NexGard Combo® Spot-On for Cats

NexGard Combo is a monthly spot-on for cats that targets fleas, ticks, heartworm, and intestinal worms. You can order with US delivery from Canada, which can help manage costs without insurance. This page explains how it works, who it suits, and how to use it safely.

What NexGard Combo Is and How It Works

NexGard Combo® is a prescription topical solution for cats. It combines three active ingredients to cover external and internal parasites. CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

It works through a multi-component approach. Esafoxolaner belongs to the isoxazoline class; it interferes with nerve signaling in fleas and ticks, leading to paralysis and death. Eprinomectin is a macrocyclic lactone that targets susceptible nematodes, including heartworm larvae, by affecting chloride channels in their nervous system. Praziquantel disrupts tapeworm integrity, helping eliminate intestinal cestodes.

This combination helps protect cats from common fleas and several tick species, prevents heartworm disease when dosed monthly, and treats or controls roundworms, hookworms, and tapeworms. For additional context on external parasites, see our resource on Feline Flea Infestation.

Who It’s For

This medicine is intended for cats and kittens as directed by a veterinarian. It may be used in healthy cats that need broad-spectrum parasite protection, including indoor cats with exposure risks.

Use care in cats with a history of neurologic disorders, as isoxazoline class products have been associated with rare neurologic adverse events. Kittens should meet the minimum age and weight on the label before starting therapy; discuss suitability if your pet is pregnant, nursing, or breeding, as safety may be unestablished. For those focused on heartworm prevention, review background information on Feline Heartworm Disease.

Some caregivers ask about nexgard combo for kittens; your veterinarian will confirm age and weight eligibility and the correct pipette size.

Dosage and Usage

This treatment is applied topically once monthly, using the entire pipette contents at a single site on intact skin. Part the hair at the base of the skull or on the neck where the cat cannot lick. Place the tip of the applicator on the skin and squeeze steadily until empty. Avoid contact with the eyes or mouth. Do not bathe immediately before application, and allow the site to dry fully.

Always select the correct weight band. Do not split a pipette between cats or use multiple pipettes unless specifically directed by a veterinarian. If your cat vomits, drools, or seems bothered by the odor shortly after dosing, isolate from other pets until the site is dry. Do not allow children to touch the area until it has dried.

For owners seeking guidance on nexgard combo for cats how to use, follow the on-box instructions and your veterinarian’s label directions. For intestinal worm topics tied to dosing intervals, you may also review Feline Intestinal Worms.

Strengths and Forms

The product is supplied as single-use pipettes in weight-based presentations for cats, commonly covering small, medium, and large weight ranges. Retail packs may include multiple pipettes (for example, 3 or 6). Availability can vary by market and by supplier. Your veterinarian will match the appropriate pipette to your cat’s current weight.

Owners sometimes search for nexgard combo 2.5 7.5 kg; this refers to one of the mid-range weight bands for adult cats, not a concentration. If your cat’s weight is near a band boundary, ask your prescriber which size is appropriate.

Missed Dose and Timing

Apply the dose as soon as you remember if you miss a monthly administration. Then resume the regular monthly schedule, keeping consistent intervals moving forward. If multiple months are missed, consult your veterinarian about re-establishing prevention, especially for heartworm exposure risk.

Do not double up doses to make up for a missed application. Keeping a calendar reminder or using a refill alert can help maintain monthly adherence. If searching by name, some refer to nexgard combo spot on when setting reminders across seasons.

Storage and Travel Basics

Store pipettes in the original foil until use, away from heat and direct sunlight, and out of reach of children and pets. Keep at room temperature as directed on the label. Do not refrigerate or freeze unless the package specifically allows it. The solvent can be flammable; keep away from open flames and ignition sources.

When traveling, pack unopened pipettes in a secure pouch to avoid puncture or leaks. Bring your prescription details and your veterinarian’s contact information. For customs or airline queries, carry the original box and leaflet. If you need to switch weight bands as your kitten grows, speak with your prescriber before your trip. For general pet care shopping while traveling, see our Pet Medications page.

Owners sometimes list cat nexgard combo on a travel checklist. Mark the calendar to maintain monthly prevention, especially in higher-risk areas.

Benefits

This medicine provides broad-spectrum parasite control in a single monthly spot-on. It can simplify prevention by combining external flea and tick control with internal parasite coverage, including heartworm larvae and common intestinal worms.

Households with multiple cats may appreciate a single-product approach. It may also help reduce the need for separate deworming appointments when used as directed by your veterinarian. To understand tick-related risks, our overview on Feline Tick Infestation offers context on exposure and prevention. For those comparing names, terms like nexgard combo feline often refer to this broad-spectrum coverage in cats.

Side Effects and Safety

Common effects can include mild, temporary reactions at the application site, such as hair changes or skin irritation. Some cats may experience vomiting, reduced appetite, lethargy, or drooling. These are usually short-lived. Bathe only after the site is fully dry if bathing is necessary.

Serious reactions are uncommon but can occur. Isoxazoline class products have been associated with neurologic events such as tremors, ataxia, and seizures, even in animals without a known history of such conditions. Seek veterinary care for persistent or severe reactions, or for signs of parasite-borne illness. If your veterinarian suspects lungworms in your area, review our resource on Feline Lungworm Infection for general background.

Drug Interactions and Cautions

Tell your veterinarian about all medicines, supplements, and preventives your cat receives. Using multiple parasite products together can increase exposure to similar drug classes. Extra caution may be advised if your cat has a history of neurologic issues.

Do not use in species other than cats. Keep treated animals separated until the application site is dry to prevent ingestion by other pets. If accidental ingestion occurs, contact your veterinarian or a poison control resource promptly.

What to Expect Over Time

With regular monthly use, you can expect fewer flea bites and reduced environmental contamination over time. Tick protection can help lower the risk of tick-borne problems in cats. Heartworm prevention is maintained by consistent monthly dosing.

Your veterinarian may recommend year-round use based on regional risk. Adherence matters; pairing administration with a recurring reminder helps maintain coverage. For background on tapeworm treatment concepts, you can read our article on Tapeworm Treatment for general education.

Compare With Alternatives

For a similar monthly topical that covers fleas, ticks, and heartworm prevention for cats, consider Revolution® Plus. If your veterinarian advises a targeted dewormer for tapeworms and other intestinal parasites, Profender® is another topical option for cats. Your clinician can help decide which product aligns with your cat’s needs and local risks.

Pricing and Access

Canadian pricing may offer value compared to some local cash rates. You can check pack sizes and current availability online and compare total out-of-pocket costs before you add to cart. We provide US shipping from Canada with a pharmacy-dispensed order after verification as required.

To estimate long-term prevention, consider multi-pack options and plan refills ahead of season changes. If you have questions about selection within the feline parasite category, explore our condition pages linked above for additional context.

Availability and Substitutions

Supply can vary by weight band and pack size. If a specific presentation is unavailable, your prescriber may recommend an alternative with comparable coverage. Broad-spectrum topicals or standalone dewormers may be suitable substitutes based on your cat’s needs and clinical history.

Patient Suitability and Cost-Saving Tips

This treatment may suit healthy adult cats and eligible kittens who need broad parasite protection. Cats with significant neurologic history, severe skin disease at the application site, or known hypersensitivity to any component may not be ideal candidates. Always discuss your cat’s medical background before starting therapy.

To manage expenses, consider 3- or 6-dose packs when appropriate, and align refills with calendar reminders. Weigh growing kittens regularly to ensure you are using the correct pipette size. Keep a written log of dosing dates, weight, and any observed reactions to share with your veterinarian at checkups.

Questions to Ask Your Clinician

• Is this the right weight band for my cat today?
• Should I use this year-round based on local parasite risk?
• How soon can I bathe my cat after application?
• What signs after dosing should prompt a call?
• Can I combine this with other parasite preventives safely?
• When should kittens transition to the next size pipette?

Authoritative Sources

For detailed, label-aligned information, consult these official references:

• Manufacturer product information from Boehringer Ingelheim; see the veterinary portfolio page for current labeling and use directions on the manufacturer’s site.
• Health Canada Drug Product Database listing for current Canadian status and monograph access, where available on the Health Canada DPD.
• When applicable, regional regulator publications provide class safety communications for isoxazoline products; see agency updates for general guidance from official sources.

Order from CanadianInsulin with prompt, express, temperature-controlled handling when required. Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.