Prandin® (repaglinide) Tablets for Type 2 Diabetes

Repaglinide is an oral prescription medicine for adults with type 2 diabetes. It lowers mealtime blood sugar by triggering quick, short insulin release from the pancreas. Repaglinide is the generic for Prandin® and is supplied as tablets. From Canada, it ships to the US with Canadian pricing and US delivery from Canada. You can review Repaglinide price without insurance before checkout.

What Repaglinide Is and How It Works

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. Repaglinide belongs to the meglitinide class, also called short-acting insulin secretagogues. It works on pancreatic beta cells to close ATP-dependent potassium channels. This action leads to calcium influx and a rapid insulin pulse. The effect starts quickly and fades within a few hours, which helps control postprandial glucose after meals. For background on oral options, see Oral Diabetes Medications.

Use of repaglinide is as an adjunct to diet and exercise in adults with type 2 diabetes mellitus. It is not for type 1 diabetes or diabetic ketoacidosis. Clinicians may combine it with metformin when appropriate. Its short action can fit varied meal schedules.

Who Repaglinide Is For

Repaglinide is indicated for adults with type 2 diabetes who need better control of mealtime blood sugar. It suits people who experience postprandial hyperglycemia despite diet, exercise, or baseline therapy. It can be used alone or with metformin when an additional agent is needed. For broader options, visit our Type 2 Diabetes category.

It should not be used in type 1 diabetes or during episodes of diabetic ketoacidosis. People with moderate to severe liver impairment may require alternative therapy. Pediatric use is not established. Discuss pregnancy or breastfeeding plans with a clinician before starting therapy.

Dosage and Usage

Repaglinide tablets are taken before meals. Typical starting doses follow widely published labeling:

• Patients not previously treated or with A1C near target: start 0.5 mg before each main meal.
• Patients previously on another oral agent: start 1 mg or 2 mg before each main meal.
• Titrate dose based on blood glucose, usually at weekly intervals.
• Maximum total daily dose is commonly 16 mg.

Timing matters. Take each dose within 30 minutes before eating. Two to four daily doses are common, aligned to meals that contain carbohydrates. Dose changes and combinations are determined by the prescriber, guided by glucose monitoring and overall regimen.

Strengths and Forms

Repaglinide is available as immediate-release tablets. Common strengths include:

• Repaglinide 0.5 mg tablets
• Repaglinide 1 mg tablets
• Repaglinide 2 mg tablets

Availability may vary by manufacturer and lot. Labels and pill appearance can differ. The same active ingredient is present across strengths.

Missed Dose and Timing

Repaglinide is tied to meals. If a meal is skipped, skip the dose. If a meal is added, add a dose before that meal as directed by the prescriber. If a dose is forgotten and the meal has already been eaten, do not double the next dose. Resume the usual schedule with the next meal. Consistent timing before meals supports stable postprandial control.

Storage and Travel Basics

Store repaglinide tablets at room temperature, typically 20 to 25°C (68 to 77°F). Protect from moisture and excessive heat. Keep tablets in the original container with the label intact. When traveling, carry medicine in a hand luggage compartment and bring an up-to-date prescription label. Use a pill organizer only if it keeps tablets dry and protected. Keep out of reach of children and pets.

Benefits

Repaglinide offers several label-aligned benefits:

• Targets mealtime glucose rises with short, flexible dosing around meals.
• Quick onset and brief duration limit effect to the post-meal window.
• Can be used alone or with metformin for added control.
• Tablets are available in multiple strengths for tailored titration.

These features suit people who need focused postprandial control and flexible meal timing.

Side Effects and Safety

Common side effects include:

• Hypoglycemia, especially with missed meals or higher doses
• Headache
• Upper respiratory tract infection symptoms
• Diarrhea or gastrointestinal discomfort
• Back pain
• Weight gain

Serious risks are uncommon but can include severe hypoglycemia requiring assistance. Hypersensitivity reactions are rare. Report persistent or severe symptoms to a clinician. The risk of hypoglycemia may increase when used with insulin or sulfonylureas. For more on tolerability, read Repaglinide Side Effects and Repaglinide Side Effects Dosage.

Drug Interactions and Cautions

Major interactions are important for safety:

• Gemfibrozil markedly increases repaglinide exposure and is generally contraindicated.
• Clopidogrel can raise repaglinide levels and increase hypoglycemia risk.
• Strong CYP2C8 or CYP3A4 inhibitors (for example, clarithromycin, itraconazole) may increase exposure.
• Rifampin and other inducers may reduce exposure and effect.
• Beta blockers can mask adrenergic warning signs of hypoglycemia.

Use caution with hepatic impairment. Repaglinide is not for type 1 diabetes or DKA. Alcohol can enhance hypoglycemia. Review all prescriptions, OTC medicines, and supplements with a clinician or pharmacist. See our overview on meal-related spikes in Postprandial Hyperglycemia Signs Symptoms Treatment.

What to Expect Over Time

Repaglinide acts quickly around each meal while taken. Post-meal glucose may improve within days as doses are adjusted. Longer-term glycemic markers, such as A1C, are typically assessed after several weeks to months of consistent therapy. Ongoing monitoring and lifestyle measures remain important.

Compare With Alternatives

Other options for mealtime control include nateglinide and sulfonylureas such as glipizide or glimepiride. Some people transition to a rapid-acting insulin analog for postprandial coverage. One example is insulin aspart in a cartridge format, available as Novorapid® Cartridge. Broader strategies may add or switch to metformin, DPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists, depending on clinical goals and tolerance.

Pricing and Access

Buy Repaglinide online with Canadian pricing and US shipping. You can order Repaglinide from Canada and receive US delivery from Canada. Check current Repaglinide cost by strength, including Repaglinide 0.5 mg tablets, Repaglinide 1 mg tablets, and Repaglinide 2 mg. Some shoppers compare Repaglinide 2 mg price across manufacturers. Encrypted checkout protects payment details. If you are looking for deals, see our Promotions. Prescription required and verified.

Availability and Substitutions

Availability can vary by manufacturer and batch. If a specific strength or brand is not in stock, a prescriber may recommend an appropriate alternative or a different strength with adjusted dosing. Our team can help coordinate options after the clinic confirms the prescription.

Patient Suitability and Cost Saving Tips

Repaglinide may suit adults with type 2 diabetes who need targeted postprandial control and prefer rapid, meal-timed dosing. It is not intended for type 1 diabetes or DKA. Caution is warranted in hepatic impairment. Consider a discussion about combination therapy if fasting or overall targets are not met.

• Ask about a multi-month supply to reduce per-fill costs.
• Align refills with other medicines to reduce shipping fees.
• Set reminders so refills arrive before running out.
• Review meal timing to optimize doses and reduce waste.

Questions to Ask Your Clinician

• How should doses be adjusted to match meal size and frequency
• What is a safe titration schedule based on glucose logs
• Could metformin be combined with repaglinide for better control
• What signs of hypoglycemia require immediate attention
• Do any current medicines interact with repaglinide, including clopidogrel or gemfibrozil
• How often should labs and follow-up visits be scheduled

Authoritative Sources

Learn more from official references:

• Prandin Prescribing Information
• DailyMed Repaglinide
• Health Canada DPD Repaglinide

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