Xigduo XR Tablets (dapagliflozin/metformin)

Xigduo XR is a prescription oral combination medicine that contains dapagliflozin and metformin for type 2 diabetes management. This page summarizes key facts about xigduo xr 5 mg 1000 mg, including how it works, how it’s typically used, and safety basics. Ships from Canada to US access may be available with a valid prescription for people paying cash without insurance.

What Xigduo Is and How It Works

This medicine combines two glucose-lowering drugs in one tablet. Dapagliflozin is an SGLT2 inhibitor (helps the kidneys pass glucose into urine), while metformin is a biguanide that reduces liver glucose production and improves insulin sensitivity. Because the mechanisms are different, the combination may be used when a single agent is not enough, alongside nutrition and activity measures recommended by a healthcare professional.

Prescription information may be confirmed with the prescriber when required. In practice, the dapagliflozin/metformin pairing used in xigduo xr 5 mg 1000 mg aims to address fasting and after-meal glucose patterns with once-daily extended-release metformin. Monitoring plans commonly include periodic A1C testing and kidney function checks, since both components have precautions tied to renal health. For browsing other oral combinations in the same therapeutic area, the Combination Tablets list can help organize options by class.

Who It’s For

The combination is generally indicated for adults with type 2 diabetes, as part of a broader management plan. It is not intended for type 1 diabetes and is not used to treat diabetic ketoacidosis. Condition-specific background and related therapies can be browsed through the Type 2 Diabetes hub, which groups medicines and resources by common clinical pathways.

Some people should not use dapagliflozin/metformin products, or may need added screening before starting. Contraindications and major cautions can include severe kidney impairment, acute or chronic metabolic acidosis (including diabetic ketoacidosis), and prior serious hypersensitivity to either active ingredient. Situations that raise dehydration risk—such as prolonged vomiting or reduced fluid intake—may also increase complications. For a broader look at non-injectable options, the Non Insulin Medications category is a practical place to compare medication classes without focusing on any single brand.

Dosage and Usage

Dapagliflozin/metformin extended-release tablets are taken by mouth on a schedule set by the prescriber, using the specific strength and instructions on the prescription label. Extended-release formulations are typically used once daily with a meal to reduce gastrointestinal effects and to match the release profile of the metformin component. Tablets are generally swallowed whole; crushing, splitting, or chewing can interfere with extended-release delivery and tolerability.

When xigduo xr 5 mg 1000 mg is prescribed, the label and prescriber directions determine timing, titration, and monitoring. Missed-dose instructions can differ by individual plan and by local labeling, so the safest approach is to follow the dispensing label and ask a pharmacist when uncertain. For background on dose concepts and common administration issues, see Metformin Dosage and the overview on Oral Diabetes Medication.

Quick tip: Keep an updated medication list in the same place as the prescription label.

Strengths and Forms (xigduo xr 5 mg 1000 mg)

This product is supplied as an oral tablet that combines dapagliflozin with metformin hydrochloride in an extended-release presentation. In the 5 mg/1000 mg strength, each tablet contains dapagliflozin 5 mg and metformin HCl 1000 mg (extended-release). Package counts can vary by pharmacy and jurisdiction; many listings are supplied as 60 tablets, but the dispensed quantity is based on the prescription and dispensing rules.

Because combination tablets come in multiple strengths in some markets, matching the bottle label to the current prescription is important, especially during therapy changes. Keeping the original container and the pharmacy label can reduce mix-ups during travel or when other household members use similar tablets. For related formats and combination presentations, the Combination Tablets category groups products by non-insulin oral combinations.

Storage and Travel Basics

Storage instructions should follow the pharmacy label and manufacturer monograph. For most tablet medicines in this class, storage is at controlled room temperature, away from excess heat and moisture. Keep the bottle tightly closed, and avoid storing it in bathrooms or other humid areas. Tablets should be kept out of reach of children and pets, and expired medication should be disposed of according to local pharmacy guidance.

For travel, carrying tablets in the original labeled container can make identification easier if questions arise at borders or during emergency care. Temperature swings in checked luggage or parked vehicles can be significant, so carry-on storage is often more stable for tablets. Planning ahead with a written medication list and a copy of the prescription can also help. Practical, condition-focused planning resources are collected under Type 2 Diabetes Articles, including general care topics beyond medication handling.

Side Effects and Safety

Side effects can come from either component. Metformin commonly causes gastrointestinal symptoms such as nausea, diarrhea, abdominal discomfort, or reduced appetite, especially early in therapy. Dapagliflozin can increase urination and may raise the risk of genital yeast infections or urinary tract infections in some people. Staying alert to new symptoms and reporting persistent issues helps clinicians decide whether the effects are expected, dose-related, or due to another cause.

Dispensing is handled by licensed Canadian pharmacies after documentation review. Important risks listed for xigduo xr 5 mg 1000 mg include lactic acidosis (a rare but serious buildup of lactic acid) and ketoacidosis (dangerously high ketones), which may occur even when blood glucose is not markedly elevated. Other serious concerns can include dehydration with low blood pressure, acute kidney problems, severe urinary tract infections, and rare perineal infection (Fournier’s gangrene). For metformin-focused context, the guide on Exploring Side Effects Of Metformin may be helpful alongside official labeling.

Why it matters: Some warning symptoms require urgent assessment, not routine follow-up.

Drug Interactions and Cautions

Drug interactions can affect safety or glucose control. Diuretics (water pills) and other medicines that lower blood pressure can add to dehydration risk. Insulin and sulfonylureas can increase hypoglycemia risk when combined with other glucose-lowering therapies, so clinicians may adjust regimens and monitoring. Alcohol use can worsen metformin-related risks in some situations and can also complicate recognition of metabolic problems.

Before starting xigduo xr 5 mg 1000 mg, medication lists should include prescription drugs, over-the-counter products, and supplements. Iodinated contrast used for some imaging procedures is a common caution for metformin-containing therapy; temporary interruption and kidney reassessment may be required based on the clinical scenario and local guidance. Other considerations include medicines that affect kidney function, and drugs that can influence glucose readings or fluid balance. For class-level context on SGLT2 inhibitor combinations, see Invokana Metformin Combination as a comparison-focused resource.

Compare With Alternatives

Alternatives depend on treatment goals, kidney function, side-effect profile, and other conditions. Some regimens use metformin alone, while others pair metformin with a different second agent such as a DPP-4 inhibitor or an SGLT2 inhibitor. In the same general category as dapagliflozin/metformin, another SGLT2 inhibitor/metformin option is empagliflozin/metformin, listed as Synjardy Details. A different combination approach is sitagliptin/metformin extended-release, listed as Janumet XR Details.

Comparisons are usually about tolerability, kidney precautions, dosing frequency, and the need for stepwise therapy adjustments rather than one product being “stronger.” Some combinations have class-specific risks (for example, SGLT2 inhibitors and genital infections), while others have different monitoring needs. A prescriber may also consider cardiovascular or kidney comorbidities, and whether other medicines in the regimen overlap in mechanism. For browsing options by category rather than brand, the Combination Tablets hub provides a structured list.

Pricing and Access

Out-of-pocket costs can vary by strength, supply, and dispensing pharmacy. Search terms like “xigduo xr 5mg 1000mg price” often reflect a need to compare cash rates across sources and packaging. When evaluating total expense, it can help to consider the prescription quantity, refill interval, and whether additional monitoring visits or labs are planned as part of therapy follow-up.

Cash-pay access is available for those without coverage. For xigduo xr 5 mg 1000 mg, documentation requirements may include a valid prescription and, in some cases, confirmation with the prescriber. The service operates as a prescription referral platform, connecting requests to dispensing through licensed Canadian pharmacies. Information on site-wide programs is listed on Current Promotions, where available, and can be reviewed without changing the prescription decision process.

Authoritative Sources

For the most reliable safety language, use official labeling and regulator communications in addition to general education articles. The links below provide primary-source context for class warnings and patient-focused medication information. Local monographs and the dispensing label should be treated as the governing instructions for the specific product supplied.

• For SGLT2 inhibitor safety warnings, review the FDA Drug Safety Communication.
• For patient-level medication details, see MedlinePlus dapagliflozin and metformin.

For additional educational reading on diabetes medicines and monitoring topics, browse Diabetes Articles. To proceed with a request, submit the prescription details and complete checkout; prompt, express, cold-chain shipping may be used when appropriate.

This content is for informational purposes only and is not a substitute for professional medical advice.