Janumet® XR Extended-Release Tablets for Type 2 Diabetes

Janumet® XR combines sitagliptin and extended-release metformin to help manage blood sugar in adults with type 2 diabetes. This page explains how it works, dosing, safety, and Canadian pricing with US delivery from Canada. You can buy Janumet XR online from Canada, even when paying without insurance.

Qué es Janumet® y cómo funciona

Janumet XR is a once-daily prescription tablet that contains two medicines: sitagliptin and metformin hydrochloride extended-release. Sitagliptin is a DPP-4 inhibitor that helps raise insulin after meals and lowers glucagon. Metformin XR reduces liver glucose production, improves insulin sensitivity, and may lessen glucose absorption in the gut. Together they improve fasting and post-meal blood sugar. The XR design supports steady release and may improve stomach tolerability.

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Para quién es Janumet

Janumet XR is approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It is not for type 1 diabetes or for treating diabetic ketoacidosis. For guidance on the condition itself, see our category on Diabetes de tipo 2.

People with severe kidney impairment or acute or chronic metabolic acidosis, including diabetic ketoacidosis, should not use medicines containing metformin. Pancreatitis has been reported with sitagliptin. Patients with a history of pancreatitis should discuss risks with their clinician. Use caution with liver disease, dehydration, hypoxia, or alcohol misuse. If pregnant, planning pregnancy, or breastfeeding, discuss options and risks with the prescriber.

Posología y utilización

Follow your prescriber and the official label. Typical once-daily dosing with the evening meal is common to reduce stomach upset. Tablets must be swallowed whole. Do not split, crush, or chew.

• For patients not on metformin, a common start is sitagliptin 100 mg plus metformin XR 1000 mg once daily with food.
• Increase metformin slowly based on tolerance and response, usually in 500 mg steps at intervals of about one to two weeks.
• Do not exceed sitagliptin 100 mg per day and metformin XR 2000 mg per day.
• When switching from immediate-release metformin, match the total daily metformin dose, and give sitagliptin up to 100 mg once daily.
• Assess kidney function before starting and periodically thereafter.

Some patients may notice an inert tablet shell in the stool. This is expected with certain XR formulations. For more details on dosing principles, see Janumet XR Dosing.

Fortalezas y formas

Janumet XR is supplied as extended-release film-coated tablets in these commonly available strengths:

• 50 mg sitagliptin / 500 mg metformin XR (Janumet XR 50/500 mg)
• 50 mg sitagliptin / 1000 mg metformin XR (Janumet XR 50/1000 mg)
• 100 mg sitagliptin / 1000 mg metformin XR (Janumet XR 100/1000 mg)

Availability, pack sizes, and tablet colors can vary by manufacturer and pharmacy. Product supply may differ between markets.

Dosis omitida y momento oportuno

If a dose is missed, take it when remembered unless it is close to the next dose. If it is near the next dose, skip the missed dose. Do not double doses. Take with a meal to help reduce stomach upset.

Almacenamiento y viaje

• Store tablets at room temperature, typically 20–25 °C (68–77 °F).
• Keep in the original, labeled container. Protect from moisture.
• Do not store in bathrooms or hot vehicles.
• When traveling, carry medicine in hand luggage and bring a copy of the prescription.

Beneficios

• Dual mechanism: sitagliptin and metformin XR target complementary pathways of glucose control.
• Once-daily XR convenience for many adults.
• Helps lower fasting and post-meal blood sugar when combined with diet and exercise.
• Low risk of hypoglycemia when not used with insulin or sulfonylureas.
• May be weight-neutral for many patients.

Effective combination therapy, plus practical once-daily dosing, can support long-term Control glucémico plans set by your care team.

Efectos secundarios y seguridad

Los efectos secundarios más comunes son:

• Diarrhea, nausea, or stomach upset
• Gas, indigestion, or abdominal discomfort
• Dolor de cabeza
• Cold-like or upper respiratory symptoms
• Fatiga

Serious risks are uncommon but require immediate medical care. Metformin can rarely cause lactic acidosis, a medical emergency. Symptoms can include unusual muscle pain, trouble breathing, extreme tiredness, stomach pain with nausea or vomiting, dizziness, or feeling cold. Sitagliptin has postmarketing reports of pancreatitis, severe joint pain, allergic reactions, and bullous pemphigoid. Long-term metformin use can lower vitamin B12 levels; periodic assessment may be appropriate. Risk of low blood sugar increases when combined with insulin or sulfonylureas.

Interacciones medicamentosas y precauciones

• Insulin or sulfonylureas: combination may increase hypoglycemia risk.
• Alcohol: excessive intake raises lactic acidosis risk; avoid heavy use.
• Iodinated contrast: metformin should be held around certain imaging procedures; follow label and clinician instructions.
• Carbonic anhydrase inhibitors (for example, topiramate, acetazolamide): may increase acidosis risk.
• Renal tubular secretion competitors (for example, cimetidine, ranolazine, dolutegravir): may raise metformin levels; monitor as directed.
• Renal or hepatic impairment, dehydration, hypoxia, or advanced age: use with caution and close monitoring.

Always tell the prescriber about all medicines, vitamins, and supplements before starting or changing therapy.

Qué esperar con el tiempo

Blood sugar improvements often appear over the first several weeks with regular use and lifestyle measures. Gastrointestinal effects usually ease as the body adjusts or with slower titration. Lab monitoring may include A1C, kidney function, and sometimes vitamin B12 with longer-term use. Ongoing diet, activity, and medication adherence remain central to success.

Comparar con alternativas

Several options may be considered if a different approach is needed. Sitagliptin alone is available as Januvia®, which may suit patients who tolerate metformin poorly. Another DPP-4 plus metformin option is Jentadueto® (linagliptin with metformin). Some patients may instead use an SGLT2 plus metformin combination, such as dapagliflozin with metformin (for example, Xigduo), when appropriate. For a helpful overview of class differences, see Januvia frente a Janumet.

Precios y acceso

See current Janumet XR price and compare options with Canadian pricing and US delivery from Canada. Many patients review the Janumet XR cash price, out of pocket cost, or Janumet XR price without insurance before placing an order. You can check the cost for Janumet XR 50/500 mg, Janumet XR 50/1000 mg, and Janumet XR 100/1000 mg. When ready, you can place an order online for Janumet XR from Canada with US shipping. Checkout is encrypted for security.

If you are looking for current deals, visit our Promociones page. Savings vary by strength and pack size, and inventory may change.

Disponibilidad y sustituciones

Supply can vary by strength. If a strength is unavailable, a clinician may recommend a suitable alternative or a different strength based on the same daily totals. Do not change strength or schedule without prescriber guidance.

Adecuación al paciente y consejos para ahorrar costes

• Good candidates are adults with type 2 diabetes needing combination therapy alongside diet and exercise.
• No es apropiado para la diabetes tipo 1 o la cetoacidosis diabética.
• Avoid with severe renal impairment or active metabolic acidosis.
• Discuss risks if there is a history of pancreatitis, liver disease, heavy alcohol use, or conditions that reduce oxygen delivery.
• Ask about a multi-month supply to lower per-unit cost and reduce pharmacy fees.
• Enroll in refill reminders so you can order on time and avoid gaps.
• Consider tablets that match the prescribed daily totals to reduce tablet burden.

Preguntas para su médico

• Is Janumet XR appropriate for my A1C and treatment goals?
• What starting dose and titration schedule fit my current regimen?
• How should kidney function and vitamin B12 be monitored?
• What signs suggest lactic acidosis or pancreatitis, and what actions are needed?
• Should doses of insulin or a sulfonylurea change when adding Janumet XR?
• What guidance applies before and after iodinated contrast imaging?
• How can diet and activity be adjusted to support results?

Fuentes autorizadas

• Merck: Janumet and Janumet XR
• DailyMed: Janumet XR Labeling
• Base de datos de medicamentos de Health Canada

Start your order for Janumet XR with US delivery from Canada using our prompt, express shipping.