Revolution Plus (selamectin/sarolaner)

Revolution Plus is a prescription topical medicine used to help control common parasites in cats. This page summarizes what it treats, how it is typically used, and what safety issues to review with a veterinarian. It also explains practical access steps for people without insurance.

What Revolution Plus for cats Is and How It Works

This product is a “spot-on” parasiticide that combines Selamectin and Sarolaner. Selamectin is a macrocyclic lactone (antiparasitic drug class) that affects nerve signaling in certain parasites. Sarolaner is an isoxazoline (flea-and-tick medicine class) that targets the nervous system of fleas and ticks. The medication is placed on the skin so the active ingredients can spread across the skin surface and be absorbed to provide ongoing parasite control.

US shipping from Canada is available where permitted, based on the prescription and destination rules. Licensed Canadian pharmacies dispense medications after referral review.

On labels where it is approved, this therapy is used for broad parasite coverage, which may include fleas, ticks, ear mites, and certain intestinal worms, and it may be used as part of heartworm disease prevention protocols. Because parasite risks vary by region and household exposure, the dispensing label and the prescribing veterinarian’s directions should be treated as the primary source for what is covered and how long protection lasts.

Related inventory can be browsed in the Pet Medications collection, which groups prescription and non-prescription options by type.

Who It’s For

This medication is intended for cats within the age and weight limits shown on the carton and prescription label. It is used for animals that need consistent parasite prevention or control, especially in settings with ongoing flea exposure or where ticks are a concern. In many households, the goal is to reduce parasite burden across the environment by treating pets on a regular schedule, while also addressing bedding, vacuuming, and any other pets as recommended by a veterinarian.

Revolution Plus for cats should not be used in species other than those listed on the label, since dosing and safety can differ significantly across animals. It is also not an appropriate fit for cats with a known allergy to any ingredient. Extra caution is often advised for animals that are sick, debilitated, or have a history of neurologic disease, because isoxazoline-class products have been associated with rare neurologic adverse events in some pets.

For condition-based browsing, the site organizes options in hubs such as Ear Mite Infestation and Heartworm Disease, which can help clarify which therapies are typically used together.

Dosage and Usage

Most labels use a once-monthly schedule, with the correct tube selected by the cat’s current body weight. The package is designed as a single-dose tube for one animal, not as a multi-dose vial. A veterinarian may recommend year-round use in some regions, seasonal use in others, or a different interval if the animal’s parasite risk is unusual.

Revolution Plus for cats is placed directly on the skin (not the hair coat) at the site described on the product label, commonly at the back of the neck where grooming is limited. Typical instructions include parting the hair, emptying the entire tube onto one spot, and washing hands afterward. Product labeling may also address bathing, swimming, or grooming timing around dosing, because water exposure can affect how well a topical spreads on the skin.

Why it matters: Weight changes can affect tube selection and safety margins.

To explore related prevention topics and products by condition, browse Flea Infestation and Tick Infestation hubs.

Strengths and Forms

Revolution Plus is supplied as pre-measured topical tubes packaged by weight range, so the correct selection depends on the cat’s current weight at the time of dispensing. Some listings are described in everyday terms such as “Revolution Plus Topical Solution for Cats” or “cat flea and tick topical,” but the practical difference is usually the labeled weight band on the carton and prescription.

Packaging configurations can vary by pharmacy and distributor, including multi-month cartons (for example, a 6-pack) intended to support consistent monthly dosing. Availability may also vary by country label and supply. If a cat is being treated for a parasite not covered by this product (for example, tapeworms), an additional therapy may be required; the article Droncit Tapeworm Treatment explains how that type of deworming medicine is typically used under veterinary direction.

Storage and Travel Basics

Storage directions are printed on the carton and may differ slightly by market, so the package insert should be followed. In general, topical parasite medicines are kept in their original packaging until use, stored away from direct light, and protected from temperature extremes. They should be kept out of reach of children and separated from food items, because accidental exposure can irritate skin, eyes, or mucous membranes.

For travel, keep each tube sealed until the day it is used and pack it in a way that prevents crushing or leaks. If a household is managing itchy skin related to flea allergy dermatitis, prevention is only one part of the plan; the article Atopica Cats Medication reviews a separate prescription approach a veterinarian may consider for allergic inflammation.

Quick tip: Record the dose date and weight to support accurate refills.

Side Effects and Safety

Many cats tolerate topical parasite preventives well, but side effects can occur. Common issues may include temporary irritation at the dosing site, mild hair changes where the product was placed, or short-lived gastrointestinal signs such as vomiting or reduced appetite. Drooling can occur if a cat licks the wet product before it dries, because the taste can trigger hypersalivation. Monitoring is especially important during the first dose or when switching from a different flea and tick regimen.

Revolution Plus for cats contains an isoxazoline ingredient, and that drug class has been associated with uncommon neurologic reactions in some pets. Signs can include tremors, unsteadiness, or seizures. Any sudden behavior change, weakness, or persistent vomiting warrants prompt veterinary assessment. Prescriptions may be confirmed with the prescribing veterinarian when required.

If nausea or vomiting becomes part of a broader illness evaluation, the article Cerenia Uses And Dosage describes an antiemetic (anti-nausea) medicine that a veterinarian may prescribe for select cases.

Drug Interactions and Cautions

Drug interaction information for topical parasiticides is often limited compared with some oral medicines, but caution is still appropriate. Combining multiple flea/tick products, using more than one product from the same class, or adding another macrocyclic lactone without veterinary guidance may increase the risk of side effects. Household use of shampoos, sprays, or environmental pesticides can also add exposure, so it is helpful for the prescriber to know what else is being used around the cat.

Special caution may be needed for cats with a history of seizures or other neurologic conditions, as well as animals that are pregnant, nursing, or intended for breeding, depending on what the local label states. If the skin is broken, infected, or severely inflamed at the intended dosing site, a veterinarian may recommend treating the skin condition first or choosing a different location to reduce irritation. For background on antibiotic treatment used in some skin infections, see Cephalexin Uses And Dosage.

Compare With Alternatives

Parasite control plans are often individualized. A common alternative is a selamectin-only topical (without the added tick-active ingredient), which may be chosen when flea control and heartworm prevention are the main goals and tick coverage is not needed. Another approach is a different combination topical that includes a flea/tick active plus additional deworming ingredients, which may better match a cat’s parasite profile in some regions.

Revolution Plus for cats may be compared with Revolution For Cat (selamectin-only topical) and NexGard Combo (a different combination topical). Some cats may also receive separate dewormers or short-acting flea adulticides alongside a monthly preventive, but those choices depend on exam findings, fecal testing, and local parasite risk.

Pricing and Access

Pricing varies mainly by the cat’s weight band and the number of doses in a carton. Larger weight ranges typically have higher costs, and multi-month packaging can change the per-month total. Because this is a prescription product, a valid veterinary prescription is required, and the dispensing label is the best reference for the selected weight range and dosing interval.

Revolution Plus for cats is offered through CanadianInsulin’s prescription referral model, coordinating dispensing through licensed pharmacies. Cash-pay access can be used when insurance coverage is limited. If a site-wide offer is available, it is listed on the Promotions page.

Authoritative Sources

For the most reliable details on indications, age and weight limits, and adverse reactions, consult the manufacturer labeling and regulatory safety communications. Product names, parasite coverage, and cautions can vary across countries and over time, so the package insert and the prescribing veterinarian’s instructions should be treated as the primary references.

These sources provide label and safety context:

• Manufacturer product information and label details are available here: Zoetis Revolution Plus
• FDA class safety communication for isoxazoline products is here: FDA isoxazoline safety alert

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This content is for informational purposes only and is not a substitute for professional medical advice.