Synjardy® Tablets for Type 2 Diabetes

What Synjardy Is and How It Works

Synjardy is a prescription tablet for adults with type 2 diabetes. It combines empagliflozin, an SGLT2 inhibitor, with metformin. This page outlines how the treatment works, who it may suit, and how to use it safely, with details on US shipping from Canada. You can review Synjardy® price without insurance in the pricing section below.

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Empagliflozin helps the kidneys remove excess glucose through urine. Metformin lowers hepatic glucose production and improves insulin sensitivity. Together, the combination can help lower blood glucose when used with diet and exercise. It is not insulin and does not replace lifestyle measures.

Learn about T2D basics in our overview of Type 2 Diabetes if you want broader context.

Who It’s For

This medicine is used to improve glycemic control in adults with type 2 diabetes. It may be considered when metformin alone is not enough, or to simplify therapy for people already taking empagliflozin and metformin separately. It is not for type 1 diabetes or diabetic ketoacidosis. People with severe kidney impairment, metabolic acidosis, or a history of serious hypersensitivity to components should not use it. Your prescriber will evaluate renal function and overall risk before starting therapy.

Dosage and Usage

Follow the dose on your prescription label. Tablets are typically taken twice daily with meals to reduce stomach upset. When switching from separate tablets, your prescriber will select comparable strengths. If you are new to metformin, a lower starting dose may be used to help tolerance, then adjusted. Swallow tablets whole with water. XR versions, if prescribed instead of the immediate-release product, are usually taken once daily with the evening meal; do not crush or chew extended-release tablets. If you need more background on oral options, explore our Oral Insulin Medications category.

Strengths and Forms

Immediate-release tablets combine empagliflozin with metformin in several strengths. Extended-release (XR) combinations also exist. Availability may vary by pharmacy and region.

• Immediate-release tablets: 5/500 mg, 5/850 mg, 5/1000 mg, 12.5/500 mg, 12.5/850 mg, 12.5/1000 mg
• Extended-release tablets (XR): commonly paired with 1000 mg metformin ER and empagliflozin 10 mg or 25 mg

Costs differ by strength and quantity. For reference, many shoppers compare Synjardy 5 mg 500 mg cost against other sizes when planning refills.

Missed Dose and Timing

If you miss a dose, take it when remembered the same day with food. If it is close to the next scheduled time, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Maintain hydration, especially during hot weather or illness, because SGLT2 inhibitors can increase urination.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle closed tightly and away from moisture, heat, and direct light. Do not store in the bathroom. Keep out of reach of children and pets. When traveling, carry the medicine in original labeled packaging. Pack enough supply for your trip, plus a small buffer. A copy of your prescription or a pharmacy receipt can help with security checks. Keep it in your carry-on to avoid temperature extremes in checked baggage.

Benefits

This combination can simplify therapy by pairing two established agents in one pill. As part of a comprehensive plan, it may help improve fasting and post-meal glucose. The class can reduce excess glucose via the kidneys, while metformin addresses hepatic glucose output and sensitivity. Many people appreciate the convenience of a single product instead of two separate prescriptions.

Side Effects and Safety

• Digestive effects: nausea, diarrhea, stomach upset, gas
• Genital yeast infections and urinary tract infections
• Increased urination and thirst
• Headache or dizziness, especially with volume depletion

Serious but less common risks include lactic acidosis with metformin, ketoacidosis with SGLT2 inhibition even at normal glucose, dehydration, acute kidney injury, severe urinary infections, and rare necrotizing fasciitis of the perineum. Hypoglycemia can occur if used with insulin or sulfonylureas. Stop the medicine and seek urgent care for signs of acidosis, severe infection, or allergic reaction. Review your full risk profile with a healthcare professional.

Drug Interactions and Cautions

Tell your prescriber about all medicines and supplements you use. Diuretics and RAAS inhibitors may increase the risk of dehydration or low blood pressure. Alcohol and carbonic anhydrase inhibitors can raise the risk of lactic acidosis with metformin. Cationic drugs eliminated by renal tubular secretion may interact with metformin transport. Insulin and insulin secretagogues can increase hypoglycemia risk when combined. Temporarily interrupt therapy during major surgery, severe illness, or restricted fluid intake, per label guidance.

What to Expect Over Time

Many people observe improved glucose readings with consistent use, diet, and exercise. Gastrointestinal effects from the metformin component may lessen after the first days to weeks as tolerance improves. Hydration helps reduce dizziness and supports kidney function. Your clinician may order periodic labs to assess renal function and overall response. Track your readings, timing, and meals to support steady routines. Adherence to the schedule and meal pairing help optimize tolerance.

If you want a deeper clinical background on the class, see our primer on SGLT2 Inhibitors. For brand-specific education, review Uses Dosage Side Effects for additional reading.

Compare With Alternatives

Therapeutic alternatives include other SGLT2-metformin combinations and metformin-only options. Invokamet® pairs canagliflozin with metformin and may be considered if your prescriber prefers that SGLT2 agent. Glumetza® is an extended-release metformin option that some people tolerate better than immediate-release metformin. Dapagliflozin is another SGLT2 alternative that can be used with metformin when appropriate. Discuss comparative fit, renal thresholds, and infection risk with your prescriber. When budgeting, factor the potential Synjardy out of pocket cost alongside alternatives.

Pricing and Access

Prices vary by strength, quantity, and pharmacy partner. Many customers value Canadian pricing when comparing options. We provide transparent listings per package size so you can plan refills accordingly. If you are comparing XR options, check listings for empagliflozin/metformin 12.5 1000 price when available, and confirm whether your prescription specifies immediate-release or extended-release. Eligible offers change over time; see our Promotions page for current events. We provide US-facing fulfilment that Ships from Canada to US through licensed partners.

For savings education, you can also review Savings Card Guide. Checkout uses encrypted processes to protect your information.

Availability and Substitutions

Supply can vary by strength and format. If a requested size is unavailable, your prescriber may recommend an alternative strength or a different metformin-containing regimen. Pharmacy teams dispense the exact product written on your prescription unless a permitted substitution is authorized by your prescriber and local rules.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with type 2 diabetes who need additional control beyond lifestyle changes and metformin alone. People with eGFR below labeled thresholds, a history of recurrent genital infections, or conditions predisposing to lactic acidosis may not be good candidates. Those on diuretics or with low blood pressure should discuss volume status. Ask your prescriber about multi-month fills to reduce per-fill fees and fewer trips. Set refill reminders so you do not run out unexpectedly. If budgeting, track Synjardy price trends by strength and quantity. Compare pack sizes, and align refills with routine lab visits when practical.

Questions to Ask Your Clinician

• Starting plan: initial strength and how it fits my current regimen
• Tolerability: ways to reduce stomach upset with meals
• Kidney health: how often to check renal function
• Safety: signs of dehydration, acidosis, or infection
• Combination risk: adjusting other agents that may cause lows
• Travel: handling during trips and sick days

Authoritative Sources

• Manufacturer: Boehringer Ingelheim Synjardy
• FDA DailyMed Label Database
• Health Canada Drug Product Database

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