Trelegy Ellipta® Inhaler for COPD and Asthma

This triple-therapy inhaler helps maintain breathing in COPD and adult asthma. Trelegy Ellipta® is taken once daily for long-term control, not for sudden symptoms. This page explains dosing, safety, and how to order Trelegy Ellipta without insurance, with US delivery from Canada.

What Trelegy Ellipta Is and How It Works

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This medicine combines three classes for maintenance control: an inhaled corticosteroid to reduce airway inflammation, a long-acting muscarinic antagonist to limit cholinergic bronchoconstriction, and a long-acting beta2-agonist to relax airway smooth muscle. It is a fluticasone umeclidinium vilanterol inhaler designed for once-daily use. The Ellipta device is breath-actuated; opening the cover loads one sealed blister for inhalation.

Who It’s For

This treatment is indicated for maintenance therapy in adults with chronic obstructive pulmonary disease and for maintenance treatment of asthma in adults. It is not a rescue inhaler and should not be used to relieve sudden breathing symptoms. For acute episodes, patients typically need a short-acting bronchodilator. Learn more about these conditions in our categories for Asthma and COPD.

People with severe milk protein allergy or known hypersensitivity to any component should not use this product. Those with narrow-angle glaucoma or urinary retention should use caution and discuss risks with a clinician.

Dosage and Usage

Use one inhalation once daily at the same time each day. Do not take more than one inhalation in 24 hours. This inhaler is for ongoing control; continue regular use as directed by your clinician.

How to use the device (high level):

• Open the cover fully until it clicks to load a dose
• Exhale away from the mouthpiece before positioning the device
• Seal lips around the mouthpiece and take a long, steady, deep breath
• Remove the inhaler, hold breath briefly, then breathe out slowly
• Rinse mouth and spit to reduce the risk of oral thrush

Do not shake the device or block the air vents. Keep the cover closed when not in use. The dose counter shows remaining inhalations on the 30-dose inhaler.

Strengths and Forms

The Ellipta device contains sealed unit-dose blisters. Common presentations include:

• Trelegy Ellipta 100/62.5/25 for once-daily maintenance
• Also available in 200/62.5/25 for patients who require a higher inhaled steroid dose per label

Each inhaler is typically a 30-dose device. Availability may vary by pharmacy and jurisdiction.

Missed Dose and Timing

If you miss a dose, inhale it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose. Do not take two doses on the same day. Maintain a consistent daily schedule whenever possible.

Storage and Travel Basics

Store the inhaler at room temperature, in a dry place, with the cover closed. Keep it in the sealed tray until first use. After opening, follow the package instructions and discard the device when the counter reads zero. Keep out of reach of children.

When you travel, pack the inhaler in your carry-on to avoid temperature extremes. Keep the label and a copy of your prescription with you for screening. Avoid moisture; do not wash the device. For broader respiratory tips, see Respiratory Health.

Benefits

Triple therapy in one device may simplify maintenance care by combining an inhaled steroid, a LAMA, and a LABA. Once-daily dosing supports consistent use. The device is breath-actuated and includes a visible dose counter. Mouth rinsing after inhalation can reduce the chance of oral thrush.

Side Effects and Safety

• Throat irritation or hoarseness
• Cough or upper respiratory infection
• Headache or back pain
• Oral candidiasis (thrush)
• Sinusitis or sore throat
• Dry mouth
• Tremor or fast heartbeat

Serious or rare risks can include pneumonia in COPD, hypersensitivity reactions including anaphylaxis, paradoxical bronchospasm, effects consistent with systemic corticosteroids, increased intraocular pressure or glaucoma, and urinary retention. Seek urgent care for swelling, rash, or breathing that worsens rapidly. This inhaler is not for relief of acute bronchospasm; keep a rescue inhaler available per your clinician’s guidance.

Drug Interactions and Cautions

• Strong CYP3A4 inhibitors (for example, ketoconazole, ritonavir) may increase systemic exposure
• Other long-acting beta2-agonists or anticholinergics may raise side-effect risk; avoid duplicate classes
• Nonselective beta-blockers may reduce bronchodilation
• MAO inhibitors or tricyclic antidepressants may potentiate cardiovascular effects
• Diuretics that lower potassium can increase hypokalemia risk with beta2-agonists

Use caution with glaucoma or urinary retention. Monitor for infections with inhaled corticosteroid use. For background topics, see Respiratory Acidosis.

What to Expect Over Time

With consistent daily use, maintenance therapy may help improve lung function and reduce exacerbations. Do not stop suddenly without talking to a clinician. Track symptoms, inhaler use, and rescue inhaler needs. If control is inadequate, your prescriber may reassess the regimen or device technique. Read about risks tied to chronic lung disease in Respiratory Complications.

Compare With Alternatives

Dual therapy ICS/LABA combinations, such as Advair Diskus, may be appropriate when triple therapy is not required. A long-acting muscarinic antagonist delivered via soft-mist device, such as Spiriva Respimat, can also be considered based on diagnosis and control needs. Selection depends on symptoms, exacerbation history, and inhaler technique.

Pricing and Access

Canadian pricing may offer cash-pay value compared with some local options. Check the Trelegy Ellipta price on this product page to review current pricing and typical out-of-pocket details. Orders Ships from Canada to US with prescription verification. We provide secure, encrypted checkout. If you are seeking a coupon, see our current notices on Promotions.

Availability and Substitutions

Supply can vary. If unavailable, a prescriber may recommend a clinically appropriate alternative within the same class or a dual therapy option. There is no approved Trelegy Ellipta generic equivalent in the United States or Canada at this time. Substitutions require a valid prescription and pharmacist review.

Patient Suitability and Cost-Saving Tips

Good candidates are adults who need once-daily maintenance control for COPD or asthma per label and have demonstrated correct inhaler technique. Those with severe milk protein allergy or significant sensitivity to any component should avoid use. People with glaucoma or urinary retention need careful monitoring.

Cost-saving basics:

• Multi-month refills: fewer fees per shipment and fewer pharmacy touches
• Refill reminders: set calendar alerts to avoid gaps
• Bundle orders: combine maintenance items when possible
• Use cash-pay comparisons: review Canadian pricing versus local pharmacy

Questions to Ask Your Clinician

• Daily use goals: what does good control look like for me
• Inhaler technique: how to optimize seal and inhalation
• Mouth rinse: how and when to reduce thrush risk
• Rescue plan: which symptoms need quick-relief medicine
• Interaction risks: which medicines or supplements to avoid
• Follow-up: when to reassess control or device fit

Authoritative Sources

Manufacturer Product SiteFDA DailyMed (Label Search)Health Canada Drug Product Database

Start your order online. Buy fluticasone umeclidinium vilanterol inhaler with prompt US shipping from Canada and temperature-controlled handling when required. This information is educational and does not replace medical advice; follow your prescription and the official label.