Wegovy vs Saxenda. Wegovy and Saxenda are both popular medications for weight loss management in overweight or obese adults. They belong to the same class of drugs called GLP-1 receptor agonists, but differ in their active ingredients and approved uses. Both semaglutide and liraglutide are synthetic versions of the hormone GLP-1, which works by regulating blood sugar levels and appetite. They also reduce hunger and increase feelings of fullness, leading to reduced calorie intake.

In addition to weight management indication, Saxenda is also FDA-approved for type 2 diabetes treatment. It reduces the risk of major adverse cardiovascular events in adults diagnosed with type 2 diabetes.


Clinical studies have shown that both Wegovy and Saxenda are effective in promoting weight loss. However, Wegovy has demonstrated slightly greater weight loss efficacy in some trials compared to Saxenda. In one trial, Wegovy resulted in an average weight loss of 15% of body weight. On the other hand, Saxenda only recorded weight loss of 8% of body weight.

Dosage and Administration

The following includes the proper dosage and administration of both Wegovy and Saxenda.

Wegovy is administered as a once-weekly subcutaneous injection. The dosage increases every four weeks until you reach a total dose of 2.4 mg once weekly. 

It comes in five strengths, such as:

  • 0.25 mg
  • 0.5 mg
  • 1 mg
  • 1.7 mg
  • 2.4 mg

Saxenda is administered as a once-daily subcutaneous injection. Its doses also slowly increase until you reach the daily dosage of 3 mg. It is available in different dosage strengths, including:

  • 0.6 mg
  • 1.2 mg
  • 1.8 mg
  • 2.4 mg
  • 3 mg

Cost Difference

Wegovy is more expensive than Saxenda, with an average cost of $1,349.02 for its complete package, while Saxenda costs $545.44 for one pack with five pre-filled syringes x 3ml each – 6 mg/ml.

Side Effects

Both Wegovy and Saxenda can cause similar side effects. These are as follows:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Decreased appetite

There is also a potential risk of severe side effects like pancreatitis and gallbladder disease, although the overall risk is relatively low.

Which is better?

Choosing between Wegovy and Saxenda depends on several factors, including your weight, age, medical history, other medications you are taking, and potential drug interactions. Consult with a healthcare professional to determine which medication is best suited for your specific needs and condition.

In conclusion, both Wegovy and Saxenda are effective medications for weight loss management. While Wegovy may offer slightly greater weight loss efficacy, Saxenda is more affordable. Ultimately, the choice between the two medications should be made with the guidance of a healthcare professional.