Synjardy Tablets and XR: Uses, Safety, Storage

Synjardy is a prescription diabetes medicine that combines empagliflozin and metformin in one tablet. It is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. This page explains how the medication works, practical handling, and common questions people research, including Synjardy price.

What Synjardy Is and How It Works

Synjardy contains two glucose-lowering medicines: empagliflozin (an SGLT2 inhibitor, meaning it helps the kidneys remove glucose in urine) and metformin (a biguanide that reduces glucose made by the liver and improves insulin sensitivity). Using them together can reduce pill burden compared with taking separate tablets, while still requiring routine monitoring and lifestyle measures. If you are reviewing different non-insulin combinations, browsing a hub like Combination Tablets can help you see what formats exist.

CanadianInsulin can coordinate prescription detail checks with your prescriber when required. Some patients explore Ships from Canada to US as part of cross-border fulfilment considerations, depending on eligibility and jurisdiction. The medication’s effects depend on kidney function, hydration, and other therapies, so clinicians often review lab results such as A1C (a 2–3 month average glucose measure) and eGFR (estimated glomerular filtration rate, a kidney filtration estimate) when choosing or continuing treatment.

Because empagliflozin increases glucose in urine, it may also increase urination and can contribute to dehydration in some people. Metformin commonly affects the gastrointestinal tract, especially when starting therapy or increasing dose. Both ingredients have important safety warnings that are best understood before starting or refilling, especially during acute illness, before major surgery, or when contrast dye studies are planned.

Who It’s For

Synjardy is indicated for adults with type 2 diabetes as an adjunct to diet and exercise to improve glycemic control. It is not used to treat type 1 diabetes, and it is not for treating diabetic ketoacidosis (DKA), which is a medical emergency. Clinicians typically consider current A1C, kidney function, cardiovascular and kidney comorbidities, and what other glucose-lowering medicines are already being taken.

People with significant kidney impairment may not be candidates, because both metformin and SGLT2 inhibitors have kidney-related limitations and precautions. Metformin is associated with a rare but serious risk of lactic acidosis (a buildup of lactic acid in the blood), and reduced kidney function can increase that risk. To learn how therapies are commonly grouped for this condition, the Type 2 Diabetes hub provides a browseable view of related options.

Other factors may also matter, including a history of recurrent genital yeast infections, frequent urinary tract infections, or episodes of low blood pressure or dehydration. Pregnancy and breastfeeding considerations should be reviewed with a clinician, since treatment goals and preferred medicines can change. If you have frequent “sick days,” drink little fluid, or take medicines that affect fluid balance, that context should be discussed before starting an SGLT2 inhibitor combination.

Dosage and Usage

Synjardy is available as immediate-release tablets and as an extended-release form (Synjardy XR). Immediate-release tablets are generally taken twice daily with meals to improve gastrointestinal tolerability from metformin. Extended-release tablets are commonly taken once daily with a meal, and they are designed to release metformin more slowly over time.

Starting doses and dose changes depend on prior treatment (for example, whether someone is already taking metformin or an SGLT2 inhibitor), kidney function, and tolerability. For Synjardy XR, tablets are typically swallowed whole; crushing or splitting may change the release pattern. If swallowing tablets is difficult, ask a pharmacist about administration options rather than altering the tablet.

If a dose is missed, the product labeling generally advises taking the next dose at the regular time rather than doubling up. Synjardy price varies by strength and formulation, so the specific tablet selected often reflects both clinical goals and practical considerations like pill burden. For broader background on treatment approaches, Diabetes Treatment offers an overview of commonly used medication classes and how they are combined.

Strengths and Forms

Synjardy is supplied as oral tablets that combine fixed amounts of empagliflozin with metformin hydrochloride (metformin HCl). Synjardy XR tablets provide extended-release metformin and are taken on a different schedule than immediate-release tablets. Availability of specific strengths can differ by country, wholesaler, and pharmacy inventory, so the tablet label should be checked each time a refill is received.

When comparing Synjardy price between options, confirm whether the product is immediate-release or XR, since the dosing schedule and tablet design are not interchangeable. For a plain-language review of diabetes medication categories, Common Diabetes Medications summarizes how different classes affect blood sugar and what people often monitor.

Storage and Travel Basics

Store Synjardy at controlled room temperature, away from excess heat and moisture, and keep the bottle tightly closed. Bathrooms and hot cars can expose tablets to humidity or heat that may affect stability. Keep medicines out of reach of children and pets, and store them in the original container so the pharmacy label and strength remain easy to verify.

For travel, pack tablets in a carry-on to reduce exposure to temperature extremes and to avoid lost baggage. If you use a pill organizer, retain the original labeled bottle for reference. Time zone changes can complicate daily routines, so it helps to plan medication timing with a clinician or pharmacist before long trips.

Quick tip: Take a photo of the tablet label and dosing instructions before travel.

Storage does not change based on Synjardy price, but it can affect whether tablets remain in good condition through the labeled expiration date. If tablets look unusual (crumbling, discoloration, strong odor), ask a pharmacist before taking further doses.

Side Effects and Safety

Common side effects can reflect either ingredient. Metformin often causes gastrointestinal symptoms such as nausea, diarrhea, abdominal discomfort, or a metallic taste, especially when therapy is started. Empagliflozin can increase urination, thirst, and the chance of genital yeast infections because more glucose is present in urine. Some people also notice mild weight changes, although outcomes vary and the medication is not indicated solely for weight management.

More serious risks require prompt clinical attention. SGLT2 inhibitors have been associated with ketoacidosis (dangerously high ketones), which can sometimes occur even if glucose is not extremely high; symptoms may include nausea, vomiting, abdominal pain, rapid breathing, or unusual fatigue. Metformin carries a warning for lactic acidosis, which may present with weakness, sleepiness, slow or irregular heartbeat, or feeling very cold. Severe urinary infections, allergic reactions, and rare but serious genital or perineal infections have also been reported with this drug class.

Why it matters: Early recognition of severe symptoms can reduce the risk of complications.

Risk can increase during dehydration, reduced food intake, heavy alcohol use, or acute illness. People taking insulin or sulfonylureas may have a higher risk of hypoglycemia (low blood sugar) when another glucose-lowering medicine is added, so clinicians often review symptoms and monitoring plans. For additional context on SGLT2-type side effects, Jardiance Side Effects provides a class-adjacent discussion that many patients find helpful when reviewing warning signs.

Drug Interactions and Cautions

Drug interaction risk depends on the full regimen and medical history. Medicines that lower blood sugar (such as insulin or sulfonylureas) can increase the chance of hypoglycemia when used together with Synjardy. Drugs that affect kidney function or fluid balance (including some diuretics and certain blood pressure medicines) may increase dizziness, dehydration, or changes in kidney labs, particularly during illness or low fluid intake.

Alcohol can raise the risk of metformin-associated lactic acidosis and can also affect glucose control. Iodinated contrast procedures for certain imaging studies may require special planning, because clinicians sometimes pause metformin-containing products around the time of contrast in appropriate patients. Always provide an up-to-date medication list, including over-the-counter products and supplements, before starting a new diabetes medicine.

If you have frequent genital infections, recurrent UTIs, low blood pressure episodes, or a history of pancreatitis, discuss that history explicitly. Clinicians may also review vitamin B12 status for long-term metformin use, since deficiency can occur over time. These considerations are part of selecting the safest combination for a given person, not a reason to self-adjust dosing.

Compare With Alternatives

Synjardy is one of several ways to combine metformin with another glucose-lowering class. An alternative approach is taking metformin and an SGLT2 inhibitor as separate tablets, which can offer flexibility if one ingredient needs to be adjusted or stopped. Another option is using an SGLT2 inhibitor alone (for those who cannot tolerate metformin) or pairing metformin with a different class such as a GLP-1 receptor agonist, DPP-4 inhibitor, or basal insulin, depending on individual goals and risks.

If you are comparing Synjardy price to related options, keep formulation differences in mind. Some people evaluate dapagliflozin-based therapy; product pages like Farxiga Dapagliflozin and Dapagliflozin can help clarify ingredient and class differences, while dosing and warnings remain label-specific. For a broader non-product comparison discussion, Invokana Vs Jardiance reviews common class questions patients raise with clinicians.

Combination products can simplify routines, but they also mean both ingredients are taken together every time. That can matter if side effects occur or kidney function changes. Browsing a hub like Non Insulin can help you see other classes that may be considered for similar treatment goals, without implying that any one option is best for everyone.

Pricing and Access

Access to Synjardy depends on prescription requirements, local regulations, and plan rules. Coverage can vary by insurer and formulary tier, and some plans may require prior authorization or documentation of previous therapies. Strength, immediate-release versus XR formulation, and monthly quantity can also change the overall out-of-pocket amount. Synjardy price without insurance may differ from insured pricing, and discount-card estimates can vary from pharmacy to pharmacy.

Generic availability for empagliflozin/metformin combination tablets can differ by jurisdiction and over time, so confirm with a pharmacist whether a therapeutically equivalent generic is available locally. When permitted, licensed partner pharmacies dispense the medication and arrange fulfilment. For people researching budget planning topics, Type 2 Diabetes Articles may offer practical context on medication classes, monitoring, and questions to bring to a visit.

If you are reviewing programs that may apply to prescription medicines, the Promotions page lists any site-wide informational program details when available. Documentation checks may be needed to confirm the prescriber, the intended formulation, and the exact strength on the prescription before a pharmacy can dispense. Keeping a current medication list and recent kidney function labs accessible can make those verifications easier to complete.

Authoritative Sources

For the most precise and up-to-date prescribing details, review official labeling and safety information.

Prescribing information and medication guide details are available via DailyMed drug label listings.

For evidence-based care standards and general medication selection frameworks, see the American Diabetes Association guidance.

When fulfilment is permitted, logistics may involve prompt, express, cold-chain shipping based on pharmacy protocols.

This content is for informational purposes only and is not a substitute for professional medical advice.