Nota: se requiere una receta válida para todos los medicamentos con receta.
An oral prescription medicine used to manage type 2 diabetes. This page explains uses, safety, and ways to access treatment with US shipping from Canada. You can review options for Metformin without insurance.
Qué es la metformina y cómo actúa
CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.
Generic Metformin belongs to the biguanide class. It helps reduce glucose production in the liver, decreases intestinal glucose absorption, and improves insulin sensitivity in muscle and fat. This medicine is taken by mouth and is often used with diet and activity guidance. It may be used alone or combined with other glucose-lowering therapies when clinically appropriate.
You can learn more about release options in our guide Metformin Vs Metformin ER.
Who It’s For
This treatment is indicated to improve glycemic control in adults living with type 2 diabetes. It can be used as initial therapy or added to existing regimens when additional control is needed. Some clinicians also use it in insulin resistance and prediabetes settings based on guidelines and clinical judgment. For reproductive health needs, it may be considered in specific cases of polycystic ovary syndrome. Metformin for PCOS should only be used under professional guidance.
Explore related conditions: Diabetes de tipo 2 y Síndrome de ovario poliquístico.
People with severe kidney impairment, active or unstable liver disease, metabolic acidosis, or known hypersensitivity should avoid this therapy. Suitability depends on your medical history, current medicines, and lab results.
Posología y utilización
Follow your prescription label. Most start with a low dose taken with meals to reduce stomach upset. Immediate-release tablets are usually taken two or three times daily with food. Extended-release tablets are typically taken once daily with the evening meal. Your prescriber may adjust the regimen gradually. Swallow extended-release tablets whole; do not crush, split, or chew. If used with insulin or a sulfonylurea, your care team may monitor for low blood sugar.
Take the medicine at the same time each day. Pair doses with consistent meals. If you experience ongoing stomach symptoms, discuss timing and formulation with your healthcare professional.
Fortalezas y formas
This therapy comes as immediate-release and extended-release oral tablets. A range of strengths supports careful titration. Common strengths include Metformin 500 mg in the immediate-release formulation, alongside several extended-release options. Availability may vary by pharmacy and manufacturer.
| Formulario | Typical Strengths | Notas |
|---|---|---|
| Immediate-release tablets | 500 mg, 850 mg, 1000 mg | Taken with meals, 2–3 times daily per label |
| Extended-release tablets | 500 mg, 750 mg, 1000 mg | Once daily in the evening with food; swallow whole |
Dosis omitida y momento oportuno
If you miss a dose, take it when you remember unless it is close to the next dose. If it is near the next scheduled time, skip the missed dose and resume your regular schedule. Do not double up. Keeping a simple reminder system can reduce missed doses. Taking the tablet with food often improves stomach tolerability.
Almacenamiento y viaje
Store tablets at room temperature in a dry place away from excess heat and moisture. Keep the bottle closed and out of reach of children and pets. Do not store tablets in a bathroom. When traveling, carry your medicine in original labeled packaging. Pack enough for the full trip plus a small buffer, and keep it in your carry-on. Bring a copy of your prescription and a medication list. Follow any local rules for transporting prescription drugs. Use temperature-controlled handling when required.
Beneficios
This treatment helps reduce fasting and post-meal glucose by lowering hepatic glucose output and improving insulin sensitivity. It is generally weight-neutral. The risk of low blood sugar is low when used alone, but can increase when combined with insulin or a sulfonylurea. Over time, improved adherence and lifestyle measures can enhance results. Some patients may see favorable changes in lipid profiles as part of comprehensive care.
Efectos secundarios y seguridad
Los efectos comunes incluyen:
- Stomach upset or cramping
- Náuseas o vómitos
- Diarrhea, especially on initiation
- Gases o hinchazón
- Sabor metálico
Serious but rare risks include lactic acidosis, especially in severe kidney dysfunction or acute illness with dehydration. Long-term therapy can lower vitamin B12 levels in some people; your prescriber may monitor levels as needed. Report new muscle pain, unusual fatigue, abdominal discomfort, rapid breathing, or persistent nausea. Hypoglycemia can occur when this medicine is used with insulin or certain other agents.
Interacciones medicamentosas y precauciones
Tell your healthcare professional about all medicines and supplements. Metformin and kidney disease requires careful assessment; many labels advise against use in significant renal impairment. Iodinated contrast procedures may require temporary interruption. Drinking excess alcohol can increase the risk of lactic acidosis. Cationic drugs eliminated by the kidneys, such as cimetidine, may raise levels of this therapy. Carbonic anhydrase inhibitors and conditions causing hypoxia or dehydration warrant extra caution. Severe liver disease generally increases risk and may preclude use.
Qué esperar con el tiempo
Digestive side effects often improve after dose adjustments or with stable meal timing. Adherence, consistent meals, and routine activity support glucose targets. Your prescriber may monitor labs, including kidney function and B12, at intervals. Expectations vary based on baseline A1C, diet, and concomitant therapies. Discuss any persistent symptoms or concerns during follow-up visits.
Comparar con alternativas
Extended-release branded options can improve tolerability for some patients. For example, Glumetza is an extended-release formulation. Combination tablets may simplify regimens when multiple agents are needed; options include Synjardy with an SGLT2 inhibitor. Another alternative is Janumet XR, which pairs a DPP-4 inhibitor with this base therapy. Your prescriber selects among these based on goals, tolerability, and medical history.
Precios y acceso
Compare Canadian pricing with US delivery from Canada. You can check current pricing, see available strengths, and upload your prescription through our checkout. If you use flexible payment or card benefits, review eligibility with your plan. Our site supports encrypted checkout to protect your information. For coupons and education, visit our rotating offers page at Promociones. If your prescriber changes the formulation, pricing may differ between immediate-release and extended-release tablets.
Disponibilidad y sustituciones
Supply can vary by manufacturer and strength. If a specific product is unavailable, your prescriber may recommend a therapeutically appropriate alternative. Pharmacists may dispense different manufacturers of the same approved formulation to fill your order. If you need a combined agent, options may include SGLT2 or DPP-4 combinations when clinically suitable.
Adecuación al paciente y consejos para ahorrar costes
This therapy suits many adults who need an oral option to improve glycemic control. It may not be appropriate for those with severe renal impairment, severe liver disease, active metabolic acidosis, or unstable cardiorespiratory conditions. People with recurrent stomach intolerance may benefit from an extended-release formulation after discussing options with their prescriber.
Ideas para ahorrar:
- Multi-month fills: Fewer refills can reduce per-fill fees
- One formulation: Avoid switching forms mid-cycle
- Refill reminders: Set calendar alerts for timely renewals
- Travel sync: Align refills with planned travel dates
- Lab alignment: Coordinate labs before renewal requests
- Generic focus: Choose a standard manufacturer when possible
- Category review: See related Medicamentos orales con insulina
For metabolic concerns beyond diabetes, review Resistencia a la insulina y Prediabetes recursos.
Preguntas para su médico
- Is immediate-release or extended-release a better starting option for me?
- How should I time doses with meals to reduce stomach symptoms?
- What lab monitoring schedule do you recommend, including kidney function and B12?
- Do any of my current medicines increase the risk of side effects?
- Should I hold this therapy before contrast imaging or major procedures?
- Could a combination tablet reduce pill burden while maintaining control?
- What signs of low blood sugar should I watch for with other medicines?
Fuentes autorizadas
FDA DailyMed: Metformin Hydrochloride Tablets
Base de datos de medicamentos de Health Canada
US FDA Label: Metformin Hydrochloride
Cerrar
Ready to proceed? Place your prescription and complete checkout for fast processing and Ships from Canada to US with express shipping. This content is for general information and does not replace professional medical advice.
Envío urgente - desde $25.00
El envío con este método tarda entre 3 y 5 días
Los precios:
- Productos envasados en seco $25.00
- Productos envasados en frío $35.00
Envío estándar - $15.00
El envío con este método tarda entre 5 y 10 días
Los precios:
- Productos envasados en seco $15.00
- No disponible para productos envasados en frío
How does this medicine work in type 2 diabetes?
This treatment reduces the amount of glucose your liver makes, decreases intestinal glucose absorption, and improves insulin sensitivity in tissues. Together, these mechanisms help lower fasting and post-meal blood sugar. It is often combined with diet, activity, and sometimes other medicines to meet targets. Your prescriber may adjust the dose gradually to improve tolerability. Extended-release tablets may be used when stomach upset limits the immediate-release form. Always follow your prescription label and clinic guidance.
Who should avoid starting therapy?
People with severe kidney impairment, active or unstable liver disease, metabolic acidosis, or known hypersensitivity should not use this medicine. Caution is advised in conditions that increase the risk of dehydration or hypoxia. Excess alcohol intake can raise the risk of lactic acidosis. Contrast imaging using iodinated agents may require a temporary hold. Provide your clinician a complete list of medicines and supplements, and share recent lab results before initiation.
What are common side effects and how can I take it to reduce stomach upset?
The most common effects are diarrhea, nausea, stomach pain, gas, and a metallic taste. Taking doses with meals often improves tolerability. Extended-release tablets may help if stomach issues persist. Hydration and gradual dose changes can also reduce symptoms. Seek medical attention if you develop signs of lactic acidosis, such as unusual fatigue, muscle pain, persistent nausea, or rapid breathing. Discuss ongoing symptoms during follow-up visits.
Can it be used during pregnancy or while breastfeeding?
Use in pregnancy depends on individual circumstances and local guidelines. Some clinicians use this therapy for gestational diabetes or polycystic ovary syndrome, but decisions are individualized. Safety while breastfeeding depends on dose and infant factors, and monitoring may be advised. Review the benefits and risks with your obstetric or endocrine clinician. You can also read our overview: Metformin Use During Pregnancy.
What about kidney or liver problems?
Kidney function strongly influences suitability and dosing. Clinicians typically review eGFR and overall stability before starting and during treatment. Severe renal impairment often precludes use due to lactic acidosis risk. Significant hepatic disease can also increase risk. If you have dehydration, sepsis, or conditions that reduce oxygen delivery, your prescriber may advise temporary interruption. Share lab results and any acute illnesses promptly.
Does it interact with other medicines or vitamins?
Some medicines can affect levels or increase risks. Examples include cationic drugs eliminated by the kidneys such as cimetidine, carbonic anhydrase inhibitors, and excessive alcohol. Iodinated contrast studies may require a temporary hold. Long-term therapy can reduce vitamin B12 levels in some people; your prescriber may monitor and supplement if needed. Always provide a complete medication and supplement list at each visit.
What is the difference between immediate-release and extended-release tablets?
Immediate-release tablets are usually taken two or three times daily with meals. Extended-release tablets are generally taken once daily with the evening meal and must be swallowed whole. Some people find the extended-release form easier on the stomach. Your clinician will balance convenience, tolerability, and glucose goals when choosing a formulation. If you notice intact-looking ER tablet shells in stool, that can be normal with some brands.
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