Xigduo® Tablets for Type 2 Diabetes

What Xigduo Is and How It Works

Xigduo® is a fixed-dose combination tablet that contains dapagliflozin and metformin hydrochloride in an extended-release base. It helps improve blood glucose control in adults with type 2 diabetes. This page covers approved uses, safety, and how to place an order with US delivery from Canada, and lets you review options without insurance.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that lowers renal glucose reabsorption, which increases urinary glucose excretion. Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity. Using both agents together targets complementary pathways that may support fasting and post‑meal control when combined with diet and activity.

This medicine is not for type 1 diabetes or diabetic ketoacidosis. Refer to the approved product label for complete prescribing information. To learn more about this class, see SGLT2 Inhibitors.

Who It’s For

The treatment is indicated as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes. It should not be used by people with severe kidney disease, metabolic acidosis, or a history of serious hypersensitivity to dapagliflozin or metformin. Clinicians generally avoid initiation in significant renal impairment and reassess use if kidney function declines. It is not a substitute for insulin in those who require insulin.

Dosage and Usage

The combination is usually taken once daily with a meal to reduce gastrointestinal side effects. Swallow tablets whole with water; do not split, crush, or chew. On initiation, prescribers often match the metformin component to the patient’s current regimen and add the SGLT2 component accordingly. Hydration matters because the SGLT2 inhibitor can increase urination. If radiologic studies with iodinated contrast are planned, or if major surgery is scheduled, a temporary hold may be advised per the official label and clinician guidance. For background on classes used in oral therapy, see Oral Insulin Medications.

Strengths and Forms

Extended-release tablets are available in multiple fixed-dose strengths. Common presentations include:

• 5 mg/500 mg extended-release tablets
• 5 mg/1000 mg extended-release tablets
• 10 mg/500 mg extended-release tablets
• 10 mg/1000 mg extended-release tablets

Availability and pack sizes may vary by pharmacy and region.

Missed Dose and Timing

If a dose is missed, take it when remembered unless it is close to the next scheduled dose. In that case, skip the missed dose and resume the regular schedule. Do not take two doses at once to make up for a missed tablet. Maintain a consistent routine with meals to support tolerability.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess heat and moisture. Keep the bottle tightly closed and out of reach of children and pets. Use the original labeled container for identification. When traveling, keep medicine in carry-on luggage with the prescription label visible. Pack enough tablets for the trip plus a short buffer. Carry a copy of the prescription and a medication list. Do not store tablets in a car glovebox or other environments with wide temperature swings.

Benefits

This medicine combines two established agents in one daily tablet. Extended-release metformin may improve gastrointestinal tolerability for some patients compared with immediate-release regimens. Using a single combination tablet can simplify routines versus taking separate products. The SGLT2 component supports urinary glucose excretion, while the biguanide component addresses hepatic glucose output, providing complementary coverage alongside diet and physical activity.

Side Effects and Safety

• Gastrointestinal upset such as nausea, diarrhea, or stomach discomfort
• Increased urination or thirst
• Genital yeast infections
• Urinary tract infections
• Headache or dizziness
• Back pain
• Mild decreases in blood pressure from fluid loss
• Metallic taste or decreased appetite

Serious effects are uncommon but can include lactic acidosis with metformin (higher risk with significant kidney disease or acute illness), ketoacidosis with SGLT2 inhibitors even when glucose is not markedly elevated, dehydration, acute kidney injury, and rare cases of necrotizing fasciitis of the perineum. Severe allergic reactions can occur. Hypoglycemia risk increases when this medicine is used with insulin or sulfonylureas. Seek medical attention for symptoms of severe infection, marked weakness, unusual shortness of breath, or persistent vomiting.

Drug Interactions and Cautions

Important interactions and cautions include:

• Iodinated contrast studies or major surgery, where temporary interruption may be recommended
• Insulin or insulin secretagogues, which can increase hypoglycemia risk
• Diuretics and renin-angiotensin agents, which can affect fluid status and kidney function
• Cationic drugs such as cimetidine, which may influence metformin levels
• Excess alcohol intake, which raises lactic acidosis risk with metformin
• Conditions causing hypoxia or dehydration

Review all medicines and supplements with a healthcare professional, including over-the-counter products.

What to Expect Over Time

Most patients use this therapy long term as part of a broader diabetes plan. Clinicians monitor A1C, fasting glucose, kidney function, and tolerability at routine intervals. Diet quality, physical activity, and hydration can influence results. Consistent daily timing with food may improve comfort. If side effects occur, contact a prescriber to discuss next steps, which may include dose adjustments, supportive care, or reassessment of therapy based on the official label.

Compare With Alternatives

Alternatives include single-agent SGLT2 inhibitors or other fixed-dose combinations that pair different mechanisms. Options we offer include Farxiga® Dapagliflozin and Invokamet®. Choice depends on goals, kidney function, tolerability, and background therapy. For broader context on treatment classes, see Diabetes Medications.

Pricing and Access

Compare Canadian pricing with US delivery from Canada to see typical cash-pay differences. If your prescription specifies Xigduo XR 5 mg 1000 mg, select the matching strength during checkout. To view current options, check the pricing section on this page. When ready, start an order to upload a prescription and choose fulfilment from licensed partners.

Looking for a coupon? See current site offers on Promotions. For related categories and background, visit Blood Sugar Control.

Availability and Substitutions

Stock may vary by strength and supplier. If a specific presentation is unavailable, a prescriber may recommend an alternative with comparable components or a different class based on clinical goals. Pharmacy teams dispense the exact product written on a valid prescription unless the prescriber authorizes substitutions.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with type 2 diabetes who need additional glycemic control and can follow the monitoring plan. Those with severe renal impairment, metabolic acidosis, or prior serious hypersensitivity to components should avoid this therapy. Discuss suitability if there is a history of frequent urinary infections, volume depletion, or conditions that raise lactic acidosis risk.

• Multi-month supply: Ask about 60- to 90-day fills to reduce per-fill costs.
• Coordinate refills: Set calendar reminders to avoid urgent replacement orders.
• Bundle items: When possible, combine non-urgent medicines in one delivery.
• Travel planning: Carry enough tablets plus a small buffer in hand luggage.
• Compare classes: Review alternatives with a clinician if tolerability or access changes.
• Education: Learn how classes work via Diabetes Medications and Buy Glumetza From Canada.

Questions to Ask Your Clinician

• Is this combination appropriate for my goals and kidney function?
• How should I coordinate timing with other diabetes therapies?
• What signs of lactic acidosis or ketoacidosis should prompt urgent care?
• When should therapy be paused for surgery or contrast imaging?
• How often will labs be checked to assess safety and effect?
• Could another class be a better fit if side effects occur?
• What steps can I take with diet and activity to support control?

Authoritative Sources

• Manufacturer Product Information
• FDA DailyMed
• Health Canada Drug Product Database

Ready to proceed? Place your order for prompt US delivery from Canada with temperature-controlled handling when required. This information is educational and does not replace advice from your healthcare professional.