Xultophy® Prefilled Pen for Type 2 Diabetes

This fixed-dose combination pairs insulin degludec with liraglutide to improve blood sugar in adults with type 2 diabetes. The overview below explains how the pen works, safe use, storage, and ways to access it, even without insurance.

What Xultophy Is and How It Works

Xultophy® combines an ultra–long-acting basal insulin (insulin degludec) with a GLP-1 receptor agonist (liraglutide) in one daily pen. It provides background insulin while enhancing glucose-dependent insulin secretion and slowing gastric emptying. Access is available with US delivery from Canada for eligible prescriptions. CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This insulin degludec liraglutide prefilled pen helps lower fasting and post-meal glucose when used with diet and exercise. The combination may reduce the number of separate injections compared with taking the two components individually. Use only as directed by a healthcare professional, and review the full prescribing information before starting.

Who It’s For

This treatment is indicated for adults with type 2 diabetes who need additional glycemic control despite diet, exercise, or prior therapy. It is not for type 1 diabetes or for treating diabetic ketoacidosis. People with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use this therapy. It is not recommended for pediatric patients, and it has not been studied in combination with another GLP-1 receptor agonist.

Those switching from a basal insulin or from a GLP-1 agent should follow the labeled initiation and titration guidance. See broader options in our Type 2 Diabetes collection.

Dosage and Usage

Inject once daily at the same time each day, with or without meals. Administer subcutaneously in the abdomen, thigh, or upper arm. Rotate injection sites within the same region to reduce skin changes. Never share a pen, even if a new needle is used. Do not mix with other insulins or use in an insulin pump.

The degludec liraglutide injection 100/3.6 is titrated based on fasting blood glucose and clinical response. Start and adjust only as described in the official label and by the prescriber. Use a new sterile pen needle for each injection, and confirm the dose on the dial before pressing the injection button fully.

Strengths and Forms

The product is supplied as a prefilled FlexTouch device. Common presentations include Xultophy 100/3.6 mg/mL 3 mL pens. Packs may include multiple pens depending on market availability. Actual supply configurations can vary by pharmacy and jurisdiction.

For a broader view of long-acting options and devices, browse our Insulin Products.

Missed Dose and Timing

If a dose is missed, take it when remembered during waking hours and then resume the usual once-daily schedule. Do not take extra doses or double up on the same day. If uncertain about timing, follow the official label or ask a healthcare professional. Monitor glucose more often after a missed dose.

Storage and Travel Basics

Unopened pens should be stored refrigerated and protected from light. Do not freeze, and discard any pen that has been frozen. After first use, keep the pen at room temperature or refrigerated as directed in the label, away from heat and direct sunlight. Keep the cap on between uses, and remove the needle after each injection. Keep out of reach of children.

For travel, carry pens in hand luggage with a copy of the prescription and supplies for needles and disposal. Use an insulated case to avoid temperature excursions. If your trip involves long flights or warm climates, plan ahead for storage. Pharmacies and couriers use temperature-controlled handling when required to protect medicine integrity.

Pen Handling and Sharps Disposal

The Xultophy FlexTouch pen is designed for single-patient use. Read the Device Instructions for Use in the package before the first injection. If uncertain, practice with a demo device in clinic or review an illustrated tutorial.

• Check the label and the dose counter
• Attach a new needle and remove both caps
• Prime the pen per label before the first daily injection
• Select the prescribed dose with the dial
• Inject into the recommended site and keep the needle in place briefly
• Remove the needle and dispose of it safely

See our stepwise overview in the Insulin Pen Guide. Dispose of used needles and pens in an FDA-cleared sharps container or a puncture-resistant household container per local regulations.

Benefits

This medicine offers convenience by combining basal insulin with a GLP-1 receptor agonist in one daily injection. It may reduce the number of separate injections and simplify titration with a single dose dial. The prefilled device helps streamline daily routines and supports adherence alongside structured diet and activity plans.

Side Effects and Safety

• Nausea or vomiting
• Diarrhea or constipation
• Decreased appetite
• Headache
• Injection site reactions
• Cold-like symptoms

Serious risks can include pancreatitis, gallbladder disease, acute kidney injury, severe gastrointestinal effects, and a risk of thyroid C-cell tumors associated with the GLP-1 component. Hypoglycemia can occur, especially if used with other glucose-lowering agents. Seek urgent care for symptoms of severe allergic reactions. For a deeper overview, read our Side Effects Guide and the official label.

Drug Interactions and Cautions

Agents that lower or raise blood glucose can change insulin needs, including corticosteroids, some diuretics, hormones, and certain antipsychotics. Alcohol may increase the risk of hypoglycemia or hyperglycemia. Beta-blockers can mask signs of low blood sugar. The GLP-1 component may slow gastric emptying, which can affect absorption of some oral medicines. Avoid combining with another GLP-1 receptor agonist unless instructed by a prescriber. Always review all medicines, vitamins, and supplements with a clinician.

What to Expect Over Time

Glucose patterns generally improve gradually as the dose is titrated according to response and safety. Some gastrointestinal effects may occur when starting and often lessen with continued use. Keep consistent meal timing and monitoring. Record fasting and pre-meal readings to support clinical adjustments. Follow scheduled follow-ups and laboratory assessments as recommended by the prescriber.

Compare With Alternatives

Another fixed-ratio option pairs glargine with lixisenatide in Soliqua® Pens. An alternative GLP-1/GIP agent for type 2 diabetes is the Mounjaro® KwikPen. Choice depends on prior therapy, glycemic goals, tolerability, and clinician guidance.

Pricing and Access

Canadian pricing reflects the dispensing pharmacy’s rates and may differ by pack size and supply. To review options and the Xultophy prefilled pen price, check the product page for current details. For eligible prescriptions, fulfillment supports US delivery from Canada. If looking to buy Xultophy Prefilled Pen, submit a valid prescription and complete the required intake.

Self-pay buyers often compare cash price with insurance copays to decide the most affordable route. Out of pocket expenses vary by quantity and needle needs. For periodic coupon events, visit our Promotions page. Encrypted checkout is used to protect payment information.

Availability and Substitutions

Supply can vary by manufacturer lots and pharmacy inventory. If a specific pack size is unavailable, a prescriber may recommend an appropriate alternative or an adjusted quantity of pens. Therapeutic substitutions, if needed, should be made only by the prescriber after review of clinical history and goals.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who require basal support plus incretin-based effects and prefer one daily pen. It may not be suitable for patients with certain thyroid tumors, active pancreatitis, or those requiring complex mealtime insulin regimens. Cost planning tips include multi-month fills when appropriate, aligning refill reminders with glucose log reviews, and combining pen orders with compatible needles to reduce separate fees. Explore broader options in Blood Sugar Control when discussing choices with a prescriber.

Questions to Ask Your Clinician

• Is this combination appropriate given current A1C and fasting readings?
• How should titration proceed if morning glucose remains above target?
• What symptoms suggest hypoglycemia, and how should they be treated?
• Are there medicines I take that could affect glucose or mask lows?
• What monitoring schedule and follow-up labs are recommended?
• How should I store pens during travel and hot weather?

Authoritative Sources

US Prescribing Information | DailyMed Monograph | Health Canada DPD

Ready to proceed? You can place your order with CanadianInsulin for US delivery from Canada, supported by cold-chain shipping when required by the product. This information is educational and not a substitute for medical advice; always consult a healthcare professional and the official label.