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Soliqua SoloStar Pens
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US shipping from Canada is available for this combination injectable used in type 2 diabetes care, and this page summarizes key product facts for Soliqua 100/33 pens. It describes what the medicine contains, how the SoloStar device is used once daily, and what to know about storage and safety. It also outlines access steps for people paying cash, including those without insurance, so site actions like prescription submission are clearer.
What Soliqua Is and How It Works (buy Soliqua Solostar Pens)
Soliqua 100/33 is a fixed-dose combination of insulin glargine (a long-acting basal insulin) and lixisenatide, a GLP-1 receptor agonist. Basal insulin helps lower glucose between meals and overnight. Lixisenatide supports glucose-dependent insulin release and can slow gastric emptying (how fast food leaves the stomach), which may reduce postprandial (after-meal) glucose rises. The product is delivered as a prefilled pen designed for subcutaneous injection.
Ships from Canada to US through this site’s referral workflow. Prescription details may be verified with the prescriber when required. The combination is not intended for treating diabetic ketoacidosis, and it is not a substitute for rapid-acting mealtime insulin when that is clinically indicated. For broader background on insulin types, see Different Types Of Insulin.
Who It’s For
This medicine is generally used for adults with type 2 diabetes when glucose goals are not met on basal insulin alone or on a GLP-1 receptor agonist alone, depending on local labeling and prescriber judgment. It combines a basal insulin component with an incretin-based component in one pen, which may be considered when simplifying a regimen is a priority. For condition context and related therapies, browse Type 2 Diabetes.
It is not used for type 1 diabetes, and it is not used to treat diabetic ketoacidosis. Do not use it during an episode of low blood sugar, and do not use it if there is a known allergy to insulin glargine, lixisenatide, or another ingredient. People with a history of pancreatitis, severe gastrointestinal disease, or significant kidney impairment may need extra caution and monitoring. If reviewing eligibility and risks while planning to buy Soliqua Solostar Pens, a prescriber should confirm whether a GLP-1 product is appropriate; related class options can be browsed under GLP-1 Agonists, and practical reading is collected in Type 2 Diabetes Articles.
Dosage and Usage
Soliqua 100/33 is taken once daily as a subcutaneous injection, typically within 1 hour before the first meal of the day, per product labeling. The dose is measured in insulin units on the pen. Starting doses and titration schedules depend on prior therapy (for example, prior basal insulin dose range or prior lixisenatide use) and on fasting blood glucose trends. Dose adjustments are made gradually according to the prescribing information, and the label sets a maximum daily dose because the lixisenatide amount increases as insulin units increase.
Administration is generally in the abdomen, thigh, or upper arm, with rotation of sites to reduce lipodystrophy (changes in the fat under the skin). This medicine is injected under the skin, not into a vein or muscle, and it should not be used in an insulin pump. Do not mix it with other insulins in the same syringe, and do not share pens, even if the needle is changed.
Using the prefilled pen device
The SoloStar device is intended for single-patient use and is designed to deliver a measured dose by dialing units and pressing the injection button. A new sterile needle is typically used for each injection, and the pen is primed per the instructions before dosing to help confirm flow. After injecting, the needle is removed and discarded in a sharps container to reduce leakage and contamination. Quick tip: Keep a spare needle and alcohol swab available when traveling, along with a backup plan for missed doses from the prescriber. For general education on dosing concepts and titration discussions, see Insulin Dosage Chart and the product overview Soliqua Dual Action Guide.
Strengths and Forms
Soliqua is supplied as a prefilled pen that contains a fixed ratio of insulin glargine and lixisenatide. The commonly referenced presentation is Soliqua 100/33 (100 units/mL insulin glargine and 33 mcg/mL lixisenatide) in a 3 mL pen. Packaging and availability can vary by dispensing pharmacy and jurisdiction, so confirm the exact carton configuration during processing.
The product listing for buy Soliqua Solostar Pens reflects the prefilled pen format rather than vials or cartridges. Needles are typically not included with prefilled pens, so they may be obtained separately if needed. For related basal insulin formats, browse Long Acting Insulin.
| Form | Strength | Fill volume |
|---|---|---|
| Prefilled pen (SoloStar) | 100 units/mL insulin glargine + 33 mcg/mL lixisenatide | 3 mL |
Storage and Travel Basics
Storage directions should be checked on the carton and prescribing information for the dispensed product. In general, unopened pens are refrigerated at 2°C to 8°C and protected from light. Do not freeze, and do not use the pen if it has been frozen. Avoid exposing the pen to excessive heat, such as a parked car or direct sunlight, because both insulin and GLP-1 components can degrade with temperature extremes.
After first use, many labels direct that the pen be kept at room temperature (within the label’s stated limit) for a limited in-use period, and the pen cap should stay on when not in use. Do not store a pen with a needle attached. Orders are dispensed by licensed Canadian pharmacies. For travel, carry supplies in hand luggage, keep the prescription label with the carton, and use an insulated bag to reduce temperature swings; avoid placing the pen directly against ice packs.
Side Effects and Safety
Side effects can reflect either component. Gastrointestinal effects such as nausea, vomiting, or diarrhea may occur because of the lixisenatide component, especially when starting or titrating. Hypoglycemia (low blood sugar) can occur due to the insulin glargine component, and the risk may increase with missed meals, changes in activity, or use with other glucose-lowering medicines. Other effects can include headache, upper respiratory symptoms, injection-site reactions, or changes in appetite.
Serious risks can include severe hypoglycemia, allergic reactions, pancreatitis, kidney problems (sometimes related to dehydration from vomiting), and low potassium. Why it matters: Recognizing severe low blood sugar early can prevent injury and emergency care. Monitoring plans (glucose checks, symptom review, and follow-up timing) should be set by a healthcare professional, particularly after starting or adjusting therapy. If documenting side-effect history while planning to buy Soliqua Solostar Pens, include prior reactions to basal insulin or GLP-1 medicines; background reading on the basal insulin component is available in Insulin Glargine Overview.
Drug Interactions and Cautions
Many medicines can affect blood glucose or how symptoms are perceived. Other diabetes medicines (such as sulfonylureas or prandial insulin) may increase hypoglycemia risk when combined with basal insulin, and clinicians may adjust the overall regimen. Beta-blockers can mask some adrenergic warning signs of low blood sugar. Corticosteroids and some antipsychotics can raise glucose and may complicate dose titration.
Because lixisenatide can slow gastric emptying, it may change absorption of certain oral medicines; the label provides guidance for time-sensitive drugs. Combination with other GLP-1 receptor agonists is generally avoided, and this product is not typically used alongside another basal insulin product. If medication reconciliation is being prepared for buy Soliqua Solostar Pens, include over-the-counter products and alcohol use, since both can affect glucose patterns. For a structured overview of basal insulin precautions and common interaction themes, see Lantus Side Effects.
Compare With Alternatives
Fixed-dose basal insulin/GLP-1 combinations are one approach for adults with type 2 diabetes who need both fasting and after-meal support. Another fixed-ratio option is insulin degludec/liraglutide, available as Xultophy Prefilled Pen. Basal insulin alone (without a GLP-1 component) is also commonly used and may be paired with separate non-insulin therapies when appropriate.
Comparisons often involve dosing schedules, titration flexibility, tolerability, and contraindications. For example, basal-only regimens may have fewer GI effects but may not address post-meal glucose as directly as a GLP-1–containing regimen. A commonly used basal insulin pen is Lantus SoloStar Pens, which contains insulin glargine without lixisenatide. Switching between therapies should follow the official prescribing information and prescriber guidance, since starting doses and monitoring needs differ.
Pricing and Access
Pricing depends on the dispensed package size, pharmacy sourcing, and prescription requirements, and totals can differ between people paying out of pocket and those using coverage. The service supports cash-pay access for people without coverage. CanadianInsulin operates as a prescription referral service, and partner pharmacies dispense approved orders after required documentation is received.
For site actions related to buy Soliqua Solostar Pens, be prepared to provide a valid prescription and prescriber contact information so verification can be completed when needed. People managing therapy without insurance may also want to keep a current medication list and recent glucose records ready for their prescriber, since dose titration depends on measured trends. To browse related diabetes therapies by class, use the Diabetes category hub.
Authoritative Sources
For official labeling, indications, and detailed warnings, consult the regulator-approved prescribing information. A neutral starting point is the FDA product record for Soliqua 100/33: FDA Drugs@FDA Application Overview.
Device steps and storage limits can vary by label version and region, so the carton insert and pharmacy-provided leaflet should be treated as the primary instructions for the dispensed pen. Clinicians can also confirm whether co-administered diabetes medicines should be adjusted during initiation and titration.
To submit an order for dispensing, complete the intake steps and select prompt, express, cold-chain shipping when available.
This content is for informational purposes only and is not a substitute for professional medical advice.
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What is Soliqua 100/33 used for?
Soliqua 100/33 is a prescription medicine used in adults with type 2 diabetes to improve blood sugar control, according to the product labeling. It combines insulin glargine, a long-acting (basal) insulin, with lixisenatide, a GLP-1 receptor agonist. Because it contains insulin, it is not used for type 1 diabetes and it is not used to treat diabetic ketoacidosis. Whether it fits a specific treatment plan depends on prior therapy, glucose patterns, and individual risk factors.
How does this pen work differently than basal insulin alone?
Basal insulin alone mainly targets fasting and between-meal glucose by providing a steady background insulin effect. Soliqua combines basal insulin glargine with lixisenatide, which can reduce after-meal glucose spikes by slowing stomach emptying and increasing insulin release in a glucose-dependent way. This means the combination may affect both fasting and post-meal readings, but it also introduces GLP-1–type side effects such as nausea in some people. Clinicians choose between approaches based on goals, tolerability, and contraindications.
When is Soliqua usually injected?
Labeling typically directs Soliqua to be injected once daily within 1 hour before the first meal of the day. It is given subcutaneously (under the skin) using the prefilled pen, with injection sites rotated among recommended areas such as the abdomen, thigh, or upper arm. Because it is a combination product with a maximum daily dose set by the lixisenatide component, dosing schedules and titration should follow the prescribing information. Timing changes or missed-dose plans should be confirmed with a prescriber.
What monitoring is important when starting or adjusting Soliqua?
Monitoring usually focuses on blood glucose trends, symptoms of hypoglycemia, and tolerability during titration. Clinicians often review fasting readings to guide gradual dose changes. Because the product includes a GLP-1 receptor agonist, new or worsening nausea, vomiting, or abdominal pain should be reported, especially if symptoms are persistent. Kidney function may also be considered if significant vomiting or dehydration occurs. Any severe low blood sugar episode, allergic reaction signs, or suspected pancreatitis needs urgent medical evaluation.
What side effects are most common with insulin glargine/lixisenatide?
Common effects may include low blood sugar (from the insulin component), nausea or diarrhea (from the GLP-1 component), headache, and injection-site reactions. Some people notice reduced appetite or mild stomach upset during initiation. More serious risks can include severe hypoglycemia, allergic reactions, pancreatitis, and kidney problems, sometimes related to dehydration from vomiting. Side effects and risk vary by co-medications, meal patterns, and other health conditions. The prescribing information and pharmacist counseling are the best sources for what to watch for.
What should I ask my clinician before switching from my current diabetes medicine?
Key questions include how the starting dose will be selected based on current basal insulin or GLP-1 use, how quickly dose titration should occur, and what glucose targets will be used for adjustments. It is also reasonable to ask whether any other diabetes medicines should be reduced to lower hypoglycemia risk. Discuss medical history that affects GLP-1 therapy, such as prior pancreatitis, severe gastrointestinal disease, or kidney impairment. Finally, confirm device technique, storage limits for the dispensed pen, and what to do if a dose is missed.
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