Prandin® (repaglinide) Tablets for Type 2 Diabetes

Repaglinide is a short-acting oral diabetes medicine for adults with type 2 diabetes. It helps reduce post-meal blood sugar when used with diet and exercise. This page explains how it works, who it suits, dosing basics, and how to order from Canada with US delivery. Many patients consider repaglinide for flexible meal control, even without insurance.

What Prandin® Is and How It Works

Repaglinide is the generic for Prandin®, a meglitinide. It stimulates the pancreas to release insulin right around meals. It acts quickly and clears from the body relatively fast. This makes it useful for targeting postprandial glucose spikes.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. You can order repaglinide online at Canadian pricing, and it ships to the US.

Repaglinide binds beta-cell potassium channels, leading to insulin release. Because its effect is meal-linked, you take it before each main meal. If you skip a meal, you skip the dose. This approach supports flexible schedules and helps limit between-meal hypoglycemia.

To learn more about clinical use, you can review Repaglinide Prandin for an overview.

Who Prandin Is For

Repaglinide is indicated for adults with type 2 diabetes to improve glycemic control when diet and exercise are not enough. It may be used alone or with other agents such as metformin. It is not approved for type 1 diabetes or for diabetic ketoacidosis.

Avoid use if you have known hypersensitivity to repaglinide. Use caution in moderate hepatic impairment. Severe hepatic impairment may require an alternative. Discuss cardiovascular disease, recurrent hypoglycemia, and nutritional status with your clinician before starting therapy.

Repaglinide is not a weight-loss medicine. It is not an insulin substitute. Pregnant or breastfeeding patients should ask their clinician about appropriate options.

Dosage and Usage

Take repaglinide by mouth before each main meal. Typical timing is 0 to 30 minutes pre-meal, often around 15 minutes. If you skip a meal, skip that dose.

• Common starting dose: 0.5 mg before each meal.
• If A1C is above target or switching from another secretagogue, a clinician may start at 1 mg or 2 mg before meals.
• Titrate based on self-monitored glucose at weekly or biweekly intervals.
• Per-meal dose range: 0.5 mg to 4 mg.
• Maximum recommended total daily dose: 16 mg.

Repaglinide can be used with metformin or other non–insulin agents. When adding to insulin or a sulfonylurea, the risk of hypoglycemia increases. Your clinician will guide the regimen. If you are uncertain about your exact dosing schedule, defer to the official label and your prescriber’s instructions.

Strengths and Forms

Repaglinide is available as oral tablets in commonly published strengths:

• 0.5 mg tablets
• 1 mg tablets
• 2 mg tablets

Tablet appearance may vary by manufacturer. Availability and pack sizes can vary by pharmacy and country.

Missed Dose and Timing

If you forget a dose but are about to eat, take it before that meal. If the meal has passed, skip the missed dose and resume with the next meal. Do not double up to make up for a missed dose.

Because repaglinide targets post-meal glucose, taking it without food increases hypoglycemia risk. Keep a source of fast-acting carbohydrate available if you are using insulin secretagogues.

Storage and Travel Basics

Store repaglinide tablets at room temperature in a dry place. Keep the bottle closed and protected from moisture and excess heat. Do not use tablets past the labeled expiration date. Keep out of reach of children and pets.

When traveling, carry the medicine in your original labeled container. Pack it in your carry-on to avoid temperature extremes and loss. Keep a simple dosing note for security checks and time-zone changes. Do not store tablets in a hot car or a damp bathroom.

Benefits

• Targets postprandial glucose with meal-based dosing.
• Short action may reduce between-meal lows compared with longer secretagogues.
• Flexible for variable mealtimes.
• Can be combined with metformin or other agents for additional A1C reduction.
• Available as a lower-cost generic option compared to brand.

For background on diabetes medicines, see Common Diabetes Medications for a plain-language review.

Side Effects and Safety

• Hypoglycemia, especially if a meal is delayed or missed
• Headache
• Upper respiratory symptoms
• Diarrhea or abdominal discomfort
• Joint or back pain
• Dizziness

Serious or rare effects can include severe hypoglycemia, allergic reactions, and liver enzyme changes. Cardiovascular events have been observed in diabetes populations; manage individual risk factors. Seek urgent care for confusion, fainting, severe sweating, palpitations, or persistent vomiting.

Review a concise overview in Repaglinide Side Effects Dosage before your visit.

Drug Interactions and Cautions

Tell your clinician and pharmacist about all medicines and supplements you take.

• Contraindicated: Gemfibrozil markedly increases repaglinide exposure.
• Increase exposure: Clopidogrel, clarithromycin, azole antifungals, and other CYP2C8/3A4 inhibitors.
• Reduce exposure: Rifampin and certain enzyme inducers.
• Additional hypoglycemia risk: Other insulin secretagogues, insulin, and heavy alcohol use.
• Masking of symptoms: Beta-blockers may mask hypoglycemia awareness.

Hepatic impairment increases exposure; dose adjustments or alternatives may be appropriate. Elderly patients may have higher hypoglycemia risk. Always individualize care with your clinician.

What to Expect Over Time

Many people see lower post-meal glucose from the first doses. A1C reduction emerges over weeks as dosing is titrated and lifestyle support continues. If your meal pattern changes, your clinician can adjust dose timing and per-meal strength. Continuous use alongside nutrition, activity, and monitoring helps sustain results.

Compare With Alternatives

Repaglinide is one option among mealtime glucose-lowering therapies. Metformin remains first-line for many patients. An extended-release form may improve gastrointestinal tolerance. Consider Glumetza® if your clinician recommends metformin ER. For combination therapy with an SGLT2 inhibitor, Invokamet® may be considered when appropriate. Mealtime insulin analogs are another path when oral agents are not enough.

Pricing and Access

You can order repaglinide online with US delivery from Canada. Check the repaglinide price on our product page to compare options. Many patients see a lower repaglinide cost with Canadian pricing. Start your order when your prescription is ready, and we will coordinate the rest with your clinic.

We offer secure, encrypted checkout. If you have questions about coverage or cash-pay savings, our team can help you review choices before you place an order.

Availability and Substitutions

Supply can vary by strength and manufacturer. If a specific strength is unavailable, your prescriber may recommend an equivalent dose using another tablet strength. If repaglinide does not suit you or remains unavailable, your clinician may suggest an alternative class.

Patient Suitability and Cost Saving Tips

Good candidates want post-meal control with a flexible schedule. Repaglinide may suit people who eat at unpredictable times. It may also suit those who need targeted postprandial support added to a metformin base.

• Ask about a 90-day supply to reduce per-tablet costs.
• Set refill reminders to avoid gaps and urgent local fills.
• Review lifestyle supports to get more value from your prescription.
• If you use a glucose meter, bring logs to each visit for efficient titration.

For broader product browsing, explore our Type 2 Diabetes or Blood Sugar Control categories.

Questions to Ask Your Clinician

• Is repaglinide appropriate for my meal pattern and goals?
• What starting dose fits my current A1C and glucose logs?
• How should I adjust if I skip or delay a meal?
• Could I combine repaglinide with metformin or another class?
• What signs of hypoglycemia should I watch for and treat?
• Do any of my medicines interact with repaglinide?
• How often should I check my blood sugar during titration?

Authoritative Sources

FDA DailyMed: Repaglinide

Novo Nordisk: Prandin Prescribing Information

Health Canada DPD: Repaglinide

Ready to get started? Place your repaglinide request with US delivery from Canada, and our team will verify your prescription and coordinate dispensing. This information is educational and not a substitute for medical advice. Always follow your clinician’s directions.