Vyzulta® Ophthalmic Solution for Open-Angle Glaucoma

Vyzulta® Ophthalmic Solution is a prescription eye drop used to lower intraocular pressure. It is indicated for adults with open-angle glaucoma or ocular hypertension. This page explains how it works, how to use it, and how to access it with US delivery from Canada, including options if you pay without insurance.

What Vyzulta Is and How It Works

This medicine contains latanoprostene bunod, a prostaglandin analog with a nitric oxide–donating component. It helps fluid leave the eye through the uveoscleral pathway and the trabecular meshwork. Lowering eye pressure can reduce the risk of optic nerve damage in susceptible patients.

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The treatment is dosed once daily and is usually taken in the evening. It can be used alone or along with other intraocular pressure–lowering agents when your clinician advises combination therapy.

Who It’s For

This therapy is for adults diagnosed with elevated intraocular pressure due to open-angle glaucoma or ocular hypertension. Your eye care professional will confirm the diagnosis with pressure measurements and optic nerve assessment.

People with a history of uveitis, macular edema, or complicated eye surgery may require added caution. Contact lens wearers should remove lenses before dosing and wait 15 minutes before reinserting. If you have questions about treatment goals for Open-Angle Glaucoma or Ocular Hypertension, speak with your clinician.

Dosage and Usage

Use one drop in the affected eye or eyes once each day in the evening. Do not use more than once daily, because more frequent dosing may reduce the pressure-lowering effect. If your regimen includes other eye drops, separate administration by at least five minutes.

Avoid touching the dropper tip to your eye, fingers, or any surface to prevent contamination. Remove contact lenses before dosing and wait 15 minutes before reinsertion. If your clinician has you on multiple agents, follow the order they recommend and keep consistent timing. Vyzulta once daily should be taken at roughly the same time each evening for best adherence.

Strengths and Forms

This product is supplied as a sterile ophthalmic solution in multi-dose bottles. Availability may vary by pharmacy, and bottle sizes commonly published include 2.5 mL and 5 mL presentations.

Many labels list latanoprostene bunod 0.024% ophthalmic solution as the active strength. Always confirm the labeled concentration and bottle size on your packaging, as local supply may differ.

Missed Dose and Timing

If you miss a dose, administer the next dose at the usual time the following day. Do not double up or use extra drops to make up for a missed dose. Keeping a simple nightly routine can help maintain consistency.

When using multiple eye medications, give each drop time to absorb. Waiting at least five minutes between products can help avoid washout. If you are using an eye gel or ointment, apply it last.

Storage and Travel Basics

Follow the storage instructions on your package insert. Many prostaglandin analog eye drops are kept in their original carton to protect from light. Do not freeze the bottle. Keep out of reach of children and pets.

When traveling, carry the bottle in your hand luggage. Keep the pharmacy label attached, and bring a copy of your prescription or a clinic note. Use a small protective pouch to prevent cap loosening. If your eye care team provided specific temperature guidelines, follow them and ask about temperature-controlled handling when required.

Benefits

The class reduces elevated intraocular pressure, a key risk factor for glaucomatous damage. It is taken once daily, which can simplify adherence compared with multi-dose regimens. It can be used as initial therapy or added to an existing regimen when further lowering is needed.

Because it targets fluid outflow through two pathways, it may be considered when additional reduction is desired under specialist guidance. Regular follow-up is important to assess pressure response and optic nerve status.

Side Effects and Safety

• Eye redness or irritation: usually mild and transient
• Temporary burning or stinging: often brief after instillation
• Blurred vision: commonly short-lived after dosing
• Eyelash growth or thickening: may occur over time
• Eyelid skin darkening: reversible in some cases
• Iris color change: increased brown pigmentation can be permanent

Serious but less common risks include macular edema, especially in certain patients after cataract surgery or with retinal conditions; inflammation inside the eye; and bacterial keratitis from dropper contamination. If you notice vision changes, new floaters, severe eye pain, or marked redness, contact your clinician promptly. Avoid using more than one prostaglandin analog at the same time unless specifically directed.

If you wear contact lenses, remember that benzalkonium chloride in many solutions can be absorbed by soft lenses. Remove lenses before dosing and wait 15 minutes to reinsert.

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Drug Interactions and Cautions

Using more than one prostaglandin analog concurrently is generally not recommended due to potential paradoxical pressure effects. When combining with beta-blockers, carbonic anhydrase inhibitors, or alpha-agonists, separate products by at least five minutes.

Tell your care team about recent eye surgery, retinal disease, or a history of uveitis. If you experience significant eye irritation or signs of infection, stop using the bottle until evaluated. Always use ophthalmic products as labeled and avoid sharing your medication.

What to Expect Over Time

Your clinician will assess your intraocular pressure over follow-up visits and may adjust your plan. Some people notice mild eye redness when starting, which can lessen with continued use. Eyelash changes and iris color shifts may develop gradually.

Consistent nightly use supports stable pressure control. Keep appointments for pressure checks and optic nerve evaluations. If your routine changes, set reminders to maintain dosing at approximately the same time each evening. For broader context on vision care, see this explainer on How Does Diabetes Affect The Eyes.

Compare With Alternatives

Eye pressure can also be treated with other classes, alone or in combination.

Beta-blocker drops such as Timolol are often used once or twice daily. Carbonic anhydrase inhibitors like Trusopt (dorzolamide) can be used as add-on therapy. Your clinician will choose based on target pressure, tolerability, and response. Some may consider another prostaglandin analog, such as bimatoprost, if appropriate.

Pricing and Access

We list current options so you can compare the Vyzulta price with alternatives and formulations. You can also review the latanoprostene bunod price to understand how the active ingredient compares across products. Our checkout reflects Canadian pricing with US shipping from Canada. For featured seasonal offers, visit our Promotions page.

Consider requesting a multi-bottle fill when appropriate, which may lower per-bottle costs and reduce pharmacy trips. If you have insurance, ask your plan about copay policies and prior authorization. If you self-pay, compare mailed options to find the best fit for your budget.

Availability and Substitutions

Supply can vary by bottle size. If your preferred package is unavailable, your prescriber may recommend a clinically suitable alternative in the same class or a different agent. We keep listings updated as inventory changes. Checkout is encrypted to protect your information.

Patient Suitability and Cost-Saving Tips

The treatment may not suit people with a history of macular edema, active uveitis, or certain postoperative states without close supervision. Those with severe dry eye or frequent lens wear may need additional comfort measures. If localized eyelash or skin changes become bothersome, discuss options with your clinician.

For budgeting, consider longer refill intervals, set reminders for timely reorders, and group shipments with other eye medications when possible. Ask your prescriber if a therapeutic alternative could meet your clinical needs at a lower overall expense. If you prefer digital management, many patients choose to Vyzulta refill online through their account dashboard.

You can also browse our broader eye care catalog in Ophthalmology to compare classes and bottle sizes with your clinician’s guidance.

Questions to Ask Your Clinician

• Evening dosing plan: best time for my schedule
• Combination therapy: how to separate multiple drops
• Contact lens timing: steps to reduce irritation
• Expected response: how pressure will be monitored
• Side effect management: when to call the clinic
• Surgery history: any added precautions for me

Authoritative Sources

For complete prescribing information and safety details, consult official sources below.

See the manufacturer’s prescribing information from Bausch + Lomb for product composition, storage, and labeled use: Bausch + Lomb Vyzulta Prescribing Information.

Review the FDA DailyMed entry for up-to-date label content, warnings, and handling: DailyMed Official Label.

See Health Canada’s Drug Product Database for Canadian regulatory information: Health Canada DPD Entry.

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.