Vetoryl® Capsules for Dogs with Cushing’s Disease

Vetoryl® is a prescription trilostane capsule for dogs with Cushing’s disease. It helps reduce excess cortisol and control clinical signs. Ordered from Canada, it ships to the US with Canadian pricing, helpful when paying without insurance.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

You can buy Vetoryl online from Canada with US shipping. Secure checkout supports prescription upload and clinic verification.

What Vetoryl® Is and How It Works

Vetoryl® contains trilostane, a reversible inhibitor of 3β-hydroxysteroid dehydrogenase. This enzyme is needed to make cortisol in the adrenal glands. By inhibiting it, trilostane lowers cortisol production. Lower cortisol helps reduce the thirst, urination, hunger, panting, and abdominal changes seen with canine Cushing’s disease.

Label indications include treatment of pituitary-dependent hyperadrenocorticism and control of clinical signs associated with an adrenal tumor in dogs. This medicine is given by mouth as trilostane capsules, usually with food.

Who Vetoryl® Is For

This therapy is for dogs diagnosed with Cushing’s disease by a veterinarian. It is suitable for pituitary-dependent disease and for dogs with an adrenal tumor when medical control of signs is needed.

Do not use in dogs that are pregnant, nursing, or intended for breeding. Do not use in dogs with known hypersensitivity to trilostane. Use caution in dogs with significant liver or kidney disease. Dogs with Addison’s disease or those at risk for adrenal insufficiency require special consideration. Always base use on diagnostic testing and veterinarian oversight.

Dosage and Usage

Vetoryl dosing is individualized. A common starting plan is around 2 mg/kg given once daily with food, typically in the morning. Some dogs may need divided dosing twice daily after reassessment. The dose is then adjusted based on clinical response and adrenal testing.

Monitoring is essential. Veterinarians usually recheck at about 10 to 14 days, at 4 weeks, and then periodically. Follow-up often includes an ACTH stimulation test and electrolyte checks. Keep the dosing routine consistent with meals and time of day unless the veterinarian changes the plan.

Do not change the dose or frequency without veterinarian guidance. If the dog becomes unwell, contact the clinic before giving more doses.

Strengths and Forms

Vetoryl is available as hard gelatin capsules in multiple strengths. Availability may vary by lot and location.

• 5 mg capsules (Vetoryl 5 mg)
• 10 mg capsules (Vetoryl 10 mg; trilostane 10 mg)
• 30 mg capsules (Vetoryl 30 mg; trilostane 30 mg)
• 60 mg capsules (Vetoryl 60 mg; trilostane 60 mg)
• 120 mg capsules (Vetoryl 120 mg; trilostane 120 mg)

Veterinarians often combine capsule strengths to reach the calculated daily dose. Capsules should be swallowed whole and not opened or split.

Missed Dose and Timing

If a dose is missed, give the next scheduled dose with food. Do not double the next dose. If vomiting, diarrhea, weakness, or collapse occurs around dosing time, seek veterinary advice before giving more medicine.

Storage and Travel Basics

Store capsules at controlled room temperature, typically 20–25°C (68–77°F). Keep the bottle tightly closed and protect from moisture. Keep out of reach of children and other pets.

For travel, carry the labeled bottle and a copy of the prescription if available. Pack extra capsules in case plans change. Avoid excessive heat in cars or direct sunlight. You can store the bottle in a small, dry travel pouch to keep it secure.

Benefits

• Oral, once-daily starting regimen for many dogs
• Multiple strengths for precise dose building
• Targets cortisol production at the adrenal gland
• Helps reduce thirst, urination, appetite changes, and panting
• Improves coat and skin condition over time in many dogs
• Supports a consistent routine when taken with food

These benefits depend on accurate diagnosis, appropriate dosing, and regular monitoring.

Side Effects and Safety

• Decreased appetite
• Vomiting or diarrhea
• Lethargy or weakness
• Electrolyte changes
• Rarely, collapse or shock

Serious adverse reactions can reflect low cortisol (iatrogenic hypoadrenocorticism). Signs include severe lethargy, vomiting, diarrhea, collapse, and possible hypoglycemia. Electrolyte abnormalities such as hyperkalemia and hyponatremia may occur. Immediate veterinary assessment is needed for severe or rapidly worsening signs. Women who are pregnant or trying to conceive should avoid handling opened or damaged capsules. Wash hands after handling intact capsules.

Drug Interactions and Cautions

Potential interactions include drugs that affect potassium or blood pressure, such as ACE inhibitors or potassium-sparing diuretics. Using trilostane with mitotane or ketoconazole can increase adrenal suppression. Systemic corticosteroids can confound adrenal testing and clinical assessment. Discuss all medicines, supplements, and diets used with the veterinarian, including heart medications and seizure therapies.

Use caution with significant liver disease, kidney disease, dehydration, or concurrent serious illness. Dogs need periodic ACTH stimulation tests and biochemical checks to support safe dosing.

What to Expect Over Time

Many dogs show early improvement in thirst, urination, and appetite within weeks. Skin and haircoat changes may take longer. Doses often need refinement after initial rechecks. Long-term therapy is usual for pituitary-dependent disease. Regular monitoring helps maintain control while minimizing adverse effects.

Compare With Alternatives

Approved alternatives include mitotane for medical adrenal destruction and selegiline for certain pituitary-dependent cases. Surgical adrenalectomy may be considered for some adrenal tumors. Choice depends on diagnosis, comorbidities, caregiver goals, and veterinarian guidance.

Pricing and Access

Canadian pricing can reduce the cash price for many pet families. This can help when orders are self pay or pay out of pocket. Many pet owners search for Vetoryl price, buy Vetoryl, or Vetoryl online to compare options. Transparent pricing is shown on the product page before checkout.

Orders are shipped from Canada to the US with prompt, express shipping. US delivery from Canada includes prescription verification and pharmacist dispensing. For periodic specials, see our Promotions page.

Availability and Substitutions

If a specific capsule strength is unavailable, a veterinarian may recommend a different combination of strengths to reach the same total daily dose. If Vetoryl is not suitable or unavailable, a prescriber may discuss other approved treatments for canine Cushing’s disease.

Patient Suitability and Cost Saving Tips

Good candidates have confirmed Cushing’s disease and can attend regular rechecks. Dogs with severe systemic illness or certain endocrine disorders need careful oversight. Keep the dosing time steady with meals to support consistent absorption and testing.

• Ask the clinic about multi-bottle refills once dosing is stable
• Combine capsule strengths to match the calculated dose efficiently
• Set refill reminders so doses are not missed
• Keep a small reserve supply for travel or weather delays

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Questions to Ask Your Clinician

• Which diagnostic tests confirmed Cushing’s disease in this dog?
• What starting dose and timing should be used with food?
• When is the first ACTH stimulation test scheduled?
• Which side effects should prompt urgent contact?
• Could twice-daily dosing improve control in this case?
• How will other medicines affect trilostane therapy?
• What signs show the dose may be too high or too low?

Authoritative Sources

• Dechra Vetoryl Capsules
• FDA Animal Drugs Database
• Health Canada Drug Product Database

Start your Vetoryl order today with US delivery from Canada.