Vetoryl (trilostane) Capsules

Vetoryl is a prescription veterinary medicine used to manage canine hyperadrenocorticism (Cushing’s disease). This page summarizes practical basics for Vetoryl for dogs, including how it works, typical monitoring, and key safety points. It also explains access steps for cash-pay options, including for those without insurance.

What Vetoryl for dogs Is and How It Works

This product contains trilostane, an adrenocortical hormone synthesis inhibitor (reduces adrenal steroid production). By limiting cortisol production, it can help control clinical signs linked to excess cortisol (a stress hormone). Licensed Canadian pharmacies dispense prescriptions through our platform, and the service model includes Ships from Canada to US when documentation is complete.

In most cases, treatment is aimed at controlling signs rather than curing the underlying cause. Canine hyperadrenocorticism is commonly pituitary-dependent (a pituitary tumor drives adrenal overproduction) or adrenal-dependent (an adrenal tumor produces hormones). Diagnosis and follow-up are veterinary-led and typically involve bloodwork and clinical sign review. Prescription details may be confirmed with the prescribing veterinarian when required. For broader background, the Canine Cushing’s Disease hub lists related options and topics.

Who It’s For

This therapy is prescribed for dogs diagnosed with naturally occurring hyperadrenocorticism. Veterinarians usually consider it when clinical signs and laboratory testing support the diagnosis. Common signs that prompt evaluation include increased thirst and urination, increased appetite, panting, skin or coat changes, and a pot-bellied appearance. Because those signs overlap with other endocrine conditions, diagnosis often includes rule-outs and baseline organ function testing.

Not every dog is a candidate. A veterinarian may avoid or use extra caution in dogs with significant liver or kidney disease, electrolyte abnormalities (blood salts out of range), or other serious concurrent illness. It is generally not used in pregnant or breeding animals unless a veterinarian determines the benefits outweigh risks. For owners managing multiple pet prescriptions, the Pet Medications category is a browseable list of veterinary products and supplies. Some signs can also resemble diabetes; the resource on Diabetes Signs in Dogs provides context for that overlap.

Dosage and Usage

Vetoryl dosing is individualized by a veterinarian based on body weight, the type of hyperadrenocorticism suspected, concurrent conditions, and follow-up test results. Vetoryl for dogs is commonly given by mouth on a consistent schedule, often with food to support predictable absorption. Capsules should be swallowed whole, and they should not be split or opened unless a veterinarian provides specific handling directions.

Ongoing follow-up is part of safe use. A veterinarian may schedule repeat blood testing after starting therapy and after dose adjustments, then at regular intervals once stable. Monitoring can include an ACTH stimulation test (a cortisol response blood test), electrolyte checks, and assessment of clinical signs at home. If a dose is missed, clinics commonly advise giving the next dose at the usual time rather than doubling up; follow the prescriber’s instructions on the label.

Dogs with endocrine comorbidities may need coordinated care plans. When diabetes management is part of the picture, the guides on Insulin for Dogs and Pet Insulin Dosing Mistakes outline general safety concepts to discuss with a clinic.

Strengths and Forms

This medication is supplied as Vetoryl capsules, not tablets. Some online searches use the phrase “Vetoryl tablets,” but the labeled presentation is a capsule intended to be swallowed whole. A veterinarian chooses a strength and capsule count that matches the prescribed regimen, and availability can vary by pharmacy supply and local regulations.

Vetoryl for dogs may be prescribed across several capsule strengths to support flexible dosing. Common labeled strengths include:

When reading a label, match the mg strength to the veterinarian’s instructions. For example, “Vetoryl 30 mg” and “Vetoryl 30mg” refer to the same strength, and “Vetoryl 60 mg” is the same as “Vetoryl 60mg.”

Storage and Travel Basics

Store capsules at room temperature and protect them from moisture and heat. Keep the medicine in its original packaging until use, and keep it out of reach of children and pets. If a capsule is damaged, avoid contact with the contents and follow the package guidance for safe cleanup and disposal.

Quick tip: Keep a photo of the prescription label for reference while traveling.

For travel, use a rigid container to prevent crushed capsules and avoid leaving medication in a hot car. If traveling with a dog that has complex endocrine disease, it can help to carry recent lab summaries and the clinic’s contact information. Dispensing is handled by licensed Canadian pharmacies once prescription documentation is accepted. If storage instructions on the pharmacy label differ from general guidance, follow the label.

Side Effects and Safety

Like many endocrine therapies, Vetoryl for dogs can cause gastrointestinal and energy-level changes, especially early in treatment or after a dose change. Reported effects can include decreased appetite, vomiting, diarrhea, and lethargy. Some dogs may also show changes in drinking or urination patterns as hormone levels shift.

More serious reactions can occur if adrenal hormone production becomes too low. Concerning signs may include marked weakness, collapse, severe vomiting or diarrhea, shaking, or signs of dehydration. These symptoms warrant urgent veterinary assessment because they can be consistent with adrenal insufficiency (too little cortisol and sometimes too little aldosterone). Clinics may recommend temporarily stopping the medicine until evaluation is complete, but any change should be directed by a veterinarian.

Why it matters: Early recognition of low-cortisol symptoms can reduce the risk of complications.

Safety planning typically includes periodic labwork and consistent observation of appetite, activity, and water intake. If a dog has diabetes or develops high blood sugar during evaluation, the overview on Hyperglycemia in Dogs provides supportive context for what the clinic may monitor.

Drug Interactions and Cautions

Vetoryl for dogs should be reviewed alongside all other prescriptions and supplements. Caution is often advised with medications that can affect blood pressure or potassium balance, including some heart and kidney drugs. NSAIDs (nonsteroidal anti-inflammatory drugs) and certain diuretics may also require closer monitoring depending on a dog’s overall health and lab trends.

Endocrine overlap is common in older dogs. If a dog is receiving insulin or other glucose-lowering therapy, a veterinarian may adjust plans based on appetite changes and shifts in cortisol status. Day-to-day technique issues can matter for diabetes supplies; the guide Insulin Pen vs Syringe reviews handling differences that owners often discuss with clinics. Preventive care still matters during long-term endocrine treatment, and the article Preventing Diabetes in Pets summarizes modifiable risk factors that may be relevant for some households.

Compare With Alternatives

Management options for canine hyperadrenocorticism depend on the suspected cause, comorbidities, and what monitoring is feasible. Another medical option sometimes used is mitotane, which works differently than trilostane and may have a separate monitoring profile. In selected cases, referral-level approaches such as adrenal tumor surgery (adrenalectomy) or radiation therapy may be discussed, especially when imaging identifies a mass or when neurologic signs are present.

The comparison below is a practical framing to support discussions with a veterinary team:

Some complications of Cushing’s treatment can resemble different adrenal disorders. If a veterinarian diagnoses hypoadrenocorticism (Addison’s disease), therapies differ and may include mineralocorticoid replacement such as Zycortal Details or Percorten V Details, which are not substitutes for trilostane but may come up in differential diagnosis discussions.

Pricing and Access

Out-of-pocket costs for Vetoryl for dogs can vary based on capsule strength, quantity dispensed, and the monitoring plan set by the veterinarian. When comparing options, focus on the full care pathway: medication supply, required follow-up testing, and refill cadence. Educational material on Support for Pet Diabetes also describes how ongoing chronic-condition routines are commonly organized, which can be helpful for multi-condition households.

CanadianInsulin operates as a prescription referral platform that coordinates access to prescription medications dispensed by licensed Canadian pharmacies. The service helps enable cross-border access using cash-pay when coverage is unavailable. To start, submit a valid veterinary prescription and ensure the clinic contact details are current in case verification is needed. For site-wide updates, see Promotions. For general guidance on evaluating online sources, the article Finding Pet Medications Online outlines practical checks such as prescription requirements and clear pharmacy documentation.

Authoritative Sources

For a detailed medical overview of canine hyperadrenocorticism, consult the veterinary reference: Hyperadrenocorticism in Dogs.

For U.S. regulatory listing information, use the FDA database: Animal Drugs @ FDA Search.

To proceed with dispensing, submit the prescription and select prompt, express, cold-chain shipping where appropriate.

This content is for informational purposes only and is not a substitute for professional medical advice.