Perindopril/Amlodipine Tablets for Hypertension

Perindopril/amlodipine is a prescription combination tablet used to lower high blood pressure. It joins an ACE inhibitor with a calcium channel blocker to relax blood vessels. This page explains how it works, safety guidance, and how to order with US delivery from Canada, including options for perindopril amlodipine without insurance.

What Perindopril/Amlodipine Is and How It Works

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The combination pairs perindopril, an angiotensin-converting enzyme inhibitor, with amlodipine, a dihydropyridine calcium channel blocker. Perindopril reduces the formation of angiotensin II and decreases aldosterone secretion, which can lower vessel constriction and fluid retention. Amlodipine relaxes vascular smooth muscle by limiting calcium entry, which reduces peripheral resistance. Used together, this medicine may help lower blood pressure in adults who need two agents.

This treatment is taken by mouth. It does not replace lifestyle measures such as sodium reduction, weight management, and regular activity advised by a prescriber. Always follow the approved label for complete directions.

Who It’s For

Perindopril and Amlodipine tablets are indicated for adults with essential hypertension when a single agent is not enough, or when patients are already stabilized on the individual components at equivalent doses. It may be used to simplify a two-drug regimen into one pill as directed by a prescriber.

Do not use this medicine if pregnant, planning pregnancy, or with a history of angioedema related to ACE inhibitors. Avoid in hereditary or idiopathic angioedema. Use caution with severe aortic stenosis, symptomatic hypotension, volume depletion, or significant renal impairment. People with diabetes should not take an ACE inhibitor together with aliskiren. For broader cardiovascular options, explore our category for High Blood Pressure.

Dosage and Usage

Take this medicine orally once daily, at the same time each day, with or without food. Swallow the tablet whole with water. Do not crush or chew. If a dose is skipped repeatedly, speak with a prescriber about adherence supports rather than altering the schedule independently.

Therapy is typically initiated in patients already tolerating each component, or as directed to replace two separate tablets with a fixed-dose combination. Dose selection and titration are individualized; rely on the official label and the prescriber’s instructions.

To promote consistency, pair the daily dose with a routine, such as breakfast. If dizziness occurs on initiation, taking the dose at bedtime may be considered after consultation with a clinician. Do not stop therapy abruptly without medical guidance.

Strengths and Forms

The product is available as generic perindopril amlodipine tablets in multiple strengths. Availability may vary by pharmacy and manufacturer.

• 5 mg/5 mg tablets
• 7 mg/5 mg tablets
• 10 mg/5 mg tablets
• 10 mg/10 mg tablets

Some markets offer brands such as Viacoram (e.g., 5/5 mg or 10/5 mg) and Acerycal (e.g., 5/5 mg). Check the imprint and packaging provided by the dispensing pharmacy.

Missed Dose and Timing

If a dose is missed, take it when remembered the same day. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not take two doses at once. If vomiting or diarrhea occurs, follow label guidance and consult a healthcare professional if unsure.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from heat and direct light. Keep medication in the original, child-resistant container with the pharmacy label. Do not store in bathrooms or glove compartments. Dispose of outdated tablets through local take-back options.

For travel, keep medicine in carry-on baggage with a copy of the prescription and the original labeled container. Plan dosing around time zone changes to maintain a consistent daily schedule. Security screenings typically allow medications; check airline and TSA guidance before departure.

During trips, carry enough tablets plus a few extra days in case of delays. Keep desiccant packets in the original bottle if supplied, and avoid repackaging into unlabeled bags. For storage in hot climates, protect from excessive heat and direct sunlight.

Benefits

This combination allows two complementary mechanisms in one pill. Using both classes may help lower blood pressure with fewer tablets to remember. Once-daily dosing can simplify long-term management. Fixed-dose combinations can also reduce pharmacy pickups compared with filling separate agents.

Side Effects and Safety

• Cough, throat irritation, or hoarseness
• Dizziness or lightheadedness, especially when standing
• Headache or flushing
• Swelling of ankles or feet
• Fatigue or weakness
• Stomach upset or nausea

Serious but less common effects can include angioedema, severe hypotension, kidney function changes, high potassium, or liver problems. Stop the medicine and seek urgent care for facial swelling, trouble breathing, or fainting. Drugs in the ACE inhibitor class carry a boxed warning: discontinue as soon as pregnancy is detected.

Drug Interactions and Cautions

Tell the prescriber and pharmacist about all medicines and supplements. Interactions may occur with potassium-sparing diuretics or potassium products, ARBs such as Diovan®, aliskiren in patients with diabetes, and NSAIDs that can affect kidney function. Lithium levels may rise when used with ACE inhibitors. Diuretics can increase the risk of low blood pressure at initiation.

Amlodipine is metabolized by CYP3A4. Strong inhibitors (for example, clarithromycin, azole antifungals, or some HIV protease inhibitors) can raise exposure; strong inducers (such as rifampin or carbamazepine) can lower exposure. Limit simvastatin to recommended doses when coadministered with amlodipine. Grapefruit may increase amlodipine levels.

For background on related classes, see Benazepril Uses and Acebutolol Uses.

What to Expect Over Time

Blood pressure may improve gradually with consistent daily use. Some people notice lightheadedness during the first days as vessels relax. Edema around the ankles can occur with calcium channel blockers; clinicians may monitor and adjust if needed. Periodic labs for kidney function and potassium are often recommended for ACE inhibitors.

Adherence supports such as pill organizers, smartphone reminders, or synchronized refill dates can help maintain regular use. Report persistent cough, swelling, or other troubling symptoms to a healthcare professional. Clinicians often assess response over several weeks and may adjust the regimen if targets are not achieved. Lifestyle measures remain important alongside medication.

Compare With Alternatives

Single-agent options include amlodipine alone, available as Norvasc®, and ACE inhibitors such as Perindopril. Fixed-dose combinations like this one can reduce pill burden compared with taking two separate products.

Depending on clinical goals, a prescriber may consider other classes or different pairings. Brands such as Viacoram tablets or Acerycal brand tablets are marketed in some regions; availability varies by country and manufacturer.

Pricing and Access

View current pricing, compare strengths, and start checkout to see pharmacy options. We show Canadian pricing with clear fees and no extra enrollment. Many customers look for a perindopril amlodipine price from Canada to estimate their cash-pay exposure. Savings vary based on manufacturer and fill length. Potential savings are often relevant for those without insurance.

For those paying cash, review the perindopril/amlodipine cash price on the product page, then proceed to encrypted checkout. Orders are fulfilled by licensed pharmacies and Ships from Canada to US for qualifying addresses. To learn about seasonal offers, see Promotions. For broader cardiovascular options to compare, visit Heart Health Medications.

Availability and Substitutions

Supply can differ by strength and manufacturer. If a selected tablet is not available, a prescriber may suggest a therapeutically equivalent strength, a different manufacturer, or separate components. When discussing options, some patients ask about the perindopril amlodipine brand name used in their region; examples include Viacoram and Acerycal where marketed. Naming may also appear as perindopril arginine plus amlodipine in certain dossiers.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults who require two antihypertensive agents and prefer a single daily pill. It may not suit people with a history of ACE inhibitor–related angioedema, pregnancy, or severe hypotension. Kidney or liver impairment may require closer monitoring.

To manage out-of-pocket exposure, consider 60- to 90-day fills, align refills for multiple medicines, and set calendar reminders before the last week of supply. Those seeking perindopril amlodipine pay out of pocket options can compare generic choices and choose longer fills to reduce dispensing fees per tablet. Ask the dispensing pharmacist about specific manufacturers in stock. To lower overall costs, compare generic manufacturers, opt for longer fills when appropriate, and combine orders to reduce per-order fees. Enable refill reminders within your account to avoid gaps in therapy.

Questions to Ask Your Clinician

• Is a fixed-dose combination appropriate for my blood pressure goals?
• What monitoring for kidney function and potassium is recommended?
• Which adverse effects should prompt a call or visit?
• Could any of my current medicines interact with this therapy?
• Is a different ratio or separate components better for my situation?
• How should I time doses if I work shifts or travel across time zones?
• Would a 90-day fill be suitable to reduce pharmacy visits?

Authoritative Sources

See official information and approved labeling:

• DailyMed: Perindopril and Amlodipine
• Health Canada Drug Product Database
• Manufacturer Information

Place your order with CanadianInsulin for prompt US shipping from Canada and temperature-controlled handling when required. Prescription required; information here does not replace professional medical advice.