Edarbyclor® Tablets for High Blood Pressure

Edarbyclor® is a prescription tablet that combines azilsartan medoxomil and chlorthalidone to treat high blood pressure in adults. CanadianInsulin offers Canadian pricing on Edarbyclor with US delivery from Canada, which helps many patients compare costs, including those paying without insurance. This page explains labeled uses, dosing, safety, and how to order online with confidence.

What Edarbyclor® Is and How It Works

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. Edarbyclor is a fixed-dose combination of an angiotensin II receptor blocker (ARB) and a thiazide-like diuretic. Azilsartan medoxomil is a prodrug converted to azilsartan. It blocks the AT1 receptor, relaxing blood vessels and reducing the effects of angiotensin II. Chlorthalidone increases sodium and water excretion in the distal tubule, which lowers blood volume and helps reduce blood pressure. Using both together can provide stronger blood pressure control than either medicine alone for many patients.

Lowering elevated blood pressure reduces the risk of stroke, heart attack, and kidney complications. Edarbyclor tablets are taken once daily and may be used when a clinician decides combination therapy is appropriate. It is not for emergency treatment of severe hypertension.

Who Edarbyclor® Is For

Edarbyclor is indicated for adults with hypertension when combination therapy with an ARB and a thiazide-like diuretic is appropriate. It may be used in patients not adequately controlled on single-agent therapy or where starting with two agents is suitable. For condition background and related options, explore our High Blood Pressure category, and see education such as Altace Supports Heart Health.

Patients who should avoid Edarbyclor include those who are pregnant. Drugs that act on the renin-angiotensin system can harm the developing fetus. Discontinue as soon as pregnancy is detected. Do not use in patients with anuria. Use caution in severe renal impairment or significant hepatic impairment. Avoid concomitant use with aliskiren in patients with diabetes. Patients with hypersensitivity to sulfonamide-derived drugs may be at increased risk of reactions due to chlorthalidone.

Dosage and Usage

Edarbyclor dosing follows labeled guidance:

• Usual initial dose: 40 mg/12.5 mg once daily.
• Titrate as needed to 40 mg/25 mg once daily after assessing response, typically within 2 to 4 weeks.
• Take consistently at the same time each day, with or without food.

Edarbyclor is not recommended in pediatric patients. Correct volume or salt depletion before initiating therapy when possible. Follow the prescriber’s plan for monitoring blood pressure and labs.

Strengths and Forms

Edarbyclor tablets are available in these commonly used strengths (availability may vary):

• 40 mg/12.5 mg tablets (azilsartan medoxomil/chlorthalidone)
• 40 mg/25 mg tablets (azilsartan medoxomil/chlorthalidone)

These are often described as Edarbyclor 40/12.5 mg and Edarbyclor 40/25 mg. You may also see the strengths written as Edarbyclor 40 mg/12.5 mg tablets or Edarbyclor 40 mg/25 mg tablets. Labeling may reference the generic components as azilsartan medoxomil chlorthalidone 40/25 mg or azilsartan chlorthalidone 40/12.5 mg.

Missed Dose and Timing

If a dose is missed, take it the same day when remembered. If it is almost time for the next dose, skip the missed dose. Do not take two doses at once.

Storage and Travel Basics

Store your Edarbyclor tablets at room temperature in the original container. Protect from moisture and excessive heat. Keep out of reach of children and pets. When traveling, keep your medicine in carry-on luggage, along with your prescription label. For cross-border travel, carry your prescription and only the amount you need.

Benefits

Edarbyclor provides once-daily dosing with two complementary mechanisms, which can simplify therapy compared with taking two separate pills. Lowering blood pressure reduces the risk of cardiovascular and renal complications when used as directed. Many patients appreciate that the chlorthalidone component is long-acting, supporting 24-hour blood pressure control. For perspective on other blood pressure options, see Bystolic Helps Control.

Side Effects and Safety

• Dizziness or lightheadedness
• Fatigue
• Increased urination
• Nausea or stomach upset
• Electrolyte changes (such as low potassium or low sodium)
• Increased uric acid or gout flare
• Headache

Serious effects are uncommon but can include severe hypotension or fainting, kidney function changes, severe electrolyte disturbances, rare angioedema, and eye symptoms consistent with acute angle-closure glaucoma or myopia. Stop the medicine if pregnancy is detected and contact a clinician. Patients with significant kidney or liver disease require careful monitoring. Report unusual swelling of the face, lips, or tongue, or difficulty breathing, as these may indicate angioedema.

Drug Interactions and Cautions

Key interactions and cautions include:

• Do not combine with aliskiren in diabetes; avoid in renal impairment unless advised by a clinician.
• ACE inhibitors or other ARBs: dual blockade increases risk of renal issues and hyperkalemia.
• Lithium: risk of lithium toxicity may increase; monitoring is recommended.
• NSAIDs: may reduce antihypertensive effect and affect kidney function, especially in older adults or volume-depleted patients.
• Potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium: monitor potassium.
• Alcohol: can enhance blood pressure lowering and dizziness.

Patients with chronic kidney disease may take additional therapies; see context in Kerendia Uses. For heart failure management trends, review SGLT2 Inhibitors.

What to Expect Over Time

Blood pressure usually begins to improve within the first couple of weeks, with full effect generally seen after dose adjustments have been maintained for several weeks. Clinicians often monitor electrolytes and kidney function at baseline and periodically. Staying consistent with daily dosing and lifestyle measures supports long-term blood pressure goals.

Compare With Alternatives

Other approved options include single-agent ARBs or different fixed-dose combinations such as losartan/hydrochlorothiazide, valsartan/hydrochlorothiazide, or olmesartan/hydrochlorothiazide. In certain clinical scenarios, a diuretic alone may be used; see Lasix® for an example sometimes used in hypertension and edema, based on clinician judgment.

Pricing and Access

Buy Edarbyclor online from Canada and have it shipped to the US. CanadianInsulin lists the current Edarbyclor price with Canadian pricing and US shipping. Compare Edarbyclor cost against US cash pay options. Patients often review Edarbyclor 40/12.5 mg and Edarbyclor 40/25 mg pricing side by side, including the Edarbyclor 40/25 price and Edarbyclor 40/12.5 price. If paying out of pocket, you can compare the Edarbyclor cash price to other options before checkout.

Order Edarbyclor with secure, encrypted checkout. Your valid prescription is required. If looking for deals, see our Promotions page for updates that may complement an Edarbyclor coupon or an Edarbyclor manufacturer coupon. For clarity on cross-border access, Edarbyclor ships to US addresses from Canada with no hidden membership fees.

Availability and Substitutions

Availability can vary by strength and pack size. If a specific presentation is not available, a prescriber may recommend a therapeutically appropriate alternative. Do not substitute without clinical guidance.

Patient Suitability and Cost Saving Tips

Good candidates for Edarbyclor include adults who need combination therapy for hypertension and can follow periodic lab monitoring. It is not appropriate during pregnancy or in anuria. Caution is warranted in severe renal or hepatic impairment, or in those with a history of sulfonamide allergy.

Cost-saving ideas include choosing a multi-month supply when appropriate, which can lower per-unit cost and reduce refills. Set refill reminders so your tablets arrive before you run out. Patients sometimes track home blood pressure readings to share at visits, supporting efficient dose decisions that avoid unnecessary changes.

Questions to Ask Your Clinician

• Is an ARB plus chlorthalidone combination suitable for my blood pressure goals?
• Which starting dose is appropriate, 40/12.5 mg or 40/25 mg later if needed?
• How often should kidney function and electrolytes be monitored?
• Are there medicines or supplements I should avoid while taking this combination?
• What signs of low blood pressure or electrolyte imbalance should prompt a call?
• How does this compare with losartan/HCTZ, valsartan/HCTZ, or an ARB alone?
• Could gout, diabetes, or kidney disease affect my treatment plan?

Authoritative Sources

• DailyMed: Edarbyclor Prescribing Information
• FDA Label: Edarbyclor (azilsartan medoxomil/chlorthalidone)
• Official Site: Edarbyclor Information

Start your order today for prompt US delivery from Canada.