Hyzaar® Tablets for High Blood Pressure

Hyzaar® is a prescription tablet used to treat high blood pressure. This page explains what it is, how it works, and how to access it with US shipping from Canada. It also covers ways to manage costs without insurance.

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What Hyzaar Is and How It Works

This medicine combines two agents in one pill. Losartan blocks angiotensin II receptors, which helps relax blood vessels. Hydrochlorothiazide is a thiazide diuretic that helps your body remove extra salt and water. Together, the treatment can lower blood pressure more than either component alone in suitable patients. See the official label for complete details on indications and use.

Lowering blood pressure reduces the risk of stroke, heart attack, and kidney problems over time. Therapy selection and duration depend on your medical history, other medicines, and response. Review your plan with your healthcare professional and follow the prescribed schedule.

For background on the condition and treatment approaches, you can read our overview of High Blood Pressure. Related options appear in our Heart Health Medications category.

Who It’s For

The combination is indicated for adults with hypertension when your prescriber believes a two-drug regimen is appropriate. It may be started in patients likely to need multiple agents, or used after inadequate response to one drug. It is not established for pediatric use in this fixed-dose form.

Do not use during pregnancy. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. Avoid use if you cannot produce urine. Use caution if you have significant kidney or liver impairment, gout, low sodium or potassium, or a history of angioedema. Discuss use if you have a sulfonamide allergy, as hydrochlorothiazide is a sulfonamide-derived diuretic.

For additional perspective on antihypertensive choices, see How Bystolic Helps and Diabetes And High Blood Pressure Hypertension.

Dosage and Usage

Follow the dosing schedule on your prescription label. The fixed-dose combination is usually taken once daily. Your prescriber may start with a lower strength and adjust based on blood pressure readings and tolerability. Take it at the same time each day, with or without food, and drink adequate water unless otherwise directed.

Swallow tablets whole. Do not split or crush unless your clinician confirms it is appropriate for your specific tablet. If you experience dizziness, rise slowly from sitting or lying positions. Avoid excessive alcohol intake, which can intensify blood pressure lowering and lightheadedness. Do not make dose changes on your own. If you miss doses frequently, ask about adherence strategies or simplified regimens.

Strengths and Forms

Tablets are available in commonly used fixed-dose strengths that pair losartan with hydrochlorothiazide, including 50/12.5 mg, 100/12.5 mg, and 100/25 mg. Availability can vary by pharmacy and manufacturer.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up. Keeping a daily reminder or using a pill organizer can help prevent missed doses.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and protect it from moisture. Do not store in bathrooms with high humidity. Keep out of reach of children and pets. When traveling, carry this medicine in your hand luggage with the pharmacy label attached. Bring a copy of your prescription. If crossing borders, allow extra time for screening and keep the medication in its original container.

Benefits

The combination offers single-pill convenience for patients who need dual therapy. It may simplify routines compared to taking two separate products. Consistent use can help maintain smoother blood pressure control across the day. The diuretic component helps reduce excess fluid, while the angiotensin receptor blocker supports vessel relaxation. Many patients appreciate once-daily dosing.

Side Effects and Safety

• Dizziness or lightheadedness
• Fatigue or headache
• Increased urination
• Low sodium or potassium changes
• Photosensitivity or mild rash
• Elevated uric acid

Serious effects are less common but can include severe hypotension, kidney function changes, significant electrolyte imbalances, or rare allergic reactions including angioedema. Stop the medicine and seek urgent care for facial swelling, trouble breathing, or severe fainting. Use caution with activities requiring alertness until you know how you respond.

Drug Interactions and Cautions

Tell your prescriber about all medicines and supplements. NSAIDs may reduce the blood pressure effect and affect kidney function, especially in older adults or those with dehydration. Lithium levels can rise with thiazides. Combining with potassium supplements, salt substitutes, or potassium-sparing diuretics can alter potassium. Other antihypertensives may enhance blood pressure lowering. Bile acid sequestrants can reduce thiazide absorption if taken together closely. Limit alcohol to avoid additive dizziness.

What to Expect Over Time

Blood pressure improvement is gradual. Your clinician will review home readings and office measurements and may order labs to monitor electrolytes and kidney function. Take the tablet consistently and keep scheduled follow-ups. If you develop cramps, weakness, or unusual thirst, contact your healthcare professional. Long-term control depends on adherence, lifestyle, and the overall regimen. Discuss nutrition, activity, and weight goals as part of your plan. For category context, see Hypertension Cardiovascular.

Compare With Alternatives

Other angiotensin receptor blocker plus thiazide combinations may be considered if you need a different component balance or formulation. Two options we offer include Edarbyclor and Diovan Hct. Your prescriber will choose based on prior response, side effect profile, and comorbid conditions. In some cases, a single-agent ARB or an ACE inhibitor may be sufficient.

Pricing and Access

We list current Canadian pharmacy pricing and show options for brand or generic when available. You can compare formulary choices and see typical cash-pay ranges. Encrypted checkout protects your information. For savings updates, check our Promotions page. Access reflects Canadian pricing with US delivery from Canada. Ask your prescriber about 90-day fills if allowed by your plan.

Many patients ask about Hyzaar price from Canada. Final amounts vary by strength, pack size, and dispensing pharmacy. We display transparent pricing before you place your request.

Availability and Substitutions

Supply can vary. If the brand is unavailable, your prescriber may consider a therapeutically appropriate substitute. A widely used option is the labeled generic combination, often referred to as Generic for Hyzaar. Pharmacy selection and regulations govern whether a brand or a generic product is dispensed. Your order is filled by licensed Canadian pharmacies in accordance with your prescription.

Patient Suitability and Cost-Saving Tips

Candidates include adults whose blood pressure is not adequately controlled with one agent, or who merit combination therapy. It is not suitable in pregnancy and may not suit patients with severe kidney disease, anuria, or marked electrolyte disturbances. If you are on lithium, high-dose NSAIDs, or potassium-altering regimens, discuss risks and monitoring.

• Multi-month fills: Ask about 60–90 day supplies to reduce refill frequency.
• Reminders: Use calendar alerts or a pillbox to keep daily dosing consistent.
• Lab checks: Keep scheduled labs to track electrolytes and kidney function.
• Lifestyle: Follow clinician guidance on sodium, activity, and weight goals.
• Coverage: If you have insurance, confirm formulary status and copay tiers.

Questions to Ask Your Clinician

• Is this combination the right first-line option for me?
• What labs will you monitor, and how often?
• Could any of my current medicines raise interaction risk?
• What signs of low sodium or potassium should I watch for?
• How should I adjust my routine if dizziness occurs?
• Can I use a 90-day supply to simplify refills?
• What is the Hyzaar tablets cost relative to generic alternatives?

Authoritative Sources

DailyMed: Hyzaar Prescribing Information

Health Canada DPD: Hyzaar

Manufacturer Prescribing Information

Order Hyzaar online today for Ships from Canada to US and prompt, express shipping with temperature-controlled handling when required. This information is educational and not a substitute for professional medical advice. Always follow your prescriber’s directions.