Bupropion SR Tablets for Depression

Bupropion SR is a prescription antidepressant used in adults. It helps treat major depressive disorder and may prevent seasonal affective disorder in some patients. A different brand of this medicine is also used to support quitting smoking.

What Bupropion SR Is and How It Works

This medicine is a norepinephrine–dopamine reuptake inhibitor (NDRI). It increases certain brain chemicals that influence mood, energy, and motivation. It is available for US delivery from Canada, which may help you manage costs without insurance. Some patients know the brand version as wellbutrin sustained release. Bupropion SR is the generic for Wellbutrin SR®, a 12-hour formulation designed to release the active ingredient gradually.

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Mechanistically, the treatment inhibits reuptake of norepinephrine and dopamine, with minimal direct effects on serotonin. It has no significant antihistaminic or anticholinergic activity. The SR formulation uses a polymer matrix to maintain steadier blood levels over the dosing interval.

Who It’s For

This therapy is indicated for adults with major depressive disorder. It may also be used for the prevention of seasonal affective disorder as directed by a prescriber. For help on conditions and care pathways, review our category for Depression.

The active ingredient is also used under other brand names to aid smoking cessation. For tobacco use treatment resources, see Nicotine Dependence. Do not use this medicine if you have a seizure disorder, a current or prior diagnosis of bulimia or anorexia nervosa, or if you are taking or recently stopped an MAOI. Discuss suitability if you are pregnant, breastfeeding, or have significant liver or kidney impairment.

Dosage and Usage

Follow the exact directions on your prescription label. The typical approach starts with once-daily dosing, then increases to twice daily if tolerated and indicated. Swallow tablets whole with water. Do not crush, split, or chew, as this can rapidly release the drug and increase adverse effects.

Dose increases should be separated by several days and taken at least eight hours apart. Taking the last dose in the late afternoon or early evening may reduce insomnia. Alcohol can increase side effects and lower the seizure threshold; discuss use with your prescriber. If your label specifies bupropion hcl sr, use it only as directed and do not substitute without approval from your clinician or pharmacist.

For more mental health options and counseling support topics, explore Mental Health.

Strengths and Forms

This product is supplied as sustained-release oral tablets. Commonly available strengths include 100 mg, 150 mg, and 200 mg, though availability may vary by pharmacy and manufacturer. Ask your prescriber which strength and total daily amount fit your treatment plan.

Each tablet uses a 12-hour mechanism. As a result, the drug releases gradually after swallowing. This helps limit peaks and troughs that can occur with immediate-release versions of sustained release bupropion.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember unless it is close to your next dose. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take extra tablets to make up for a missed dose. Space doses by at least eight hours to reduce the risk of side effects such as insomnia or tremor.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess heat and moisture. Keep the bottle tightly closed, in the original container with the label intact. Protect from light and keep out of reach of children and pets. Do not use tablets that are chipped, broken, or discolored.

When traveling, keep your medication in your carry-on. Carry a copy of your prescription and a medication list. Use a pill organizer that preserves the whole tablet shape. If you cross time zones, maintain even spacing between doses rather than exact clock times until you settle into a new schedule.

Benefits

The treatment can help improve mood, concentration, and energy in major depressive disorder. It may be an option for patients who prefer to avoid certain side effects more common with some other antidepressant classes. Its twice-daily schedule can provide steady coverage through the day.

Because the formulation controls release over hours, many patients find it easier to tolerate than immediate-release versions. It may be considered when prior therapies were not suitable or well tolerated.

Side Effects and Safety

• Insomnia or trouble sleeping
• Dry mouth and sore throat
• Nausea or stomach upset
• Headache or dizziness
• Constipation
• Sweating or tremor
• Agitation or anxiety

Serious but less common risks include seizures, high blood pressure, severe allergic reactions, mood or behavioral changes, and angle-closure glaucoma. The risk of seizures increases with higher doses, abrupt alcohol or benzodiazepine withdrawal, eating disorders, and certain drug interactions. Young adults may experience suicidal thoughts during initiation or dose changes; monitoring is recommended. Some references group modified-release forms together and may mention bupropion er sr when describing release technologies; monitoring for adverse effects is similar across extended-release versions.

Drug Interactions and Cautions

Do not use with MAO inhibitors, or within the required washout periods after using linezolid or IV methylene blue. This medicine can lower the seizure threshold; use caution with other drugs that share this risk, including certain antipsychotics, antidepressants, tramadol, theophylline, and systemic corticosteroids. If you use nicotine replacement therapy, monitor blood pressure as advised by your clinician.

The active ingredient is a CYP2D6 inhibitor and can raise levels of 2D6 substrates, including some SSRIs, SNRIs, tricyclics, antipsychotics, beta-blockers, and type 1C antiarrhythmics. Dose adjustments of the affected drugs may be necessary. As an example of adjunctive care, review Abilify Uses to understand how clinicians may combine treatments in specific situations.

What to Expect Over Time

Some patients notice changes in energy, sleep, or appetite early in therapy. Mood and interest in activities may take longer to improve. Keep taking the medicine as prescribed, even if you feel better, unless your prescriber directs otherwise. If side effects occur, many are transient; tell your clinician if they persist or worsen.

Supportive routines can help. Take doses at consistent times, avoid late-evening dosing, and limit alcohol. For coping strategies and community resources, you may find Mental Health Awareness helpful for general education.

Compare With Alternatives

A once-daily extended-release option contains the same active ingredient and may suit certain schedules. You can discuss switching or staying with twice-daily dosing with your prescriber. Consider Wellbutrin® XL if a single daily dose is preferred.

For those managing weight, a combination product pairs naltrexone with this active ingredient and has a different indication. Learn more at Contrave® and review practical dosing guidance in Contrave Dosage Guide. The SR formulation described on this page is the generic for wellbutrin sr, which is indicated for depression; your prescriber can advise on appropriate choices.

Pricing and Access

You can review current pricing on the product page and compare options at checkout. Canadian pricing with US fulfillment can offer meaningful savings for many cash-pay patients. This includes those seeking bupropion sr smoking cessation under appropriate medical guidance. Ships from Canada to US availability helps patients who prefer mail-order pharmacy services from licensed Canadian dispensaries.

Check our periodic Promotions for any applicable offers. Final costs depend on quantity, manufacturer, and your prescription. You can place an order online and upload your script for verification.

Availability and Substitutions

Stock can vary by strength and manufacturer. If a specific strength is temporarily unavailable, your prescriber may recommend an alternative schedule, a different release form, or a comparable therapy from another class. Pharmacist-led substitution occurs only with prescriber approval, following your local regulations.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults who have not responded to or tolerated other antidepressant classes. It is generally avoided in patients with seizure risk factors or active eating disorders. Tell your clinician about all medicines, supplements, and alcohol use before starting therapy.

To reduce pharmacy visits, ask about multi-month fills if appropriate. Set refill reminders so you do not miss doses. Generics typically cost less than brands, and selecting a consistent manufacturer can improve predictability of response. Our checkout is encrypted to help protect your personal information.

Questions to Ask Your Clinician

• Is this SR formulation appropriate for my diagnosis and history?
• How should I time doses to limit insomnia?
• What signs suggest I should call you promptly?
• Could other medicines I take raise seizure risk?
• When should I consider switching to a once-daily release?
• How long should I continue treatment after I feel better?

Authoritative Sources

FDA DailyMed: Bupropion Hydrochloride SR Prescribing Information

FDA Labeling Archive: Approved Bupropion Labeling Documents

Health Canada Drug Product Database: Bupropion SR Products

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.