Uloric® (Febuxostat) Tablets for Gout

Febuxostat is a prescription tablet used to lower uric acid in adults with gout. This page explains what it is, how it works, and how to use it safely. At CanadianInsulin, orders are priced in Canada and ship to the US, with US delivery from Canada. Many people also compare Febuxostat 40 mg price without insurance when paying cash.

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What Uloric® Is and How It Works

Uloric® is the brand name for febuxostat, a xanthine oxidase inhibitor. It lowers serum uric acid by blocking xanthine oxidase, the enzyme that produces uric acid. Lowering uric acid helps prevent gout flares, dissolve urate crystal deposits over time, and reduce tophi formation. Febuxostat is intended for long-term control of hyperuricemia in gout. It is not a pain medicine for acute flares.

The US label includes a boxed warning about higher cardiovascular death risk compared with allopurinol in one outcomes trial. In the United States, reserve febuxostat for patients who have failed or cannot tolerate allopurinol. Discuss personal cardiovascular risk and history with a clinician before starting febuxostat.

At CanadianInsulin, US patients can access Canadian pricing. Your medicine ships from Canada to the US using prompt, express shipping after prescription verification.

Who Uloric® Is For

Febuxostat is indicated for adults with gout who need long-term uric acid lowering. It is not indicated for asymptomatic hyperuricemia and is not approved for hyperuricemia due to cancer therapies (tumor lysis). It can be continued during a gout flare, but separate treatment is needed for flare pain and inflammation.

Who should avoid it or use caution:

• History of severe hypersensitivity to febuxostat
• Concurrent use of azathioprine or mercaptopurine (contraindicated)
• Significant cardiovascular disease, recent heart attack, or stroke
• Serious liver disease or severe kidney impairment, unless a prescriber determines benefits outweigh risks

Explore more gout options under the Gout category.

Dosage and Usage

Typical dosing follows the approved label:

• Start: 40 mg by mouth once daily
• Assess serum uric acid after two weeks
• If uric acid remains above goal, increase to 80 mg once daily

Take with or without food. Do not crush or split unless advised. Prophylaxis against gout flares with an NSAID or colchicine is commonly recommended when beginning urate-lowering therapy and may continue for at least six months, per guideline and label practice. Always follow the prescriber’s instructions.

Strengths and Forms

Film-coated tablets in commonly available strengths:

• Febuxostat 40 mg tablets
• Febuxostat 80 mg tablets

Availability may vary by pharmacy and market.

Missed Dose and Timing

If a dose is missed, take it when remembered the same day. If it is close to the next dose, skip the missed dose and take the next dose at the regular time. Do not double up to make up for a missed dose.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and out of reach of children and pets. When traveling, carry the original labeled container and a copy of the prescription. Pack enough for the entire trip, plus a small buffer. Avoid excess heat and moisture.

Benefits

Label-aligned benefits include:

• Reduces serum uric acid to a target that helps prevent flares
• Once-daily dosing and no routine food restrictions
• Can be used without dose adjustment in mild to moderate kidney impairment
• Long-term management supports gradual tophus reduction when sustained targets are achieved

Side Effects and Safety

Common side effects can include:

• Abnormal liver tests
• Nausea
• Rash
• Joint pain or gout flares during initiation
• Diarrhea
• Headache

Serious risks are uncommon but important. The US label carries a boxed warning for higher rates of cardiovascular death versus allopurinol in one clinical trial. Other serious reactions include severe hypersensitivity, serious skin reactions (such as Stevens-Johnson syndrome), liver injury, and rare anaphylaxis. Seek emergency care for chest pain, shortness of breath, severe rash, facial swelling, or symptoms of liver injury such as dark urine or jaundice. Hypoglycemia is not an expected effect because febuxostat is not an insulin or sulfonylurea.

Drug Interactions and Cautions

Key interactions:

• Azathioprine and mercaptopurine: Contraindicated. Febuxostat can markedly raise exposure to these drugs.
• Theophylline: Use caution and monitor as advised.
• Warfarin: No clinically meaningful effect reported on INR in studies, but monitoring is standard with any medication changes.

Other considerations:

• Diuretics can raise uric acid and may affect gout control. Discuss thiazides such as Hydrochlorothiazide and loop diuretics such as Furosemide.
• Combination antihypertensives that include a diuretic, such as Hyzaar DS, may influence uric acid due to the HCTZ component.
• Liver function tests are often checked during therapy. Report symptoms of liver problems.

Always share a full medication list, including nonprescription products, with your prescriber and pharmacist.

What to Expect Over Time

Uric acid levels usually respond within the first few weeks, and goals are often reassessed at about two weeks and beyond. Early in therapy, flares may occur more often as urate stores shift. Prophylaxis is commonly used during initiation. With sustained uric acid control, flare frequency typically decreases over time, and tophi may shrink gradually. Long-term therapy is usually needed to maintain benefits.

Compare With Alternatives

Allopurinol is a first-line xanthine oxidase inhibitor and is often tried before febuxostat. See Allopurinol for details. Other options, when appropriate, may include uricosurics such as probenecid or biologic therapy such as pegloticase. Choice depends on history, comorbidities, and treatment goals determined by the prescriber.

Pricing and Access

Canadian pricing may offer meaningful cash-pay value compared with typical US cash rates. You can review the Febuxostat 40 mg price, the Febuxostat 40 mg tablet price, and the price of Febuxostat 40 mg versus 80 mg on this page. Many patients also search for Febuxostat 40 mg cost, the cost of Febuxostat 40, and Febuxostat 40 mg cash price. We list Canadian pricing clearly and provide US delivery from Canada after the prescription check.

Related search terms in some markets include Uloric 40 mg cost and Uloric tab 40mg cost. Febuxostat is also known by regional brands such as Atenurix 40 mg price, Feburic 40 mg price, Furic 40 mg price, Febustat 40 price, Febuget 40 tablet price, Febucip 40 mg tablet price, Febuday 40 mg tablet price, Zurig 40 mg price, and Urinorm 40 mg price. Names vary by country; availability and labeling differ. We dispense according to your valid prescription and local regulations.

If paying out of pocket, some compare the Febuxostat 40 mg out of pocket cost or Febuxostat 40 mg Canadian pricing with US options. You can view current pricing on this page and proceed to checkout when ready. Encrypted checkout protects your information.

Looking for broader savings ideas? See our editorial on strategies to lower prescription costs, including Canadian price comparisons, in Buy Glumetza From Canada. For kidney and heart considerations in chronic disease care, read Kerendia Kidney Health.

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Availability and Substitutions

Product availability can vary. If febuxostat is unavailable, a prescriber may recommend an alternative urate-lowering therapy based on history and lab results. We cannot provide restock dates, but we can help coordinate alternatives after your clinician advises.

Patient Suitability and Cost Saving Tips

Febuxostat may be considered when allopurinol is not tolerated or ineffective and when cardiovascular risks have been discussed. It may suit adults who prefer once-daily dosing and need urate control despite kidney impairment where dose changes are challenging. It is not for asymptomatic hyperuricemia.

Cost tips:

• Ask your prescriber about a 90-day supply to reduce per-tablet cost.
• Use refill reminders to avoid gaps that might trigger flares.
• Coordinate lab draws with follow-up visits to streamline care.
• Compare Febuxostat 40 mg price from Canada and Febuxostat 40 mg price with US shipping before placing your order.

Questions to Ask Your Clinician

• Is febuxostat appropriate given my history with allopurinol and my cardiovascular risk?
• What is my uric acid goal and when should we recheck labs?
• How long should I use flare prophylaxis during initiation?
• What signs of liver problems or allergic reactions should prompt immediate care?
• Will any of my current medicines interact with febuxostat?
• If I miss a dose, what should I do next?
• How long should I continue therapy after my uric acid reaches goal?

Authoritative Sources

US FDA Label for Uloric

DailyMed: Febuxostat

Health Canada Drug Product Database

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