Renvela® (Sevelamer Carbonate) for High Phosphorus in CKD

Renvela® is sevelamer carbonate, a phosphate binder used to control high blood phosphorus in adults with chronic kidney disease on dialysis. CanadianInsulin supplies Renvela from Canada with US delivery from Canada and Canadian pricing. This page helps compare Renvela price and Renvela cost, including self-pay options for patients without insurance.

What Renvela® Is and How It Works

Renvela® is indicated to control serum phosphorus in adult patients with chronic kidney disease on dialysis. It belongs to a class of non-calcium, non-metal phosphate binders. Taken with meals, it binds dietary phosphate in the gut. The bound phosphate is not absorbed and is excreted in stool. By reducing phosphate absorption, Renvela lowers serum phosphorus over time.

The active ingredient, sevelamer carbonate, is not absorbed into the bloodstream. This local action helps limit systemic drug interactions. Diet remains important, and binder therapy complements phosphate restriction recommended by the dialysis team.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

Who Renvela® Is For

Renvela is for adults with chronic kidney disease on hemodialysis or peritoneal dialysis who need control of high phosphorus as part of a comprehensive plan. It is not for patients who have low phosphorus or those without clinical need for phosphate binding.

Patients with bowel obstruction must not use sevelamer. Extra caution is advised in those with swallowing disorders, severe gastrointestinal motility problems, or a history of major bowel surgery. The powder for oral suspension can be considered for patients who cannot swallow tablets, as directed by a prescriber.

Use during pregnancy or breastfeeding requires clinician guidance. Pediatric use and other special populations should follow official labeling and clinician judgment. For broader kidney health topics, see the Chronic Kidney Disease category.

Dosage and Usage

Dosing is individualized based on baseline serum phosphorus and clinical goals. Typical starting doses range from 800 mg to 1600 mg three times daily with meals. Tablets or powder doses are titrated at intervals, often every two weeks, to reach target phosphorus per lab results. Doses are divided across meals to match phosphate intake.

• Take with meals to bind dietary phosphate.
• Swallow tablets whole. Do not chew, crush, or split due to choking risk.
• For oral suspension packets, mix the contents with water and drink promptly per label directions. Rinse the cup and drink the rinse to receive the full dose.
• Adhere to diet and dialysis recommendations for best effect.

If switching from another phosphate binder, a prescriber will provide a safe conversion and titration plan.

Strengths and Forms

• Tablets: 800 mg film-coated.
• Oral suspension packets: 0.8 g (800 mg) and 2.4 g (2400 mg).

Availability may vary by pharmacy and supplier.

Missed Dose and Timing

If a dose is missed, the next dose should be taken with the next meal. Do not take extra doses to make up for a missed dose. Consistent dosing with meals supports stable phosphate control.

Storage and Travel Basics

Store tablets and packets at room temperature, typically 20–25°C (68–77°F). Protect from moisture and keep in original packaging until use. For travel, carry medicine in original, labeled containers, keep it dry, and pack enough for the full trip. Place medicine in a carry-on where possible to avoid temperature extremes.

Benefits

• Helps reduce high serum phosphorus when used with diet and dialysis.
• Non-absorbed polymer with local action in the gut.
• Calcium- and metal-free binder option.
• Available as tablets or oral suspension packets to support administration needs.

Lowering phosphorus supports bone health and reduces mineral accumulation in tissues associated with chronic kidney disease.

Side Effects and Safety

• Nausea or vomiting
• Abdominal pain or discomfort
• Constipation
• Diarrhea
• Dyspepsia, gas, or bloating

Serious gastrointestinal events have been reported, including bowel obstruction, ileus, perforation, and swallowing difficulties. Patients with significant GI risk need careful evaluation. Electrolytes, including calcium and bicarbonate, are monitored by the dialysis team. Report persistent severe abdominal symptoms or signs of bowel blockage to a clinician right away.

Drug Interactions and Cautions

Because sevelamer binds substances in the gut, it may reduce the absorption of some oral medicines. A prescriber or pharmacist may advise spacing other medicines away from sevelamer dosing. Examples include certain antibiotics (such as ciprofloxacin), thyroid hormone (levothyroxine), and some immunosuppressants (for example, cyclosporine or tacrolimus). Always consult a clinician or pharmacist before adding, stopping, or rescheduling any medicine.

Nutrient absorption can be affected. Dialysis teams often review vitamin D analogs and fat‑soluble vitamins. For background on acid-base topics relevant to kidney disease, explore Different Types Lactic Acidosis and Lactic Acidosis Signs Symptoms Causes Treatment.

What to Expect Over Time

With consistent use and dietary measures, serum phosphorus often begins to trend down over several weeks. Dose adjustments are common and guided by regular lab tests. Long-term therapy is typical while dialysis continues and hyperphosphatemia persists. The care team monitors tolerability and adjusts the binder regimen as needs change.

Compare With Alternatives

Other approved phosphate binders include calcium acetate, lanthanum carbonate, and sevelamer hydrochloride. Choice depends on lab values, calcium balance, pill burden, and individual tolerability. Clinicians may combine binders to meet targets while managing side effects.

Pricing and Access

Canadian pricing with US delivery from Canada can help many patients compare total costs. This page supports common searches such as Renvela price and Renvela cost. Patients also review Renvela 800 mg price, Renvela 800 mg tablets price, Renvela 800 mg powder price, and sevelamer carbonate 800 mg price when planning therapy budgets. Some compare Renvela 90 count price to larger supplies.

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US shipping is available from Canada after prescription verification. Many patients compare Renvela cost US shipping and Renvela price Canadian pricing when evaluating options. Ordering from Canada helps align self-pay price and out-of-pocket cost with treatment goals.

Availability and Substitutions

If a specific strength or form is temporarily unavailable, a prescriber may recommend an appropriate alternative phosphate binder or an equivalent dose using a different presentation. Pharmacy teams work with the prescriber to ensure continuity of care. No restock dates are promised; availability can change.

Patient Suitability and Cost Saving Tips

• Candidates include adults on dialysis with persistent hyperphosphatemia despite diet.
• Avoid use in bowel obstruction. Use caution in severe GI motility disorders.
• Consider oral suspension packets if swallowing tablets is difficult.
• Ask about multi-month supplies to reduce per-shipment costs.
• Align refills with other medicines to consolidate deliveries.
• Set up refill reminders so doses are not missed.

Care plans for chronic kidney disease often include volume management alongside phosphate control. Some patients may receive loop diuretics for fluid management, such as Salix®. In acute settings managed by clinicians, an option like Furosemide Injection may be used when appropriate. These therapies are not substitutes for phosphate binders and are used for different goals.

Questions to Ask Your Clinician

• Which binder form fits best: tablets or oral suspension packets?
• What is the initial dose and how will titration occur?
• How should other oral medicines be spaced around sevelamer?
• Do lab results suggest adding or reducing vitamin D or calcium?
• How often should phosphorus, calcium, and bicarbonate be checked?
• Which symptoms indicate a possible bowel obstruction or severe GI event?
• What diet changes most effectively lower phosphorus intake?

Authoritative Sources

• DailyMed: Renvela (sevelamer carbonate)
• FDA Drug Labeling Database
• Health Canada Drug Product Database

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