overview of biguanides: Biguanides Drugs.

Dosage and Usage

Follow your prescription label exactly. Your clinician will choose a tablet strength based on your current regimen. The therapy is usually taken with meals to reduce stomach upset. Swallow tablets whole with water. If you are switching from separate tablets, your prescriber will select a nearest-equivalent fixed dose and adjust as tolerated.

Take doses at the same times each day. Consistent timing helps maintain steady glucose control. Do not change your schedule or add extra doses without medical advice. If you use other glucose-lowering drugs, your clinician may monitor for low blood sugar and adjust those agents if needed.

Read the patient information leaflet that comes with your medication. When uncertain, defer to the official label or ask your clinician or pharmacist.

Strengths and Forms

This medicine is supplied as film-coated oral tablets in multiple fixed-dose combinations. Common strengths include 2.5/500 mg and 2.5/1000 mg. Availability may vary by pharmacy and manufacturer. Extended-release combinations exist in some markets, but offerings can differ. Your prescriber will select a strength suited to your needs.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to your next scheduled dose. If it is almost time for the next dose, skip the missed one and resume your regular schedule. Do not double up to make up a missed tablet. If you miss doses often, set reminders to help keep a steady routine.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from moisture and excessive heat. Keep the bottle tightly closed and out of reach of children and pets. Do not store in a bathroom where humidity can build.

For travel, carry your medication in the original labeled container. Pack it in your carry-on to avoid temperature swings and lost luggage. Bring a copy of your prescription and a medication list. Keep tablets away from direct sunlight inside cars. If your clinician provided a dosing schedule, consider setting phone alarms to stay on track while traveling.

Benefits

The combination targets fasting and post-meal glucose through two complementary mechanisms. Using a single tablet may reduce pill burden compared to taking both components separately. Taking with meals can improve stomach tolerability for many patients. When used as directed, the treatment may help maintain consistent glycemic control alongside diet and exercise.

Side Effects and Safety

• Stomach upset or diarrhea
• Nausea or abdominal discomfort
• Headache
• Upper respiratory symptoms
• Fatigue

More serious effects are uncommon but can occur. Metformin has a rare risk of lactic acidosis, which is serious and needs urgent care. DPP-4 inhibitors have reported pancreatitis, severe joint pain, and rare skin reactions such as bullous pemphigoid. Saxagliptin has been associated with an increased risk of hospitalization for heart failure in some patients. Long-term use of metformin may reduce vitamin B12 levels. Stop the medicine and seek care if you develop severe abdominal pain, persistent vomiting, blistering skin, signs of heart failure, or symptoms of lactic acidosis. Hypoglycemia can occur, especially when combined with insulin or a sulfonylurea.

Report new or worsening symptoms to your clinician promptly. Review the full safety information in the official label.

Drug Interactions and Cautions

Tell your clinician about all medicines you take. Strong CYP3A4/5 inhibitors may raise saxagliptin levels, and inducers can lower them. Alcohol increases the risk of lactic acidosis and should be limited. Certain imaging contrast agents can affect kidney function; metformin may need to be held around those procedures per label guidance. Medications that impair kidney function may increase metformin exposure. Use caution with diuretics and other agents that affect hydration or renal status.

Kidney function should be assessed before starting and periodically thereafter. If you develop dehydration, severe infection, or conditions associated with hypoxia, discuss temporary interruption with your clinician. Do not start if you have known hypersensitivity to any component.

What to Expect Over Time

Many patients notice steadier blood sugars with consistent daily use, meals, and activity. You may see changes in fasting and after-meal readings as part of a broader diabetes plan. Your clinician may monitor A1C at routine intervals. Adherence matters. Taking tablets with food, staying hydrated, and following your meal plan can improve tolerability. Keep a log of your readings and bring it to appointments. If goals are not met, your care plan may be adjusted.

To see how this therapy compares within its classes, read our overview: Common Diabetes Medications.

Compare With Alternatives

Some patients may use a DPP-4 inhibitor alone when metformin is not tolerated. An example is Onglyza Online. Others may combine metformin with an SGLT2 inhibitor if appropriate, such as Invokamet. Your clinician will choose based on your glucose profile, kidney function, cardiovascular history, and tolerability.

Pricing and Access

We list transparent options so you can compare supply sizes and dispensing pharmacies. Check the Komboglyze tablets price in your selected quantity, then review available fills. For those paying cash, some patients search for Komboglyze Canadian pricing to understand potential differences across pharmacies and fills. We provide itemized details so you can discuss affordability with your clinician and pharmacist.

Orders Ships from Canada to US through our partner pharmacies. Current availability, refill options, and dispensing pharmacy may vary by state and prescriber verification. For occasional discounts, see our Promotions page.

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Availability and Substitutions

Supply can vary. If a selected strength is unavailable, a prescriber may recommend a therapeutically appropriate alternative. We cannot guarantee restock dates. If your care plan requires a change, your clinician may choose a similar class option or separate components based on your health status and goals. If you need clarification about cross-border fulfilment, note that Komboglyze ships to US when offered by our dispensing partners and permitted.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with type 2 diabetes who may benefit from both a DPP-4 inhibitor and metformin in a single tablet. It may not suit those with severe renal impairment, active metabolic acidosis, or a history of serious hypersensitivity to either component. Discuss risks if you have heart failure or a history of pancreatitis.

• Multi-month fills: Fewer refills can reduce per-fill fees.
• Schedule reminders: Keep steady dosing to avoid gaps.
• Review medicines: Remove duplicates with your clinician.
• Lab monitoring: Keep routine labs to ensure safe use.
• Travel prep: Carry prescriptions and dosing notes.

If you compare cash options, some patients ask about Komboglyze cash price during visits. Ask your clinician and pharmacist about generic or alternative pathways that maintain safety and adherence.

Questions to Ask Your Clinician

• Is this combination the best fit for my glucose pattern?
• How should I take it with my meals each day?
• What symptoms warrant stopping and calling you right away?
• How will we monitor kidney function and vitamin B12?
• Could other classes, like SGLT2 inhibitors, be a better fit?
• What should I do before imaging that uses contrast dye?
• How can I reduce stomach side effects while staying adherent?

Authoritative Sources

Health Canada Product Monograph

FDA DailyMed Index

Manufacturer PI Library

Ready to proceed? You can add your quantity, upload your prescription, and complete checkout with prompt, express, US shipping from Canada and temperature-controlled handling when required. This information is not a substitute for medical advice; always follow your clinician’s directions.