Monopril® (Fosinopril) Tablets

Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor for adults with high blood pressure and for symptomatic chronic heart failure. CanadianInsulin arranges US delivery from Canada at Canadian pricing, which can help cash-pay patients, including those without insurance, maintain consistent access to therapy.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

What Monopril® Is and How It Works

Monopril® (fosinopril) lowers blood pressure by blocking the angiotensin-converting enzyme, which decreases angiotensin II and aldosterone activity. The result is relaxed blood vessels and less sodium and water retention. In heart failure, these effects reduce afterload and support cardiac output. Fosinopril is a prodrug converted to the active metabolite fosinoprilat. It has dual elimination through the liver and the kidneys, a feature that can be useful across a range of kidney function.

ACE inhibition is a core approach in hypertension alongside lifestyle changes and other medicines. Explore related options in High Blood Pressure and broader cardiovascular choices in Hypertension Cardiovascular.

Who Monopril Is For

Approved uses include treatment of hypertension in adults and use in stable heart failure to improve symptoms and reduce hospitalization risk when added to standard therapy. It is not appropriate for anyone with a history of ACE inhibitor–related angioedema, hereditary angioedema, current pregnancy, or those planning pregnancy. Concomitant use with aliskiren in people with diabetes is generally avoided. A washout interval is recommended when switching to or from sacubitril/valsartan to lower angioedema risk. Caution is warranted with advanced kidney disease, renal artery stenosis, or baseline high potassium. Some individuals of Black ancestry may have a reduced blood pressure response and higher angioedema risk with ACE inhibitors; clinicians consider this when selecting therapy.

Heart failure regimens may also include diuretics or other agents. A commonly paired diuretic is furosemide; see Furosemide Injection for clinical context. Condition education is available in our Heart Failure and Heart Disease categories.

Dosage and Usage

Fosinopril is typically started once daily, with or without food. A common initial dose for hypertension is 10 mg once daily, then titrated based on blood pressure and tolerability; many patients stabilize within a 20–40 mg once-daily range. In heart failure, clinicians often initiate 10 mg once daily and up-titrate as tolerated. Individuals who are volume-depleted or on high-dose diuretics may begin at a lower dose to minimize first-dose hypotension. Take tablets at the same time each day. If uncertain about any instructions, follow the prescriber’s label and clinic guidance.

For a wider view of options used alongside ACE inhibitors, browse Hypertension Cardiovascular.

Strengths and Forms

Fosinopril is supplied as oral tablets in strengths commonly published as 10 mg, 20 mg, and 40 mg. Specific strengths, manufacturers, and packaging can vary by availability. Generic fosinopril contains the same active ingredient as the brand.

Missed Dose and Timing

If a dose is missed, take it when remembered unless it is close to the next scheduled dose. If it is near the next dose, skip the missed dose and resume the regular schedule. Do not double up doses. Consistent daily timing supports steady blood levels.

Storage and Travel Basics

Store tablets at room temperature in a dry place, in the original labeled container, and away from moisture, heat, and direct light. Keep out of reach of children and pets. During travel, carry medicine in a carry-on bag, keep it in the original labeled container for security screening, and bring a copy of the prescription. For general packing and in-transit tips that apply to many therapies, see Travel With Ozempic.

Benefits

• Helps reduce blood pressure, which lowers the risk of stroke, heart attack, and kidney complications associated with hypertension.
• Supports heart failure management by decreasing afterload and neurohormonal activation, often improving exercise tolerance and symptoms when combined with standard therapy.
• Once-daily dosing that can fit routine schedules.
• Dual hepatic and renal elimination, which can be practical across a range of kidney function.
• Generically available, offering access and potential cost savings compared with some branded options.

Side Effects and Safety

• Cough (typically dry and persistent)
• Dizziness or lightheadedness, especially after the first few doses or with dose increases
• Headache or fatigue
• Nausea, diarrhea, or abdominal discomfort
• Skin rash or taste changes

Serious effects are uncommon but require urgent attention: swelling of the face, lips, tongue, or throat (angioedema); severe dizziness or fainting; signs of high potassium such as muscle weakness or abnormal heart rhythm; reduced urine output; or unusual yellowing of the skin/eyes. Clinicians commonly monitor serum creatinine and potassium after initiation or dose changes, particularly in those with kidney disease or on interacting drugs. Avoid use during pregnancy due to the risk of fetal harm.

Drug Interactions and Cautions

• Potassium-sparing diuretics (e.g., spironolactone), potassium supplements, or salt substitutes with potassium may increase hyperkalemia risk.
• Other renin–angiotensin system blockers (e.g., ARBs) or aliskiren increase hypotension, kidney, and potassium risks; combination strategies are generally avoided unless specifically directed by a specialist.
• Sacubitril/valsartan requires a washout period when switching to or from an ACE inhibitor to lower angioedema risk.
• Diuretics and volume depletion can heighten first-dose hypotension; clinicians may adjust dosing.
• NSAIDs can blunt antihypertensive effect and, with ACE inhibitors, may impact kidney function.
• Lithium levels can rise; monitoring or alternative therapy may be needed.
• Alcohol may amplify blood pressure–lowering effects and dizziness.

Clinicians may combine ACE inhibitors with beta blockers in heart failure or post-MI care. For background reading on one option in that class, see Acebutolol Uses.

What to Expect Over Time

Blood pressure typically improves with consistent daily use and lifestyle measures such as sodium reduction and activity as recommended by a clinician. A dry cough can emerge in some patients; if persistent or troublesome, clinicians may consider alternatives. Periodic lab checks for kidney function and potassium are routine. Many patients remain on an ACE inhibitor long term when benefits outweigh risks.

Compare With Alternatives

Alternatives in the same class include lisinopril, enalapril, and ramipril. Angiotensin receptor blockers (e.g., losartan, valsartan) are commonly chosen when ACE inhibitor–related cough or angioedema occurs. Other options in hypertension include calcium channel blockers (e.g., amlodipine) and thiazide diuretics. To review options by condition, visit Hypertension Cardiovascular or browse Heart Health Medications. Therapy selection depends on medical history, other medications, and treatment goals.

Pricing and Access

Canadian pricing and US delivery from Canada can offer meaningful savings compared with typical cash-pay retail. Ordering is straightforward: submit the prescription, and Canadian pharmacies dispense after verification. Generics like fosinopril may reduce out-of-pocket costs, including for those paying without insurance. For current offers, see Promotions. Checkout and customer data are protected by encrypted transfer.

Availability and Substitutions

Availability can vary by manufacturer and strength. If a specific presentation is temporarily unavailable, a prescriber may recommend a suitable alternative within the class or a different class based on clinical needs. Equivalent generics contain the same active ingredient and meet quality standards.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with hypertension or heart failure where an ACE inhibitor is indicated and tolerated. Individuals with prior angioedema on an ACE inhibitor, pregnancy, or severe hyperkalemia risk generally require different therapy. Cost-saving approaches can include choosing a generic formulation, consolidating to a multi-month supply, and aligning refills with routine lab checks. You can set simple refill reminders and keep a small buffer of tablets when approved by the prescriber to avoid interruptions.

Questions to Ask Your Clinician

• Is an ACE inhibitor appropriate given my history and current medications?
• What starting dose of fosinopril fits my blood pressure and kidney function?
• How often should labs for creatinine and potassium be checked after I start?
• What signs of low blood pressure or high potassium should prompt medical attention?
• Would an ARB be preferable if cough develops?
• How should therapy adjust if pregnancy is planned?

Authoritative Sources

• DailyMed Fosinopril Sodium
• FDA Prescribing Information
• AHA High Blood Pressure

Ready when your prescription is? Request Monopril (fosinopril) through CanadianInsulin for prompt, express, cold-chain shipping and dependable US delivery from Canada.

Disclaimer: This information is educational and not a substitute for professional medical advice, diagnosis, or treatment. Always follow the prescribing clinician’s instructions and the approved labeling.