Invokamet® Tablets for Type 2 Diabetes

Invokamet® combines canagliflozin and metformin to help adults with type 2 diabetes improve blood sugar control alongside diet and exercise. It is intended for people not adequately managed on metformin alone or already taking both medicines separately. With US delivery from Canada and support for cash‑pay without insurance, access is straightforward while care stays guided by a clinician.

What Invokamet® Is and How It Works

Invokamet® contains two well‑studied diabetes medicines. Canagliflozin is an SGLT2 inhibitor that helps the kidneys remove excess glucose through urine. Metformin reduces the liver’s glucose production and improves how the body uses insulin. Together, they address complementary pathways to lower fasting and post‑meal blood glucose. Every CanadianInsulin order is prescription‑checked with your clinic and dispensed by a licensed Canadian pharmacy.

Invokamet® is used along with a balanced diet and regular physical activity. It is a prescription therapy for adults with type 2 diabetes and is not approved for type 1 diabetes or diabetic ketoacidosis. For background on this combination approach, see our article on the Invokana Metformin Combination. Orders ship from Canada to the US using prompt, express, cold‑chain shipping when needed. Cash‑pay options are available, including without insurance, subject to a valid prescription.

Who Invokamet® Is For

Invokamet® is indicated for adults with type 2 diabetes to improve glycemic control when used with diet and exercise. It may be considered for those not reaching A1C goals on metformin alone or for individuals already taking canagliflozin and metformin as separate tablets. It is not for type 1 diabetes or for treating diabetic ketoacidosis. People with moderate to severe kidney impairment require careful assessment, since metformin has specific renal thresholds and canagliflozin dosing depends on kidney function. Those with a history of serious genital or urinary infections, volume depletion, peripheral arterial disease, or foot ulcers need additional caution. For condition‑specific browsing, explore our Type 2 Diabetes category.

Use in pregnancy or while breastfeeding should be guided by risk–benefit discussions with a healthcare professional. Alcohol intake and very low‑carbohydrate diets can raise the risk of ketoacidosis with SGLT2 inhibitors. Metformin is associated with rare lactic acidosis, especially in settings of significant renal or hepatic impairment, acute illness, dehydration, or excessive alcohol intake.

Dosage and Usage

Invokamet® tablets are usually taken twice daily with meals to reduce gastrointestinal side effects from metformin. The starting dose and titration plan depend on the current or prior exposure to canagliflozin and metformin, kidney function, and tolerance.

• When converting from separate tablets, prescribers typically match the dose components as closely as possible and adjust based on response and tolerability.
• When adding canagliflozin to ongoing metformin, a common approach is to start at a lower canagliflozin component and titrate if additional control is needed and kidney function permits.
• For those newly starting both components, a conservative metformin dose may be used at first to minimize stomach upset, then slowly increased.

Take each dose with food. Maintain hydration, especially in warm weather or when exercising. Kidney function is monitored at baseline and periodically thereafter to ensure safe use and to guide dose adjustments. If a single‑ingredient SGLT2 inhibitor is preferred or needed, see Buy Invokana 100mg 300mg for canagliflozin tablets that your clinician may consider.

Special situations: SGLT2 inhibitors are often paused before major surgery or prolonged fasting, and metformin is commonly held before iodinated contrast imaging in certain patients, per label and clinical guidelines. Your care team will provide individual instructions.

Strengths and Forms

Invokamet® is supplied as immediate‑release tablets combining canagliflozin with metformin hydrochloride. Commonly available combinations include canagliflozin 50 mg or 150 mg paired with metformin 500 mg or 1000 mg. An extended‑release version, Invokamet XR, exists in some markets, pairing canagliflozin with metformin ER for once‑daily dosing. Availability, strengths, and packaging can vary between Canada and the US.

Missed Dose and Timing

If a dose is missed, take it when remembered with food. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not double doses. Consistent daily timing, aligned with meals, helps minimize stomach upset and supports stable glucose control.

Storage and Travel Basics

Store tablets at room temperature in a dry place away from direct heat and humidity. Keep the bottle closed tightly and protect it from moisture. For travel, carry medicine in original labeled packaging, pack enough for the entire trip plus a small buffer, and keep it in a carry‑on to avoid extreme temperatures. A simple pill organizer can help maintain adherence across time zones. Temperature‑sensitive items ship with cold‑chain handling and insulated packaging.

Benefits

Invokamet® simplifies therapy by combining two complementary agents with established efficacy and safety profiles. Many patients achieve additional A1C reduction compared with metformin alone. SGLT2 inhibitors such as canagliflozin often contribute to modest weight loss and mild blood pressure reduction, outcomes that can support overall metabolic health. Cardiovascular and kidney outcome data with SGLT2 inhibitors inform use in appropriate adults with type 2 diabetes and risk factors. For a primer on the class, see our overview of Jardiance Drug Class. Benefits vary by individual and should be interpreted alongside lifestyle measures and routine monitoring.

Side Effects and Safety

• Common: increased urination, thirst, genital yeast infections, mild urinary tract infections, nausea, diarrhea, stomach upset, gas, or headache.
• Less common: dizziness from low blood pressure, dehydration, muscle cramps, or rash.
• Metformin‑related: transient GI upset at initiation and potential vitamin B12 reduction with long‑term use.

Serious but uncommon risks include lactic acidosis with metformin, euglycemic ketoacidosis with SGLT2 inhibitors, severe urinary or genital infections including rare cases of Fournier’s gangrene, acute kidney injury, bone fractures, and increased risk of lower limb amputation observed with canagliflozin in some studies. Individuals with peripheral vascular disease, neuropathy, prior amputations, or active foot ulcers need heightened foot care and risk assessment. Hypoglycemia risk is generally low with Invokamet® alone but increases when used with insulin or sulfonylureas; dose adjustments of those agents may be considered by a clinician.

Drug Interactions and Cautions

• Diuretics and antihypertensives may increase the risk of volume depletion or low blood pressure.
• RAAS blockers, NSAIDs, or other nephrotoxic agents can affect kidney function; monitoring is important.
• Carbonic anhydrase inhibitors or topiramate may increase metabolic acidosis risk with metformin.
• Cationic drugs eliminated by renal tubular secretion, such as cimetidine, can interact with metformin.
• Insulin and sulfonylureas can raise hypoglycemia risk when combined with Invokamet®.
• Alcohol excess increases the risk of lactic acidosis and ketoacidosis; counsel on moderation.
• Hold metformin around iodinated contrast procedures in at‑risk patients per labeling, and consider pausing SGLT2 inhibitors before major surgery or prolonged fasting to reduce ketoacidosis risk.

Discuss all prescription, OTC, and herbal products with a clinician or pharmacist who knows the full medication list.

What to Expect Over Time

Blood glucose often improves within days to weeks of consistent use, while A1C reflects average control over roughly three months. Some individuals notice increased urination at first, which often stabilizes. GI tolerance to metformin typically improves with food and gradual titration. Sustainable lifestyle changes, routine lab checks, and foot care complement medicine benefits over the long term. Prescribers periodically reassess kidney function, A1C, and tolerability to keep the plan on track.

Compare With Alternatives

Other SGLT2‑based options may fit different needs. Canagliflozin is available as a single‑ingredient tablet, and other agents in the class include dapagliflozin and empagliflozin. Two commonly considered alternatives are Farxiga Dapagliflozin and Buy Jardiance 10 25 mg. Metformin extended‑release is another option when GI tolerability limits immediate‑release use. For a head‑to‑head perspective, see Invokana vs Metformin.

Pricing and Access

Many patients look to Canadian pricing for meaningful cash‑pay savings compared with typical US retail costs. If Invokamet® is not covered or if deductibles are high, cash‑pay without insurance may help reduce out‑of‑pocket spending. Orders are verified and dispensed by licensed Canadian pharmacies, with US delivery from Canada via prompt, express, cold‑chain shipping. For tips on stretching budgets, explore Buy Glumetza From Canada. Check our current promotions for occasional offers.

Availability and Substitutions

Availability can vary by strength and pack size. If a specific combination is temporarily unavailable, a prescriber may suggest suitable alternatives, such as adjusting doses of single‑ingredient tablets or switching to an alternative SGLT2 inhibitor plus metformin. Pharmacy teams coordinate any changes only with clinician approval.

Patient Suitability and Cost‑Saving Tips

Candidates include adults with type 2 diabetes requiring additional glycemic control beyond metformin. Careful consideration is needed in chronic kidney disease, peripheral vascular disease, recurrent genital or urinary infections, or those at risk for dehydration or ketoacidosis. Multi‑month supplies may reduce per‑fill fees and help maintain adherence. Setting refill reminders and travel checklists can prevent missed doses. Lifestyle measures, glucose monitoring, and routine lab checks amplify the benefits of therapy.

Questions to Ask Your Clinician

• Is Invokamet® appropriate for my A1C target and kidney function?
• How should the dose be adjusted if I have side effects or do not reach goals?
• Should I change insulin or sulfonylurea doses to reduce hypoglycemia risk?
• What labs should be monitored and how often?
• Do I need to pause this medicine before surgery, fasting, or contrast imaging?
• What foot care steps should I follow given SGLT2 inhibitor risks?
• Could metformin extended‑release or an alternative SGLT2 inhibitor suit me better?

Authoritative Sources

• DailyMed Official Labeling
• Janssen Product Information
• American Diabetes Association

Ready to request Invokamet® from CanadianInsulin? Your order is handled with prescription verification and prompt, express, cold‑chain shipping. Our team is available to support ordering, storage, and travel planning.

Disclaimer: This information is educational and does not replace advice from a licensed healthcare professional. Always follow the guidance of your prescriber and the approved product labeling.