Familial Adenomatous Polyposis (FAP) is a hereditary condition characterized by the development of numerous polyps in the epithelium of the large intestine. If left untreated, these polyps have a high likelihood of becoming cancerous, leading to colorectal cancer. Understanding the causes, symptoms, treatment, and prevention of FAP is crucial for managing this condition effectively.
FAP is primarily caused by mutations in the APC gene, which is responsible for controlling cell growth and apoptosis. This gene mutation is inherited in an autosomal dominant pattern, meaning that a single copy of the altered gene in each cell is sufficient to increase the risk of developing the condition. In some cases, new mutations can occur spontaneously in individuals with no family history of FAP. The APC gene mutation leads to uncontrolled cell division, resulting in the formation of numerous polyps in the colon and rectum.
The symptoms of FAP can vary, but they generally include:
The primary goal of treating FAP is to prevent the development of colorectal cancer. Treatment options include:
While FAP itself cannot be prevented due to its genetic nature, early detection and management are key to preventing complications such as colorectal cancer. Strategies include:
In conclusion, Familial Adenomatous Polyposis is a serious genetic condition that requires vigilant monitoring and management to prevent the progression to colorectal cancer. Our pharmacy offers medications that can aid in the treatment and management of FAP-related symptoms and associated conditions. For more information on available treatments, please visit our product pages for Metformin, Farxiga (Dapagliflozin), and Pioglitazone.