Jentadueto® Tablets for Type 2 Diabetes

Jentadueto is a prescription combination medicine for adults with type 2 diabetes. It contains linagliptin and metformin to help improve blood sugar control alongside diet and exercise. This page explains how it works, who it suits, and how to access it with US shipping from Canada, including options without insurance.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

What Jentadueto Is and How It Works

Jentadueto® combines two agents. Linagliptin is a DPP-4 inhibitor that increases incretin hormones, which can enhance glucose-dependent insulin release and reduce glucagon levels. Metformin is a biguanide that can lower hepatic glucose production and improve peripheral insulin sensitivity. Together, the treatment helps reduce fasting and post-meal glucose.

This medicine is indicated as an adjunct to diet and exercise for adults with type 2 diabetes. It is not for type 1 diabetes or diabetic ketoacidosis. For background reading on the class, see Can Expect Taking Dpp 4 Inhibitors and Can Expect Taking Biguanides Drugs. You can also review our Type 2 Diabetes hub for condition basics.

Some patients may be prescribed Jentadueto 2.5 mg/1000 mg tablets when an additional agent is needed alongside metformin. Your prescriber selects a regimen based on prior therapy and tolerability. Always follow the official label and your clinician’s directions.

Who It’s For

This combination is for adults with type 2 diabetes who require dual therapy to improve glycemic control. It may be considered when metformin alone does not achieve targets or when combination therapy is appropriate.

Do not use if you have type 1 diabetes or active ketoacidosis. It is generally avoided in severe renal impairment. The metformin component carries a risk of lactic acidosis, especially with significant kidney disease, hypoxic states, or heavy alcohol use. Safety and effectiveness are not established in pediatric patients. Discuss pregnancy and breastfeeding considerations with your healthcare professional.

Dosage and Usage

Dosing is individualized. Clinicians often consider a patient’s current regimen and tolerability to metformin. Tablets are typically taken with meals to help reduce stomach-side effects. Swallow tablets whole with water. Do not crush or split unless directed on the label.

If you are switching from metformin alone, a healthcare professional may start the combination at doses matching or close to your existing metformin regimen. The linagliptin daily dose target is usually 5 mg total per day. To minimize gastrointestinal symptoms, prescribers may titrate the metformin component gradually as tolerated. Always consult the official prescribing information for complete instructions.

Extended-release options exist for some combination products. For a once-daily alternative in a related class, review Janumet XR and the overview Common Diabetes Medications And How They Work.

Strengths and Forms

Immediate-release tablets are commonly available in:

• 2.5 mg/500 mg
• 2.5 mg/850 mg
• 2.5 mg/1000 mg

Extended-release presentations vary by market and may include once-daily combinations such as 2.5 mg/1000 mg and 5 mg/1000 mg. Availability can differ by country and dispensing pharmacy. Some markets offer Jentadueto XR 2.5/1000 mg tablets for specific dosing needs. Check current listings for what is in stock.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember with food. If it is almost time for your next dose, skip the missed dose and return to your regular schedule. Do not take two doses at once. Establishing consistent meal-time dosing can help maintain steady control and reduce stomach upset.

Storage and Travel Basics

Store tablets at room temperature away from excess heat and moisture, and keep the bottle tightly closed. Protect from light. Keep out of reach of children and pets. For travel, carry this medicine in your hand luggage with the original labeled container. Bring a copy of your prescription and a medication list. If crossing time zones, aim to take doses with meals at roughly similar intervals. Do not store tablets in a hot car or a steamy bathroom.

When flying, pack an extra small supply in a separate carry-on compartment in case one bag is misplaced. If your regimen includes a glucose meter, bring spare batteries and strips. For questions on meal timing during travel, consult your prescriber or pharmacist. See practical metformin-specific points in Metformin Dosage.

Pen Handling and Sharps Disposal

This therapy comes as oral tablets. No pen priming, needles, or sharps containers are required. If you use separate diabetes supplies like lancets, follow local rules for sharps disposal.

Benefits

This combination can support A1C reduction through two complementary mechanisms. It may help lower both fasting and post-meal glucose when used with diet and exercise. Compared with some agents, the class has a low risk of hypoglycemia when used without insulin or sulfonylureas. The tablet format may simplify routines for people who need more than one mechanism of action.

Side Effects and Safety

• Stomach upset, diarrhea, or nausea
• Gas or abdominal discomfort
• Headache or nasopharyngitis
• Cough or sore throat
• Reduced vitamin B12 levels with long-term metformin

Serious but less common risks include lactic acidosis associated with metformin, pancreatitis, severe hypersensitivity reactions, and bullous pemphigoid reported with DPP-4 inhibitors. Hypoglycemia can occur if used with insulin or a sulfonylurea. Stop the medicine and seek urgent care for symptoms of severe abdominal pain, difficulty breathing, confusion, or a widespread blistering rash.

Drug Interactions and Cautions

Tell your prescriber about all medicines and supplements you use. Strong inducers of P-gp/CYP3A4 such as rifampin can lower linagliptin exposure. Carbonic anhydrase inhibitors and excessive alcohol use may raise the risk of lactic acidosis with metformin. Iodinated contrast can affect kidney function; temporary interruption of metformin may be needed around imaging procedures per label. Cationic drugs eliminated by renal tubular secretion (for example, cimetidine) may increase metformin levels. Review the label and consult your healthcare professional for full interaction details.

What to Expect Over Time

With regular use and consistent meals, many patients see gradual improvements in daily glucose patterns. Gastrointestinal side effects often lessen as the body adapts and with dose titration guided by the prescriber. Periodic A1C checks and kidney function monitoring are common. Sustained benefits depend on adherence, meal planning, and routine activity. If your readings change or symptoms arise, contact your clinician for guidance.

Compare With Alternatives

Other options in this therapeutic space include sitagliptin plus metformin products such as Janumet XR. For background on how these two combinations differ in components and schedules, see Janumet Vs Jentadueto. Some patients may also use metformin alone or a DPP-4 inhibitor alone when appropriate per label.

Pricing and Access

You can check Jentadueto price in your cart and compare Canadian pricing before you finalize. We also list any active Jentadueto coupon when available. For additional site-wide offers, visit our promotions page. Orders are fulfilled by licensed pharmacies, and items Ships from Canada to US with prescription verification. If you prefer to view class-based options, browse our Dpp 4 Inhibitors category.

Many shoppers compare cash-pay options for linagliptin and metformin combinations. If you are evaluating total out-of-pocket amounts, review any employer or plan requirements and keep an eye on refills to avoid last-minute gaps. Our checkout uses encrypted checkout to protect your information.

Availability and Substitutions

Availability can vary by strength and pack size. If a specific tablet is out of stock, your prescriber may recommend a therapeutically appropriate alternative in the same class or a different class based on your history. We cannot guarantee restock dates. Always use the exact product and strength written on your prescription unless your clinician authorizes a change.

Patient Suitability and Cost-Saving Tips

You may be a candidate if you are an adult with type 2 diabetes who needs more than one mechanism to reach targets and you can use metformin safely. You may not be a candidate if you have significant kidney disease, metabolic acidosis, heavy alcohol use, or a history of pancreatitis without careful evaluation. Discuss risks and monitoring with your healthcare professional before starting.

To manage spending, consider multi-month fills if appropriate. Align refills with routine lab visits to simplify scheduling. Use reminders for dosing and refill dates. Review plan formularies each year. If metformin causes stomach upset, ask your prescriber about administration with meals and whether a slower titration plan is suitable per label. For additional background on metformin scheduling, see Metformin Dosage.

Questions to Ask Your Clinician

• Is this combination appropriate given my A1C and prior therapies?
• Which starting dose aligns with my current metformin regimen?
• What labs should I complete before and after starting?
• How should I time doses with meals during travel or shift work?
• What side effects mean I should call the office promptly?
• Could my other medicines raise the risk of lactic acidosis?
• If I develop stomach upset, what label-guided strategies can help?

Authoritative Sources

• US Prescribing Information (FDA)
• DailyMed Official Label
• Health Canada DPD

Ready to proceed with CanadianInsulin? Place your order for US delivery from Canada and choose prompt, express, temperature-controlled handling when required. This information is educational and not a substitute for professional medical advice. Use only as directed by your prescriber and the official label.