Entresto

Uses of Entresto

Entresto, known by its generic name sacubitril and valsartan, is part of a class of medications called angiotensin receptor blockers and neprilysin inhibitors. This combination drug is designed to address chronic heart failure in adults, offering a dual mechanism of action to improve heart function and reduce the risk of hospitalization and mortality associated with the condition. 

Sacubitril works by increasing certain proteins in the body that widen blood vessels, thereby lowering blood pressure and reducing strain on the heart. Valsartan, in contrast, acts as an angiotensin II receptor blocker, preventing blood vessels from narrowing and improving blood flow.

Precautions and Warnings

Before taking Entresto, it’s important to consider some precautions. If you’re pregnant, especially in the later stages, it’s best to avoid Entresto as it could harm the unborn baby. Also, if you have diabetes, avoid taking Entresto with medications containing Aliskiren. 

Don’t take Entresto within 36 hours of an ACE inhibitor medication. Tell your doctor about any existing health conditions like liver disease, diabetes, or if you’re on a low-salt diet or often get dehydrated. If you’re considering Entresto, make sure to use effective birth control and don’t breastfeed while taking it. 

Dosage

The initial dose of Entresto is Sacubitril 49 mg-Valsartan 51 mg orally twice a day for adults with congestive heart failure. The maintenance dose is Sacubitril 97 mg-Valsartan 103 mg orally twice a day.

Side Effects

Common side effects:

• High potassium levels
• Dizziness
• Lightheadedness
• Cough

Severe side effects:

• Extreme tiredness
• Slow heart rate
• Muscle weakness
• Painful urination
• Shortness of breath

More information about Entresto

• Product Monograph – Health Canada
• U.S. Food and Drug Administration Medication Guide