Perindopril/Amlodipine Tablets for Hypertension

Perindopril/amlodipine is a fixed‑dose combination tablet for high blood pressure. It pairs an ACE inhibitor with a calcium channel blocker to help lower readings. You can access this therapy with US delivery from Canada, even if you pay without insurance.

What Perindopril/Amlodipine Is and How It Works

Perindopril/Amlodipine® combines perindopril, an angiotensin converting enzyme (ACE) inhibitor, with amlodipine, a dihydropyridine calcium channel blocker. The ACE inhibitor reduces angiotensin II production, which can relax blood vessels and lower vascular resistance. Amlodipine blocks calcium influx in vascular smooth muscle, which may ease arterial stiffness and reduce afterload. Together, the combination targets two pathways that influence blood pressure.

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The term perindopril amlodipine usually refers to fixed‑dose tablets taken once daily. This medicine is intended for adults who need combination therapy after evaluating single‑agent response. For background on the condition it treats, see our overview of Hypertension.

Who It’s For

This treatment is used for adults with essential hypertension when single agents do not adequately control blood pressure or when a fixed‑dose combination is appropriate. It may be considered when patients benefit from both an ACE inhibitor and a calcium channel blocker.

Do not use if you are pregnant. Avoid use if you have a history of angioedema with ACE inhibitors, hereditary or idiopathic angioedema, or hypersensitivity to either component. People with severe hypotension, significant aortic stenosis, or unstable heart failure should be assessed carefully by their clinician. If coronary risk is present, see related information on Coronary Artery Disease and episodes of Angina.

Dosage and Usage

Typical administration is once daily, at the same time each day, with or without food. Swallow tablets whole with water. If you are switching from individual components, a clinician may choose a fixed strength that matches your current regimen.

Follow your prescriber’s instructions and the official patient information for perindopril amlodipine dosage. When uncertain about a starting or target dose, defer to the product label or your clinician’s advice. Do not adjust or stop therapy without medical guidance.

Administration tips include monitoring blood pressure regularly, rising slowly from sitting to reduce dizziness, and maintaining hydration. If cough develops or swelling of the legs occurs, contact your prescriber to discuss next steps.

Strengths and Forms

This medicine is available as oral tablets in fixed‑dose combinations. Common presentations use the arginine salt of perindopril paired with amlodipine. Frequently available strengths include 3.5 mg/2.5 mg, 7 mg/5 mg, and 14 mg/10 mg. Availability can vary by market and manufacturer. Brand names in some regions include Viacoram and Acerycal.

Labeling may list perindopril as the arginine or erbumine salt. Naming conventions differ by country, so check the exact strength printed on your package. If you are considering perindopril arginine amlodipine, confirm the corresponding dose with your prescriber.

Missed Dose and Timing

If you miss a dose, take it when you remember on the same day. If it is close to the next scheduled dose, skip the missed dose and resume your regular timing. Do not take two doses at once. Consistent daily timing can help reduce fluctuations in blood pressure.

Storage and Travel Basics

Store tablets at room temperature in the original container, away from excessive moisture and direct light. Keep out of reach of children and pets. Do not use tablets that are damaged or show unusual discoloration.

When traveling, keep your medicine in carry‑on baggage, along with a copy of your prescription and your prescriber’s contact information. Use a daily pill organizer if it helps adherence, but retain the labeled package for identification when crossing borders. For patients managing cardiovascular risks, our category page on Cardiovascular health offers related therapies.

For clarity, perindopril amlodipine tablets should remain in a dry place and closed tightly after each use. If you have climate concerns during travel, ask your pharmacist about suitable storage ranges for your specific product.

Benefits

This combination can simplify treatment by delivering two mechanisms in one tablet. Fewer separate pills may support adherence for people on multi‑drug regimens. The ACE inhibitor component can benefit patients with certain comorbid risks, while the calcium channel blocker can help reduce vascular resistance.

Many patients appreciate once‑daily dosing and a stable 24‑hour effect. The therapy may be combined with other classes if additional control is needed, following clinical advice.

Side Effects and Safety

• Dry cough: persistent, tickling cough can occur with ACE inhibitors.
• Dizziness or lightheadedness: especially when starting or increasing strength.
• Headache or flushing: usually mild and transient.
• Peripheral edema: ankle or leg swelling related to amlodipine.
• Fatigue or nausea: typically improves with continued use.

Serious but uncommon reactions include angioedema of the face, lips, tongue, or throat; severe hypotension; kidney function changes; and elevated potassium. Seek urgent care for swelling with breathing difficulty or fainting. Use caution with a history of renal artery stenosis or volume depletion. Avoid use during pregnancy; ACE inhibitors can harm the fetus. If breastfeeding, discuss risks and alternatives with your clinician.

Drug Interactions and Cautions

Tell your healthcare provider about all medicines, vitamins, and herbal products you use. Potential interactions include:

• Potassium‑sparing agents or supplements: may increase potassium levels.
• Lithium: risk of increased lithium toxicity when used with ACE inhibitors.
• NSAIDs: may reduce antihypertensive effect and impact kidney function.
• Strong CYP3A4 inhibitors or inducers: can alter amlodipine levels.
• Simvastatin: limit simvastatin dose per labeling when coadministered with amlodipine.

Other antihypertensives can have additive effects on blood pressure. Clinicians may consider alternatives within ACE inhibitors such as Lisinopril or Ramipril, or within calcium channel blockers like Verapamil, depending on your clinical profile.

What to Expect Over Time

Blood pressure response is typically gradual. It may take regular, daily dosing and adherence to lifestyle measures to see stable readings. Your prescriber may monitor kidney function and electrolytes, especially after changes in dose or regimen.

Keep a home blood pressure log and bring it to appointments. If you experience ankle swelling, dizziness, or cough that does not settle, discuss adjustments or alternatives with your clinician. Educational resources such as Diabetes And High Blood Pressure and Hypertension Best Practices can support your routine.

Compare With Alternatives

Some patients are maintained on single‑agent therapy rather than a fixed‑dose combination. For calcium channel blocker monotherapy, see Norvasc®. If an ACE inhibitor alone is appropriate, review Perindopril as an individual option. Choice depends on treatment goals, tolerance, and clinician guidance.

Pricing and Access

Canadian pricing can reduce out‑of‑pocket burden for eligible US patients. To compare options and see the current perindopril amlodipine price, view the product page and available strengths. If you prefer to buy perindopril amlodipine, you can add the item to your cart and proceed through secure checkout.

We also list periodic site offers. For neutral details on current promotions, visit our Promotions page. We provide transparent product information with US shipping from Canada for qualified orders.

Availability and Substitutions

Supply can vary by manufacturer and strength. If your selection is unavailable, a prescriber may suggest an alternative strength or class‑appropriate substitute. Where appropriate, a pharmacist may discuss a perindopril amlodipine generic sourced from a licensed producer in Canada.

If you have been stabilized on a specific brand or salt form, remain consistent unless your clinician recommends a change. Differences in salt form can affect labeled strength expressions.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults who need two mechanisms to reach targets, especially those managing multiple cardiovascular risks. It is not appropriate in pregnancy, during certain types of angioedema history, or when severe hypotension is present.

To lower overall costs, consider multi‑month fills when your prescriber approves, and use refill reminders to avoid lapses. People with diabetes may benefit from lifestyle advice alongside medication; see our article Heart Health And Diabetes for general guidance. Patients already on other ACE inhibitors or calcium channel blockers, such as Diltiazem, should consult their clinician before switching.

Questions to Ask Your Clinician

• Fit with history: Is this combination right for my conditions?
• Strength choice: Which tablet strength matches my current regimen?
• Monitoring: How often should I check blood pressure and labs?
• Side effects: What should I do if cough or swelling occurs?
• Interactions: Are any of my medicines likely to interact?
• Pregnancy planning: What are safer alternatives if I conceive?
• Adherence: How can I simplify my daily schedule to stay consistent?

Authoritative Sources

For Canadian labeling details, review the Health Canada Drug Product Database entry for Viacoram: Health Canada DPD search portal.

For background on the ACE inhibitor component, consult DailyMed information for perindopril: U.S. DailyMed database search.

For calcium channel blocker labeling context, see DailyMed for amlodipine: Amlodipine on DailyMed.

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.