Revolution Plus® Topical Solution for Cats

Revolution Plus® is a monthly prescription topical solution for cats and kittens. It helps prevent heartworm disease and controls fleas, ticks, ear mites, roundworms, and hookworms. From Canada, ships to the US with Canadian pricing so you can check savings even if you pay without insurance.

What Revolution Plus® Is and How It Works

Revolution Plus is a combination of selamectin and sarolaner topical solution for cats. It targets key parasites with a single monthly spot-on dose. At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. This cross-border service provides US delivery from Canada.

Selamectin is an avermectin that prevents heartworm disease in cats and treats certain intestinal worms. Sarolaner is an isoxazoline that kills fleas and ticks. Together, they provide broad protection across parasites that commonly affect indoor and outdoor cats. This product treats active infestations and prevents new ones when used as directed.

Label indications include prevention of heartworm disease, killing adult fleas, treating ear mites, treating and controlling roundworms and hookworms, and killing ticks. It is a comprehensive flea and tick for cats solution that also addresses ear mites and intestinal worms. Many pet owners choose it as a monthly foundation for parasite prevention.

Who Revolution Plus Is For

Revolution Plus is for cats and kittens 8 weeks of age and older that weigh at least 2.8 lb (1.25 kg). It provides coverage for households dealing with fleas, ticks, ear mites, roundworms, and hookworms, while also preventing heartworm disease.

Do not use in kittens under the labeled age or weight minimum. Avoid use in animals that are ill, underweight, or recovering from serious illness unless a veterinarian advises otherwise. Cats with known sensitivity to selamectin or sarolaner should not receive this medicine. Use caution in cats with a history of neurologic disorders or seizures.

For very small kittens below the Revolution Plus weight range, discuss options with a veterinarian. A kitten-focused product such as Revolution® For Puppies Kittens may be considered under veterinary guidance.

Dosage and Usage

Revolution Plus is applied to the skin at the base of the neck once every month. One tube is given per monthly dose, matched to the cat’s weight band. Administer year-round for consistent protection, especially for heartworm prevention in cats.

• Choose the correct weight band at each refill.
• Part the fur until the skin is visible and apply the full tube contents to one spot on clean, dry skin.
• Do not massage into the skin. Allow the site to dry.
• Keep treated cats away from flame or heat sources until the site is dry, as the solution is flammable while wet.
• Avoid contact with the eyes and mouth. Prevent grooming the application area until dry.

If switching from a different heartworm preventive, start Revolution Plus when the next dose is due. Keep a 30-day interval between topical doses. For multiple cats, dose each cat with its own weight-appropriate tube.

Strengths and Forms

Revolution Plus is a prescription topical solution for cats available in color-coded, weight-based tubes. Availability may vary by pack size and weight range.

• Cats 2.8–5.5 lb: Kittens and small cats pack
• Cats 5.6–11 lb: Adult mid-weight pack
• Cats 11.1–22 lb: Adult large-weight pack
• Common pack sizes include 3-pack and 6 pack options

The active ingredients are selamectin and sarolaner in a ready-to-use single-dose tube. There is no generic selamectin and sarolaner topical solution for cats that matches Revolution Plus at this time.

Missed Dose and Timing

Apply a missed dose as soon as it is remembered, then continue with monthly dosing. Try to maintain a consistent schedule. If a dose is missed by more than one month, the risk of heartworm exposure increases. In that situation, a veterinarian may recommend testing before restarting prevention. Do not give two doses at once.

Storage and Travel Basics

Store Revolution Plus in the original box at room temperature, away from heat, light, and moisture. Keep tubes in the foil until use. The product is flammable while wet, so store away from open flames.

When you travel, carry the tubes in a sealed pouch within their cartons. Keep out of reach of children and other animals. This medicine is not a cold-chain product, so standard room temperature handling is typically sufficient. For flights, keep doses in a carry-on so you can access them and avoid extreme temperatures.

Benefits

• Six-in-one coverage: heartworm prevention plus fleas, ticks, ear mites, roundworms, and hookworms
• Monthly dosing simplifies parasite control for many households
• Topical solution avoids pills and complicated schedules
• Fast flea kill helps break the infestation cycle
• Tick control helps reduce exposure to tick-borne pathogens
• Effective ear mites treatment for cats in a single monthly spot-on
• Broad intestinal coverage including common roundworms and hookworms

Side Effects and Safety

Common effects are usually mild and temporary. These can include application-site hair loss, redness, or dandruff-like flakes, pruritus, lethargy, decreased appetite, drooling if the product is licked, vomiting, or diarrhea. Most cats tolerate treatment well when dosed correctly by weight.

Serious adverse reactions are uncommon but can occur. Isoxazoline products, including sarolaner, have been associated with neurologic signs such as tremors, ataxia, and seizures, even in animals without a prior history. Seek veterinary care if unusual behavior, persistent vomiting, difficulty breathing, or neurologic signs appear. Use with caution in cats with a seizure history. As with any parasite preventive, keep tubes away from children and do not ingest.

Drug Interactions and Cautions

Tell the veterinarian about all medicines, supplements, and topical products in use. Combining multiple parasite preventives can lead to duplication or increased side effects. Use caution with other isoxazoline products. Do not apply a dog-only product to cats. Do not split tubes between animals or across doses.

Revolution Plus is labeled for prevention of heartworm disease; it does not treat existing adult heartworm infections. Cats with suspected heartworm exposure may need testing before starting or restarting prevention. Follow professional guidance for pregnant or lactating queens.

What to Expect Over Time

Most cats experience quick flea relief after the first dose. Tick kill begins promptly and is maintained with monthly use. Ear mites, roundworms, and hookworms are treated with labeled dosing, while ongoing monthly doses help prevent re-infestation. For heartworm prevention, consistent month-to-month coverage matters most. Many households keep Revolution Plus on a repeating schedule year-round.

Compare With Alternatives

Revolution Plus adds tick control (via sarolaner) compared with original selamectin-only products. For cats that need heartworm, fleas, and ear mites but not tick coverage, consider Revolution® For Cat under veterinary advice. Some caregivers prefer an all-in-one topical that also addresses tapeworms; in that case, discuss Nexgard® Combo with the veterinarian to determine fit, based on age and weight.

Pricing and Access

See current pricing for each weight band and pack size, including 6 pack options for adult cats 5.6–11 lb and 11.1–22 lb. Canadian pricing with US delivery helps many households lower the cash pay cost. Check availability and compare options alongside other Pet Medications on our site.

Want to stretch the budget when paying out of pocket? Consider multi-month packs when appropriate and set refill reminders. You may also review limited-time offers on our Promotions page. Checkout is encrypted for your security.

Availability and Substitutions

Supply can vary by weight band and pack size. If the exact size is not available, a veterinarian may recommend an alternative. For cats needing an intestinal dewormer only, a product such as Profender® may be considered. Use only cat-labeled products and match age and weight requirements. Contact a clinic before switching preventives.

Patient Suitability and Cost Saving Tips

Good candidates include healthy cats and kittens 8 weeks and older who need broad parasite control. Cats living with dogs, outdoor exposure, or multi-pet homes may especially benefit from tick and flea protection. Cats with a seizure history may require extra caution; veterinary guidance is essential.

• Buy enough doses to cover a full season or year when appropriate.
• Use a calendar or phone reminder to stay on schedule.
• Weigh growing kittens regularly and update the weight band as they cross thresholds.
• Store extra tubes properly to avoid waste.
• Schedule refills before the last dose runs out, especially during peak parasite months.

Questions to Ask Your Clinician

• Is Revolution Plus the right choice for this cat’s age, weight, and health?
• Should tick control be included based on local risk and lifestyle?
• How long should monthly prevention continue each year in this region?
• What signs of side effects should I watch for after application?
• Is bathing or grooming timing important around the dose day?
• How should dosing change as a kitten moves from 5.6–11 lb to 11.1–22 lb?
• Can this be used alongside other parasite or prescription products the cat needs?

Authoritative Sources

• Zoetis Revolution Plus Product Information
• FDA Isoxazoline Safety Communication
• Health Canada Drug Product Database

Start your order for prompt US delivery from Canada. This information is educational and does not replace your veterinarian’s advice.