What is Macugen?

Macugen (pegaptanib sodium injection) is a sterile solution that contains the active ingredient pegaptanib sodium. Macugen solution is supplied in a single-dose, pre-filled syringe and it is administered via intravitreous injection (into the eye).

Pegaptanib (the active ingredient) belongs to a class of drugs called selective vascular endothelial growth factor (VEGF) antagonists. VEGF causes angiogenesis, and increases vascular permeability and inflammation, all of which are thought to contribute to the development and progression of the neovascular (wet) form of age-related macular degeneration (AMD), which is known to be a leading cause of blindness.

What is Lucentis?

Lucentis (ranibizumab injection) is a prescription medication indicated for the following conditions: wet age-related macular degeneration (AMD), macular edema following retinal vein occlusion (RVO), diabetic macular edema (DME), diabetic retinopathy (DR), and myopic choroidal neovascularization (mCNV).

Lucentis is supplied as a single-use prefilled syringe for ophthalmic intravitreous injection. It is a recombinant monoclonal antibody. This product inhibits the activity of VEGF-a by binding action. The use of this drug can cause retinal detachment. Intravitreal injections are also associated with endophthalmitis and increases in intraocular pressure.

What is the difference between Macugen vs. Lucentis?

Macugen and Lucentis are both anti-VEGF drugs that have shown promise in treating age-related macular degeneration. Both are capable of effective action against the disease. However, the main consideration to evaluate is the side effect profiles of each product. Patients should consult closely with their prescribing physician before undertaking a treatment regimen with either Macugen or Lucentis.

Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.