Stelara® Prefilled Syringe for Plaque Psoriasis

What Stelara Is and How It Works

The Stelara® prefilled syringe contains ustekinumab, a monoclonal antibody that targets interleukin-12 and interleukin-23. It is used for moderate to severe plaque psoriasis, active psoriatic arthritis, and maintenance therapy in Crohn’s disease and ulcerative colitis. You can access US delivery from Canada through our platform, including options for those paying without insurance.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This biologic reduces overactive immune signaling that drives skin inflammation and certain gastrointestinal symptoms. By binding IL‑12/23, it can help decrease plaques, joint symptoms, and maintain remission in inflammatory bowel disease.

For skin conditions, results are typically assessed over weeks to months under clinician supervision. For inflammatory bowel disease, many patients receive an intravenous induction dose in clinic, then continue subcutaneous maintenance with the prefilled syringe.

Learn more about the condition background and treatment goals in Psoriasis.

Who It’s For

Indications include adults with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy. It is also indicated for active psoriatic arthritis, either alone or with methotrexate. In Crohn’s disease and ulcerative colitis, it is used after an initial intravenous dose for maintenance therapy.

People with active, serious infections should not start therapy until the infection is controlled. A tuberculosis evaluation is recommended before initiating treatment. The Crohn’s Disease, Ulcerative Colitis, and Psoriatic Arthritis pages provide additional context about each condition.

Prescription Stelara Prefilled Syringe may be appropriate for patients who have not responded adequately to other systemic agents or who require a maintenance biologic as part of their treatment plan.

Dosage and Usage

Use this product exactly as prescribed and per the official label. For plaque psoriasis and psoriatic arthritis, an initial subcutaneous dose is followed by another dose 4 weeks later, then maintenance dosing at longer intervals as directed by your clinician. For Crohn’s disease and ulcerative colitis, an intravenous induction dose is administered first in a healthcare setting, followed by subcutaneous maintenance dosing at prescribed intervals.

Let the syringe reach room temperature as directed before injection. Inspect the solution; do not use if discolored, frozen, or containing particles. Inject into the thigh, abdomen, or upper outer arm if instructed, rotating injection sites to reduce local skin reactions. A caregiver may assist if needed.

Stelara injection prefilled syringe should be used according to your prescribed schedule. Do not change the dose or frequency without consulting your prescriber. For background on biologic mechanisms and safety considerations, see Ustekinumab vs Adalimumab.

Strengths and Forms

The prefilled syringe is a single-dose, subcutaneous presentation of ustekinumab. Commonly available strengths include Ustekinumab 45 mg prefilled syringe and a higher-strength prefilled option suitable for patients above certain weight thresholds; availability may vary by jurisdiction and supplier.

After an intravenous induction regimen for inflammatory bowel disease, maintenance typically uses the subcutaneous syringe. The exact strength and interval are chosen by your prescriber based on indication and patient factors.

Missed Dose and Timing

If a scheduled dose is missed, administer it when remembered unless it is close to the next planned dose. In that case, ask your prescriber for guidance on the timing of the next injection. Keeping a dosing calendar or reminder can help maintain your schedule.

Storage and Travel Basics

Store the prefilled syringe in the refrigerator in its original carton to protect it from light. Do not freeze, and do not shake. If the syringe has been exposed to freezing temperatures, do not use it. Keep out of reach of children.

For planned travel, place the carton in an insulated container with cold packs as instructed by your clinic, keeping the product within the recommended temperature range. Do not place the syringe directly against ice packs. Carry a copy of your prescription and a travel letter if available. When flying, keep the medication in your carry-on bag rather than checked luggage.

Once a syringe is kept at room temperature for the maximum time on the label, it should not be returned to the refrigerator. Discard any syringe that has been out longer than directed by the manufacturer’s instructions.

Pen Handling and Sharps Disposal

This product is a prefilled syringe, not a pen. Review the Instructions for Use before the first injection. Wash hands, choose a clean site, and use an alcohol swab prior to injection. Do not reuse needles or syringes.

After injecting, place the used syringe into an FDA-cleared sharps container. If one is not available, use a heavy-duty household container with a tight, puncture-resistant lid, labeled appropriately, and follow local regulations for disposal. Never throw loose needles into household trash or recycling.

Benefits

This treatment offers infrequent maintenance dosing compared to some other biologics for dermatologic and rheumatologic conditions. It may help reduce plaque thickness, scale, and redness, and support joint symptom control in psoriatic arthritis.

In inflammatory bowel disease, the therapy is used to help maintain remission after induction. Prefilled syringes allow at-home administration when your prescriber confirms you are trained for self-injection.

Side Effects and Safety

• Upper respiratory infections
• Nasal congestion or sore throat
• Headache
• Fatigue
• Injection site redness or pain
• Diarrhea or abdominal discomfort

Serious risks can include severe infections, reactivation of latent tuberculosis, allergic reactions including anaphylaxis or angioedema, and rare neurologic events. Report symptoms of infection, persistent fever, shortness of breath, or severe rash immediately. Your clinician may screen for TB before starting therapy and monitor for infection during treatment.

Live vaccines should be avoided during therapy. Inactivated vaccines may be given if your clinician approves the timing.

Drug Interactions and Cautions

Tell your clinician about all prescription drugs, over-the-counter medicines, and supplements you use. Combining multiple immunosuppressive agents can increase infection risk. Discuss any planned phototherapy, systemic steroids, or other biologics.

Avoid live vaccines while on therapy and for an appropriate interval before and after treatment, per official guidance. Inform your care team if you develop signs of infection, or if you have a history of recurrent infections.

What to Expect Over Time

Effects are typically assessed periodically by your prescriber. Skin findings may improve gradually with maintenance dosing. Joint symptoms may take time to respond and can vary between individuals.

For Crohn’s disease or ulcerative colitis, this medicine is used to help maintain remission after induction. Adherence to the dosing schedule, routine follow-up, and reporting new symptoms allow your care team to adjust your plan as needed.

Compare With Alternatives

Other biologics for plaque psoriasis and psoriatic arthritis include IL‑17 or IL‑23 inhibitors. Depending on your diagnosis, prescribers may consider options like Skyrizi Cartridge or Cosentyx. Selection depends on clinical factors, prior therapies, and safety profile.

For inflammatory bowel disease, your gastroenterologist may compare classes based on response history and comorbidities. Review risks and benefits of each option with your clinician.

Pricing and Access

We list current Stelara Prefilled Syringe price for the prefilled presentation when available. Canadian pricing with US shipping from Canada can offer meaningful cash-pay value versus typical local retail rates, subject to change. See our overview of costs and background in Ustekinumab Cost Guide.

You can review product availability within Dermatology and Gastrointestinal categories. If you use a savings card, assistance program, or other cash-pay options, add details during checkout so our team can coordinate as appropriate. For occasional promotions, see Promotions. We support encrypted checkout.

Ustekinumab prefilled syringe price can vary by strength and pack size. Contact support for guidance on documentation needed for cross-border fulfillment.

Availability and Substitutions

Supply can vary. If the requested presentation is temporarily unavailable, your prescriber may recommend a therapeutic alternative from the same or a different class. For joint and skin involvement, clinicians may also consider agents used in Psoriatic Arthritis or Psoriasis depending on your diagnosis.

Patient Suitability and Cost-Saving Tips

This therapy may not suit people with active infections, uncontrolled TB risk, or prior severe hypersensitivity to ustekinumab or its excipients. Tell your clinician if you are pregnant, planning to become pregnant, or breastfeeding; they will weigh risks and benefits.

To help manage out-of-pocket costs, consider multi-month quantities when appropriate and permitted. Set refill reminders ahead of your dosing interval to avoid gaps in therapy. If a manufacturer assistance program or payer exception is relevant, your clinic may guide supporting paperwork.

Questions to Ask Your Clinician

• Indication and goals: which symptoms this biologic targets
• Dose plan: timing for initial and maintenance injections
• Monitoring: labs, infection screening, and follow-up visits
• Vaccinations: which vaccines to avoid and when
• Self-injection: training, injection sites, and comfort tips
• Travel: packing, temperature protection, and documentation
• Alternatives: how other biologics compare for my condition

Authoritative Sources

See the full US prescribing information on the manufacturer’s site for complete dosing and safety details: Janssen prescribing information for ustekinumab injection.

Review the FDA label summary for universally published safety information: DailyMed monograph for ustekinumab prefilled syringe.

For Canadian product details, consult Health Canada’s database: Health Canada Drug Product Database for ustekinumab.

Buy Stelara Prefilled Syringe online through CanadianInsulin with prompt, express, cold-chain shipping to maintain product integrity during transit.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.