Janumet® Tablets for Type 2 Diabetes

What Janumet Is and How It Works

Janumet® is a prescription combination of sitagliptin and metformin for adults with type 2 diabetes. It helps lower blood sugar when used with diet and exercise. You can access it with US shipping from Canada, and this page explains how it works, who it suits, and ordering basics. Many customers also look for Janumet XR price without insurance, which we address in Pricing and Access below.

Sitagliptin is a DPP-4 inhibitor. It increases incretin hormones that help the pancreas release insulin after meals and reduce glucagon. Metformin is a biguanide. It decreases liver glucose output and improves insulin sensitivity. Together, this medicine targets fasting and post-meal glucose. CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This treatment is not insulin. It does not replace lifestyle changes. It may be used alone or with other glucose-lowering therapies if a prescriber recommends combination therapy. Review the official label and speak with your clinician before starting or changing any regimen.

Who It’s For

This medicine is indicated to improve glycemic control in adults with type 2 diabetes, alongside diet and exercise. It is not approved for type 1 diabetes or for diabetic ketoacidosis. For an overview of the condition and goals of care, see our resource on Type 2 Diabetes.

People with significant kidney problems, liver disease, or a history of lactic acidosis should discuss risks carefully. Those with a history of pancreatitis should review pancreatitis risk. If you are pregnant, planning pregnancy, or breastfeeding, consult your clinician to weigh benefits and risks.

Dosage and Usage

Follow your prescriber’s instructions and the approved label. Immediate-release tablets are typically taken twice daily with meals. Extended-release tablets are usually taken once daily with an evening meal. If your regimen includes other agents, your clinician may adjust the schedule. When uncertain, defer to the official label.

Swallow tablets whole. Do not crush, split, or chew extended-release tablets. Take doses with food to reduce stomach upset. If you are transitioning from metformin alone, your prescriber may select a dose that matches your current metformin intake. For practical guidance on taking this class, see Janumet Dosage. For background on DPP-4 inhibitors, review Januvia Drug Class.

Limit alcohol. Excessive alcohol increases the risk of lactic acidosis with metformin. Keep a consistent meal routine to support steady glucose control. Do not make dose changes without prescriber input.

Strengths and Forms

Two oral forms are available: immediate-release and extended-release (XR) tablets. Common combinations include sitagliptin with metformin in strengths such as 50/500 mg, 50/1000 mg, and 100/1000 mg. Availability can vary by pharmacy and jurisdiction.

Some patients start on lower-dose combinations and adjust as tolerated. Your prescriber selects the strength that aligns with your current regimen and treatment goals.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is near the time for your next dose. In that case, skip the missed dose and resume your regular schedule. Do not take two doses at once. Keeping a daily reminder can help prevent missed doses.

Take extended-release tablets with the evening meal as directed. If you notice a tablet-like shell in your stool after XR dosing, this can be normal for the extended-release formulation.

Storage and Travel Basics

Store tablets at room temperature in the original, child-resistant container. Protect from moisture and excessive heat. Keep the bottle tightly closed between uses. Do not store in a bathroom cabinet where humidity is high.

For travel, carry medicines in your hand luggage and keep them in the labeled container. Bring a copy of your prescription or a medication list. Use a pill organizer only if it does not expose tablets to moisture. If changing time zones, keep dosing tied to meals to maintain a consistent routine.

Benefits

This combination targets both fasting and post-meal glucose. It can be used with diet and exercise to help reach individualized A1C targets. Many patients appreciate once-daily XR scheduling, which may simplify routines.

Because this therapy is not insulin, the risk of hypoglycemia is generally lower when used alone. When paired with agents that increase insulin, the low blood sugar risk can rise, so monitor as directed.

Side Effects and Safety

• Gastrointestinal upset: nausea, diarrhea, stomach discomfort
• Headache
• Upper respiratory symptoms
• Fatigue
• Loss of appetite or taste changes

Serious but less common risks include lactic acidosis with metformin, acute pancreatitis with sitagliptin, kidney problems, and severe allergic reactions. Vitamin B12 levels may decline with long-term metformin use; monitoring may be considered. Seek urgent care for severe abdominal pain, unexplained vomiting, trouble breathing, or signs of a serious allergic reaction.

If used with insulin or sulfonylureas, the risk of hypoglycemia can increase. Know the signs of low blood sugar and keep a source of rapid-acting carbohydrate available if advised by your care team.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements. Iodinated contrast used for imaging may require temporary changes to metformin-containing regimens. Excessive alcohol heightens lactic acidosis risk. Certain medicines that affect kidney function may increase exposure to components of this therapy.

Review kidney function before starting and at intervals thereafter. Use caution with liver disease, heart failure, or dehydration. If you develop new abdominal pain, stop the medicine and contact your clinician promptly to evaluate for pancreatitis.

What to Expect Over Time

With regular use and a healthy meal plan, fasting and post-meal glucose may improve. A1C changes are typically assessed over months during routine visits. Individual responses vary.

Keep a daily schedule tied to meals to support adherence. If you track glucose at home, bring readings to your appointments. For more background on treatment options and comparisons, see our overview of Diabetes Medications.

Compare With Alternatives

Other combination tablets may suit specific needs. Linagliptin with metformin is available as Jentadueto, a DPP-4 inhibitor paired with metformin. An SGLT2 inhibitor with metformin, such as Synjardy, may be considered if your clinician recommends an SGLT2-based regimen.

Each option has distinct safety considerations and dosing schedules. Your prescriber can help select the most appropriate therapy for your history and goals.

Pricing and Access

We list transparent pricing so you can compare options. Many readers search for Price of Janumet 50 1000; you can review current rates on the product page. We also provide context on Janumet generic sitagliptin metformin price when discussing alternatives and authorized generics, if available in your region.

Our pharmacy partners dispense from Canada with licensed oversight. This supports competitive pricing and reliable service. If you use cash pay, you can assess total out-of-pocket costs easily. Some users ask about Janumet XR price without insurance, which varies by strength, quantity, and form. For occasional promotions, see our current offers on Promotions. Checkout is encrypted for your security.

Availability and Substitutions

Inventory can vary by strength and pack size. If a specific presentation is unavailable, your prescriber may recommend a therapeutically appropriate alternative or a different combination tablet. For customers comparing access options, Janumet 50 1000 ships to US through our cross-border partners.

When substitutions are needed, your prescription must match the selected product. We cannot change therapy without prescriber authorization.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with type 2 diabetes who need both hepatic glucose control and post-meal support. It is not for type 1 diabetes or for ketoacidosis. Those with reduced kidney function, liver disease, or prior pancreatitis require careful review with a clinician.

To save on total costs, consider multi-month quantities if appropriate, align refills with routine visits, and set reminders. Patients comparing cash options often look up Janumet price cash pay to estimate expenses. For broader non-insulin options, browse our Non-Insulin Tablets catalogue to compare classes and dosing schedules.

Questions to Ask Your Clinician

• Is the immediate-release or XR form better for my schedule?
• How should I monitor for side effects like stomach upset or low B12?
• What signs of pancreatitis should prompt urgent care?
• How do my kidney tests affect dose selection?
• Should I adjust other diabetes medicines to reduce hypoglycemia risk?
• What goals should I set for A1C and home glucose readings?

Authoritative Sources

Review official labeling and safety information before use. See the manufacturer’s prescribing information on Merck’s site, FDA DailyMed, and Health Canada’s Drug Product Database for current details.

• Merck prescribing information for Janumet and Janumet XR
• FDA DailyMed label for sitagliptin/metformin tablets
• Health Canada Drug Product Database listing

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.