Hyzaar® DS Tablets for Hypertension

Hyzaar DS is a prescription combination tablet used to lower high blood pressure. It contains losartan, an angiotensin II receptor blocker, and hydrochlorothiazide, a thiazide diuretic. Patients often compare costs for Hyzaar DS without insurance, and many value US delivery from Canada for convenience.

This page explains what the medicine is, how it works, and how clinicians typically use it. You will also find practical details on storage, safety, and access options.

What Hyzaar Is and How It Works

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

Hyzaar® combines two blood pressure agents. Losartan blocks the angiotensin II type 1 receptor, which helps relax blood vessels. Hydrochlorothiazide increases urine output by reducing salt reabsorption in the kidneys. Together, the treatment can reduce vascular resistance and blood volume, which may lower blood pressure.

It can be used alone or with other antihypertensive agents. This medicine is not a rescue drug for hypertensive emergencies.

Who It’s For

This therapy is indicated for adults with hypertension when combination treatment is appropriate. It may be considered when a single agent does not adequately control blood pressure.

Do not use it during pregnancy. Drugs that act directly on the renin–angiotensin system can injure or kill the developing fetus. Avoid use in anuria. Patients with severe kidney or liver impairment, gout, sulfonamide allergy, or volume depletion need careful review by a clinician before starting. Breastfeeding requires a risk–benefit discussion.

If you have diabetes taking aliskiren, this combination is generally not recommended. People with bilateral renal artery stenosis or a history of angioedema should also discuss risks with their prescriber.

Dosage and Usage

Clinicians usually prescribe one tablet once daily. It may be taken with or without food. Because the diuretic component can increase urination, many patients take it in the morning. Swallow tablets whole. Do not crush unless your clinician confirms it is appropriate.

Prescribers individualize dosing based on prior therapy and blood pressure response. Changes are guided by monitoring and tolerability. If you feel dizzy when standing, sit or lie down and speak with your clinician about volume status.

Limit alcohol intake, as it can enhance blood pressure lowering and dizziness. Maintain adequate hydration, especially in hot weather or with illness causing fluid losses.

Strengths and Forms

The double-strength presentation is a film-coated tablet. Availability can vary by pharmacy and jurisdiction.

Commonly referenced strength includes losartan hydrochlorothiazide 100/25 mg. Lower-dose combinations exist; your clinician will select based on your treatment plan.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is close to your next scheduled dose, skip the missed dose. Do not double up.

If vomiting, diarrhea, or heavy sweating occurs for more than a short period, contact your clinician. Excess fluid loss can affect blood pressure and electrolytes.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and away from moisture and direct light. Use child-resistant containers and keep out of reach of children and pets.

When traveling, carry your medication in original labeled packaging, and bring a copy of your prescription. Pack it in your carry-on bag and avoid leaving it in a hot car. If you cross time zones, keep your daily schedule consistent to maintain steady blood pressure control.

Benefits

This combination treats hypertension with a single daily tablet. Many patients prefer a two-in-one option rather than taking separate agents. The ARB component may be suitable for patients who experienced cough with an ACE inhibitor, though individual tolerability varies.

Effective blood pressure control can reduce the risk of stroke and heart attack over time when used as part of a comprehensive plan that includes diet, activity, and other prescribed therapies.

Side Effects and Safety

• Dizziness or lightheadedness, especially when standing
• Increased urination
• Fatigue or weakness
• Low blood pressure sensations
• Electrolyte changes, including low sodium or low potassium
• Photosensitivity or mild rash
• In rare cases, muscle cramps

Serious but less common risks can include kidney function changes, severe electrolyte disturbances, gout flare, eye symptoms (sudden vision changes), or angioedema. Stop the medicine and seek urgent care for facial or throat swelling, severe shortness of breath, or sudden eye pain or vision loss. This treatment is contraindicated in pregnancy; inform your clinician if you plan to become pregnant.

If you use insulin or sulfonylureas for diabetes, monitor for changes in glucose control. Diuretics can also affect lipid and uric acid levels; periodic labs may be recommended.

Drug Interactions and Cautions

Important interactions can occur with lithium, potassium supplements, potassium-sparing diuretics, and high-dose NSAIDs. Lithium levels may rise; NSAIDs can reduce the blood pressure effect and affect kidney function.

Other antihypertensive drugs, alcohol, and certain diuretics can increase lowering of blood pressure. Bile acid sequestrants can reduce hydrochlorothiazide absorption if taken simultaneously. If you have diabetes, using aliskiren with an ARB is generally avoided. Discuss all medications and supplements with your prescriber.

What to Expect Over Time

Blood pressure reduction typically develops over days to weeks as you take the medicine consistently. You may notice increased urination at first. Dizziness may occur when standing quickly, especially early in treatment or after dose adjustments.

Your clinician may check blood tests for electrolytes and kidney function at intervals. Consistent dosing, limited alcohol, and steady salt intake can support stable results. Keep appointments so your care team can assess response and tolerability.

Compare With Alternatives

Several other combination therapies treat hypertension. If an ARB–diuretic option is preferred but a different ARB suits your history, a prescriber may consider Diovan HCT or Valsartan HCT. Monotherapy options or ACE inhibitor combinations can also be appropriate depending on your clinical profile.

Pricing and Access

Canadian pharmacy pricing may lower your overall spend. For questions about Hyzaar DS price, compare options on this page, then add to cart to see current totals at checkout. We provide US shipping from Canada to support access for eligible patients.

You can review availability, see potential generic pathways, and compare combination therapies. If you are looking for additional ways to save, check our Promotions page for current offers. Encrypted checkout protects your information during payment.

Availability and Substitutions

If this exact product is unavailable, a prescriber may recommend a therapeutically appropriate alternative. Some patients may choose to buy losartan HCTZ 100/25 as a comparable generic formulation when suitable and prescribed.

Monotherapy with an ARB can be considered when diuresis is not needed. If your prescriber shifts therapy, they will usually reassess blood pressure and labs after the change.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults needing combination treatment to reach blood pressure goals. It may not be appropriate for pregnancy, severe kidney disease with anuria, or a history of angioedema. Patients with gout or significant electrolyte disturbances may need additional monitoring.

Ask your clinician about multi-month dispensing if stable on therapy. Schedule refills before you run out to avoid gaps. If your prescriber agrees, generic options may reduce out-of-pocket costs. For patients starting therapy, review your plan for lab checks and follow-up visits.

For monotherapy alternatives, discuss whether an ARB alone could fit your plan. If an ACE inhibitor is suitable, you may review options such as Lisinopril. If losartan alone is considered, see Cozaar for details. For background on hypertension care, see our Hypertension category and browse related Cardiovascular medicines. For additional education, read our Atenolol Guide and Altace and Heart Health. Articles on beta-blocker use, such as Bystolic Overview, can also help you discuss options with your prescriber.

Questions to Ask Your Clinician

• Is a two-drug combination appropriate for my blood pressure?
• How should I monitor for dizziness or low blood pressure?
• Do I need lab checks for electrolytes or kidney function?
• What should I do if I develop gout symptoms?
• Are there medicines or supplements I should avoid?
• Could a single-agent ARB or ACE inhibitor work for me?
• When should I take my dose each day?

Authoritative Sources

For complete prescribing details, see the manufacturer’s official labeling and government drug databases. Access the U.S. DailyMed entry for losartan and hydrochlorothiazide, which provides full prescribing information, black box warnings, and safety data: DailyMed official prescribing information for losartan/hydrochlorothiazide. For Canadian regulatory information and product listings, consult Health Canada’s Drug Product Database: Health Canada Drug Product Database listing. Manufacturer background information is available from the product sponsor’s site: Merck corporate information and product portfolio.

Ready when your prescription is verified? You can order Hyzaar DS online with prompt, express service and temperature-controlled handling when required.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.