Vetoryl® Capsules for Cushing's Disease in Dogs

What Vetoryl Is and How It Works

Vetoryl is a veterinary prescription capsule used to manage canine Cushing’s disease. Orders are available with US delivery from Canada, helping many pet owners who pay without insurance. CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

The active ingredient in Vetoryl® trilostane reduces cortisol production in the adrenal glands. Trilostane inhibits a key enzyme in the steroid pathway, which can lower excessive cortisol levels. This medicine is used for both pituitary-dependent and adrenal-dependent forms of the condition. Your veterinarian monitors response and safety with scheduled blood tests.

Who It’s For

Vetoryl for dogs is indicated for the treatment of hyperadrenocorticism due to pituitary or adrenal disease. It may help reduce excessive thirst, urination, panting, and abdominal changes associated with cortisol excess. This treatment is for dogs only and is not for other species.

Do not use this medicine in dogs that are pregnant, nursing, or intended for breeding. Avoid use in dogs with known hypersensitivity to trilostane. Caution is advised in dogs with kidney or liver disease, low blood pressure, or electrolyte abnormalities. Dogs with primary hypoadrenocorticism should not receive this therapy.

For condition education and related options, see Canine Cushing’s Disease.

Dosage and Usage

Administer capsules by mouth with food, at the same time each day, or as directed by your veterinarian. Your veterinarian determines vetoryl dosing based on weight, clinical signs, and lab results. Do not change the dose or schedule without veterinary guidance.

Swallow the capsule whole. Do not open, split, or crush. If you handle broken capsules or contents, wash hands promptly and avoid contact with eyes or mouth. Keep a dosing log to track administration and observed changes at home.

Regular monitoring is important. Veterinarians commonly use ACTH stimulation testing and resting cortisol checks to assess effect and safety. Never discontinue abruptly unless your veterinarian instructs you to stop.

Strengths and Forms

This treatment is supplied as oral capsules in multiple strengths to support tailored therapy. Commonly available sizes include 5 mg, 10 mg, 30 mg, 60 mg, and 120 mg capsules. Your veterinarian will select an appropriate strength for your dog’s weight and condition.

Do not interchange products without consulting your veterinarian. When filling refills, confirm the same strength and capsule count to maintain consistency. The term vetoryl capsules refers to these trilostane oral capsule presentations for dogs.

Missed Dose and Timing

If you miss a dose, give it when you remember unless it is close to the next scheduled dose. If it is near the time for the next dose, skip the missed dose and resume the regular schedule. Do not give two doses at once.

If your dog vomits soon after a dose, contact your veterinarian for guidance. Maintaining a consistent dosing time and giving with food can support steady absorption.

Storage and Travel Basics

Store at room temperature as directed on the label. Keep the bottle tightly closed and protect the capsules from moisture. Keep vetoryl capsules for dogs out of reach of children and other animals.

Do not use capsules that are damaged or opened. If a capsule breaks, avoid contact with the contents. Wash hands after handling the bottle. When traveling, carry the prescription label and enough supply for the trip. Use the original container, and pack it in a dry, secure place in your carry-on if flying. Ask your veterinarian for a travel letter if needed.

Benefits

This medicine targets cortisol overproduction at its source. Many dogs may show improved thirst, urination, panting, and energy with appropriate monitoring. The capsule strengths allow precise adjustments guided by clinical response and lab testing.

Once-daily administration is common, though some dogs may receive a split schedule based on veterinary judgment. Consistent administration with food helps support predictable absorption.

Side Effects and Safety

• Reduced appetite
• Vomiting
• Diarrhea or soft stool
• Lethargy or decreased activity
• Weakness
• Electrolyte changes on bloodwork

Serious effects can occur if cortisol is suppressed too much. Signs may include severe lethargy, collapse, vomiting, diarrhea, or hypovolemic shock. Rarely, adrenal necrosis or acute adrenal insufficiency can develop. Seek immediate veterinary care if severe signs occur. Routine blood testing helps detect issues early.

Use caution in dogs receiving medications that affect electrolytes or blood pressure. Dogs with underlying cardiac, renal, or hepatic disease may require closer supervision.

Drug Interactions and Cautions

Tell your veterinarian about all medicines, supplements, and diets. Caution may be needed with ACE inhibitors, potassium-sparing diuretics, or drugs that can increase potassium levels. Concurrent glucocorticoids can alter testing and clinical response; your veterinarian will guide if steroids are indicated.

Drugs that affect adrenal steroid synthesis or metabolism may interact. Your veterinarian will determine appropriate intervals for testing relative to dosing and other therapies.

What to Expect Over Time

With careful titration and monitoring, clinical signs may gradually improve. Your veterinarian will interpret lab results alongside your observations at home. Dose adjustments, if needed, are based on tests and clinical response.

Keep a daily log of water intake, urination, appetite, activity, and any gastrointestinal signs. Provide this information during rechecks. Consistency with administration and follow-up testing supports long-term control.

Compare With Alternatives

Other veterinary options for canine Cushing’s disease include mitotane and selegiline in selected cases. Each option has distinct monitoring needs and risk profiles. Your veterinarian can advise the best path based on pituitary versus adrenal disease and your dog’s overall health.

For broader education about the condition, review our category resource on Canine Cushing’s Disease.

Pricing and Access

Many owners compare vetoryl cost across pharmacies when managing a chronic condition. Canadian pricing with US fulfilment can be a practical option. You can review capsule strengths, check availability, and place an order through our secure checkout. We do not display pharmacy coupons, but periodic offers may appear on our Promotions page.

Orders ship from licensed Canadian pharmacies to the United States. You can compare sizes and quantities to fit your veterinarian’s plan. If you pay without insurance, multi-pack fills may reduce per-bottle fees compared with smaller repeats.

Availability and Substitutions

Availability can vary by strength. If a specific capsule size is temporarily unavailable, your veterinarian may recommend a different strength or schedule. Do not substitute or change products without veterinary approval.

Note for horse owners: pituitary pars intermedia dysfunction is managed with pergolide. See Prascend® for equine PPID information. For pet owners seeking a broader selection, browse our category for Pet Medications.

Patient Suitability and Cost-Saving Tips

This therapy may suit adult dogs with confirmed hyperadrenocorticism who can attend scheduled blood tests. It may not be appropriate for breeding animals or dogs with adrenal insufficiency. Dogs with significant renal, hepatic, or cardiac disease need careful evaluation.

To manage ongoing costs, ask your veterinarian about longer-duration prescriptions, if appropriate. Align refills with planned recheck dates to avoid gaps. Consider ordering multiple bottles when stable on a dose to reduce per-order fees. Set calendar reminders so you do not run out before testing appointments.

Questions to Ask Your Clinician

• Diagnosis details: pituitary versus adrenal disease
• Initial dose range and timing with food
• Monitoring plan: tests and visit schedule
• Signs of over-suppression to watch for
• What to do if vomiting or diarrhea occurs
• When to adjust dose or timing
• Plans if surgery is being considered

Authoritative Sources

For official prescribing and safety information, consult these sources:

• Manufacturer information from Dechra Veterinary Products describing trilostane capsules and labeled use in dogs. Dechra Vetoryl Capsules
• FDA Center for Veterinary Medicine listing for trilostane capsules with labeling and updates. FDA Animal Drugs Listing
• Health Canada Drug Product Database entry for trilostane veterinary product details. Health Canada DPD

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.