Synjardy® Tablets for Type 2 Diabetes

What Synjardy Is and How It Works

Synjardy® combines empagliflozin, an SGLT2 inhibitor, with metformin, a biguanide. It helps lower blood sugar in adults with type 2 diabetes when used with diet and exercise. Ships from Canada to US through our platform, and options may fit if you pay without insurance.

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Empagliflozin increases glucose loss in urine by reducing kidney reabsorption. Metformin decreases liver glucose production and improves insulin sensitivity. Together, the treatment targets complementary pathways for glycemic control. For a broader overview of uses and directions, see our resource on Uses and Dosage.

Who It’s For

This medicine is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It may be started in patients already taking empagliflozin or metformin separately, or switched from other combination therapies under prescriber guidance.

It is not approved for type 1 diabetes or for treatment of diabetic ketoacidosis. People with severe kidney problems or with metabolic acidosis, including diabetic ketoacidosis, should not use this product. Discuss cardiovascular history, kidney function, and alcohol intake with your clinician before starting therapy. Learn more about the condition context in our Type 2 Diabetes guide.

Dosage and Usage

Follow your prescriber’s instructions and the official label. Immediate-release tablets are typically taken twice daily with meals. Extended-release tablets are usually taken once daily with a meal. Your starting dose depends on prior therapy and kidney function. Titration may be gradual to reduce stomach upset.

Swallow tablets whole. Stay hydrated, particularly during hot weather or illness. Your clinician will check kidney function before initiation and periodically thereafter. If you take insulin or a sulfonylurea, your prescriber may adjust those agents to lower hypoglycemia risk.

Strengths and Forms

Two oral tablet options exist: immediate-release and extended-release (XR). Immediate-release strengths commonly combine empagliflozin 5 mg or 12.5 mg with metformin 500 mg, 850 mg, or 1000 mg. Examples include 5/500, 5/850, 5/1000, 12.5/500, 12.5/850, and 12.5/1000 mg. Availability may vary by pharmacy.

Extended-release formulations typically combine empagliflozin 10 mg or 25 mg with metformin XR 1000 mg. Tablet counts and packaging formats can differ. If you compare formulations, consider your dosing schedule, tolerability, and prescriber advice. Some shoppers also review Empagliflozin metformin XR price when deciding between once-daily and twice-daily options.

Missed Dose and Timing

If you miss a dose, take it when remembered unless it is close to your next scheduled dose. Do not take two doses at once. For XR tablets, resume at the next regular time if more than a day has passed. Consistency with meals may improve stomach tolerance.

Storage and Travel Basics

Store tablets at controlled room temperature in a dry place. Keep in the original container with the label intact. Protect from moisture and keep out of reach of children and pets. Do not use tablets that are damaged or past the labeled expiration date.

For travel, pack enough medication and keep it with you in carry-on luggage. Bring your prescription, prescriber contact details, and a current medication list. Maintain your dosing routine across time zones by planning ahead. If you become ill with vomiting or dehydration, contact your care team for guidance on sick-day management.

Benefits

This combination treats type 2 diabetes through two mechanisms in one tablet. The SGLT2 component can promote modest weight reduction and lower blood pressure in some people. Metformin is a first-line agent that improves insulin sensitivity and supports A1C reduction. A once-daily XR option may suit people seeking a simplified routine.

Side Effects and Safety

• Genital yeast infections: itching, redness, or discharge
• Urinary tract infections: burning or urgency
• Increased urination or thirst
• Stomach upset: nausea, diarrhea, or gas
• Headache or fatigue

Serious risks are uncommon but require urgent care. These include lactic acidosis with metformin (symptoms may include profound weakness, trouble breathing, unusual sleepiness, or abdominal discomfort) and ketoacidosis with SGLT2 inhibitors (nausea, vomiting, abdominal pain, and labored breathing even with normal glucose). Severe urinary infections, dehydration leading to acute kidney injury, and a rare perineal infection can occur. Hypoglycemia can occur when used with insulin or sulfonylureas. Long-term metformin use can lower vitamin B12 levels; your clinician may monitor this.

For context on lactic acidosis, review our safety explainer on Lactic Acidosis. If you take other agents that lower glucose, this article on Metformin Hypoglycemia describes how low blood sugar can present and how it is typically managed.

Drug Interactions and Cautions

Tell your clinician about all medicines, supplements, and herbs you use. Diuretics and blood pressure medications may increase the chance of volume depletion. Alcohol can raise the risk of lactic acidosis with metformin. Carbonic anhydrase inhibitors, topiramate, and certain cationic drugs (for example, cimetidine or dolutegravir) can affect metformin levels.

Contrast studies with iodinated contrast may require temporary interruption of metformin under label guidance. Use caution with insulin or sulfonylureas due to hypoglycemia risk. If you follow a very low-carbohydrate diet or have conditions that predispose to ketosis, discuss this therapy carefully with your clinician.

What to Expect Over Time

Blood sugar may improve within days, with A1C changes evident over weeks to months. Gastrointestinal effects often lessen after dose titration and consistent administration with meals. Increased urination can occur, especially after initiation; maintaining hydration can help.

Your clinician will periodically assess kidney function, A1C, and vitamin B12 as appropriate. Adherence, meal timing, and regular activity can influence day-to-day readings. Notify your prescriber if you experience persistent side effects or signs of infection.

Compare With Alternatives

Other oral combinations may be appropriate depending on your goals and tolerability. Canagliflozin with metformin offers a different SGLT2 option; see Invokamet for details. A DPP-4 inhibitor plus metformin may fit those prioritizing gastrointestinal tolerability; learn more at Janumet XR.

Choices vary by side-effect profile, dosing schedule, and coexisting conditions. Discuss your history and preferences with your prescriber to select an appropriate regimen.

Pricing and Access

We display current Synjardy price and available pack sizes when you view the product page. Listings reflect Canadian pharmacy pricing with transparent checkout. For shoppers comparing combination therapies, you can also review Empagliflozin/metformin cost on relevant product listings to understand category-level differences.

US shipping from Canada helps many customers access competitive options. If you are evaluating savings tools, see our information on seasonal offers at Promotions. We do not require membership to browse or place an order with a valid prescription.

Availability and Substitutions

Stock and strengths can vary. If an item is unavailable, your prescriber may consider a therapeutically appropriate alternative or separate components. Discuss whether a Synjardy generic equivalent is suitable in your case, as availability can differ by market and timeframe.

If a change is recommended, ask how to transition safely and whether additional monitoring is suggested during the switch.

Patient Suitability and Cost-Saving Tips

This treatment may not be suitable for people with advanced kidney disease, active metabolic acidosis, or those at high risk for dehydration. It is not for pregnancy unless specifically advised, and breastfeeding considerations should be discussed. Older adults and those on diuretics may need closer monitoring.

To reduce costs, consider multi-month quantities if approved by your prescriber. Compare immediate-release and XR formats to match your routine. Use refill reminders to avoid gaps in therapy. If you are seeking offers, explore whether a Synjardy coupon or manufacturer assistance might apply based on eligibility. Category context on combined oral agents is available under Combination Tablets.

Questions to Ask Your Clinician

• Appropriate starting dose: how it fits my current therapy
• Kidney checks: how often and what thresholds matter
• Sick-day rules: when to pause and when to resume
• Hypoglycemia risk: if used with insulin or sulfonylureas
• Infection signs: when to seek urgent evaluation
• XR vs immediate-release: which schedule best fits me

Authoritative Sources

For the full US prescribing information, including boxed warnings and detailed instructions, consult the FDA DailyMed label available here: FDA DailyMed Official Database.

For Canadian regulatory details and product listings, see Health Canada’s database entry for authorized products: Health Canada Drug Product Database.

For manufacturer-provided resources on composition and safety communications, refer to Boehringer Ingelheim’s product information pages: Boehringer Ingelheim Official Site.

Pricing and Access FAQs

To explore broader diabetes therapy categories, you can browse Diabetes Medications for related options and education. This can help frame discussions with your clinician about class choices, dosing schedules, and monitoring.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.

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