Duloxetine, marketed under the brand name Cymbalta, is a medication developed by Eli Lilly and Company. Approved by the FDA in 2004, Cymbalta is commonly used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and diabetic peripheral neuropathic pain. It belongs to a class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). Duloxetine works by increasing the levels of serotonin and norepinephrine in the brain, which helps to improve mood and alleviate pain. Available in capsule form, Cymbalta is typically taken once or twice daily. Patients should follow their prescribed dosage and consult their healthcare provider regularly to manage any potential side effects or interactions with other medications.