Komboglyze® Tablets for Type 2 Diabetes

Komboglyze® is a prescription tablet that combines saxagliptin, a DPP‑4 inhibitor, with metformin, a biguanide. It is used alongside diet and exercise to help adults with type 2 diabetes improve blood sugar control. Available from Canada with US delivery from Canada, this fixed‑dose combination offers a convenient way to take two well‑studied medicines in one tablet.

What Komboglyze® Is and How It Works

Komboglyze® contains two active ingredients that work in complementary ways. Saxagliptin helps raise incretin hormones by blocking the DPP‑4 enzyme. This supports glucose‑dependent insulin release and reduces glucagon, which can lower blood sugar after meals. Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues.

Using the two together can provide broader coverage across fasting and post‑meal glucose control compared with either medicine alone. The combination is not insulin and is not a weight loss treatment, but it is often weight neutral and has a low risk of hypoglycemia when used without insulin or a sulfonylurea. For background on each class, see taking dpp 4 inhibitors and biguanides drugs.

CanadianInsulin partners with licensed Canadian pharmacies and verifies prescriptions directly with your clinic before your medicine ships.

People paying cash or without insurance sometimes consider fixed‑dose combinations like this to simplify therapy under clinician guidance.

Who Komboglyze® Is For

Komboglyze is intended for adults with type 2 diabetes when diet and exercise alone do not provide adequate control, or when treatment with metformin and saxagliptin as separate tablets is already established. It is not for type 1 diabetes, diabetic ketoacidosis, or acute metabolic complications. Use is generally avoided in significant renal impairment and used cautiously in hepatic disease or conditions that increase the risk of lactic acidosis.

Caution is advised in patients with a history of pancreatitis, heart failure, or severe gastrointestinal issues. Saxagliptin has labeling about a possible increased risk of heart failure in some patients, and rare events such as severe joint pain and bullous pemphigoid have been reported with the DPP‑4 class. Metformin can reduce vitamin B12 levels over time and carries a rare risk of lactic acidosis, especially with renal or hepatic dysfunction or hypoxic states.

Dosage and Usage

Komboglyze tablets are typically taken with meals, commonly twice daily for immediate‑release combinations. Clinicians usually choose a starting strength based on the patient’s current metformin and saxagliptin dose, then titrate metformin gradually to improve tolerability. Do not exceed the total daily saxagliptin dose recommended in the labeling.

Take the tablets with food to reduce gastrointestinal side effects. Continue diet and exercise measures as advised by a clinician. If therapy is combined with insulin or a sulfonylurea, a dose adjustment of those agents may be considered to reduce the risk of hypoglycemia. If kidney function is reduced or if strong CYP3A4/5 inhibitors are used, clinicians may adjust the saxagliptin component; fixed‑dose combinations may not be suitable in some of these settings.

If unsure about a step in your daily routine, the product label and your clinic’s instructions should guide the schedule.

Strengths and Forms

Komboglyze is supplied as tablets containing saxagliptin paired with metformin. Commonly available combinations include 2.5 mg saxagliptin with 500 mg, 850 mg, or 1000 mg of metformin. Availability can vary by market and pharmacy inventory.

Missed Dose and Timing

General label guidance recommends taking a missed dose as soon as it is remembered with food, unless it is close to the next scheduled dose. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not take two doses at once to make up for a missed tablet. Consistent timing with meals can help minimize stomach upset.

Storage and Travel Basics

Store tablets at room temperature away from moisture and heat, and keep the bottle tightly closed. For travel, carry the original labeled container in hand luggage, along with a copy of the prescription. Maintain your dosing schedule as consistently as possible across time zones. Most oral tablets do not require refrigeration. For practical travel ideas that many patients find helpful, see travel with ozempic tips that also apply to many chronic medicines.

When planning longer trips, consider a spare supply, a medication list, and a simple reminder system. If your routine includes glucose monitoring or other diabetes medicines, pack those items together and check battery or strip supplies before departure.

Benefits

The combination of saxagliptin and metformin can lower A1C and improve both fasting and post‑meal glucose. It simplifies treatment by combining two complementary agents into one tablet, which may support adherence. The risk of hypoglycemia is low when used without insulin or a sulfonylurea, and weight effects are often neutral. Many people also appreciate having one prescription rather than two separate tablets.

Side Effects and Safety

• Common effects: diarrhea, nausea, stomach upset, gas, loss of appetite, mild headache, and symptoms of upper respiratory tract infection.
• Less common: fatigue, mild edema, and changes in taste. Long‑term metformin use may reduce vitamin B12 levels.

Serious but uncommon risks include lactic acidosis with metformin in susceptible situations, pancreatitis with DPP‑4 inhibitors, severe joint pain, bullous skin reactions, allergic or hypersensitivity reactions, and a potential increased risk of heart failure in some patients. Seek urgent medical attention for symptoms suggestive of lactic acidosis, pancreatitis, severe rash, facial or throat swelling, or shortness of breath. Hypoglycemia can occur when this medicine is used with insulin or sulfonylureas.

Drug Interactions and Cautions

Tell a clinician about all prescription drugs, OTC medicines, and supplements. Points commonly reviewed include:

• Strong CYP3A4/5 inhibitors or inducers that affect saxagliptin exposure, such as certain azole antifungals, macrolide antibiotics, anticonvulsants, or HIV protease inhibitors.
• Drugs that raise lactic acidosis risk with metformin, including carbonic anhydrase inhibitors like topiramate, or conditions that reduce renal perfusion.
• Insulin and sulfonylureas, which can increase hypoglycemia risk when combined.
• Excessive alcohol intake, dehydration, or acute illness, which may elevate risk for lactic acidosis.
• Iodinated contrast imaging in patients with reduced kidney function; metformin may be held around the time of contrast per label guidance.

Kidney function is usually assessed at baseline and periodically. Clinicians consider dose, kidney and liver status, heart failure history, and any prior pancreatitis when deciding on therapy.

What to Expect Over Time

Blood glucose and A1C typically improve progressively with consistent use, diet, and activity. Gastrointestinal effects from metformin often lessen after dose titration and regular use. If goals are not reached on a stable dose, clinicians may adjust diet, activity, or medicines. Many patients continue metformin long term even if additional agents are added later.

For a broad overview of medication options and how they differ, see common diabetes medications.

Compare With Alternatives

Other options may be considered based on glucose patterns, kidney function, cardiovascular history, weight goals, and tolerance:

• Metformin extended release alone, such as glumetza, can simplify dosing for those who tolerate metformin but do not need a DPP‑4 inhibitor.
• A sodium‑glucose cotransporter‑2 combination like invokamet pairs canagliflozin with metformin and may be chosen for certain cardiometabolic profiles.

Clinicians may also consider GLP‑1 receptor agonists or basal insulin in different scenarios. The choice depends on individual targets and comorbidities.

Pricing and Access

Ordering through CanadianInsulin provides access to Canadian pricing with US shipping from Canada. Many patients see meaningful cash‑pay savings compared with typical US retail. If you plan to buy Komboglyze online, review the product page for current options and refills you can manage in your account. See promotions for occasional savings updates. Checkout and customer data are protected by encrypted transfer.

For additional cost‑saving ideas around metformin formulations, you can also review buy glumetza from canada.

Availability and Substitutions

Stock and strengths may vary. If a chosen strength is unavailable, a prescriber may recommend suitable alternatives such as separate components or another fixed‑dose combination. Any substitution should match clinical needs, kidney function, and tolerability. Category listings like type 2 diabetes can help you compare related options carried by our partner pharmacies.

Patient Suitability and Cost‑Saving Tips

Good candidates typically need metformin plus a DPP‑4 inhibitor in a single tablet, have adequate kidney function, and have no history of severe pancreatitis or recent heart failure decompensation. Those with significant renal or hepatic impairment, or a history of lactic acidosis, generally require alternatives or careful specialist evaluation.

• Ask about a multi‑month prescription to reduce per‑order fees.
• Set refill reminders in your account so your supply does not run low.
• Bundle other stable medicines in the same order when appropriate.
• Keep a simple medication log when traveling to maintain consistent dosing.

Questions to Ask Your Clinician

• Is the saxagliptin plus metformin combination appropriate given my kidney and liver tests?
• Should I start with an initial lower metformin dose to reduce stomach upset?
• How will this interact with any insulin or sulfonylurea I am taking?
• What A1C and fasting targets are realistic for me over the next few months?
• Do I need B12 checks during long‑term metformin therapy?
• What signs of pancreatitis or lactic acidosis should prompt urgent care?
• Would a GLP‑1 or SGLT2 alternative be better for my risk profile?

Authoritative Sources

• EMA Komboglyze
• ADA Oral Medications

Ready to request Komboglyze with Canadian pricing and US delivery from Canada? Place your order with our prompt, express, cold‑chain shipping.

Disclaimer: This information is educational and not a substitute for professional medical advice. Always follow the advice and labeling provided by your prescriber and the medicine manufacturer.