Hyzaar® DS Tablets for High Blood Pressure

What Hyzaar® DS Is and How It Works

Hyzaar® DS is a prescription tablet that combines losartan potassium and hydrochlorothiazide to help lower blood pressure in adults. Through CanadianInsulin, it is ordered from Canada and ships to the US, giving you US delivery from Canada with Canadian pricing. Many patients compare the Hyzaar DS price without insurance to understand their out-of-pocket costs.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

Losartan belongs to the angiotensin II receptor blocker class. It helps blood vessels relax by blocking the action of angiotensin II. Hydrochlorothiazide is a thiazide diuretic that helps your body remove excess salt and water through the kidneys. Together, these medicines lower blood pressure more effectively than either one alone for many patients. Lowering blood pressure reduces the risk of long-term complications of hypertension when used as part of a comprehensive treatment plan.

Who Hyzaar® DS Is For

Hyzaar DS is used to treat hypertension in adults. Your clinician may consider this combination if blood pressure is not controlled with a single medicine, or if you are already taking losartan and hydrochlorothiazide separately. Treatment goals follow standard care for High Blood Pressure.

Do not use Hyzaar DS during pregnancy because drugs that act on the renin-angiotensin system can harm or end the pregnancy. Avoid it if you cannot pass urine, if you are allergic to any component, or if you are allergic to sulfonamide-derived drugs. Do not take aliskiren with Hyzaar DS if you have diabetes. People with severe kidney disease, severe liver impairment, gout, or low sodium or potassium may need special monitoring or a different approach. If you have type 2 diabetes and hypertension, your prescriber will balance benefits and risks across your full treatment plan; this topic is discussed in our article on Diabetes And Hypertension.

Dosage and Usage

Follow your prescriber’s directions on when and how to take Hyzaar DS. Tablets are taken by mouth once daily, with or without food. Many patients take the dose in the morning.

• When switching from losartan or hydrochlorothiazide alone, your clinician may choose a combination that matches your current doses.
• When adding combination therapy, clinicians often start with a lower-strength tablet and adjust after evaluating blood pressure response.
• Titration generally occurs after several weeks. Some patients reach a maximum recommended dose of 100 mg losartan and 25 mg hydrochlorothiazide once daily.

If you have low blood volume or are on high-dose diuretics, clinicians may correct this before starting combination therapy to reduce the risk of low blood pressure.

Strengths and Forms

Hyzaar DS is an oral tablet. Commonly published strengths for this combination include:

• Losartan 50 mg with hydrochlorothiazide 12.5 mg
• Losartan 100 mg with hydrochlorothiazide 25 mg

Availability may vary by pharmacy and country. The 100/25 mg strength is often referred to as Hyzaar DS. If you need a different strength, your prescriber may select another combination tablet or adjust individual components.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is close to your next dose, skip the missed tablet and take the next dose at the regular time. Do not take two doses at once. Keeping a daily routine or using reminders can help maintain steady blood pressure control.

Storage and Travel Basics

Store tablets at room temperature, typically 20 to 25°C (68 to 77°F). Keep the bottle tightly closed and protect it from moisture. Do not store in the bathroom. Keep out of reach of children and pets.

When traveling, carry your medication in your hand luggage with the original label. You can store your tablets with a copy of your prescription. If crossing borders, allow extra time for screening and carry only what you need for the trip plus a small buffer.

Benefits

Combination therapy simplifies treatment by delivering two blood pressure medicines in one tablet. This can reduce pill burden and support adherence. The losartan component helps relax blood vessels, while hydrochlorothiazide helps remove excess fluid. Many patients experience improved control compared with increasing a single agent alone, as guided by clinical practice and your prescriber’s judgment.

Side Effects and Safety

• Dizziness or lightheadedness, especially when standing up
• Headache
• Upper respiratory symptoms or cough
• Fatigue
• Nausea or stomach upset
• Increased urination
• Sun sensitivity or mild rash
• Back or muscle cramps
• Electrolyte changes, including low sodium or low potassium

Serious effects are less common but can occur. Seek medical attention for signs of angioedema, severe dizziness or fainting, sudden changes in vision or eye pain, very low urine output, or symptoms of severe electrolyte imbalance such as irregular heartbeat or confusion. Hydrochlorothiazide can rarely trigger acute angle-closure glaucoma. Losartan can raise potassium in some patients, particularly when combined with potassium supplements or potassium-sparing diuretics. Kidney function changes can occur, especially in dehydrated patients, those taking NSAIDs, or those with renal artery stenosis.

Drug Interactions and Cautions

Provide your clinician and pharmacist with an updated medication list. Important interactions and cautions include:

• Potassium supplements, salt substitutes containing potassium, or potassium-sparing diuretics may increase the risk of high potassium.
• NSAIDs such as ibuprofen or naproxen may reduce blood pressure effects and increase kidney risks, especially in older adults or those who are dehydrated.
• Lithium levels may rise, increasing toxicity risk; monitoring is often required.
• Other blood pressure medicines can enhance effects; clinicians adjust doses accordingly.
• Bile acid sequestrants such as cholestyramine can reduce hydrochlorothiazide absorption; spacing doses may be recommended.
• Antidiabetic medicines may require monitoring because hydrochlorothiazide can affect glucose control.
• Alcohol may increase dizziness or low blood pressure.

If you need broader support for cardiovascular therapy options, review our category for Heart Health Medications. For patients who also manage heart failure, our editorial overview of SGLT2 Inhibitors may help you discuss therapy combinations with your clinician.

What to Expect Over Time

Blood pressure may begin to improve within the first one to two weeks. Full effect is often seen after several weeks of consistent use. Your clinician will check blood pressure and, when appropriate, kidney function and electrolytes. Ongoing lifestyle measures such as sodium reduction, exercise as advised, and weight management strengthen results across time.

Compare With Alternatives

Some patients who need a lower diuretic dose may use the standard combination rather than the DS strength. Others may prefer a different ARB plus hydrochlorothiazide. Options include the standard Hyzaar® tablet and Micardis® Plus in strengths tailored by prescribers. Your clinician will match the medicine and dose to your treatment goals, tolerability, and lab results.

Pricing and Access

CanadianInsulin offers Canadian pricing with US delivery from Canada. Patients often look for Hyzaar DS price details to plan budgets. You can check Hyzaar DS tablets price from Canada, compare Hyzaar DS 100/25 mg Canadian pricing, and review Hyzaar DS 100/25 mg cost comparison alongside alternatives. Many patients search for Buy Hyzaar DS 100/25 mg tablets and Order Hyzaar DS 100/25 mg online to access this medication through our service. We also see interest in Hyzaar DS 100/25 mg US shipping and Hyzaar DS ships to US for cross-border access.

Some patients evaluate Losartan/HCTZ 100/25 mg tablets cost as part of a broader therapy review. Others check the Losartan 100 mg hydrochlorothiazide 25 mg price against comparable options. If you self-pay, you can review Hyzaar DS price with US shipping and Hyzaar DS cost from Canada in your cart before placing an order.

Your checkout is encrypted, and we verify prescriptions before dispensing. If you are comparing offers, see our current Promotions page for general savings information.

Availability and Substitutions

Availability can vary by strength and packaging. If the requested strength is not available, your prescriber may recommend a therapeutically appropriate alternative in the same class or a different dose combination. CanadianInsulin coordinates with licensed Canadian pharmacies to dispense the medication once your prescription is confirmed.

Patient Suitability and Cost Saving Tips

Hyzaar DS may suit adults who need combination therapy for hypertension and can take an ARB plus a thiazide diuretic. It is not appropriate during pregnancy or in people with anuria. Caution is advised in patients with kidney or liver impairment, a history of angioedema, low sodium or potassium, or gout.

• Ask your prescriber about multi-month supplies to reduce per-shipment costs.
• Set refill reminders so you can re-order in time for prompt, express shipping.
• If costs are a concern, discuss whether a different strength or related combination could meet your goals at a lower overall cost.
• Share your full medication list to avoid duplications and unnecessary expenses.

Questions to Ask Your Clinician

• Is the 100/25 mg DS strength the right starting point for me
• How often should I check blood pressure at home
• Which lab tests will you monitor for potassium and kidney function
• Should I take the tablet in the morning to limit nighttime urination
• Are any of my current medicines likely to interact with Hyzaar DS
• What signs should prompt me to contact your office between visits
• How long should we wait before adjusting the dose if needed

Authoritative Sources

• Merck Hyzaar Prescribing Information
• FDA DailyMed Search: Hyzaar
• Health Canada Drug Product Database

Start your Hyzaar DS request today for US delivery from Canada.