Synjardy® Tablets for Type 2 Diabetes

Synjardy® is a prescription combination tablet with empagliflozin and metformin for adults with type 2 diabetes. This page explains how it works, who it suits, safety, dosing, and how to access Canadian pricing with US delivery.

What Synjardy® Is and How It Works

Synjardy® combines two proven diabetes medicines. Empagliflozin is an SGLT2 inhibitor that helps the kidneys remove excess glucose in urine. Metformin lowers glucose production in the liver and improves insulin sensitivity in the gut and muscle. Together they help reduce A1C when used with diet and exercise.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

Synjardy is not insulin and does not treat type 1 diabetes or diabetic ketoacidosis. The empagliflozin component may also help reduce heart and kidney risks in indicated patients, consistent with its approved uses. For a practical overview, see Synjardy® Uses.

Who Synjardy® Is For

Synjardy is indicated for adults with type 2 diabetes who need improved glycemic control. It can be used in those already taking metformin, empagliflozin, or both, when a single pill may simplify therapy. Learn more about the condition at Type 2 Diabetes.

It is not for patients with type 1 diabetes or for treatment of diabetic ketoacidosis. Do not use in severe kidney disease or dialysis. Initiation is generally avoided in significant renal impairment; renal function should be assessed before starting and periodically. Use caution in those with frequent urinary tract or genital yeast infections, dehydration, low blood pressure, or a history of lactic acidosis. Discuss use in pregnancy or breastfeeding with a clinician.

Dosage and Usage

Synjardy tablets are taken twice daily with meals to improve tolerability. Doses are individualized based on the current regimen and tolerance of metformin.

• Typical initiation uses the nearest metformin dose already tolerated plus empagliflozin 5 mg twice daily.
• For additional glucose lowering, the empagliflozin component may be increased to 12.5 mg twice daily as tolerated.
• The usual maximum daily dose is empagliflozin 25 mg and metformin 2000 mg, given in two divided doses.
• Titrate metformin in 500 mg steps at intervals that minimize gastrointestinal side effects.
• Assess renal function before starting and at least annually, or more often if at risk.

Many patients use the 12.5 mg/1000 mg strength after step-wise titration. For details on common strengths and how they are used, see Synjardy® 12.5 1000. Always follow the prescriber’s directions and the official label.

Strengths and Forms

Immediate-release tablets taken twice daily. Common combinations include:

• 5 mg empagliflozin / 500 mg metformin
• 5 mg empagliflozin / 850 mg metformin
• 5 mg empagliflozin / 1000 mg metformin
• 12.5 mg empagliflozin / 500 mg metformin
• 12.5 mg empagliflozin / 850 mg metformin
• 12.5 mg empagliflozin / 1000 mg metformin

Availability may vary based on pharmacy stock and prescriber recommendations.

Missed Dose and Timing

If a dose is missed, take it when remembered with food. If it is close to the next dose, skip the missed dose. Do not double doses. Maintain consistent meal timing to reduce stomach upset from metformin.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed to protect from moisture. For travel, carry medicine in your hand luggage with the original labeled container. Bring a copy of the prescription for screening. Keep a small backup supply in a separate bag. Avoid storing in a hot car or near sinks.

Benefits

• Two medicines in one tablet for convenient twice-daily dosing.
• Helps lower fasting and post-meal glucose when used with diet and exercise.
• Low intrinsic risk of hypoglycemia unless combined with insulin or a sulfonylurea.
• The SGLT2 component may promote modest weight reduction in some patients.
• Empagliflozin has proven heart and kidney outcomes benefits in approved populations.
• Canadian pricing with US shipping can reduce out-of-pocket costs.

Side Effects and Safety

• Genital yeast infections
• Urinary tract infections and increased urination
• Nausea, diarrhea, stomach upset, or gas
• Headache or fatigue
• Thirst or dehydration, especially in hot weather or with diuretics
• Reduced vitamin B12 levels with long-term metformin use

Serious but less common risks include lactic acidosis from metformin, diabetic ketoacidosis even with lower blood glucose, severe urinary infections, Fournier’s gangrene, low blood pressure, acute kidney injury, and allergic reactions. Hypoglycemia can occur when used with insulin or insulin secretagogues. Seek urgent care for severe abdominal pain, vomiting, breathing trouble, confusion, or signs of infection. Learn more in Synjardy® Side Effects.

Drug Interactions and Cautions

• Insulin and sulfonylureas increase hypoglycemia risk; monitoring is advised.
• Diuretics or ACE inhibitors may increase dehydration or low blood pressure risk.
• Alcohol increases the risk of lactic acidosis; limit intake.
• Iodinated contrast procedures may require holding metformin temporarily.
• Cationic drugs excreted by the kidney (for example, cimetidine) can affect metformin levels.
• Assess kidney function before starting and during treatment; dose plans may change in renal decline.

Review all prescriptions, OTC medicines, and supplements with the prescriber or pharmacist.

What to Expect Over Time

Blood glucose often improves within the first weeks as the medicine takes effect. A1C changes are typically assessed at about three months. Tolerability of metformin-related stomach symptoms often improves after gradual titration and regular meals. Results vary by diet, activity, baseline control, and other medicines.

Compare With Alternatives

Other options combine metformin with different agents or use a single SGLT2 inhibitor. Canagliflozin plus metformin is available as Invokamet®, which pairs a similar SGLT2 inhibitor with metformin in twice-daily tablets. A single-agent SGLT2 option is canagliflozin, offered as Invokana® 100mg 300mg. The best choice depends on prior therapy, tolerability, kidney function, and goals.

Pricing and Access

Canadian pricing with US shipping from Canada can lower the cash price compared to typical US retail. Check today’s cost and available strengths, then place an order with a valid prescription. Many patients compare Synjardy price options and choose multi-month fills to reduce per-tablet costs and shipping fees.

Start by reviewing in-stock strengths, then proceed to checkout. US delivery from Canada is available after prescription verification. Secure checkout protects payment details.

Availability and Substitutions

Supply may vary by strength. If a specific combination is not available, a prescriber may recommend a different strength or a therapeutic alternative. Pharmacists will not substitute without prescriber direction for this combination product.

Patient Suitability and Cost Saving Tips

Good candidates include adults with type 2 diabetes who tolerate metformin and have adequate kidney function. It may not suit those with advanced kidney disease, recurrent genital infections, heavy alcohol use, severe dehydration, or a history of lactic acidosis. Discuss risks in pregnancy or while breastfeeding.

Cost-saving ideas include 90-day refills, aligning doses to widely stocked strengths, and using reminders for timely refills. Explore broader diabetes options in Diabetes. Store tablets correctly and plan travel refills early.

Questions to Ask Your Clinician

• Which starting strength matches my current metformin dose?
• When should labs check kidney function and A1C after initiation?
• How should I adjust if I develop stomach upset?
• What signs of ketoacidosis or lactic acidosis require urgent care?
• Do I need changes to insulin or sulfonylurea doses?
• Is this medicine appropriate with my diuretic or blood pressure regimen?
• How long should I hold metformin around contrast imaging?

Authoritative Sources

• DailyMed: Synjardy
• Manufacturer: Synjardy
• Health Canada DPD: Synjardy

Ready to compare options and save? View strengths, check pricing, and start your order today for US delivery from Canada. This information is not a substitute for professional medical advice. Always follow your prescriber and the official label.