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Repaglinide Tablets for Type 2 Diabetes
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Repaglinide is a short-acting oral medicine for type 2 diabetes. It helps reduce after-meal blood sugar when used with diet and exercise. US delivery from Canada is available, and we outline repaglinide price without insurance so you can plan your out-of-pocket spend.
What Repaglinide Is and How It Works
Repaglinide belongs to the meglitinide class. It stimulates the pancreas to release insulin in response to meals, which helps control postprandial glucose. This effect is rapid and brief, aligning with mealtimes. The brand version is Prandin®, and this medicine is the same active ingredient.
CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.
Repaglinide tablets are typically used with diet and exercise and may be combined with other glucose-lowering medicines when advised by your clinician. It is not for type 1 diabetes or diabetic ketoacidosis.
To learn more about its class, see Insulin Secretagogues.
Who It’s For
This treatment is indicated for adults with type 2 diabetes to improve glycemic control alongside nutrition and activity. It may be added to metformin or other therapies when additional mealtime coverage is needed. It is not indicated for type 1 diabetes or for treating ketoacidosis. People with severe liver impairment, recurrent hypoglycemia, or known hypersensitivity to components should avoid use.
Discuss your history of heart disease, kidney or liver problems, pregnancy or plans to conceive, and all current medicines with a healthcare professional before starting. For background on the condition, see Type 2 Diabetes.
Dosage and Usage
Use as directed by your prescriber and follow the official label. This medicine is taken before meals, generally within 30 minutes of eating. Frequency depends on how many meals you eat, often two to four times per day. If you skip a meal, you usually skip the dose for that meal. If your meals change, your prescriber may adjust timing.
Swallow tablets with water. Monitor your blood glucose as instructed. Keep a source of fast-acting sugar available in case of low blood sugar. Avoid making dose changes on your own; defer to the label and your prescriber’s guidance.
Strengths and Forms
Availability may vary by pharmacy. Common presentations include:
- Repaglinide 0.5 mg tablets
- 1 mg tablets
- 2 mg tablets
Film-coated tablets are supplied in bottles or blister packs depending on the manufacturer.
Missed Dose and Timing
If you miss a pre-meal dose but have not eaten yet, take it when you are about to eat. If the meal has already passed, skip the missed dose and take the next scheduled dose before the next meal. Do not double doses. If you frequently miss doses, speak with your prescriber about simplifying your routine.
Storage and Travel Basics
Store at room temperature in a dry place away from excessive heat and moisture. Keep tablets in the original container with the label intact and out of reach of children and pets. Do not use tablets that are damaged or past their labeled expiry.
When traveling, pack this medicine in your carry-on with your prescription label. Bring a list of your medicines and prescriber contact details. Keep your glucose meter and hypoglycemia treatments accessible. If crossing borders, carry documentation to avoid delays at security or customs.
Benefits
This therapy focuses on mealtime control. It can reduce postprandial spikes, offering flexible dosing that follows your eating schedule. The short duration can limit exposure between meals. It may be used alone or alongside other agents when advised by your prescriber.
For a deeper overview, see Repaglinide Prandin.
Side Effects and Safety
- Low blood sugar: sweating, shakiness, headache, hunger
- Headache or dizziness
- Upper respiratory symptoms
- Stomach discomfort or diarrhea
Serious effects can include severe hypoglycemia, allergic reactions, or liver-related issues. The risk of hypoglycemia increases if you eat less than usual, drink alcohol, or combine with other glucose-lowering drugs. If symptoms of severe low blood sugar or allergic reaction occur, seek urgent care. For more detail, see Repaglinide Side Effects.
Drug Interactions and Cautions
Tell your prescriber about all medicines, vitamins, and herbal products you use. Strong inhibitors of CYP2C8 can raise levels; gemfibrozil is a well-known example and is typically avoided. Inducers such as rifampin can lower effectiveness. Certain antibiotics and antifungals may increase exposure. Examples include macrolides and azole antifungals like Fluconazole.
Using insulin or sulfonylureas together can elevate hypoglycemia risk. Beta-blockers can mask low blood sugar symptoms. Alcohol may increase the chance of hypoglycemia. Review all over-the-counter products with your clinician.
What to Expect Over Time
With consistent use before meals, you may see smoother after-meal readings as part of an overall plan. Effects depend on meal composition, activity, and other medicines. Regular home monitoring helps you and your prescriber see patterns. Keep a log of meals, readings, and symptoms to support adjustments based on the official label. Learn more about post-meal patterns in Postprandial Hyperglycemia.
Compare With Alternatives
Within the same class, nateglinide offers similar mealtime coverage. Other oral options include metformin, DPP-4 inhibitors, and SGLT2 inhibitors, each with distinct profiles and label indications. If you need broader options by class, explore Oral Insulin Medications. Some patients may transition between a brand and its generic; this is sometimes referred to as Prandin repaglinide generic under prescriber direction.
Pricing and Access
Canadian pricing with US fulfilment helps many patients manage ongoing therapy. We display options so you can evaluate Repaglinide cost before requesting a fill. Ships from Canada to US, subject to valid prescription and availability. If you use coupons, see current offers on our Promotions page. Checkout is encrypted for your security.
Availability and Substitutions
Supply can vary by manufacturer and strength. A Repaglinide prescription from your clinician is required. If an item is unavailable, your prescriber may recommend an alternative with similar mealtime coverage. We cannot guarantee restock dates; check back for updated availability.
Patient Suitability and Cost-Saving Tips
This medicine may suit adults needing focused mealtime control who can coordinate dosing with meals. It may not suit those with frequent hypoglycemia, significant liver disease, or those who cannot maintain regular meals. Always review your history and current regimen with a clinician.
- Multi-month fills: fewer refills and fewer copays if allowed
- Plan ahead: request refills before travel or holidays
- Set reminders: align dosing with meal alerts
- Glucose logs: share data to support label-guided adjustments
- Lifestyle: consistent meals to reduce lows
Questions to Ask Your Clinician
- Is this therapy appropriate for my mealtime patterns?
- How should I time doses if my meals vary?
- Which signs of low blood sugar should I watch for?
- Which of my medicines could interact with this treatment?
- How often should I check my glucose and review results with you?
Authoritative Sources
- FDA DailyMed: Repaglinide
- Health Canada DPD: Repaglinide
- Novo Nordisk Prescribing Information: Prandin
Buy Repaglinide online with prompt US shipping from Canada. This information is educational and does not replace the approved label or your clinician’s advice.
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How does repaglinide work during meals?
Repaglinide is a meglitinide that triggers insulin release from pancreatic beta cells when you eat. It acts quickly and has a short duration, which targets post-meal glucose rises. Because its effect aligns with meals, timing matters. You usually take it shortly before eating and skip it when you skip a meal. This design helps limit exposure between meals while focusing on postprandial control. Always follow the official label and your prescriber’s guidance.
Can repaglinide be combined with metformin?
Yes, clinicians may combine repaglinide with metformin when additional mealtime coverage is needed. The two medicines work differently, so the combination can address fasting and post-meal glucose. Your prescriber will decide if the combination fits your goals and safety profile. Monitor your blood glucose regularly and know the signs of low blood sugar, especially when therapies are added or changed. Follow the label for each medicine and report concerns promptly.
What should I do if I skip a meal?
If you skip a meal, you typically skip the dose tied to that meal. If you remember close to eating, take it before the meal. If the meal has passed, wait until the next scheduled meal dose. Do not double doses to “catch up.” Keep glucose tablets or another fast carbohydrate available in case of low blood sugar, and speak with your prescriber if skipped meals are frequent.
Which medicines interact with repaglinide?
Gemfibrozil is a strong CYP2C8 inhibitor and is generally avoided with repaglinide. Rifampin can reduce its effect by inducing metabolism. Some antibiotics and antifungals, such as macrolides and azoles, may raise exposure. Beta-blockers can mask hypoglycemia symptoms. Alcohol may increase the risk of low blood sugar. Share an up-to-date medication list with your prescriber and pharmacist to assess interactions based on the official label.
Who should not take repaglinide?
It is not for type 1 diabetes or diabetic ketoacidosis. People with a known hypersensitivity to ingredients should not use it. Those with significant liver impairment, recurrent hypoglycemia, or inconsistent meal intake may not be good candidates. Discuss pregnancy, breastfeeding, and all medical conditions with your clinician. Your prescriber will determine suitability and monitoring needs using the official prescribing information.
How is repaglinide different from sulfonylureas?
Both increase insulin release, but repaglinide is shorter-acting and tied to meals. Many sulfonylureas have longer durations, affecting glucose between meals and overnight. The choice depends on your goals, meal pattern, risk of low blood sugar, and other factors. Your clinician will select a therapy that aligns with your needs and label guidance. Do not switch or adjust medicines without professional advice.
What monitoring do I need while taking repaglinide?
Check blood glucose as directed, especially around meals. Know the symptoms of hypoglycemia and keep a fast sugar source available. Periodic lab tests, including A1C and possibly liver-related labs, may be recommended. Track meals, activity, and readings to help your prescriber evaluate response. Report significant lows, changes in appetite, or new medicines so your plan can be adjusted based on the official label.
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