Invokamet (canagliflozin/metformin HCl)

Invokamet is a prescription combination tablet used for blood sugar control in adults with type 2 diabetes, alongside diet and exercise. This page summarizes what to know about Invokamet price, dosing basics, safety topics, and practical handling for routine use. Requests on this site can be arranged with US shipping from Canada and may support access without insurance.

What Invokamet Is and How It Works (Invokamet price)

Invokamet contains two medicines: canagliflozin and metformin. Canagliflozin is an SGLT2 inhibitor (a medicine that helps the kidneys remove glucose in urine). Metformin is a biguanide that lowers glucose production in the liver and improves insulin sensitivity. Together, the treatment targets fasting and after-meal blood glucose through complementary mechanisms.

CanadianInsulin.com operates as a prescription referral service connecting patients to dispensing pharmacies. Clinical effects and risks depend on kidney function, hydration status, and other medicines used at the same time. Because canagliflozin increases urinary glucose, some side effects relate to the urinary and genital tract, while metformin-related effects often involve the stomach and intestines.

Why it matters: Combination therapy can simplify a regimen, but it also combines the precautions of both components.

Who It’s For

This medicine is generally prescribed for adults with type 2 diabetes who need additional glucose lowering beyond lifestyle measures. It may be considered when a clinician wants an oral combination that includes an SGLT2 inhibitor plus metformin. For condition-level background, browse Type 2 Diabetes and the broader Diabetes hub.

Invokamet is not used for type 1 diabetes. It is not for treatment of diabetic ketoacidosis, a serious emergency state. Contraindications and “not appropriate for” situations can include severe kidney impairment and metabolic acidosis, including diabetic ketoacidosis. A prescriber also typically reviews history of recurrent genital infections, risk of dehydration (for example with diuretics), and conditions that raise lactic acidosis risk with metformin.

Dosage and Usage

Invokamet tablets are taken by mouth, usually with meals to reduce gastrointestinal side effects linked to metformin. Many regimens are scheduled twice daily because the metformin component is immediate-release in the standard product. Clinicians may start at a lower metformin dose and adjust based on tolerance, blood glucose response, and kidney function, following official labeling.

Invokamet XR (extended-release tablets) is a related product form designed for once-daily dosing in some patients. Because extended-release formulations change how metformin is released, tablets should be swallowed whole and not crushed or split unless the labeling specifically allows it. For related reading on combinations in this class, see Invokana Metformin Combination.

Immediate-release versus extended-release scheduling

Immediate-release canagliflozin/metformin products are commonly aligned to morning and evening meals, which can help with metformin stomach upset and support consistent routine. Extended-release metformin combinations are often aligned to a single daily meal to match the slower release profile across the day. The canagliflozin portion still relies on kidney filtration, so prescribers typically consider renal function tests before starting and during therapy. Any change between formulations is generally treated as a medication switch that requires prescriber direction to match total daily metformin exposure.

Quick tip: When managing refills, confirm whether the prescription specifies IR or XR tablets.

Strengths and Forms

Invokamet is supplied as oral tablets that combine canagliflozin with metformin. Common presentations are described by the canagliflozin dose paired with a metformin dose, and availability can vary by pharmacy and country supply. In listings and prescriptions, the product may also be described as Canagliflozin metformin tablets or Canagliflozin/metformin HCl.

The strength on the label matters for safe dispensing, especially if other metformin products are also being used. For reference, prescriptions may specify combinations such as canagliflozin 50 mg or 150 mg with metformin 500 mg or 1000 mg. When comparing options, the recorded Invokamet price is often tied to strength, tablet count, and whether the prescription is IR or XR.

Storage and Travel Basics

Store tablets at controlled room temperature, protected from excess heat and moisture. Keep the medicine in its original container until use when possible, because packaging helps limit humidity exposure. Bathrooms and kitchen areas near sinks can be poor storage locations due to steam and temperature swings.

For travel, carry tablets in hand luggage to avoid temperature extremes in checked baggage. Keep a copy of the prescription or pharmacy label available in case identification is needed during transit. If traveling across time zones, dosing times are typically adjusted by the prescriber’s plan to maintain overall daily schedule consistency without doubling doses.

Side Effects and Safety

Many side effects are related to either increased urinary glucose (canagliflozin) or gastrointestinal intolerance (metformin). Commonly reported issues can include increased urination, thirst, genital yeast infections, urinary tract infections, nausea, diarrhea, and abdominal discomfort. Some people notice mild weight change, but individual outcomes vary and should not be treated as a therapeutic target without clinician guidance.

Serious risks require prompt medical assessment. Metformin carries a rare but dangerous risk of lactic acidosis (dangerous acid build-up), especially with severe kidney disease, severe dehydration, heavy alcohol use, or hypoxia. SGLT2 inhibitors can be associated with ketoacidosis, severe urinary infections, low blood pressure from volume depletion, and rare genital or perineal infections such as Fournier’s gangrene. Prescriptions may be confirmed with the prescriber before dispensing when clinical details are needed. In safety reviews, Invokamet price should not be the only factor considered; tolerability and risk profile often drive selection.

• Common: GI upset, thirst
• Infection-related: yeast or UTI
• Urgent: acidosis symptoms, severe weakness

Drug Interactions and Cautions

Invokamet can interact with medicines that affect kidney function, blood pressure, or glucose levels. Diuretics may raise dehydration and low blood pressure risk when combined with SGLT2 inhibitors. Insulin or insulin secretagogues (such as sulfonylureas) can increase the risk of hypoglycemia when used with additional glucose-lowering therapy, so prescribers may adjust companion therapy.

Metformin has important cautions around iodinated contrast imaging procedures, because kidney function changes can increase lactic acidosis risk; labeling outlines when temporary interruption may be needed. Alcohol excess increases risk and is generally cautioned against. Other interactions can include drugs that affect metformin clearance (for example certain cationic medicines) and agents that influence canagliflozin exposure. Medication reconciliation should include over-the-counter products and supplements.

Compare With Alternatives

Invokamet is one option among several non-insulin combination tablets used in type 2 diabetes care. Another SGLT2 inhibitor plus metformin combination is empagliflozin/metformin, found as Synjardy. A DPP-4 inhibitor plus metformin combination is sitagliptin/metformin, including extended-release options such as Janumet XR.

Each alternative has different benefits, contraindications, and monitoring focus. For example, DPP-4 inhibitor combinations may have a different infection and dehydration profile than SGLT2 inhibitor combinations, while still sharing metformin precautions when included. For deeper comparisons on metformin combinations, the site’s guides such as Understanding Janumet Dosage and Xigduo Uses Dosage can provide context. In practice, Invokamet price comparisons are typically made alongside renal suitability, prior side effects, and regimen simplicity.

Pricing and Access

For many patients, the main access considerations include formulation (IR vs XR), strength, and monthly quantity. When evaluating Invokamet price without insurance, the total out-of-pocket amount can be influenced by prescriber-selected dose, country supply channels, and whether manufacturer support or third-party assistance applies. The Promotions page may list general site-wide programs when available.

Licensed Canadian pharmacies dispense medications after required documentation is confirmed. For cross-border fulfillment, Ships from Canada to US is supported through the platform’s referral workflow, and checkout typically includes prescription upload or prescriber contact details when needed. To proceed with a request, submit prescription details and select prompt, express, cold-chain shipping.

Authoritative Sources

For official prescribing information and safety updates, these references can help:

• FDA Drugs@FDA database listing
• Health Canada Drug Product Database
• American Diabetes Association overview

This content is for informational purposes only and is not a substitute for professional medical advice.