Prestalia® Tablets for Hypertension

What Prestalia® Is and How It Works

Prestalia® is a prescription tablet that combines perindopril and amlodipine to help adults with high blood pressure. It lowers blood pressure by relaxing and widening blood vessels through two well-studied mechanisms. Available with US delivery from Canada, the perindopril/amlodipine combination can be a practical option when paying without insurance.

CanadianInsulin is a prescription referral service. We verify your prescription with your clinic, and licensed Canadian pharmacies dispense your order.

Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. After activation to perindoprilat, it reduces angiotensin II and aldosterone activity, easing vascular resistance. Amlodipine is a dihydropyridine calcium channel blocker that relaxes arterial smooth muscle and improves blood flow. Together, these actions complement each other to reduce blood pressure steadily over 24 hours. For more on the ACE inhibitor component, see Perindopril.

Who Prestalia® Is For

Prestalia is indicated for adults with essential hypertension when treatment with perindopril or amlodipine alone is inadequate, or when a clinician prefers to start with combination therapy. It may also replace separate perindopril and amlodipine tablets to simplify a regimen.

Avoid use during pregnancy and while breastfeeding. ACE inhibitors carry a boxed warning for fetal toxicity; discontinue if pregnancy is detected. Do not use in patients with a history of ACE inhibitor-related angioedema, hereditary or idiopathic angioedema, or in those hypersensitive to any component. Use caution in conditions such as severe aortic stenosis, symptomatic hypotension, volume depletion, renal impairment, or hepatic impairment. Patients with bilateral renal artery stenosis or those on dialysis require close supervision.

Dosage and Usage

The combination is generally taken once daily, preferably at the same time each day, with or without food. Initial dosing and later titration are individualized based on prior therapy and blood pressure response. Many patients start at a lower tablet strength, with the dose adjusted at intervals to achieve target blood pressure while maintaining tolerability.

Prestalia may be used to substitute for the two single-ingredient tablets when appropriate. When switching from amlodipine alone or perindopril alone, clinicians consider the current dose of each component to select a comparable combination tablet. Do not split the tablet. If dizziness occurs after starting or increasing the dose, rise slowly from sitting or lying positions.

Because Prestalia contains an ACE inhibitor, periodic monitoring of kidney function and potassium is commonly recommended, especially after dose changes, in older adults, or in those with chronic kidney disease. For broader background on ACE-inhibitor therapy, see our article Benazepril Uses.

Strengths and Forms

Prestalia tablets are commonly available in strengths that pair perindopril arginine with amlodipine: 3.5/2.5 mg, 7/5 mg, and 14/10 mg. Packaging and available strengths may vary by manufacturer and country. Note that some references list perindopril as the erbumine or arginine salt; strength numbers are not interchangeable across salts, so dispense and take exactly as labeled.

Missed Dose and Timing

If a dose is missed, take it when remembered unless the next dose is near. If it is close to the next scheduled dose, skip the missed dose and resume the regular schedule. Do not take two doses at once. Consistent daily dosing supports steady blood pressure control; a simple reminder or pill organizer can help.

Storage and Travel Basics

Store tablets at standard room temperature, away from excess moisture and heat, and keep them in the original, labeled container. For home storage, a cool, dry cabinet is preferable to a bathroom medicine chest. Keep out of reach of children and pets.

For travel, keep your medication in carry-on luggage with the pharmacy label attached. Bring enough tablets for the full trip plus a small buffer, and set phone reminders for daily dosing. If using a weekly pill organizer, carry the original bottle as backup for security checks. Medicines are dispensed and labeled by licensed Canadian pharmacies.

Benefits

By combining two complementary agents in a single tablet, Prestalia supports simple, once-daily dosing and may improve adherence. ACE inhibition addresses hormonal drivers of vasoconstriction, while amlodipine relaxes arterial smooth muscle. Together, the pair helps reduce blood pressure and, when used as part of guideline-based care, can reduce cardiovascular risks over time.

Some patients who previously needed separate pills may find a single combination tablet more manageable. Others who have edema with dihydropyridine calcium channel blockers alone may benefit when an ACE inhibitor is included. Related options include long-acting dihydropyridines like Nifedipine Xr, depending on clinical goals.

Side Effects and Safety

• Common: headache, dizziness or lightheadedness, flushing, fatigue, cough, ankle or foot swelling, palpitations, nausea, abdominal discomfort.
• Less common: muscle cramps, rash or itching, sleep disturbance, constipation, hypotension.
• Serious but rare: angioedema of the face, lips, tongue, or throat; very low blood pressure; fainting; high potassium; kidney function changes; chest pain or worsening angina.

Seek urgent care for signs of angioedema or severe allergic reaction. Swelling from amlodipine may improve with dose adjustments or combination therapy, but persistent or severe edema warrants evaluation. Those with chronic kidney disease, heart failure, or on diuretics may be more sensitive to blood pressure changes, especially when starting or increasing the dose.

Drug Interactions and Cautions

Potential interactions include potassium-sparing diuretics (e.g., spironolactone, eplerenone), potassium supplements, or salt substitutes containing potassium, which may raise potassium levels with ACE inhibitors. Combining ACE inhibitors with ARBs or with aliskiren increases adverse-event risk; avoid dual renin-angiotensin system blockade, and aliskiren is generally contraindicated in patients with diabetes taking an ACE inhibitor.

Nonsteroidal anti-inflammatory drugs can blunt antihypertensive effects and affect kidney function, especially in dehydrated states or in older adults. Lithium levels may rise when given with ACE inhibitors; monitor closely if used together. Amlodipine is a CYP3A4 substrate: strong inhibitors or inducers can change its levels. When used with simvastatin, many labels recommend limiting simvastatin to 20 mg daily. Grapefruit products can modestly increase amlodipine exposure; consistent intake patterns help clinicians interpret dosing. Alcohol can amplify hypotension and dizziness.

If chest pain, fainting, or new swelling develops, or if pregnancy occurs, prompt medical evaluation is important. Do not stop or change doses without clinician guidance.

What to Expect Over Time

Blood pressure often improves progressively over days to weeks, with full effects after dose titration and consistent daily use. Some individuals notice transient dizziness, flushing, or ankle swelling early on; these effects are typically mild but should be monitored. Ongoing follow-up may include home blood pressure tracking, office readings, and periodic labs for kidney function and potassium. Long-term cardiovascular protection depends on sustained blood pressure control and broader risk management such as lipid, kidney, and lifestyle care.

Compare With Alternatives

For those who do well on amlodipine alone but need a higher dose or different profile, the branded amlodipine product Norvasc is one option. If an ARB-based strategy is preferred, combinations like Candesartan Hctz may be considered. Other calcium channel blockers, such as controlled-release Diltiazem Hcl Cd, are alternatives in particular clinical settings. Discuss goals and tolerability with a clinician to choose among options.

Pricing and Access

Many shoppers appreciate Canadian pricing on brand and generic blood pressure medicines. Ordering through CanadianInsulin is straightforward, and US shipping from Canada is available after prescription verification. Add Prestalia to the cart, upload a valid prescription, and our team coordinates clinic confirmation. For savings updates and occasional offers, see promotions. We provide prompt, express, cold-chain shipping for eligible items.

Availability and Substitutions

Supply can vary by manufacturer and strength. If a specific strength is unavailable, a prescriber may recommend a therapeutically appropriate alternative or a different combination tablet. You can also browse related options in Heart Health Medications to discuss with a clinician.

Patient Suitability and Cost‑Saving Tips

Suitable candidates are adults with essential hypertension who benefit from dual therapy or a simplified one-pill regimen. It is not appropriate in pregnancy, in those with prior ACE inhibitor-related angioedema, or for individuals with known intolerance to either component. People with advanced kidney disease, liver impairment, severe aortic stenosis, or baseline low blood pressure need tailored management and closer monitoring.

Cost considerations can include selecting a generic, choosing multi-month refills to reduce per-fill fees, and aligning prescription quantities with insurance plan cycles or personal budgets. Ordering a 90-day supply when appropriate can reduce overall shipping and per-tablet costs. Set refill reminders before travel, and keep a small reserve where allowed so you have your medicines when needed.

Questions to Ask Your Clinician

• Is a perindopril/amlodipine combination appropriate for my treatment goals?
• Which tablet strength best matches my current regimen, and when should titration be considered?
• How should kidney function and potassium be monitored after starting or changing the dose?
• Could a diuretic or ARB-based alternative, such as Ramipril Hctz, be reasonable for me?
• What symptoms should prompt a call or visit, especially related to swelling, cough, or dizziness?
• Are there medicines or supplements I should avoid, such as NSAIDs or potassium products?
• Is amlodipine alone, like the brand linked above, sufficient for my blood pressure?

Authoritative Sources

• FDA label for Prestalia
• MedlinePlus amlodipine overview
• Health Canada product monograph

Ready to proceed? Place your order with CanadianInsulin for prompt, express, cold-chain shipping and careful dispensing from licensed Canadian pharmacies. Always keep medicines in their labeled container during travel for easy verification.

Disclaimer: This information is educational and not a substitute for professional medical advice. Use medications only as prescribed by a licensed clinician and follow the supplied patient leaflet.