Allopurinol Tablets for Gout

Allopurinol® is a prescription xanthine oxidase inhibitor that lowers uric acid. It helps prevent gout flares and reduces the risk of uric acid kidney stones. Ships from Canada to US with transparent options for those paying without insurance.

What Allopurinol Is and How It Works

This allopurinol medication reduces production of uric acid by blocking xanthine oxidase. Lower serum urate helps prevent new crystal formation in joints and tissues. It also supports prevention of stone formation in people with uric acid nephrolithiasis.

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In gout, urate crystals trigger inflammation and pain. By reducing urate, this medicine helps control recurrent gout. It may also be used to reduce hyperuricemia associated with certain cancer treatments when clinically indicated. Learn more about gout in our condition guide for Gout and the biochemical context under Hyperuricemia.

Who It’s For

This treatment is indicated for chronic management of gout and for prevention of uric acid kidney stones in appropriate patients. It may be used to manage high uric acid related to tumor lysis risk per clinical direction. Explore our resources on Kidney Stones Uric Acid and Tumor Lysis Syndrome for background.

People with a history of severe hypersensitivity to this drug should not use it. The risk of serious skin reactions is higher in certain populations with the HLA-B*58:01 allele; screening may be considered based on clinical guidance. Those with significant kidney or liver impairment require careful assessment before use. Starting therapy during an acute gout flare is generally avoided; continue maintenance therapy if a flare occurs while already on treatment, per prescriber advice.

Dosage and Usage

Take tablets once daily or as directed, preferably after food to reduce stomach upset. Maintain good hydration unless your clinician advises otherwise. Dose is usually increased gradually to reach a target serum urate and reduce flare frequency.

Some patients stabilize at allopurinol 300 mg when directed. Do not change your dose or stop therapy without clinical guidance. If you experience a rash or signs of allergic reaction, seek medical attention promptly.

Early in therapy, gout flares can occur as existing urate deposits mobilize. Your clinician may recommend prophylaxis with a separate anti-inflammatory agent during the initial months. Avoid high-purine foods and limit alcohol, which can raise uric acid.

Strengths and Forms

Common presentations include 100 mg and 300 mg oral tablets. Availability may vary by manufacturer and dispensing pharmacy.

Missed Dose and Timing

If you miss a dose, take it when remembered unless it is close to the next dose. Skip the missed dose if timing is near your regular schedule and resume your normal routine. Do not double doses. Aim for consistent daily use, as long-term adherence supports urate control.

Storage and Travel Basics

Store tablets at room temperature in a dry place away from excess heat and moisture. Keep the bottle closed tightly and out of the reach of children and pets. Do not store medications in a bathroom where humidity fluctuates.

For travel, pack medicine in your carry-on with the original labeled container and a copy of your prescription. Allow extra time for security screening. Keep doses on your normal schedule when crossing time zones by consulting your clinician for a simple plan. Bring enough supply plus a small buffer in case of delays. Use a child-resistant cap and store away from direct sunlight.

Benefits

By lowering uric acid, the treatment helps reduce the frequency of gout flares over time. It can also limit tophus development and protect joints with ongoing use. For those with uric acid stones, reducing urate can decrease stone recurrence when paired with hydration and dietary measures.

The therapy is taken once daily for many patients, which can support adherence. As an allopurinol generic, it is widely accessible and typically less expensive than some brand-only options. If you manage gout alongside metabolic conditions, our article on the connection between gout and diabetes may be helpful: Gout and Diabetes. For context on kidney stones and weight-loss medicines, see this overview: Wegovy Kidney Stones.

Side Effects and Safety

• Rash or itching: stop and seek care if severe
• Gastrointestinal upset: nausea, diarrhea, abdominal discomfort
• Headache or drowsiness: usually mild
• Changes in liver enzymes: periodic monitoring may be advised
• Edema or malaise: uncommon

Serious but rare reactions include severe cutaneous adverse reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, bone marrow suppression, and severe hypersensitivity. Seek immediate care for widespread rash, fever, mucosal lesions, swollen lymph nodes, or facial swelling. The risk of rash appears higher with certain antibiotics. Report all medicines and supplements you take to your clinician.

Drug Interactions and Cautions

Important interactions include azathioprine and 6-mercaptopurine, which can require major dose reductions if co-administered under specialist oversight. Warfarin effects may be enhanced, and monitoring may be needed. Theophylline exposure can increase; antibiotic use with ampicillin or amoxicillin may raise rash risk. Diuretics and certain immunosuppressants such as cyclosporine may interact clinically.

Limit alcohol, which can increase urate production. Maintain hydration unless otherwise instructed. People with reduced kidney function need individualized dosing plans. If you develop any signs of hypersensitivity, stop the medicine and seek immediate medical evaluation.

What to Expect Over Time

Uric acid levels may begin to fall after starting therapy, but symptom improvement often takes time. Flares can occur early as stores of urate shift; adherence to your regimen helps reduce future flares. With consistent use, many patients experience fewer attacks and improved joint comfort over the long term. Keep follow-up appointments so your clinician can assess urate and adjust therapy.

Compare With Alternatives

Febuxostat is another xanthine oxidase inhibitor used for chronic urate lowering in adults when clinically appropriate. You can review its profile here: Febuxostat. In select cases, uricosuric therapy such as probenecid may be considered by clinicians. During acute flares, separate anti-inflammatory agents are often used short-term; see our category overview on Pain and Inflammation.

Pricing and Access

Canadian pricing can offer meaningful savings on maintenance therapies. You can review options and compare allopurinol cost before placing an order. We offer US shipping from Canada with clear checkout steps. People paying without insurance may find multi-month fills helpful for overall affordability.

Availability and Substitutions

This product is a widely supplied generic. Packaging and manufacturer can vary, but the active ingredient remains the same. If a specific presentation is temporarily unavailable, your prescriber may recommend an equivalent alternative. You can order allopurinol online once a valid prescription is provided. Our encrypted checkout helps protect your information.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with recurrent gout or chronic hyperuricemia who need urate lowering. It is not intended to start during a flare, and it is unsuitable for anyone with a prior severe hypersensitivity to this medicine. Discuss genetic risk factors such as HLA-B*58:01 with your clinician if relevant to your background.

To manage costs, consider 60- or 90-day supplies when appropriate. Set refill reminders so you do not miss doses. Consolidate orders with other maintenance therapies when feasible to reduce separate handling fees. Educational resources about comorbid conditions are available in our guides on Gout and Hyperuricemia.

Questions to Ask Your Clinician

• Best urate target: what level should I aim for
• Flare plan: what to do if symptoms return
• Prophylaxis: whether I need an anti-inflammatory early on
• Lab monitoring: how often should labs be checked
• Allergy risk: do I need genetic testing for safety
• Kidney function: how it affects dose planning
• Dietary guidance: hydration, purines, and alcohol moderation

Authoritative Sources

For full prescribing details and safety information, review FDA labeling on DailyMed: FDA DailyMed labeling for allopurinol tablets. Health Canada also lists product records and monographs: Health Canada Drug Product Database for allopurinol search. Manufacturer information for the injectable formulation is available from Hikma: Hikma Aloprim injection product page.

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.