Perindopril/Amlodipine Tablets for Hypertension

Perindopril/amlodipine is a prescription tablet used for high blood pressure. It combines an ACE inhibitor with a calcium channel blocker to control readings when one medicine is not enough. This page explains how it works, who it suits, and how to access US delivery from Canada without insurance.

What Perindopril/Amlodipine Is and How It Works

Perindopril/amlodipine combines two blood pressure medicines with complementary actions. Perindopril is an ACE inhibitor that is converted to perindoprilat, which lowers angiotensin II and reduces vasoconstriction and aldosterone effects. Amlodipine is a dihydropyridine calcium channel blocker that relaxes vascular smooth muscle and decreases peripheral resistance. Using both may help when a single agent does not provide adequate control.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

This combination is typically prescribed for adults who need two agents, or to replace separate perindopril and amlodipine tablets at equivalent doses. Decisions on starting or adjusting therapy are made by your clinician based on clinical response and tolerability.

Who It’s For

This treatment is intended for adults with hypertension who would benefit from an ACE inhibitor plus a calcium channel blocker. It may be used when blood pressure remains above target on one agent, or when switching from the individual components for convenience.

Do not use during pregnancy. Stop the ACE inhibitor component and contact a clinician if pregnancy is suspected. Avoid if you have a history of angioedema related to ACE inhibitors. Use caution with kidney impairment, liver disease, aortic stenosis, low baseline blood pressure, dehydration, or in combination with other medications that affect potassium. People with diabetes should not take ACE inhibitors together with aliskiren.

For condition-specific options and education, see High Blood Pressure.

Dosage and Usage

Perindopril/amlodipine is generally taken once daily, at the same time each day. It may be taken with or without food. Swallow tablets whole with water. Consistency supports stable blood pressure control. If you are switching from separate perindopril and amlodipine tablets, your prescriber will match the fixed-dose strength to your current regimen.

Grapefruit or grapefruit juice can affect amlodipine metabolism; follow clinician advice about dietary restrictions. Alcohol can increase the risk of dizziness or lightheadedness. Always follow the Patient Information and your clinician’s directions on how to take this medicine.

Strengths and Forms

Film‑coated tablets are available in multiple fixed-dose strengths. Common presentations include perindopril arginine with amlodipine in combinations such as 3.5 mg/2.5 mg, 7 mg/5 mg, and 14 mg/10 mg. Availability, color, and packaging may vary by manufacturer and country.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time. Do not double up to make up for a missed tablet. If vomiting or severe diarrhea occurs after a dose, contact your clinician for guidance on monitoring and when to resume.

Storage and Travel Basics

Store tablets at room temperature in a dry place away from excess heat and light. Keep the medicine in the original, child‑resistant container with the prescription label. Do not store in a bathroom due to humidity. For travel, keep your medication in carry‑on luggage with a copy of your prescription and your clinician’s contact information. Maintain your usual dosing time when crossing time zones if possible, and set reminders to avoid missed doses.

Benefits

• Two mechanisms in one: complementary effects on the renin‑angiotensin system and vascular tone.
• Once‑daily schedule designed for steady blood pressure control.
• Single tablet can reduce pill burden compared with separate components.
• Option to replace two prescriptions with one fixed‑dose product when appropriate.
• May limit dose‑limiting effects of one class by pairing with another, as advised by a clinician.

Side Effects and Safety

• Dizziness or lightheadedness, especially when starting or increasing the dose
• Headache
• Cough
• Flushing or warmth
• Swelling of ankles or feet
• Fatigue
• Nausea or stomach discomfort
• Palpitations

Serious reactions can occur but are less common. Angioedema (swelling of the face, lips, tongue, or throat) requires urgent care and permanent discontinuation of ACE inhibitors. Severe hypotension, fainting, high potassium, or changes in kidney function can occur, particularly in people with kidney disease or those on diuretics, potassium supplements, or salt substitutes containing potassium. Rarely, liver problems or worsening chest pain may occur. Report concerning symptoms to a healthcare professional immediately.

Drug Interactions and Cautions

Tell your clinician and pharmacist about all medicines, vitamins, and herbal products you use. Important interactions include:

• Potassium‑sparing diuretics, potassium supplements, or salt substitutes: risk of hyperkalemia
• Lithium: increased lithium levels and toxicity risk
• NSAIDs, including COX‑2 inhibitors: reduced antihypertensive effect and kidney risk
• Diuretics or other antihypertensives: additive blood pressure lowering
• Strong or moderate CYP3A4 inhibitors/inducers (e.g., certain macrolides, azoles, rifampin): altered amlodipine exposure
• Simvastatin: amlodipine requires limiting simvastatin to approved maximum daily doses
• Aliskiren in diabetes: avoid with ACE inhibitors
• Sacubitril/valsartan: washout is required to reduce angioedema risk

To learn more about ACE inhibitor use and related cautions, see Benazepril Uses. For beta‑blocker considerations sometimes paired with other regimens, review Acebutolol Uses. Your pharmacist can help screen for interactions alongside your prescriber.

What to Expect Over Time

Blood pressure typically improves as the combination reaches steady levels with regular daily use. Your clinician may monitor home and office readings and adjust therapy if needed. Some effects, such as ankle swelling or cough, may appear after initiation or changes; many are mild and transient. Lifestyle measures, such as sodium reduction, physical activity, and weight management, can further support control. Keep a log of blood pressure and symptoms to share at follow‑up visits.

For a broader view of related treatments, explore Heart Health Medications.

Compare With Alternatives

Several approved options may be considered depending on clinical goals and tolerability:

• Norvasc® (amlodipine) offers calcium channel blocker monotherapy when a single agent is appropriate or as part of a multi‑drug plan.
• Diovan® (valsartan) is an angiotensin receptor blocker used when an ACE inhibitor is not suitable or when a different class is preferred.

Alternatives are chosen by a prescriber based on blood pressure targets, comorbidities, and prior response. Switching or combining therapies should be supervised by a clinician.

Pricing and Access

Canadian pricing can offer meaningful cash‑pay value compared with many local options. Check current availability and see perindopril amlodipine Canadian pricing on this product page. Orders are processed with prescription verification, and packages Ships from Canada to US. Checkout is encrypted to protect your information. If you are looking for seasonal or limited offers, see Promotions.

Availability and Substitutions

Supply can vary. If a particular strength is unavailable, a prescriber may recommend an equivalent dose using separate components or an alternative class. Do not switch products or doses without professional guidance. To compare classes that treat the same condition, view Hypertension Cardiovascular.

Patient Suitability and Cost-Saving Tips

This therapy may fit adults who need two agents to reach blood pressure goals or who prefer the convenience of a single daily tablet replacing separate components. It is not appropriate during pregnancy and should be used carefully with kidney or liver issues, or in people at risk of high potassium. Regular monitoring is advised after initiation or changes.

• Ask about a 60‑ to 90‑day supply to reduce pharmacy visits.
• Use refill reminders so you do not miss doses.
• Bring a current medication list to every appointment.
• Discuss generic options and dose combinations that match your plan.
• Keep a home blood pressure log to aid clinical decisions.

Questions to Ask Your Clinician

• Is this combination appropriate for my stage of hypertension?
• How should I monitor at home and how often should I record readings?
• What signs of low blood pressure or high potassium should I watch for?
• Do I need blood tests to monitor kidney function or electrolytes?
• Are there any foods or medicines I should avoid while taking it?
• If ankle swelling occurs, what adjustments might be considered?
• Would a multi‑month fill be suitable for my treatment plan?

Authoritative Sources

• Manufacturer: Coveram (Perindopril/Amlodipine)
• Health Canada Drug Product Database
• DailyMed: Amlodipine

Start your order today for secure US shipping from Canada. This information is educational and does not replace advice from your healthcare professional; use only as prescribed.