Januvia (sitagliptin) oral tablets

Januvia is a prescription oral medicine used to help manage blood sugar in type 2 diabetes. This page summarizes how Januvia 100 mg is used, along with dosage basics, safety considerations, and storage. Site requests are supported with US shipping from Canada and a cash-pay pathway for people without insurance.

It is not insulin, and it is taken by mouth as a tablet. For background on the condition this therapy is used in, see Type 2 Diabetes.

What Januvia 100 mg Is and How It Works

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Januvia contains sitagliptin, a DPP-4 (dipeptidyl peptidase-4) inhibitor. DPP-4 inhibitors work by increasing incretin hormones (gut hormones that help regulate post-meal glucose). This can support glucose-dependent insulin release and reduce glucagon signaling after meals. Because the effect is glucose-dependent, this class generally has a lower risk of hypoglycemia when used alone, but low blood sugar can still occur when combined with insulin or medicines that increase insulin release.

In practice, the goal is to improve A1C and daily glucose patterns as part of a broader type 2 diabetes plan. For a plain-language overview of common indications and how this medicine fits into therapy, review Januvia Uses. For similar medicines in the same class, browse DPP 4 Inhibitors.

Who It’s For

This medicine is indicated for adults with type 2 diabetes, typically alongside diet and physical activity. It may be used alone or in combination with other glucose-lowering therapies, depending on the prescriber’s plan. People looking for a broader view of treatment categories can also browse Diabetes and Non Insulin Medications to see different non-insulin options in one place.

High-level situations where sitagliptin is generally not used include type 1 diabetes and diabetic ketoacidosis (DKA). A key contraindication is a known serious hypersensitivity reaction to sitagliptin or any component of the product. Kidney disease is not an absolute contraindication, but it can require dose adjustment and closer follow-up. Pancreatitis (pancreas inflammation) has been reported with this class; a prescriber may weigh risks if there is a prior history.

Dosage and Usage

Januvia tablets are taken by mouth, usually once daily, with or without food. For many adults, the typical maintenance dose is 100 mg daily, but the labeled dose depends heavily on kidney function. The product labeling includes reduced dosing for moderate or severe renal impairment and for end-stage renal disease, because sitagliptin is cleared primarily through the kidneys.

When required, prescriptions are confirmed with the prescriber before fulfillment.

For product-specific dosing details and examples of how clinicians think about adjustments, see Januvia Dosage. If the therapy is used with insulin or a sulfonylurea, a prescriber may change the companion medicine to reduce hypoglycemia risk. Tablets should be swallowed whole with water unless the official label states otherwise for a specific presentation.

Why it matters: Kidney function can change over time, and the labeled dose may change with it.

Strengths and Forms

This medicine is supplied as an oral tablet, and the available strengths commonly include 25 mg, 50 mg, and 100 mg. Some listings may describe the active ingredient as sitagliptin (as sitagliptin phosphate). You may also see strength wording written as sitagliptin phosphate 100 mg tablet on certain references, which reflects the salt form used to deliver sitagliptin.

Januvia 100 mg is one of the available tablet strengths and is typically used when kidney function supports the full labeled dose. The generic for januvia 100mg is sitagliptin in many markets, but availability can vary by country and by dispensing pharmacy. If a substitution is appropriate, it is handled according to prescriber authorization and applicable pharmacy rules.

Storage and Travel Basics

Store tablets at controlled room temperature and keep them dry. Avoid prolonged exposure to heat, high humidity, or direct sunlight, such as leaving the medicine in a car. Keep tablets in the original packaging when possible so the lot number and expiration date remain available for reference.

Januvia 100 mg does not require refrigeration under standard labeling. For travel, pack doses in a carry-on bag and keep a copy of the prescription label if you will be crossing borders. If your routine involves pill organizers, try to refill them weekly so the medicine spends less time outside the original container. If a tablet appears damaged, discolored, or crumbling, confirm next steps with a pharmacist.

Quick tip: Keep one extra labeled blister or bottle section for identification.

Side Effects and Safety

Many people tolerate sitagliptin well, but side effects can occur. Commonly reported effects include upper respiratory symptoms (such as a stuffy nose or sore throat), headache, and gastrointestinal upset. Low blood sugar is more likely when this therapy is used with insulin or a sulfonylurea, rather than when it is used alone. Monitoring plans vary by regimen, but A1C, home glucose data, and kidney function are typical follow-up points.

Januvia 100 mg should be stopped and assessed if a serious reaction is suspected, following the prescriber’s instructions. It is also important to review other medicines and supplements, because combinations can affect safety or change monitoring needs.

Serious reactions to watch for

Seek urgent medical assessment for symptoms that could signal a severe problem. This includes intense or persistent abdominal pain (with or without vomiting) that may indicate pancreatitis (pancreas inflammation). Get help right away for facial swelling, trouble breathing, or widespread rash, which can be signs of a serious allergic reaction. Unusual blistering skin lesions have been reported (including bullous pemphigoid), and severe joint pain has also been described with DPP-4 inhibitors. Worsening swelling, shortness of breath, or sudden weight gain should be evaluated, especially in people with heart or kidney disease.

Drug Interactions and Cautions

Overall, sitagliptin has relatively few direct drug–drug interactions, but clinically relevant cautions still apply. Hypoglycemia risk rises when used with insulin or insulin secretagogues (medicines that prompt the pancreas to release insulin). In those combinations, prescribers may adjust the companion drug rather than changing this therapy. Kidney impairment can raise exposure to sitagliptin, which is why dose selection is linked to renal function and periodic reassessment.

Januvia 100 mg may interact with digoxin in a way that can increase digoxin levels in some people, so clinicians may monitor if both are used. Avoid taking more than one DPP-4 inhibitor at the same time unless a prescriber has a specific reason. Always share an updated medication list that includes over-the-counter products and herbal supplements.

Compare With Alternatives

Several other non-insulin options may be considered for type 2 diabetes, and selection often depends on kidney function, cardiovascular history, weight goals, and tolerance. Within the same DPP-4 inhibitor class, alternatives include linagliptin and saxagliptin. Practical differences can include renal dosing requirements and whether drug interactions are more relevant for a given person.

For examples of how class-to-class comparisons are discussed, see Tradjenta Vs Januvia and Linagliptin Vs Sitagliptin. Other classes sometimes compared against DPP-4 inhibitors include SGLT2 inhibitors and GLP-1 receptor agonists; a longer comparison discussion is available in Jardiance Vs Januvia. Related product pages include Tradjenta and Jardiance.

Pricing and Access

Out-of-pocket costs can vary widely by dose, pack size, and dispensing channel. People often search phrases such as januvia 100 mg price in usa, sitagliptin 100 mg price, or cost of januvia 100 mg at walmart when comparing cash-pay options. Others look up tools like goodrx januvia 100 mg, or check whether a marketplace listing such as januvia 100 mg amazon can process a valid prescription in their area. Comparing sources is reasonable, but make sure the option you choose is tied to a licensed pharmacy and a verified prescription.

Licensed Canadian pharmacies dispense medications for approved orders.

For cross-border access, documentation requirements and product availability may differ from local retail channels, and some people use this route when seeking januvia 100 mg without insurance. If you want to review site-wide offers that may apply to eligible medications, see Promotions. For logistics planning, some orders may be arranged as Ships from Canada to US depending on destination and pharmacy routing.

Authoritative Sources

Official labeling is the best reference for indications, contraindications, and renal dose adjustments. For the U.S. regulator’s drug record, use this neutral reference: Drugs@FDA Januvia Application Overview.

For patient-friendly medication information that is updated regularly, this government resource is a helpful complement: MedlinePlus Sitagliptin. If a prescription is on file and approved, checkout can initiate prompt, express, cold-chain shipping based on pharmacy handling requirements.

This content is for informational purposes only and is not a substitute for professional medical advice.