Humira® Injection for Autoimmune Conditions

Humira® is adalimumab, a TNF blocker used for several autoimmune diseases. This page explains what it is, how it works, common dosing, and safety basics. From Canada, it ships to the US, with US delivery from Canada at Canadian pricing. Many patients also compare Humira price without insurance before checkout.

What Humira® Is and How It Works

Humira® contains adalimumab, a monoclonal antibody that targets tumor necrosis factor (TNF). By blocking excess TNF, it helps reduce inflammation and immune overactivity. It is given by subcutaneous injection using a prefilled syringe or a pen auto-injector. Patients may see it referred to as an adalimumab injection or a Humira auto-injector.

Available from Canada with US shipping, this medicine is dispensed by licensed Canadian pharmacies after prescription verification.

CanadianInsulin is a prescription referral service. We verify your prescription with your clinic, and licensed Canadian pharmacies dispense your order.

Humira reduces signs and symptoms in conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, Crohn’s disease, ulcerative colitis, hidradenitis suppurativa, juvenile idiopathic arthritis, and certain non-infectious uveitis. Exact indications vary by age group and country labeling. Use only under the guidance of a licensed prescriber.

Who Humira® Is For

Humira is used in adults for moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, Crohn’s disease, ulcerative colitis, hidradenitis suppurativa, and non-infectious intermediate, posterior, and panuveitis. Pediatric use applies to select conditions, including juvenile idiopathic arthritis, Crohn’s disease, ulcerative colitis, and uveitis, based on weight and label criteria. For condition background, see Rheumatoid Arthritis.

People with active infections should not start a TNF blocker. Screening for latent tuberculosis is recommended before treatment. Providers may also check for hepatitis B risk. Tell the care team about past demyelinating disease, moderate to severe heart failure, or a history of certain cancers. Let the clinic know about allergies to latex or any component of the pen or syringe if applicable.

Live vaccines are generally avoided during therapy. Non-live vaccines may be considered per guidance.

Dosage and Usage

Dosing is condition-specific. Follow the official label and your prescriber’s plan.

• Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis: common adult dosing is 40 mg subcutaneously every other week. Some patients may use weekly dosing if needed per label.
• Plaque psoriasis and non-infectious uveitis (adults): initial 80 mg dose, then 40 mg every other week starting one week later.
• Hidradenitis suppurativa (adults): initial 160 mg at week 0, then 80 mg at week 2, then 40 mg every week starting at week 4.
• Crohn’s disease and ulcerative colitis (adults): induction 160 mg at week 0 and 80 mg at week 2, followed by 40 mg every other week; some patients may use weekly dosing per label.
• Pediatric dosing is weight-based and condition-specific. The prescriber will select the appropriate strength and schedule.

Use a consistent injection day. Rotate injection sites on the thighs or abdomen, avoiding tender, bruised, or scarred skin. Do not inject into psoriatic plaques or active hidradenitis nodules.

Strengths and Forms

Humira comes as prefilled syringes and pen injectors. Common presentations include citrate-free and legacy concentrations. Availability can vary.

• 10 mg/0.1 mL and 20 mg/0.2 mL syringes for certain pediatric dosing
• 40 mg/0.4 mL citrate-free pen or syringe
• 40 mg/0.8 mL pen or syringe
• 80 mg/0.8 mL citrate-free dose for induction or maintenance in select conditions

Patients may see product descriptions like Humira 40mg Pen, Humira 40mg 0.8 mL Pen, Humira Pen Injector, and Adalimumab 40mg Pen. All are subcutaneous adalimumab injections. Exact packaging and needles differ, so review the device guide included with your box.

Missed Dose and Timing

If a dose is missed, inject when remembered. Then continue the regular schedule from that new date. If the next dose is due soon, some patients skip the missed dose and resume on the next planned day. Do not double up. For condition-specific questions, follow the official label or contact the prescriber’s office.

Storage and Travel Basics

Store refrigerated at 2°C to 8°C (36°F to 46°F). Keep in the original carton to protect from light. Do not freeze. If needed, most presentations can be kept at room temperature once for up to 14 days; do not return to the refrigerator after warming. Check the package insert for the exact room-temperature allowance that applies to your product.

For travel, keep your pen or syringe in an insulated pack with cold gel packs. Avoid direct contact between the medicine and ice. During flights, carry your medication on board and keep it with you. For convenience, you can choose prompt, express, cold-chain shipping for replacement supplies when ordering from Canada to the US.

Before injecting, allow the pen or syringe to reach room temperature naturally. Do not heat it with a microwave, hot water, or direct sunlight.

Pen Handling and Sharps Disposal

Wash hands. Check the pen window or syringe for clarity and absence of particles. Confirm the dose and expiration date. Let the device sit at room temperature for 15 to 30 minutes before use.

Choose an injection site on the front thighs or abdomen, at least two inches away from the navel. Clean the area with an alcohol swab. Use the Humira auto-injector or prefilled syringe per the device instructions. Hold the device steady for the full time noted in the guide to ensure a complete dose. Do not rub the site afterward.

Dispose of used pens and needles in an FDA-cleared sharps container. When the container is three-quarters full, follow local rules for disposal. Do not throw loose needles in household trash or recycling.

Benefits

Humira reduces signs and symptoms and helps improve physical function in several inflammatory conditions. In Crohn’s disease and ulcerative colitis, it helps induce and maintain response and remission when used as directed. In plaque psoriasis and hidradenitis suppurativa, it can reduce skin lesions and flares. Benefits depend on the condition, disease severity, and adherence to the prescribed schedule.

Side Effects and Safety

• Injection site pain, redness, or swelling
• Upper respiratory infections or sinus symptoms
• Headache or fatigue
• Nausea or abdominal discomfort
• Rash or itching
• Back pain or joint pain
• Cough or sore throat
• Dizziness

Serious risks include severe infections (including tuberculosis and opportunistic fungi), reactivation of hepatitis B, malignancies, blood disorders, heart failure worsening, demyelinating disease, lupus-like reactions, and severe allergic reactions. Screening for TB is recommended before starting. Report fevers, weight loss, night sweats, persistent cough, shortness of breath, or unusual bruising to your care team promptly. For context on class safety, see Ustekinumab Vs Adalimumab.

Drug Interactions and Cautions

Do not use Humira with other biologic immunomodulators that target TNF or interleukins unless specifically directed, as combined immunosuppression can raise infection risk. Avoid live vaccines during therapy and for a period before and after treatment per vaccine guidance. Tell the prescriber about all medicines, including methotrexate, azathioprine, 6-mercaptopurine, corticosteroids, and JAK inhibitors, as combined effects may require monitoring. Patients with moderate to severe heart failure, demyelinating disease, chronic infections, or previous hepatitis B should discuss risks and alternatives.

What to Expect Over Time

Some patients notice symptom relief within weeks, while others take longer. For chronic conditions, maintenance dosing aims to sustain response and reduce flares. Regular follow-ups, vaccination planning, and lab monitoring help manage safety. If response wanes, clinicians may adjust the schedule or consider an alternative therapy in the same or a different class.

Compare With Alternatives

Other biologics treat similar conditions. Interleukin inhibitors and TNF blockers are common options. For example, Cosentyx® (secukinumab) is used in plaque psoriasis and certain arthritides. Stelara® Pre Filled Syringe (ustekinumab) is used in plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. Enbrel (etanercept) is another TNF blocker used in several arthritides. For background on TNF blockers, see Enbrel Etanercept Guide. The choice depends on diagnosis, prior therapies, and safety profile.

Pricing and Access

Canadian pricing often helps lower the Humira cost compared with typical US list pricing. Patients compare Humira Pen price, Humira cash price, and monthly cost of Humira when budgeting. Many also review Humira from Canada details and Humira US shipping steps before checkout. We display current options so you can buy Humira with transparent pricing.

Pricing can vary by strength and format, such as a Humira 40mg Pen or a Humira 40mg 0.8 mL Pen. If comparing adalimumab price across brands, consider device type and whether citrate-free versions are used. Some patients research Humira list price and Humira medicine cost alongside insurance coverage. Others compare Humira for sale offers with the Humira biosimilar price landscape.

For those paying cash, you can also check Humira cost without insurance on our product page. For seasonal or category offers, see Promotions. Orders are processed with encrypted checkout, and US delivery from Canada uses cold-chain materials for temperature control.

Availability and Substitutions

Availability can change by strength or device. If a specific pen or syringe is unavailable, the prescriber may recommend a comparable presentation or a different therapy. Biosimilar adalimumab options exist in some markets; clinicians may discuss whether a biosimilar is appropriate. If a substitution is considered, pharmacies will follow prescriber direction and local regulations.

Patient Suitability and Cost Saving Tips

Humira is not right for everyone. Patients with active serious infections should not start treatment. Those with prior TB, chronic hepatitis B, demyelinating disease, certain cancers, or moderate to severe heart failure should review risks with their clinician. Discuss vaccination plans before starting therapy.

To manage costs, patients often choose multi-month supplies, which may reduce per-shipment fees. Consolidating refills and selecting an auto-injector or syringe that matches the prescribed dosing frequency can also help. You can set refill reminders, review Humira Canadian pricing in advance, and use prompt, express, cold-chain shipping for time-sensitive orders. These steps support steady access and reduce last-minute rush costs.

Questions to Ask Your Clinician

• Which Humira strength and device best fit my condition and weight?
• How should I time doses if I have an intercurrent illness or vaccine?
• What TB and hepatitis B tests do I need before starting?
• How long should I continue therapy if I respond well?
• What signs of infection or adverse effects should trigger a call?
• Could a biosimilar or another class be appropriate later?
• Are there non-live vaccines I should update before treatment?

Authoritative Sources

AbbVie Humira Prescribing InformationFDA DailyMed: AdalimumabHealth Canada Drug Product Database: Humira

Start your order with US delivery from Canada and prompt, express, cold-chain shipping.