Trazodone Tablets for Major Depressive Disorder

Trazodone is a prescription antidepressant used to treat major depressive disorder. This page explains how it works, how it is taken, and key safety points. You can explore pharmacy access with US delivery from Canada even without insurance.

What Trazodone Is and How It Works

Trazodone belongs to the serotonin antagonist and reuptake inhibitor class. It helps restore serotonin balance by blocking certain 5-HT2 receptors and modestly inhibiting serotonin reuptake. These actions may improve mood, reduce anxious distress linked to depression, and support sleep continuity for some patients. Sedation and lightheadedness can occur because it also affects histamine and alpha-adrenergic receptors.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. This prescription referral model helps ensure dispensing occurs safely through regulated partners.

Who It’s For

This medicine is indicated for adults with major depressive disorder. It is not approved for use in children. People with a history of hypersensitivity to trazodone should not use it. Avoid use with monoamine oxidase inhibitors or within two weeks of stopping an MAOI. Discuss your medical history, including heart rhythm problems, recent heart attack, bipolar disorder, seizures, angle-closure glaucoma, or low sodium states. Your prescriber will weigh benefits and risks in pregnancy or while breastfeeding.

Dosage and Usage

Follow the dosing schedule provided by your prescriber and the pharmacy label. Tablets are commonly taken after a meal or light snack to reduce stomach upset. Some patients take divided doses during the day and at bedtime; others may take a single bedtime dose as directed. Swallow extended-release tablets whole if prescribed; do not crush or chew them. If given scored tablets, split only along the score line. Do not stop this treatment suddenly unless your clinician directs you to do so.

Strengths and Forms

• Tablets: commonly available in 50 mg, 100 mg, and 150 mg strengths; availability can vary by manufacturer and pharmacy.
• Formats: immediate-release tablets are most common; some markets carry extended-release tablets. Actual stock may differ.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to the next scheduled dose. If it is almost time for the next dose, skip the missed dose. Do not take two doses at the same time. For once-daily bedtime dosing, avoid taking a make-up dose during the day if it causes unwanted drowsiness. Return to your usual schedule the following day.

Storage and Travel Basics

Store tablets at room temperature, away from moisture, heat, and direct light. Keep the bottle tightly closed and out of reach of children and pets. Do not store in a bathroom cabinet where humidity is high. For travel, keep the medicine in your carry-on bag in its original labeled container. Bring a copy of your prescription and your prescriber’s contact information for customs or security checks. If your trip crosses time zones, maintain consistent intervals between doses and ask your healthcare professional for guidance if you are unsure.

Benefits

When used as prescribed, this therapy may help improve core symptoms of depression, including low mood, poor sleep continuity, and anxious distress. Many patients take it at night, which can align with its sedating effects. Generic availability may support broader access. Tablets can be taken with food, which may improve stomach tolerance. Extended-release versions, where available, can simplify schedules for some patients.

Side Effects and Safety

• Drowsiness or fatigue: often most noticeable when starting.
• Dizziness or lightheadedness: may worsen when standing quickly.
• Dry mouth: frequent sips of water can help.
• Nausea or stomach upset: tends to lessen with food.
• Headache: usually mild and transient.
• Blurred vision: typically short-lived.
• Constipation: increase fluids and fiber as advised.
• Sweating or nervousness: monitor and report if persistent.

Serious but less common risks include serotonin syndrome, prolonged or painful erections, heart rhythm changes, severe low blood pressure, severe allergic reactions, and low sodium levels. Antidepressants carry a boxed warning about suicidal thoughts and behaviors in children, adolescents, and young adults. Seek urgent care for symptoms of serotonin toxicity (agitation, confusion, rapid heart rate, fever, stiff muscles) or for priapism. Report mood changes, worsening depression, or unusual behavior promptly.

Drug Interactions and Cautions

Do not use with MAOIs, or within 14 days of MAOI treatment. Combining with other serotonergic drugs can raise the risk of serotonin syndrome; this includes certain SSRIs, SNRIs, triptans, linezolid, and methylene blue. Strong CYP3A4 inhibitors (such as some azoles, macrolide antibiotics, and certain HIV/HCV antivirals) may increase levels of the medicine. CYP3A4 inducers (such as carbamazepine and some anticonvulsants) may lower levels. Alcohol and other sedatives can add to drowsiness and impair coordination. Use caution with medicines that affect heart rhythm. Always provide a full medication and supplement list to your prescriber.

What to Expect Over Time

Effects on sleep and anxiety related to depression may appear earlier, while improvements in mood can take longer. Stay consistent with your dosing schedule and follow up with your clinician to assess response and tolerability. Many side effects lessen as your body adjusts. If you do not feel better or experience troublesome effects, your prescriber may adjust your plan. Never change your regimen on your own.

Compare With Alternatives

Several antidepressants are available if this option is not suitable. SSRIs such as sertraline and fluoxetine are commonly used for major depressive disorder and have different side-effect profiles. Bupropion is another alternative that tends to be less sedating for many patients. Your prescriber can help choose a therapy based on symptoms, medical history, and prior response.

Pricing and Access

Canadian pharmacy pricing can be competitive for many generics, with US delivery from Canada for eligible prescriptions. You can review options and checkout through a secure portal. For those comparing cash-pay choices, see current trazodone price information on the product page before placing an order. Availability varies by strength and quantity.

To look for seasonal offers, visit Promotions. Payment methods are shown at checkout, and encrypted processing helps protect your information. If your doctor sends updated directions, upload them so the pharmacist can dispense accordingly. Ordering multiple months at once may reduce per-unit costs when permitted by your prescriber and your state’s regulations.

Availability and Substitutions

Stock can vary by strength and manufacturer. If a specific version is unavailable, your prescriber may recommend a therapeutically appropriate alternative or a different quantity that fits your regimen. We cannot guarantee restock dates. Pharmacists will dispense an equivalent generic from licensed suppliers that meet regulatory standards.

Patient Suitability and Cost-Saving Tips

• Good candidates: adults diagnosed with major depressive disorder.
• Use caution: cardiac disease, low blood pressure, seizures, glaucoma.
• Avoid: current or recent MAOI therapy, known allergy to trazodone.
• Multi-month fills: ask about 60- or 90-day supplies when appropriate.
• Reminders: set calendar alerts for refills and follow-ups.
• Consistency: take with food at similar times each day.

Questions to Ask Your Clinician

• Is this therapy appropriate for my depression symptoms and medical history?
• How should I take it with meals, and at what time of day?
• Which side effects should prompt a call or visit?
• Could my other medicines raise interaction risks?
• What signs of serotonin syndrome should I watch for?
• How long should I continue before reassessing response?
• If this option is not suitable, which alternatives fit my goals?

Authoritative Sources

• FDA DailyMed
• Health Canada DPD
• FDA: Information About Antidepressants

Ready to proceed? Start your order with US delivery from Canada. This information is educational and does not replace your prescriber’s advice or the approved labeling.