Nifedipine XR Extended-Release Tablets for Hypertension and Angina

Nifedipine XR is an extended-release calcium channel blocker used to treat high blood pressure and chronic angina. CanadianInsulin provides Canadian pricing with US delivery from Canada, so patients can access therapy shipped to the US. You can order online, compare Nifedipine XR 30 mg price, and review options even if paying without insurance.

What Nifedipine XR Is and How It Works

Nifedipine XR is a dihydropyridine calcium channel blocker. It relaxes vascular smooth muscle by inhibiting L-type calcium channels in arterial walls. This lowers peripheral resistance and helps reduce blood pressure. In chronic stable or vasospastic angina, it improves oxygen supply-demand balance by decreasing afterload and dilating coronary arteries. Nifedipine XR is not for immediate relief of chest pain or hypertensive emergencies.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

The extended-release design delivers medicine slowly across the day. XR, ER, XL, and prolonged-release terms are often used for long-acting nifedipine tablets. Patients should swallow the tablet whole, as crushing or chewing disrupts the release profile and can lead to dose dumping.

Who Nifedipine XR Is For

Nifedipine XR is prescribed for adults with essential hypertension and for chronic stable or vasospastic angina when a long-acting calcium channel blocker is appropriate. It may be used alone or with other antihypertensives. Prescribers consider comorbidities, current therapy, and overall cardiovascular risk before choosing dose and combination therapy.

People who should avoid or use caution include those with:

• Known hypersensitivity to nifedipine or formulation components
• Cardiogenic shock or severe hypotension
• Severe aortic stenosis (risk of profound hypotension)
• Unstable angina or within a short interval after myocardial infarction, unless clearly directed
• Significant hepatic impairment, which may require careful dose selection

Discuss pregnancy, breastfeeding, and any planned procedures with a clinician before starting or adjusting therapy.

Dosage and Usage

Follow the exact instructions on the prescription label. Widely published dosing for hypertension often begins at 30 mg or 60 mg once daily. Titration usually occurs in intervals of about 7 to 14 days, as tolerated and based on blood pressure response. Many patients maintain control within the 30 mg to 90 mg once-daily range.

• Take at the same time each day for consistent levels
• Swallow whole; do not crush, split, or chew the tablet
• Take with or without food, but try to keep timing and meals consistent
• A non-absorbed tablet shell may appear in stool; this is expected for some extended-release designs

The extended-release tablet is not a substitute for sublingual or immediate-release therapy for acute chest pain. Carry out any rescue plan for angina as directed by a clinician.

Strengths and Forms

Availability may vary by manufacturer and dispensing pharmacy. Common presentations include:

Descriptions sometimes use ER, XR, XL, or prolonged-release interchangeably to denote extended-release tablets. If a specific release technology is prescribed, dispensing should match the prescriber’s intent.

Missed Dose and Timing

If a dose is missed, take it when remembered the same day unless it is close to the next scheduled dose. If it is near the next dose, skip the missed dose and resume the regular schedule. Do not double doses. If multiple doses are missed, contact a clinician for guidance.

Storage and Travel Basics

Store your tablets at room temperature, typically 20°C to 25°C (68°F to 77°F). Protect from excessive moisture and light. Keep medication in the original packaging until use, and secure it out of reach of children and pets.

When you travel, keep your medication in carry-on luggage, with the prescription label visible. Avoid storing tablets in vehicles or other areas with extreme heat or cold. Carry a current medication list and prescriber contact information.

Benefits

Nifedipine XR offers steady, once-daily blood pressure control for many patients. This can help reduce cardiovascular risk when combined with diet, activity, and other therapies. For chronic stable or vasospastic angina, long-acting nifedipine can reduce the frequency of episodes and improve exercise tolerance. The extended-release design may lower the chance of peak-related side effects that can occur with shorter-acting forms.

To explore similar treatments and supportive options, review our High Blood Pressure category.

Side Effects and Safety

Common side effects include:

• Headache or lightheadedness
• Flushing or warmth
• Peripheral edema (ankle or leg swelling)
• Fatigue
• Nausea or stomach discomfort
• Palpitations
• Dizziness, especially when standing quickly
• Gingival overgrowth with long-term use

Serious effects are less common but can include severe hypotension, syncope, worsening angina, or rare myocardial ischemia, especially with abrupt changes in therapy. Liver enzyme elevations and hypersensitivity reactions have been reported. Patients should seek urgent care for chest pain that is new, persistent, or severe, or for signs of an allergic reaction.

Drug Interactions and Cautions

Nifedipine is metabolized by CYP3A4. Strong inhibitors can raise levels and increase side effects. Strong inducers can reduce efficacy. Always review new prescriptions, over-the-counter medicines, and supplements for interactions.

• Avoid grapefruit or grapefruit juice
• Strong CYP3A inhibitors (for example, certain azoles or macrolides) may increase exposure
• Strong CYP3A inducers (for example, rifampin, some anticonvulsants, St. John’s wort) may decrease exposure
• Use with other antihypertensives, nitrates, or diuretics can add to blood pressure lowering
• Monitor when combined with beta-blockers; see this overview on related therapy: Acebutolol Uses
• Limit alcohol, which can enhance dizziness or hypotension

People with significant hepatic impairment may need careful monitoring and dosing considerations. Do not stop long-acting nifedipine abruptly without clinical guidance.

What to Expect Over Time

Blood pressure often begins to improve after initiation and titration, with a steadier effect after consistent daily use. Angina frequency may decrease when the maintenance dose is reached. Clinicians typically reassess response and tolerability over the first several weeks and adjust the dose to maintain control. Long-term benefits depend on daily adherence and broader cardiovascular risk management.

Compare With Alternatives

Extended-release calcium channel blockers and other antihypertensives can be considered if nifedipine is not suitable. Options include once-daily diltiazem formulations such as Diltiazem XC, which has additional heart rate effects compared to dihydropyridines. Another common choice is amlodipine, marketed as Norvasc®, widely used for hypertension and angina with a long half-life and once-daily dosing.

Pricing and Access

See current Canadian pricing with US shipping for Nifedipine XR tablets. Patients often compare Nifedipine XR 30 mg price and Nifedipine XR 60 mg price before deciding. You can place your order online and have Nifedipine XR 30 mg ships to US addresses with prompt, express shipping from Canada. Many patients review Nifedipine XR cash price options and consider Nifedipine XR price without insurance when budgeting therapy. For occasional deals, visit our Promotions page.

Order Nifedipine XR online from Canada through our secure checkout. We use encrypted checkout to protect personal details.

Availability and Substitutions

If a specific strength is unavailable, a prescriber may recommend a different strength or an alternative long-acting calcium channel blocker. Do not split or crush XR tablets, and do not substitute immediate-release formulations without clinical direction.

In some cases, clinicians consider switching classes or combinations. Immediate-release Nifedipine has different release characteristics and is not interchangeable with XR dosing. Other once-daily diltiazem options such as Diltiazem HCl CD may be used when rate control is needed. Combination therapy can also be appropriate, such as an ACE inhibitor plus a calcium channel blocker like Perindopril Amlodipine.

Patient Suitability and Cost Saving Tips

Nifedipine XR suits many adults needing once-daily blood pressure control or long-acting management of chronic angina. It may not be appropriate in severe aortic stenosis, marked hypotension, or cardiogenic shock. Careful assessment is needed following a recent myocardial infarction or in unstable angina. Patients with liver impairment often require closer oversight. Discuss all health conditions, including pregnancy and breastfeeding.

• Ask about a 90-day supply to reduce refill trips and per-fill fees
• Use one pharmacy to support coordination and interaction checks
• Sign up for refill reminders to avoid gaps in therapy
• Keep a blood pressure log to help guide titration decisions
• Maintain consistent timing of daily doses and follow-up appointments

Questions to Ask Your Clinician

• What starting dose of Nifedipine XR is appropriate for my condition?
• How soon should we check blood pressure and side effects after initiation?
• Would an alternative such as diltiazem or amlodipine be better for my goals?
• Are there medicines, supplements, or foods I should avoid with nifedipine?
• What should I do if I notice ankle swelling or persistent dizziness?
• Is combination therapy reasonable if one medicine does not reach my targets?
• How long should I continue therapy once blood pressure improves?

Authoritative Sources

• FDA DailyMed: Nifedipine Extended-Release
• FDA DailyMed: Search Nifedipine ER/XR
• Health Canada Drug Product Database: Nifedipine

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