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Candesartan HCTZ Tablets for Hypertension
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Candesartan with hydrochlorothiazide is a prescription tablet for high blood pressure. It combines an angiotensin receptor blocker with a diuretic to help reduce blood pressure. This page summarizes strengths, label basics, and access options with US delivery from Canada, including options without insurance.
What Candesartan HCTZ Is and How It Works
Brand-name Atacand HCT® contains candesartan cilexetil and hydrochlorothiazide in a single oral tablet. The first component blocks angiotensin II receptors to relax blood vessels. The second raises urine output to reduce excess fluid. Together they can lower blood pressure more than either alone.
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This medicine is used as part of comprehensive hypertension care, which may include diet, activity, and other agents. It is intended for adults. For education on the condition, see our High Blood Pressure category.
Who It’s For
The combination is indicated for adults with hypertension when a single agent is not enough, or when a clinician decides a two-drug regimen is appropriate. Many patients transition to a fixed-dose combination for simplicity and consistent control.
People with specific risks should not use candesartan cilexetil and hydrochlorothiazide without clinician guidance. Do not use during pregnancy; drugs acting on the renin-angiotensin system can harm the fetus. Avoid in anuria or with hypersensitivity to sulfonamide-derived drugs. Use caution with kidney or liver impairment, electrolyte abnormalities, gout, or a history of angioedema.
Dosage and Usage
Tablets are taken once daily, with or without food, at about the same time each day. Swallow whole with water. This therapy is often used after trying an angiotensin receptor blocker or a thiazide alone. Clinicians may adjust the strength based on blood pressure response and tolerability.
Patients who are volume-depleted (for example, from diuretics) may be at risk for dizziness or low blood pressure. Discuss all medicines and supplements with a healthcare professional. Follow the official prescribing information for detailed directions.
Strengths and Forms
The product is supplied as candesartan hydrochlorothiazide tablets in multiple fixed-dose strengths. Availability can vary by pharmacy and manufacturer.
- 16/12.5 mg tablets
- 32/12.5 mg tablets
- 32/25 mg tablets
All strengths are film-coated oral tablets. Packaging and imprint may differ by manufacturer.
Missed Dose and Timing
If a dose is missed, take it when remembered the same day. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not take two doses at once. Consistent daily timing can support steadier blood pressure.
Storage and Travel Basics
Store tablets at room temperature in a dry place, away from moisture and direct light. Keep in the original container with the label intact, and out of reach of children and pets. When traveling, keep medicine in carry-on baggage with a copy of your prescription. Bring enough tablets for the full trip plus a small buffer. If driving long distances, avoid storing medicine in a hot car.
Benefits
This treatment streamlines blood pressure care by combining two complementary mechanisms in one pill. The once-daily schedule can simplify routines. Using a fixed dose may help maintain adherence compared with taking two separate medications. Strength options allow a prescriber to tailor therapy while keeping the regimen straightforward.
Side Effects and Safety
- Dizziness or lightheadedness
- Headache or fatigue
- Increased urination
- Electrolyte changes (for example, sodium or potassium shifts)
- Gout flare or higher uric acid
- Photosensitivity or rash
Serious but uncommon risks include kidney function changes, severe hypotension, angioedema, and eye findings such as acute angle-closure glaucoma or myopia with thiazides. Fetal toxicity can occur with exposure during pregnancy. Report facial swelling, breathing difficulty, or vision changes right away. Monitoring may include electrolytes, kidney function, and blood pressure checks.
Drug Interactions and Cautions
Interactions may occur with lithium, NSAIDs, other antihypertensives, potassium-sparing diuretics, potassium supplements, or salt substitutes. Resins such as cholestyramine can reduce thiazide absorption. Alcohol can increase dizziness. Diabetes medicines may require monitoring because fluid and electrolyte shifts can alter response. Some labeling abbreviates the combination as hct candesartan, which should be reviewed under the same precautions.
For background on related agents, see Ramipril Uses. Always consult the official label for full interaction details.
What to Expect Over Time
Blood pressure typically improves progressively with regular use and lifestyle measures. Clinicians often assess response over several weeks, checking for dizziness, swelling, or cough history, and reviewing lab work for electrolytes and kidney function. Patients who stay consistent with dosing, limit excess salt, and keep follow-up appointments tend to have steadier control. If goals are not met, the care plan may be adjusted by the prescriber.
Compare With Alternatives
Other angiotensin receptor blocker and thiazide combinations may be considered. Losartan with hydrochlorothiazide is available as Hyzaar. Valsartan with hydrochlorothiazide is offered as Diovan HCT. Choice depends on prior response, side effect profile, and clinician judgment. Therapeutic alternatives within the class are used when access, tolerance, or lab results suggest a switch.
Pricing and Access
Canadian pricing may offer meaningful value compared with typical local rates. Current candesartan hctz price information is shown on this page when available. US shipping from Canada is available to eligible addresses after a valid prescription is received. Many patients buy as self-pay when insurance coverage is limited, or use a cash price at checkout. Our checkout is encrypted.
Looking for discounts? See current offers on our Promotions page when available. Availability and pricing can change with manufacturer supply and market conditions.
Availability and Substitutions
If a certain strength is temporarily unavailable, a prescriber may recommend a different strength or an alternative in the same class. One option some clinicians consider is Telmisartan HCT, depending on history and lab parameters. Any substitution requires a valid prescription reflecting the alternative.
Patient Suitability and Cost-Saving Tips
The combination suits adults who need two agents to reach blood pressure goals and prefer a single daily pill. It is not appropriate during pregnancy, in anuria, or with a known allergy to sulfonamide-derived components. Those with advanced kidney or liver disease, gout, or electrolyte concerns need close monitoring.
For budgeting, larger fills can reduce per-tablet costs. Many patients choose 60- or 90-day supplies to limit refill fees and maintain continuity. Set refill reminders to avoid interruptions. Patients paying out of pocket may find that generic candesartan cilexetil hctz helps manage expenses. Discuss affordability with the prescriber or pharmacist to align therapy with clinical needs.
Questions to Ask Your Clinician
- Combination fit: Why add a thiazide to an angiotensin receptor blocker?
- Strength choice: Which tablet strength aligns with my current readings?
- Monitoring plan: How often will labs and blood pressure be checked?
- Side effects: What symptoms mean I should call the office promptly?
- Other medicines: Do any of my current drugs raise interaction concerns?
- Sun exposure: Should I take extra precautions for photosensitivity?
Authoritative Sources
DailyMed: Atacand HCT Prescribing Information
DailyMed: Candesartan Cilexetil and Hydrochlorothiazide
Health Canada DPD: Candesartan/Hydrochlorothiazide
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Can this combination be used as initial therapy for hypertension?
It is often added when one medicine does not adequately control blood pressure. Some clinicians may start the combination when they believe two mechanisms are likely needed from the outset, particularly when readings are significantly elevated. Labeling typically emphasizes using the lowest effective dose. The decision to begin with a fixed-dose combination depends on individual risk, prior treatment, and monitoring plans set by the prescriber.
Can the tablet be split or crushed?
Tablets are generally swallowed whole once daily. Some presentations may be scored, but not all. Crushing or splitting can affect dose accuracy. If pill size is a concern, discuss available strengths or alternative combinations with a pharmacist or clinician. Follow the product’s package insert or the guidance provided by your prescriber for the specific manufacturer’s tablet.
What monitoring is commonly recommended with this therapy?
Monitoring often includes blood pressure checks, kidney function (serum creatinine), and electrolytes such as potassium and sodium. Clinicians may also assess uric acid if gout is a concern. After dose changes, the care team may recheck labs to evaluate tolerability. Frequency depends on clinical status, coexisting conditions, and other medicines. Patients should report dizziness, swelling, or vision changes promptly for assessment.
Is it safe during pregnancy or breastfeeding?
Medicines that act on the renin-angiotensin system can harm the developing fetus and are contraindicated during pregnancy. If pregnancy is detected, the therapy should be discontinued and the care plan re-evaluated by a clinician. Hydrochlorothiazide appears in breast milk; risk–benefit should be considered when nursing. Discuss family planning and contraceptive needs with a healthcare professional before starting treatment.
What lifestyle steps support blood pressure control while taking this medicine?
Lifestyle measures can complement medication. Common steps include reducing excess dietary sodium, moderating alcohol, maintaining a balanced diet, regular physical activity as tolerated, and consistent sleep. Keeping an at-home blood pressure log can help clinicians fine-tune therapy. Follow individualized advice from your care team, especially if you have kidney or metabolic conditions that affect fluid and electrolytes.
Are there medicines or supplements I should avoid?
Lithium, NSAIDs, potassium-sparing diuretics, and high-dose potassium supplements can interact. Salt substitutes containing potassium may raise potassium levels. Bile acid sequestrants can reduce thiazide absorption if taken together. Alcohol can increase dizziness. Always provide a complete medication and supplement list to your prescriber and pharmacist, and follow label instructions on timing and monitoring.
What if my blood pressure remains high on this treatment?
Clinicians may titrate the strength, address adherence and lifestyle factors, or consider a different combination. Some people respond better to another angiotensin receptor blocker with a thiazide, or to adding a third agent from a different class. Do not change doses on your own; work with your healthcare professional to adjust the plan based on readings, side effects, and lab results.
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