Januvia® Tablets for Type 2 Diabetes

Januvia® is sitagliptin, an oral DPP-4 inhibitor used with diet and exercise to help control blood sugar in adults with type 2 diabetes. This page explains how it works, who it suits, and how to arrange US delivery from Canada with Canadian pricing. It also covers ordering options if paying without insurance.

What Januvia® Is and How It Works

Every CanadianInsulin order is prescription-checked with your clinic and dispensed by a licensed Canadian pharmacy.

Januvia® belongs to the dipeptidyl peptidase-4 (DPP-4) inhibitor class. By inhibiting DPP-4, it increases active incretin hormones (GLP-1 and GIP). These hormones help the pancreas release insulin in a glucose-dependent manner and reduce liver glucagon output. The result is improved fasting and after-meal blood glucose. On its own, sitagliptin has a low risk of hypoglycemia because its action depends on blood sugar levels.

Januvia contains sitagliptin phosphate as the active ingredient. It is taken by mouth as a tablet. It is often used together with metformin or other agents when diet and exercise alone are not enough. For background on class effects and uses, see Januvia Uses.

Who Januvia® Is For

Januvia is indicated for adults with Type 2 Diabetes as an adjunct to diet and exercise. It is not for people with type 1 diabetes, and it does not treat diabetic ketoacidosis.

People with a history of serious hypersensitivity to sitagliptin should not use it. Caution is appropriate in those with pancreatitis history, severe kidney impairment, or skin blistering disorders such as bullous pemphigoid. Discuss risks and benefits with a clinician if pregnant or breastfeeding.

Dosage and Usage

The usual adult dose is 100 mg by mouth once daily, with or without food. Many treatment plans use the 100 mg strength when kidney function is normal. When sitagliptin is combined with a sulfonylurea or insulin, clinicians may reduce the dose of those agents to lower hypoglycemia risk.

For reduced kidney function, labeling recommends lower daily doses. Typical adjustments are 50 mg once daily for moderate impairment and 25 mg once daily for severe impairment or dialysis. Specific dosing depends on renal function tests and prescriber judgment. For practical tips on timing and titration discussions, see Fine Tuning Januvia Dosage.

Strengths and Forms

Januvia is available as film‑coated tablets in these strengths: 25 mg, 50 mg, and 100 mg. Availability can vary by pharmacy and package size.

The most common presentation is the Januvia 100 mg tablet. Some patients and clinicians refer to it as sitagliptin 100 mg tablet or sitagliptin phosphate 100 mg. If the care plan specifies once-daily dosing, the 100 mg tablet may be used when appropriate. Listings on this page help compare the Januvia 100 mg price across options with Canadian pricing and US shipping.

If you plan to buy Januvia 100 mg or order Januvia 100 mg online, note that the same active ingredient is present across strengths. Selecting a strength should follow the prescriber’s plan, especially when kidney function requires adjustment. At CanadianInsulin, products are supplied from Canada and ship to the US.

Missed Dose and Timing

If a dose is missed, take it when remembered the same day. If it is close to the time for the next dose, skip the missed dose and resume the regular schedule. Do not take two doses at once.

Storage and Travel Basics

Store your tablets at room temperature, typically 20 to 25°C (68 to 77°F). Keep the bottle tightly closed, away from moisture and heat. No refrigeration is required. When traveling, keep your medicine in carry-on baggage with a copy of your prescription. Use a daily reminder so timing stays consistent across time zones.

Benefits

Januvia helps lower blood glucose and A1C when used as directed. Because it works in a glucose-dependent way, it has a low risk of hypoglycemia when taken without insulin or a sulfonylurea. It is weight neutral for most people. Once-daily dosing makes it convenient, and it can be combined with metformin or other diabetes medicines if needed. Dose adjustments for kidney function are supported in labeling.

Side Effects and Safety

• Common effects: stuffy or runny nose, sore throat, cough
• Headache or dizziness
• Stomach discomfort, diarrhea, or gas
• Joint pain
• Upper respiratory infection symptoms

Serious reactions are uncommon but require medical attention. Pancreatitis has been reported; symptoms may include severe, persistent abdominal pain that may radiate to the back, sometimes with vomiting. Severe joint pain, allergic reactions including rash, hives, angioedema, and rare bullous pemphigoid have occurred. Kidney problems can worsen in susceptible patients. Hypoglycemia can occur, especially when used with insulin or a sulfonylurea.

Drug Interactions and Cautions

Using sitagliptin with insulin or a sulfonylurea increases hypoglycemia risk. Clinicians often monitor for this and may adjust the other agents. Digoxin levels can increase slightly when taken with sitagliptin; monitoring is recommended if digoxin is part of the regimen. Always share a full medication list, including over-the-counter supplements, with the prescriber.

Do not use Januvia for type 1 diabetes or to treat diabetic ketoacidosis. People with reduced kidney function may require a lower dose. Those with a history of pancreatitis should discuss risks. Stop the medicine and seek care if signs of a serious allergic or blistering skin reaction appear.

For a comparison within the DPP-4 class, see Difference Linagliptin Vs Sitagliptin.

What to Expect Over Time

Blood sugar may improve within the first weeks as daily dosing continues. Full A1C changes are typically assessed at routine follow-up visits. Many plans include lifestyle changes and, if needed, combination therapy. Regular lab monitoring helps ensure the chosen dose remains appropriate, especially when kidney function changes.

Compare With Alternatives

Other DPP-4 inhibitors may be considered if a prescriber recommends a change. Tradjenta® (linagliptin) is taken once daily and does not require renal dose adjustment in most cases. Nesina® (alogliptin) is another option within the class. Some patients use a sitagliptin plus metformin combination, such as Janumet XR, when appropriate. For a broader overview, see our editorial comparison of sitagliptin combinations in Januvia Vs Janumet.

Pricing and Access

Shop with Canadian pricing and US delivery from Canada. Many people search for terms like Buy Januvia 100 mg, Order Januvia 100 mg online, Januvia 100 mg price, and Januvia 100 mg cost. This page also highlights the Januvia 100 mg Canadian pricing and explains how Januvia 100 mg ships to US addresses with prompt, express shipping. If comparing brands by molecule, some look for sitagliptin 100 mg tablet or sitagliptin phosphate 100 mg when reviewing options. You can also order sitagliptin 100 mg online through our secure checkout.

Looking for seasonal offers or bundles? Visit our Promotions page if available. Our checkout is encrypted, and pricing displays show the current cash-pay view, including a typical Januvia 100 mg cash price presentation for those who pay out of pocket.

Availability and Substitutions

Product availability can vary by strength and package size. If a preferred option is unavailable, a prescriber may recommend a suitable alternative from the same class or a combination product. Pharmacy teams dispense substitutions only when written as allowed by the prescription and applicable regulations.

Patient Suitability and Cost Saving Tips

Januvia may suit adults who need an oral option to improve glycemic control without frequent hypoglycemia, especially when used without insulin or a sulfonylurea. It may not suit people with a history of serious hypersensitivity to sitagliptin, active pancreatitis, or those with conditions where the prescriber advises against DPP-4 inhibitors.

To save on overall costs, consider multi-month supplies if approved by the prescriber, and enroll in refill reminders so doses are not missed. When traveling, keep your tablets in original packaging and carry extra doses in case of delays. For broader medication planning, review our editorial overview in Common Diabetes Medications.

Questions to Ask Your Clinician

• Is Januvia appropriate for my type 2 diabetes plan right now?
• Which strength fits my kidney function and other medicines?
• How should low blood sugar be managed if I use insulin or a sulfonylurea?
• What signs of pancreatitis or allergic reaction should I watch for?
• Would adding metformin or changing to a combination tablet be helpful?
• How often should I complete lab tests to monitor safety?

Authoritative Sources

• Merck Januvia Prescribing Information
• FDA DailyMed: Januvia
• Health Canada Drug Product Database

Start your Januvia order with US delivery from Canada and prompt, express shipping.