Synjardy Tablets (empagliflozin/metformin)

Synjardy is a prescription oral tablet that combines empagliflozin and metformin for type 2 diabetes. This page outlines uses, dosage basics, safety topics, and what can influence Synjardy price for cash-pay requests. Ships from Canada to US is available for verified prescriptions, including options for people without insurance.

For additional context, browse condition and medication hubs like Type 2 Diabetes and Diabetes.

What Synjardy Is and How It Works (Synjardy price)

Synjardy is a fixed-dose combination of empagliflozin (an SGLT2 inhibitor (kidney glucose blocker)) and metformin (a biguanide (insulin-sensitizer)). Empagliflozin helps the kidneys remove glucose through urine. Metformin lowers glucose made by the liver and improves the body’s response to insulin. Together, these actions can improve blood sugar control when used alongside nutrition and activity plans set by a prescriber.

CanadianInsulin operates as a prescription-referral service connecting patients to licensed Canadian pharmacies for dispensing.

Empagliflozin/metformin tablets Synjardy are used for adults with type 2 diabetes; they are not used to treat type 1 diabetes, and they are not for diabetic ketoacidosis (a dangerous acid buildup). The combination may also affect weight and blood pressure for some people, but responses vary and should be monitored clinically. For broader background on oral therapies, see Oral Diabetes Medication.

Who It’s For

This medicine is generally prescribed for adults with type 2 diabetes who need more than one oral medication to reach blood sugar targets. It may be considered when metformin alone is not enough, or when an SGLT2 inhibitor is appropriate as part of a broader plan. Clinical decisions depend on kidney function, cardiovascular history, and other comorbidities.

When comparing Synjardy price across strengths, eligibility still depends on safety screening. The treatment is typically avoided in people with severe kidney impairment or those on dialysis, because both components rely on kidney function for safe use. It is also used cautiously during acute illness that can cause dehydration (vomiting, diarrhea, reduced intake), and in people with heavy alcohol use, due to metformin-associated lactic acidosis risk. A prescriber may also avoid it when there is a history of hypersensitivity to either ingredient.

Browse similar fixed-dose options in the Combination Tablets category to understand how combinations are organized.

Dosage and Usage

Synjardy oral tablets are taken by mouth with food, following the prescriber’s directions. The immediate-release product is commonly taken in divided doses with meals. The extended-release version (XR) is commonly taken once daily with a meal, and tablets are typically swallowed whole rather than crushed or split. Dose selection is individualized and usually considers prior metformin exposure, kidney function, and tolerability.

Synjardy price comparisons can be clearer when the same formulation and tablet count are used. People switching from separate empagliflozin and metformin tablets to a fixed-dose combination may need counseling on what changes (number of tablets per day) and what does not (active ingredients). If a dose is missed, directions on the label should be followed; double-dosing can increase side effect risk.

Why it matters: Taking metformin-containing products with food can reduce stomach upset.

Some monitoring is routine for this class, such as kidney function checks, periodic A1C testing, and review of blood pressure and hydration status. For background on metformin formulations, see Metformin Vs Metformin ER.

Strengths and Forms

Synjardy tablets are available as immediate-release tablets and as extended-release tablets (Synjardy XR tablets). Availability can vary by market and dispensing pharmacy, so specific combinations may not always be offered. The strength is expressed as empagliflozin (mg) / metformin (mg) per tablet.

Common presentations referenced by prescribers include Synjardy 5 mg/1000 mg tablets, Synjardy 12.5 mg/850 mg tablets, and Synjardy 12.5 mg/1000 mg tablets. For extended-release, Synjardy XR 25 mg/1000 mg tablets are one example of an XR option. Other strengths and counts may exist depending on the manufacturer and jurisdiction.

A true Synjardy generic (a fixed-dose empagliflozin/metformin equivalent) may not be available in all regions. Some pharmacies may dispense the brand product or an authorized equivalent when permitted.

Storage and Travel Basics

Store tablets at controlled room temperature in the original container, protected from moisture. Keep the cap tightly closed and avoid storing in humid areas such as bathrooms. Do not use tablets past the labeled expiration date, and keep all prescription medicines out of reach of children and pets.

For travel, carry tablets in hand luggage to reduce exposure to temperature extremes. Bring a copy of the prescription label in case identification is needed. If a trip could disrupt access, plan refills ahead rather than interrupting therapy. Synjardy price may also vary by tablet strength and count, so keeping a consistent regimen can simplify refills.

Quick tip: Keep tablets in the original bottle to reduce moisture exposure.

Side Effects and Safety

Side effects can come from either ingredient. Metformin commonly causes gastrointestinal effects such as nausea, diarrhea, stomach discomfort, and reduced appetite, especially during dose changes. Empagliflozin can increase urination and may increase the chance of genital yeast infections or urinary tract infections. Some people report thirst or dizziness, which can relate to fluid loss.

Prescription details may be checked with your prescriber when required before the pharmacy dispenses.

Hypoglycemia (low blood sugar) is less common with these ingredients alone, but risk can rise when combined with insulin or sulfonylureas. Dehydration risk may be higher with diuretics, hot weather, or reduced intake. Vitamin B12 levels may decline with long-term metformin use in some people; a clinician may monitor for anemia or neuropathy symptoms.

When to seek urgent help

Serious reactions are uncommon but important to recognize early. Seek urgent medical attention for symptoms that could suggest ketoacidosis (nausea, vomiting, abdominal pain, rapid breathing, unusual fatigue), lactic acidosis (extreme weakness, worsening sleepiness, slow or irregular heartbeat), or severe allergic reaction (swelling of face or throat, trouble breathing). Empagliflozin has also been associated with rare but serious genital infections (including Fournier’s gangrene). Acute kidney injury can occur in susceptible people, especially during dehydration or when using certain medicines.

For additional reading on metformin tolerability, review Metformin Possible Side Effects.

Drug Interactions and Cautions

Several interactions are clinically relevant. Alcohol can increase the risk of lactic acidosis with metformin, so clinicians often counsel moderation or avoidance. Diuretics and medicines that lower blood pressure can increase dehydration risk when combined with an SGLT2 inhibitor. Other glucose-lowering drugs (insulin, sulfonylureas) may increase hypoglycemia risk, which may require closer monitoring.

Synjardy price shopping should not replace a medication review, because interaction screening can affect whether a prescription is appropriate. Imaging procedures using iodinated contrast may require temporary interruption of metformin-containing products in some situations, depending on kidney function and the type of study. Certain anticonvulsants and carbonic anhydrase inhibitors (such as topiramate) may also raise acidosis risk. A pharmacist or prescriber can check a full medication list, including over-the-counter products and supplements.

For comparison discussions about other combination approaches, see Janumet Vs Jentadueto.

Compare With Alternatives

Several other non-insulin combinations are used in type 2 diabetes. DPP-4 inhibitor/metformin combinations (such as sitagliptin/metformin) focus on incretin pathways, while SGLT2 inhibitor/metformin combinations use a similar kidney glucose-blocking strategy with a different SGLT2 ingredient. Some people use separate tablets instead of a fixed-dose combination to allow more flexible titration.

Examples that may be discussed with a clinician include Janumet XR (a DPP-4 inhibitor plus metformin XR) and Invokamet (an SGLT2 inhibitor plus metformin). Another SGLT2/metformin combination sometimes considered is dapagliflozin/metformin. For a broader look at SGLT2 and DPP-4 comparisons, read Jardiance Vs Janumet. A prescriber can weigh kidney thresholds, side effect profiles, and dosing convenience.

Pricing and Access

Pricing for this medicine can vary based on formulation (immediate-release vs XR), tablet strength, package size, and dispensing source. If you are comparing Synjardy XR cost to immediate-release versions, make sure the comparison uses equivalent days of therapy and the same metformin release type. Third-party tools such as GoodRx Synjardy estimates may not reflect Canadian pharmacy cash-pay totals, and they may not include referral or processing steps.

The service supports cash-pay access for people without insurance through cross-border dispensing where permitted.

To start a request through CanadianInsulin, you typically provide a valid prescription, prescriber contact information, and required identification details. If you are checking Synjardy out of pocket cost for planning, confirm the strength and quantity your prescriber wrote. Optional site-wide offers may be listed on Promotions. Home delivery and mail-order fulfillment depend on destination and pharmacy workflow, and requirements can vary by medication class.

Authoritative Sources

For official labeling and safety updates, consult these primary references:

• FDA Drugs@FDA database entry and labeling access
• DailyMed label listings for Synjardy products

To request dispensing through CanadianInsulin, upload a valid prescription and select prompt, express, cold-chain shipping when available.

This content is for informational purposes only and is not a substitute for professional medical advice.