Percorten-V® Injection for Dogs

Percorten-V® is a desoxycorticosterone pivalate (DOCP) injection for dogs with Addison’s disease. CanadianInsulin offers access from Canada with US delivery from Canada and Canadian pricing. You can order online even when paying without insurance.

What Percorten-V® Is and How It Works

Percorten-V® provides a long-acting mineralocorticoid, desoxycorticosterone pivalate. Dogs with primary adrenocortical insufficiency cannot maintain normal sodium and potassium balance. DOCP replaces the missing mineralocorticoid signal so the kidneys retain sodium and excrete potassium as needed. Stabilizing electrolytes supports hydration, blood pressure, and heart function. Most dogs receive injections about every 25 to 30 days once stabilized.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. This cross-border service helps US pet owners access vetted medicines with US shipping from Canada.

DOCP addresses the mineralocorticoid deficit only. Many dogs also need a daily glucocorticoid, such as prednisone, as directed by the veterinarian.

Who Percorten-V® Is For

This medicine is indicated as replacement therapy for the mineralocorticoid deficit in dogs with primary adrenocortical insufficiency (Addison’s disease). It is a prescription-only veterinary product. It is not for cats or people.

Avoid use or use with extra caution in dogs with congestive heart failure, severe kidney disease, edema, or uncontrolled high blood pressure. Use only under veterinary supervision during pregnancy or lactation. Do not use in dogs known to be hypersensitive to desoxycorticosterone pivalate or formulation components.

Dosage and Usage

Percorten-V is administered by a veterinarian as an intramuscular injection. The commonly referenced initial dose is 2.2 mg per kg body weight. Electrolytes are typically checked around days 14 and 25 to 30 after the first dose. The dose and interval are then adjusted to maintain normal sodium and potassium and good clinical control.

Many dogs transition to a maintenance dose given approximately every 25 to 30 days. Some may need dose reductions or interval extensions as stability improves. Because this is a sterile suspension, the vial is typically shaken well before drawing up the dose. Use sterile technique. Do not give intravenously.

DOCP replaces mineralocorticoid activity. A separate daily glucocorticoid is usually prescribed to replace cortisol. Follow the veterinarian’s monitoring plan and label instructions at all times.

Strengths and Forms

• Percorten-V injection: desoxycorticosterone pivalate 25 mg/mL
• Multi-dose 4 mL vial

Availability may vary by lot and by dispensing pharmacy.

Missed Dose and Timing

If a scheduled injection is missed or significantly delayed, veterinary guidance is needed. Do not double a dose. The veterinarian may adjust the timing or dose after reviewing electrolytes and clinical signs. Consistent monthly scheduling helps maintain steady control.

Storage and Travel Basics

Store your vial at controlled room temperature per the label, typically 20 to 25°C (68 to 77°F). Protect from light. Do not freeze. Keep the vial in the original packaging until use. Keep out of reach of children and other animals.

If you travel, carry your prescription details and keep the vial with you in a small insulated but not frozen pouch when temperatures are extreme. Avoid leaving it in a hot car. Use clean syringes and needles and dispose of sharps in an approved puncture-resistant container according to local rules.

Benefits

Label-directed Percorten-V can help normalize sodium and potassium in dogs with Addison’s disease. Restoring mineralocorticoid activity supports hydration, appetite, energy, and stable blood pressure. A monthly injection schedule can be convenient for long-term management. The 25 mg/mL concentration and 4 mL vial allow accurate dosing for a wide range of dog sizes.

Side Effects and Safety

• Increased thirst or urination
• Fluid retention or swelling
• Changes in appetite or weight
• Lethargy or reduced activity
• Vomiting or diarrhea
• Injection site irritation

Serious or rare risks include hypertension, electrolyte disturbances (especially low potassium), edema, and allergic reactions. Use caution in dogs with heart or kidney disease. Overdosage or oversupplementation may cause fluid retention and elevated blood pressure. Contact the veterinarian promptly if adverse effects occur.

Drug Interactions and Cautions

Mineralocorticoid therapy affects sodium and potassium balance. Drugs that also change electrolytes or fluid status may require closer monitoring. Examples include diuretics such as Furosemide Injection, ACE inhibitors, and certain antifungals or antibiotics. Using DOCP together with glucocorticoids is common, but combined effects on sodium, water retention, and blood pressure should be considered. Never change your dog’s dose or schedule without veterinary guidance.

What to Expect Over Time

During the first one to two cycles, veterinarians usually check electrolytes and clinical signs and then fine-tune the dose or interval. Many dogs show improved hydration, appetite, and energy as electrolytes normalize. Long-term, stable monthly injections and periodic bloodwork are typical. Some dogs need adjustments over time due to growth, weight change, or concurrent conditions.

Compare With Alternatives

Another approved DOCP product is Zycortal®. Both contain desoxycorticosterone pivalate and are used to address the mineralocorticoid deficit in canine Addison’s disease. Your veterinarian may prefer one formulation or route over another for individual reasons. An oral alternative is fludrocortisone acetate tablets, which provide mineralocorticoid activity as a daily medicine instead of a monthly injection. The choice depends on clinical goals, monitoring, and how a dog responds to treatment.

Pricing and Access

Buy Percorten-V online with Canadian pricing and US shipping through CanadianInsulin. Check the Percorten-V price and compare the Percorten-V cost by strength and pack size. View the Percorten-V 4 mL vial and the Percorten-V 25 mg/mL concentration on the product page to see current pricing. Many pet owners compare options when paying a cash price.

You can place an order, upload or have us request the prescription, and track your Percorten-V refill online. Encrypted checkout helps protect your information. For seasonal offers, see our Promotions.

Availability and Substitutions

Supply can vary. If Percorten-V is temporarily unavailable, a prescriber may recommend a suitable alternative or a different fill schedule. Substitution decisions should be made by the veterinarian based on your dog’s diagnosis and monitoring plan.

Patient Suitability and Cost Saving Tips

Good candidates are dogs diagnosed with primary adrenocortical insufficiency who need mineralocorticoid replacement. Dogs with congestive heart failure, severe kidney disease, edema, or uncontrolled hypertension may need other approaches. Follow the clinician’s advice for glucocorticoid use alongside DOCP.

To reduce overall costs, consider ordering multi-month supplies when appropriate, keeping an extra vial on hand for timing flexibility, and using automatic reminders. You can manage reorders on your account and align refills with scheduled bloodwork. Browse related items in Pet Medications. For educational reading on other common dog therapies, visit Apoquel For Dogs, Deramaxx For Dogs, Clavamox For Dogs And Cats, and Azithromycin For Dogs Cats.

Questions to Ask Your Clinician

• What starting dose and interval are appropriate for my dog?
• When should electrolytes be checked after the first injection?
• What signs suggest dose or interval adjustments are needed?
• Should a daily glucocorticoid be used and at what dose?
• How should injections be scheduled around travel or procedures?
• What interactions matter with my dog’s current medicines?
• What is the plan if a dose is late or missed?

Authoritative Sources

• Elanco Products and Services
• FDA Animal Drugs Search
• Health Canada Drug Product Database

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