Jentadueto® Tablets for Type 2 Diabetes

What Jentadueto® Is and How It Works

Jentadueto® combines linagliptin and metformin HCl in one tablet. It helps adults with type 2 diabetes improve blood sugar control. You can buy it online with Canadian pricing, and it ships to the US. Many patients compare costs without insurance to reduce their out-of-pocket spending.

CanadianInsulin connects patients with licensed Canadian pharmacies. Prescriptions are verified with your clinic before dispensing.

Linagliptin is a DPP-4 inhibitor. It increases incretin hormones, which raise insulin when glucose is high and lower glucagon. Metformin is a biguanide. It reduces liver glucose production and improves insulin sensitivity. Together, these actions target fasting and post-meal glucose.

Who Jentadueto® Is For

Jentadueto is indicated for adults with type 2 diabetes as an adjunct to diet and exercise. It may be used when metformin alone is not enough or to replace separate linagliptin and metformin tablets with one pill.

It is not for people with type 1 diabetes or for treating diabetic ketoacidosis. Do not use if you have severe kidney impairment. Metformin-containing products are contraindicated with an eGFR below 30 mL/min/1.73 m². Avoid starting therapy if your eGFR is between 30 and 45 unless your prescriber decides the benefit outweighs risk.

Tell your clinician about liver disease, heart failure, dehydration, heavy alcohol use, or recent surgery. These conditions raise the risk of lactic acidosis with metformin. Discuss any history of pancreatitis before starting a DPP-4 inhibitor.

Dosage and Usage

Follow your prescriber’s instructions and the official label. Jentadueto is taken twice daily with meals to reduce stomach upset.

• Typical starting dose: 2.5 mg/500 mg twice daily with food.
• Titration: increase metformin in 500 mg steps as tolerated to improve control.
• Usual maintenance: individualized to your A1C goal and tolerance.
• Maximum recommended: linagliptin 5 mg daily total and metformin 2,000 mg daily.

If you are switching from separate linagliptin and metformin, choose the nearest matching strengths. If you are already on metformin, your prescriber may add linagliptin and adjust the metformin component based on your current dose and kidney function.

Jentadueto can be combined with other agents when needed. When used with insulin or a sulfonylurea, your clinician may lower those agents to reduce hypoglycemia risk.

Strengths and Forms

Film-coated tablets. Strengths commonly available include:

• 2.5 mg/500 mg
• 2.5 mg/850 mg
• 2.5 mg/1,000 mg

Availability may vary by pharmacy and country of origin.

Missed Dose and Timing

Take Jentadueto with morning and evening meals. If you miss a dose, take it when you remember unless it is almost time for your next dose. In that case, skip the missed tablet and resume your schedule. Do not double up to make up for a missed dose.

Storage and Travel Basics

Store tablets at room temperature and keep them dry. Protect from excess heat, moisture, and light. Leave the medication in its original bottle until use. Keep away from children and pets.

When traveling, pack your medication in your carry-on. Bring a copy of your prescription and your prescriber’s contact details. If crossing borders, keep your medicine in original labeled packaging for inspection.

Benefits

Jentadueto offers dual-mechanism control in one pill. Taking a DPP-4 inhibitor with metformin helps reduce both fasting and post-meal glucose. Most people do not gain weight with this combination. The twice-daily schedule pairs well with breakfast and dinner routines, which can improve adherence.

Side Effects and Safety

• Common: diarrhea, nausea, stomach upset, gas, and abdominal discomfort.
• Upper respiratory symptoms: stuffy nose, sore throat, or cough.
• Headache or mild joint pain.
• Reduced vitamin B12 levels with long-term metformin use.

Serious but uncommon risks include lactic acidosis with metformin, pancreatitis with DPP-4 inhibitors, severe joint pain, hypersensitivity reactions, and a rare skin condition called bullous pemphigoid. Seek urgent care for severe abdominal pain that may radiate to the back, unexplained rapid breathing, extreme weakness, or allergic symptoms such as swelling or hives. Hypoglycemia can occur when Jentadueto is combined with insulin or a sulfonylurea.

Learn more about metformin’s low risk of hypoglycemia in Metformin Hypoglycemia.

Drug Interactions and Cautions

Tell your clinician about all medications, vitamins, and herbal products you take.

• Iodinated contrast imaging: stop metformin-containing products before or at the time of contrast in certain patients. Restart only after kidney function is re-evaluated.
• Alcohol: binge or chronic heavy use increases lactic acidosis risk.
• Carbonic anhydrase inhibitors: topiramate and acetazolamide may raise acidosis risk.
• Cationic drugs: cimetidine and similar agents may affect metformin elimination.
• Rifampin: may reduce linagliptin exposure; avoid or use an alternative.
• Insulin and sulfonylureas: higher risk of low blood sugar in combination.

Use in pregnancy or breastfeeding only if clearly needed and directed by your clinician. Monitor B12 periodically during long-term metformin therapy.

What to Expect Over Time

Many patients notice improved premeal and postmeal glucose within the first weeks. A1C reflects average control over about three months. Your clinician will review readings and adjust therapy as needed. Consistent diet, activity, and adherence to dosing help you get the most benefit.

Compare With Alternatives

Several combinations and metformin formulations offer different profiles. If you need a DPP-4 inhibitor plus metformin in an extended-release tablet, your prescriber may consider Janumet XR®. If you would benefit from pairing metformin with an SGLT2 inhibitor, another option is Invokamet®. Your choice depends on glucose patterns, kidney function, and tolerability. Discuss the pros and cons of each alternative with your clinician.

For a broader overview of medicine classes, see Common Diabetes Medications and compare sitagliptin and metformin in Janumet® Vs Jentadueto.

Pricing and Access

We offer Canadian pricing with US delivery from Canada. You can review Jentadueto price details and complete checkout online. You may see meaningful savings compared with typical US retail costs.

To see current promotions, visit our Promotions page. Check product pages for current Jentadueto cost information and available strengths. Encrypted checkout helps protect your personal data.

Availability and Substitutions

Stock can vary by strength. If a specific tablet is unavailable, your prescriber may recommend a clinically appropriate alternative or a different strength combination. Do not change your regimen without guidance from your clinician.

Patient Suitability and Cost Saving Tips

Good candidates include adults with type 2 diabetes who need additional control beyond metformin alone. It may suit those who prefer a combination tablet to reduce pill burden.

It may not be appropriate if you have severe kidney disease, unstable heart failure, significant liver disease, or active pancreatitis. Avoid use for type 1 diabetes or ketoacidosis.

• Ask about 90-day refills to lower per-tablet cost and reduce pharmacy fees.
• Compare Canadian pricing for US shipping to manage expenses.
• If you primarily need metformin, discuss metformin-only options to reduce cost.
• Set refill reminders so you do not miss doses.
• Track fasting and postmeal glucose to help your clinician optimize therapy.

Questions to Ask Your Clinician

• Is the 2.5/500 mg strength a good starting dose for me?
• How should I adjust if I have stomach upset during titration?
• Do my kidney labs support starting or continuing therapy?
• Should I lower my insulin or sulfonylurea dose to reduce lows?
• What are warning signs of pancreatitis or lactic acidosis?
• Do I need to hold my dose before contrast imaging?
• How often should we check vitamin B12 levels?

Authoritative Sources

FDA DailyMed: JENTADUETO

Health Canada DPD: Jentadueto

Manufacturer Site: Jentadueto

Ready to start? Place your order for US delivery from Canada. Always follow your clinician’s advice and read the Medication Guide. This content is educational and not a substitute for professional medical guidance.

Explore more condition details in our Type 2 Diabetes section and browse related therapies under Oral Insulin Medications.