In type 2 diabetes, several medications are available that can help regulate blood sugar levels and improve overall health. Two commonly prescribed drugs for this purpose are Avandia and Metformin. However, it’s challenging to determine which one is more suitable for an individual. In this article, we will explore the key differences between Avandia and Metformin, providing valuable insights to assist you in making an informed decision with the guidance of your healthcare provider.

Metformin vs Avandia: Definition and Uses

Metformin belongs to the biguanide class of drugs and effectively reduces the liver’s glucose production while improving the body’s response to insulin. Doctors prescribe it widely, available in various forms such as tablets, extended-release tablets, and liquids. Typically, we take Metformin once or twice daily, usually with meals.

Avandia, also known by its generic name Rosiglitazone, is classified as a thiazolidinedione medication. Its primary mode of action is increasing the sensitivity of the body’s cells to insulin. By doing so, Avandia helps the body use insulin more efficiently to lower blood sugar levels. Avandia is typically available in pill form, and we take it once or twice daily, often with meals.


Metformin is a potent medication for treating type 2 diabetes and is highly effective in reducing the incidence of diabetes in at-risk individuals. A study called the Diabetes Prevention Program found that intensive lifestyle alterations and Metformin therapy decreased the risk of developing diabetes by 58% and 31%, compared with a placebo, in at-risk individuals. The study also showed that Metformin was even more effective for those who were more overweight, had higher fasting glucose levels, had a history of gestational diabetes, or were younger. Over 15 years, Metformin reduced diabetes risk by 18% compared to placebo while minimizing complications in those who didn’t develop diabetes and potentially positively affecting heart health in men based on calcium assessments.

In contrast, Avandia or Rosiglitazone belongs to the thiazolidinedione class of medications and effectively enhances insulin sensitivity in the body’s cells. Numerous studies have analyzed the effectiveness and safety of this medication in treating type 2 diabetes. A study involving 493 patients with type 2 diabetes tested the efficacy and safety of Rosiglitazone by dividing them into two groups after a four-week placebo period. One group received Rosiglitazone at various doses, while the other continued receiving the placebo for 26 weeks. The study measured hemoglobin A1c, blood sugar levels, insulin, urinary albumin, cholesterol, and side effects. The results showed that Rosiglitazone significantly decreased hemoglobin A1c, blood sugar, and urinary albumin levels, especially at higher doses. It also boosted insulin sensitivity and improved how well the pancreas works. According to the research, there were no notable side effects.

In conclusion, Metformin is an effective treatment for type 2 diabetes and is highly effective in reducing the incidence of diabetes, particularly in those who are overweight, have high fasting glucose levels, have a history of gestational diabetes, or are younger. On the other hand, Rosiglitazone can be a safe and effective type 2 diabetes treatment, especially when lifestyle modifications alone are insufficient.


Cost can also be a significant element when choosing between Metformin and Avandia. Metformin is usually available as a low-cost generic medication, making it more accessible for many individuals. Avandia, being a brand-name drug, is often more expensive.

The average price for a month’s supply of generic Metformin ranged from $4 to $20, depending on the dosage and quantity. Meanwhile, the cost of Avandia or its generic version, Rosiglitazone, can vary, ranging from $100 to over $300.

You can buy Metformin and Avandia at a lower rate for a more budget-friendly option from a reputable online pharmacy like

Side Effects

Metformin is well-tolerated, but like any medication, it can cause side effects in some individuals. Common side effects of Metformin include gastrointestinal symptoms such as diarrhea, nausea, vomiting, stomach discomfort, and loss of appetite. However, having Metformin with meals can minimize these side effects. In rare cases, Metformin may cause a serious condition called lactic acidosis, characterized by an accumulation of lactic acid in the blood. This condition is more likely to occur in individuals with kidney or liver problems and those with certain medical conditions. You must inform your healthcare provider if you experience any unusual symptoms while taking Metformin.

As for Avandia (Rosiglitazone), studies have shown potential side effects, although they are usually well-tolerated. Common side effects of Avandia include weight gain, edema (swelling), increased cholesterol levels, and bone fractures in women. Experts have often associated Avandia with an increased risk of heart problems, although risk remains a subject of ongoing debate and research. In fact, because of concerns regarding cardiovascular safety, Avandia has been subject to regulatory restrictions in some countries. It is essential to discuss the potential risks and benefits of Avandia treatment with your healthcare provider.

It is worth noting that side effects can vary from person to person, and not everyone experiences them. It is crucial to consult with your healthcare provider for personalized information about the side effects of these medications and to discuss any concerns you may have. They can provide the most up-to-date information based on your health condition and individual factors.

Which is better?

Avandia and Metformin are valuable medications for managing type 2 diabetes, but they have different mechanisms of action, potential side effects, and costs. Your healthcare provider is the best resource for helping you decide which is right based on your health and financial considerations.

Maintaining regular communication with your healthcare team while taking either of these medications is essential, especially in monitoring your condition and adjusting your treatment plan.

Always follow your healthcare provider’s recommendations and never change your diabetes medication regimen without their guidance. They will work with you to find the most effective and safe treatment plan to manage your diabetes and improve your overall well-being.