NexGard Combo® Topical Solution for Cats

This topical combination protects cats from fleas, ticks, heartworm, and intestinal worms. NexGard Combo® is a veterinarian-prescribed spot-on with US delivery from Canada. You can request this medicine even when paying without insurance.

What NexGard Combo Is and How It Works

NexGard Combo topical solution for cats pairs three proven actives. Afoxolaner targets the nervous system of fleas and ticks. Eprinomectin acts on heartworm larvae and intestinal nematodes. Praziquantel disrupts tapeworm integrity. Together, the treatment helps break parasite lifecycles on the animal. It is applied to the skin and spreads across the coat’s lipid layer. Correct use reduces re-infestation pressure when paired with environmental control.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This medicine is prescription-only. A prescriber may recommend year-round prevention, especially in regions where vector exposure is common. Review the approved label for full details, including specific parasites covered and any limitations.

Explore related options in Pet Medications.

Who It’s For

This therapy is indicated for cats and kittens when protection against external and internal parasites is needed. NexGard Combo for kittens may be appropriate at and above the label’s minimum age and weight. Cats with a history of neurologic disorders may require additional caution. Safety in breeding, pregnant, or lactating cats has not been established in all cases. Do not use in animals with known hypersensitivity to isoxazolines, macrocyclic lactones, or praziquantel.

Always confirm the right pack for the cat’s weight band and discuss any chronic conditions with a veterinarian before starting treatment.

Dosage and Usage

NexGard Combo dosage for cats follows the labeled directions by weight. Apply one full pipette to intact skin at the base of the skull or neck. Part the hair until skin is visible, place the tip directly on the skin, and empty the pipette in one spot. Do not rub in. Keep the application site dry until absorbed. Apply on a regular monthly schedule for ongoing protection. If bathing is planned, allow the site to dry fully before exposure to water. Wash hands after application and avoid contact with the treated area until dry.

Always follow the official label for timing, frequency, and any seasonal recommendations for heartworm prevention and ectoparasite control.

Strengths and Forms

This prescription is supplied as single-use pipettes in weight-based presentations for cats. Packs are typically labeled for small, medium, and larger cats, including options suitable for 2.5–7.5 kg cats. The actives are combined as Afoxolaner eprinomectin praziquantel for cats, presented as a ready-to-use spot-on. Pack sizes and weights may vary by market and availability. Use only the pack that matches the cat’s current weight; do not split or combine pipettes.

For tapeworm-specific information, see Droncit For Cats.

Missed Dose and Timing

If a monthly dose is missed, apply as soon as remembered and resume the regular monthly schedule. Avoid applying two doses at the same time. For significant delays or uncertain exposure to heartworm vectors, consult a veterinarian. Maintain a consistent monthly cadence to support continuous protection. Mark application dates on a calendar or set phone reminders to help adherence.

Storage and Travel Basics

Store pipettes in the original box, out of reach of children and other animals. Keep at a controlled room temperature and protect from excessive heat and direct sunlight. Do not freeze. Keep sealed until use and discard empty containers safely. If you travel, keep the carton and leaflet with the pipettes, and bring the prescription or a copy if authorities may request documentation. When flying, pack in a leak-proof pouch. You should wash hands after use and prevent the treated area from contact with your skin until dry.

Benefits

NexGard Combo spot-on solution for cats provides broad parasite coverage in a single monthly application. The combination reduces the need for multiple separate products. It targets fleas and ticks on the animal while also providing heartworm prevention and treatment of common gastrointestinal worms. The topical format avoids oral dosing, which may be helpful for cats that resist tablets.

Side Effects and Safety

• Application site effects: temporary hair changes, residue, or mild skin irritation
• Gastrointestinal signs: vomiting, soft stool, or decreased appetite
• Behavioral changes: lethargy or restlessness
• Pruritus: scratching at or near the application site
• Hypersalivation: often related to grooming the wet site

Serious but less common events can include neurologic signs such as tremors, ataxia, or seizures. Isoxazolines have been associated with neurologic adverse reactions in a small number of cats, including those without a prior history. Seek veterinary care if concerning signs occur. Use only as directed and avoid use in animals with contraindications listed on the label.

Drug Interactions and Cautions

Discuss all current medicines, supplements, and parasite preventives with a veterinarian. Combining products from the same class, such as other isoxazolines or macrocyclic lactones, may increase the risk of side effects. Use caution in cats with neurologic disorders or significant systemic illness. If concurrent antibiotics are needed, review compatibility and timing with the prescriber. For background on a common antibiotic used in cats, see Cephalexin For Cats.

What to Expect Over Time

With regular monthly use, this medicine helps reduce flea burdens and tick attachment on the animal while maintaining heartworm prevention. Intestinal worm control follows the labeled spectrum. Environmental management, such as vacuuming and washing bedding, supports better outcomes. Monitor the coat and skin after each application. If the cat’s weight changes enough to move into a different weight band, access the appropriate pack at the next refill.

For broader context on feline therapies, explore this overview: Cat Medicine. If the cat also requires antimicrobials, this guide may help: Pet Antibiotics.

Compare With Alternatives

Two prescription alternatives address similar needs. Revolution Plus combines selamectin and sarolaner for broad ecto- and endoparasite coverage in cats. See Revolution Plus for details. For tapeworm-only treatment, a single-ingredient praziquantel product can be considered; see Droncit. Your veterinarian can advise which option aligns with the cat’s risk profile and medical history.

Pricing and Access

Canadian pricing applies, and NexGard Combo price for cats varies by weight band and pack size. Orders are dispensed by licensed Canadian pharmacies and Ships from Canada to US. Start a request to review current pricing, compare options, and see typical cash-pay savings. If you are looking for seasonal offers, check our Promotions page.

Availability and Substitutions

Supply can vary by strength or pack size. If a particular weight band is unavailable, a prescriber may recommend a comparable alternative from the same class or a different product suited to the cat’s needs. Do not substitute or combine packs without veterinary guidance. Check back for updates if the desired presentation is temporarily out of stock.

Patient Suitability and Cost-Saving Tips

Good candidates are healthy cats needing broad monthly parasite control. Cats with neurologic conditions or those under the label’s minimum age or weight may not be suitable. Discuss concurrent conditions with a veterinarian before starting any new parasite prevention plan. To reduce overall costs, consider requesting multi-month quantities when the prescription allows, and set calendar reminders for monthly dosing. For those paying cash, NexGard Combo cash price may be lower when ordering multiple months at once.

Questions to Ask Your Clinician

• Coverage scope: which fleas, ticks, and worms are addressed
• Timing plan: when to start and how long to continue
• Weight band fit: which pack matches the cat today
• Concurrent therapies: how to coordinate with other preventives or antibiotics
• Adverse event signs: what to watch for after dosing
• Bathing guidance: how long to wait before water exposure
• Travel needs: documents to carry for border crossings

Authoritative Sources

Manufacturer Site | EMA EPAR | Boehringer Ingelheim

Ready to proceed? Start your order for prompt, express shipping with temperature-controlled handling when required and US shipping from Canada. This page is informational and does not replace veterinary advice; follow your veterinarian’s directions.