Komboglyze® Tablets for Type 2 Diabetes

Komboglyze® combines saxagliptin and metformin in one extended-release tablet for adults with type 2 diabetes. It helps lower blood sugar alongside diet and exercise. This page explains how it works, who it suits, safety basics, and how to buy with US delivery from Canada.

Every CanadianInsulin order is prescription-checked with your clinic and dispensed by a licensed Canadian pharmacy.

What Komboglyze® Is and How It Works

Komboglyze® contains two proven diabetes medicines. Saxagliptin is a DPP-4 inhibitor. It helps your body raise insulin after meals and reduce glucose output from the liver. Metformin is a biguanide. It lowers liver glucose production and improves insulin sensitivity. Together, they target fasting and post-meal blood sugar.

This is an oral, extended-release therapy taken with food. Using one tablet may simplify your routine compared to taking separate metformin and saxagliptin products. It is not insulin and does not treat type 1 diabetes or diabetic ketoacidosis.

For more background on DPP-4 therapy, see DPP 4 Inhibitors. For metformin’s role, see Biguanides Drugs. A detailed overview is also available in Komboglyze Uses.

Who Komboglyze® Is For

Komboglyze is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. Clinicians may use it when metformin alone is not enough, or to replace separate metformin and saxagliptin tablets with a single daily tablet. It is not approved for type 1 diabetes or for patients with diabetic ketoacidosis.

People with significant kidney disease, unstable heart failure, severe liver disease, metabolic acidosis, or known allergy to saxagliptin or metformin should not use this medicine. Your clinician will assess kidney function and overall risk before prescribing.

Dosage and Usage

Follow your prescriber’s directions and the official label. Typical use is once daily with the evening meal. Swallow tablets whole. Do not split, crush, or chew extended-release tablets.

• Initiation: The starting strength is usually based on your current metformin dose. If you already take metformin, your prescriber may choose a comparable metformin amount and add saxagliptin.
• Titration: Doses may be increased gradually to reduce stomach side effects from metformin. Step-ups often occur in weekly or longer intervals as tolerated.
• Maximum: The daily saxagliptin dose should not exceed 5 mg. The usual maximum metformin extended-release dose is 2000 mg per day.
• Kidney function: Use is guided by estimated glomerular filtration rate. Your clinician may avoid starting metformin-containing products with advanced kidney impairment.
• With CYP3A4/5 inhibitors: Strong inhibitors can raise saxagliptin levels. A lower saxagliptin dose may be required.

Your prescriber may adjust other diabetes medicines to reduce low blood sugar risk.

Strengths and Forms

Komboglyze is supplied as extended-release tablets in several saxagliptin/metformin strengths. Commonly available combinations include:

• 2.5 mg / 500 mg
• 2.5 mg / 1000 mg
• 5 mg / 500 mg
• 5 mg / 1000 mg

Availability can vary by country and supplier. Your pharmacist will dispense the strength written on your prescription.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is almost time for your next dose. If it is close to the next dose, skip the missed tablet and resume your regular schedule. Do not take two doses at once. Consistent daily timing with a meal can improve tolerability.

Storage and Travel Basics

Store tablets at room temperature in the original container. Protect from moisture and excessive heat. Keep out of reach of children. When traveling, carry your medicine in your hand luggage with a copy of your prescription. Keep it with your daily pill organizer or original labeled bottle.

Benefits

• Dual action control: Addresses both fasting and post-meal glucose.
• Once-daily convenience: Extended-release tablets support simpler routines.
• Metformin foundation: Longstanding first-line backbone therapy.
• Weight neutral profile: Generally does not cause weight gain.
• Low hypoglycemia risk alone: Risk rises if used with insulin or sulfonylureas.

Side Effects and Safety

• Common: Diarrhea, nausea, stomach upset, gas, or abdominal discomfort.
• Headache, nasopharyngitis, or upper respiratory symptoms.
• Decreased vitamin B12 levels with long-term metformin use.

Serious but less common risks include lactic acidosis with metformin, pancreatitis with DPP-4 inhibitors, and heart failure risk with saxagliptin in susceptible patients. Severe allergic reactions, skin blistering, or severe joint pain can occur. Stop the medication and seek urgent care if you develop symptoms of pancreatitis, allergic reaction, or acidosis such as severe abdominal pain, vomiting, rapid breathing, or unusual sleepiness. Hypoglycemia is more likely when used with insulin or a sulfonylurea; your clinician may adjust those agents.

Drug Interactions and Cautions

• Strong CYP3A4/5 inhibitors (for example, certain azoles or macrolides) can raise saxagliptin exposure.
• Alcohol misuse increases lactic acidosis risk with metformin.
• Iodinated contrast may affect kidney function; metformin may be paused for certain imaging procedures.
• Carbonic anhydrase inhibitors or topiramate can increase acidosis risk.
• Cationic drugs eliminated by renal tubular secretion may interact with metformin.
• Insulin and sulfonylureas increase low blood sugar risk when combined.

Share a full medication list with your clinician and pharmacist. Kidney function should be checked before starting and periodically during treatment.

What to Expect Over Time

Many patients see improved fasting and post-meal glucose as therapy stabilizes. Gastrointestinal effects from metformin often lessen after dose titration and consistent use with food. Your A1C is commonly reassessed after several months. Ongoing lifestyle measures remain important.

Compare With Alternatives

Your prescriber might consider other DPP-4 options or combination tablets. A single-agent DPP-4 inhibitor such as Onglyza® may be used with separate metformin. Another option is a metformin plus SGLT2 combination such as Invokamet®, depending on clinical goals and kidney function.

Pricing and Access

Canadian pricing can offer meaningful cash-pay savings compared to typical US retail costs. You can check the cost of Komboglyze online and decide if it fits your budget. Orders are processed through Canadian pharmacies with US delivery from Canada.

To review options, see our Diabetes selection and browse related therapies. For broader condition guidance, visit Type 2 Diabetes. Checkout is encrypted.

Availability and Substitutions

If a specific strength is unavailable, your prescriber may consider a different approved strength or a therapeutic alternative. Examples include separate saxagliptin plus metformin tablets or other DPP-4 combinations such as sitagliptin with metformin, depending on your history and lab results. Pharmacy stock can vary. We do not guarantee restock dates.

Patient Suitability and Cost Saving Tips

Komboglyze may suit adults with type 2 diabetes who need more control than metformin alone provides and prefer a once-daily tablet. It may not fit those with advanced kidney disease, unstable heart failure, pancreatitis history, or frequent heavy alcohol use. Discuss benefits and risks with your clinician.

• Ask about a multi-month fill to reduce per-shipment costs.
• Align refills with your A1C testing schedule for steady supply.
• Use reminders and a pill organizer for consistent dosing.
• Share any new medicines or supplements to check for interactions.

Questions to Ask Your Clinician

• Is Komboglyze appropriate with my kidney function and heart history?
• Which starting strength matches my current metformin dose?
• How should I time doses with meals to reduce stomach upset?
• Do I need to adjust insulin or a sulfonylurea to limit lows?
• What labs and how often should we monitor?
• What symptoms of pancreatitis or lactic acidosis should I watch for?
• Could a different combination or class better fit my goals?

Authoritative Sources

• European Medicines Agency: Komboglyze EPAR
• Health Canada Drug Product Database
• FDA DailyMed

Ready to get started? You can place your request for US delivery from Canada today.

Disclaimer: This information is educational and does not replace medical advice. Always follow your prescriber’s instructions and the official product label.